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11. 发明申请

US20230021254A1 RAPID INTRA-CELLULAR ASSAY AND USE OF THE SAME 有权
公开(公告)号：US20230021254A1
公开(公告)日：2023-01-19
申请号：US17776979
申请日：2021-01-13
申请人： Essenlix Corporation
发明人： Stephen Y. CHOU , Susan Y. SUN , Shengjian CAI , Wei DING
IPC分类号： G01N1/30 , G01N33/52 , G01N33/569 , G01N33/68 , G01N21/64
摘要： The present invention is to provide methods and devices that monitoring health and diagnosing a disease by directly measuring the biomarkers inside a cell (intra-cellular detection) rapidly and easily.

12. 发明申请

US20230017439A1 PRESERVATION OF NUCLEIC ACID SEQUENCES BY FIXING TISSUES IN BUFFERED FORMALIN PREPARED WITH ACID-DEPRIVED FORMALDEHYDE 有权
公开(公告)号：US20230017439A1
公开(公告)日：2023-01-19
申请号：US17757463
申请日：2020-12-15
申请人： ADDAX BIOSCIENCES S.R.L.
发明人： Giovanni Bussolati , Benedetta Bussolati , Nicolo' Bussolati
IPC分类号： G01N1/30 , A01N1/02
摘要： The invention relates to a method of preservation of nucleic acid sequences in histological tissues which comprises: treating a concentrated formaldehyde solution in water with basic ion-exchange resins; diluting the resulting acid-deprived formaldehyde solution with phosphate buffer pH 7.2-7.4 up to a concentration ranging between 2 and 4%; contacting the resulting acid-deprived formaldehyde solution obtained with the tissue samples; optionally embedding the samples fixed in paraffin.

13. 发明申请

US20230014647A1 METHODS AND SYSTEMS FOR SLIDE PROCESSING 有权
公开(公告)号：US20230014647A1
公开(公告)日：2023-01-19
申请号：US17940629
申请日：2022-09-08
申请人： ZOMEDICA INC.
发明人： William Eugene CAMPBELL
IPC分类号： G01N1/31 , G01N1/28 , G01N1/30
摘要： Various examples of systems and methods are provided for slide processing. In one example, among others, a system for processing microscope slides includes a slide positioner that can adjust a position of a slide and a slide treatment system that can dispense a micro stream of a fluid at a location on the slide when the slide is positioned beneath a jet nozzle of the slide treatment system. The system can include a slide sled that can align a smearing slide with a surface of the slide including a fluid sample is disposed, and support the smearing slide at a predefined angle with respect to the surface of the slide. In another example, a method includes obtaining a slide including a sample disposed on a surface, positioning the slide below to a jet nozzle, and dispensing a micro stream of a fluid onto the sample using the jet nozzle.

14. 发明申请

US20230010963A1 TREATMENT EFFICACY PREDICTION SYSTEMS AND METHODS 有权
公开(公告)号：US20230010963A1
公开(公告)日：2023-01-12
申请号：US17511125
申请日：2021-10-26
申请人： OUROTECH, INC.
发明人： Duleeka Nimantha Bandara RANATUNGA , Eleonora PEERANI , Gastón Agustín PRIMO , Zhi Yuan LIN , Sacha HU , Aston Martin CRAWLEY
IPC分类号： G06T7/00 , G01N1/30
摘要： Systems and methods for predicting a patient response to various agents and/or combinations of agents using ex vivo dosing and imaging are disclosed. In one example, a method of determining treatment efficacy includes analyzing a solid cell culture over time, e.g., first and second responses to a solid cell culture to respective treatments may be compared to determine a treatment efficacy of each treatment. Systems and methods for applying the treatments to the cell culture and analyzing the cell culture and efficacy are disclosed.

15. 发明申请

US20230009655A1 ANTIBODY-PROVIDING KIT, ANTIBODY-CONTAINING PATCH, METHOD AND DEVICE FOR IMMUNOASSAY USING THE SAME 有权
公开(公告)号：US20230009655A1
公开(公告)日：2023-01-12
申请号：US17842651
申请日：2022-06-16
申请人： NOUL CO., LTD.
发明人： Dong Young LEE , Chan Yang LIM , Kyung Hwan KIM
IPC分类号： G01N1/31 , G01N1/30 , C12Q1/6844 , C12Q1/6848 , G01N33/50 , G01N21/77 , G01N33/558 , B01L3/00 , G01N15/06 , G01N33/52 , G01N33/574 , G01N15/14 , G01N33/49 , G01N33/60 , C12Q1/686 , C07K16/30 , C12Q1/70 , G01N33/483 , G06T7/00 , G01N33/53 , G01N33/533
摘要： The present disclosure relates to an immunoassay method for performing immunoassay by using a patch that contains antibodies. An immunoassay method according to an aspect of the present disclosure performs diagnosis by detecting a target protein from a sample to be diagnosed by using a patch which includes a mesh structural body forming micro-cavities and is configured to contain a liquid substance in the micro-cavities, and includes placing the sample to be diagnosed in a reaction region, and providing an antibodies that react specifically with a target protein to the reaction region by using a patch that contains the antibodies.

16. 发明授权

US11549870B2 Cell preserving solution 有权
公开(公告)号：US11549870B2
公开(公告)日：2023-01-10
申请号：US16023772
申请日：2018-06-29
申请人： DNA Genotek, INC.
发明人： Youssef Biadillah , Stephen D. Andrews
IPC分类号： G01N1/30 , A61B10/00 , B01L3/00 , G01N1/10 , G01N1/00
摘要： The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.

17. 发明申请

US20230005133A1 AUTOMATED PLACENTAL MEASUREMENT 有权
公开(公告)号：US20230005133A1
公开(公告)日：2023-01-05
申请号：US17356699
申请日：2021-06-24
申请人： Carolyn M Salafia
发明人： Carolyn M Salafia
IPC分类号： G06T7/00 , G01N1/30 , G16H50/20 , G16H50/30 , G16H30/40
摘要： The present invention teaches a method of predicting the potential for manifestation of various medical conditions by analyzing human placenta comprising and including determining the need for early monitoring, intervention or potential treatment for medical conditions likely to manifest as a child grows older and investigating the potential for various medical conditions. The method includes selecting and identifying a sample of the placenta to analyze by algorithms and preparing the sample to be analyzed. The sample is captured by obtaining a three-dimensional digital image of the chorionic surface of the sample by a selected capturing device. The physician corrects for errors in the digital image and loads the data into a computer for analysis. The digital image data is analyzed using algorithms to determine the vascular structure of the placenta, which is interpreted and analyzed to determine the potential for manifestation of various medical conditions.

18. 发明授权

US11543408B2 Device and system for analyzing a sample, particularly blood, as well as methods of using the same 有权
公开(公告)号：US11543408B2
公开(公告)日：2023-01-03
申请号：US16653936
申请日：2019-10-15
申请人： Essenlix Corporation
发明人： Stephen Y. Chou , Wei Ding
IPC分类号： G01N1/00 , G01N33/543 , G01N1/28 , G16B25/00 , G16B50/00 , G16H80/00 , B01L3/00 , G01N1/30 , G01N33/50
摘要： The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.

19. 发明授权

US11536632B2 Biological collection system 有权
公开(公告)号：US11536632B2
公开(公告)日：2022-12-27
申请号：US17510003
申请日：2021-10-25
申请人： DNA GENOTEK, INC.
发明人： Youssef Biadillah , Stephen D. Andrews
IPC分类号： G01N1/30 , A61B10/00 , B01L3/00 , G01N1/10 , G01N1/00
摘要： The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.

20. 发明申请

US20220404359A1 DEVICE FOR EVALUATING NEUROVIRULENCE OF MUMPS VIRUS 有权
公开(公告)号：US20220404359A1
公开(公告)日：2022-12-22
申请号：US17755664
申请日：2020-11-03
申请人： SHANGHAI KING-CELL BIOTECHNOLOGY CO. LTD. , BEIJING CELL-FUSION BIOTECHNOLOGY CO., LTD.
发明人： Dayong TIAN , Juncheng RUAN , Zhenfang FU , Yajing ZHANG , Yulin GU , Qi AN
IPC分类号： G01N33/569 , G01N1/28 , G01N1/36 , G01N1/30
摘要： A device for evaluating the neurovirulence of a mumps virus, comprising: (I) a virus inoculation module, which is used for performing virus inoculation of a mumps virus to be evaluated on the lateral ventricle of a rat; (II) a processing module, which is used for performing vibration slicing on the fixed rat brain; (III) an imaging module, which is used for scanning and imaging the obtained rat brain slices; and (IV) an analysis module, which is used in the obtained imaging for calculating a neurovirulence index by using a formula I: the neurovirulence index=S1/S0×100 (formula I) according to the cross-sectional area S1 of a cavity formed by hydrocephalus in the longitudinal section of the rat brain and the total cross-sectional area S0 of the rat brain. Multiple results show that the results are stable, repeatability is high, and a wild strain may be distinguished from a vaccine strain. In addition, relative to a current monkey body neurovirulence model, animal cost and difficulty of operation are greatly reduced.

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