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31. 发明申请

US20060171582A1 Systems and methods for viewing three dimensional virtual slides 有权
标题翻译：用于查看三维虚拟幻灯片的系统和方法
公开(公告)号：US20060171582A1
公开(公告)日：2006-08-03
申请号：US11341097
申请日：2006-01-27
申请人： Ole Eichhorn
发明人： Ole Eichhorn
IPC分类号： G06K9/00 , G06T15/00
CPC分类号： G06T15/00 , G02B21/34 , G02B21/367 , G06T5/50 , G06T15/08 , G06T15/10 , G06T2207/20212 , G06T2207/20224 , G06T2207/30024 , G06T2207/30056
摘要： Systems and methods for retrieving, manipulating, and viewing 3D image objects from 3D virtual microscope slide images are provided. An image library module provides access to the imagery data in a 3D virtual slide and constructs 3D image objects that are coextensive with the 3D virtual slide or a 3D sub-portion thereof. From within the 3D image object, cross layer planar views spanning various depths of the 3D virtual slide are constructed as well as 3D prisms and other shaped image areas. The image library module allows a 3D image object to be sliced into horizontal and vertical views, skewed cross layer views and regular and irregular shaped 3D image areas for viewing by a user.
摘要翻译：提供了从3D虚拟显微镜幻灯片图像检索，操作和查看3D图像对象的系统和方法。图像库模块提供对3D虚拟幻灯片中的图像数据的访问，并且构造与3D虚拟幻灯片或其3D子部分共同延伸的3D图像对象。从3D图像对象中，构建跨越3D虚拟幻灯片的各种深度的跨层平面视图以及3D棱镜和其他形状的图像区域。图像库模块允许3D图像对象被切割成水平和垂直视图，倾斜的交叉层视图和规则和不规则形状的3D图像区域以供用户观看。

32. 发明授权

US07035478B2 System and method for data management in a linear-array-based microscope slide scanner 有权
标题翻译：基于线性阵列的显微镜幻灯片扫描仪的数据管理系统和方法
公开(公告)号：US07035478B2
公开(公告)日：2006-04-25
申请号：US10371586
申请日：2003-02-21
申请人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
发明人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
IPC分类号： G06K9/36
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： A data management system and method for processing, storing, and viewing the extremely large imagery data that is rapidly produced by a linear-array-based microscope slide scanner is provided. The system receives, processes, and stores imagery data produced by the linear-array-based microscope slide scanner at approximately 3 GB per minute. The data are received as a series of overlapping image stripes and combined into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The data management system enables imagery data compression while scanning and capturing new image stripes. This advantageously eliminates the overhead associated with storing uncompressed image stripes. The image compression also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The data management system efficiently converts image stripes into a high quality virtual slide that allows rapid panning and zooming by image viewing software in accordance with the individually addressed regions. The virtual slide also allows efficient processing by an algorithm framework. The data management system is costs effective and scaleable, employs standard image file formats and supports the use of virtual slides in desirable applications such as telemedicine, telepathology, microscopy education, and the analysis of high value specimens such as tissue arrays.
摘要翻译：提供了一种用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速产生的极大图像数据的数据管理系统和方法。系统以每分钟3 GB的速度接收，处理和存储由基于线性阵列的显微镜幻灯片扫描仪生成的图像数据。数据被接收为一系列重叠的图像条纹并组合成无缝和连续的基线图像。基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。数据管理系统在扫描和捕获新的图像条纹时可以进行图像数据压缩。这有利地消除了与存储未压缩图像条纹相关联的开销。图像压缩还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。数据管理系统有效地将图像条纹转换成高质量的虚拟幻灯片，其允许通过图像查看软件根据单独寻址的区域进行快速平移和缩放。虚拟幻灯片还允许通过算法框架进行有效的处理。数据管理系统具有成本效益和可扩展性，采用标准图像文件格式，并支持虚拟幻灯片在远程医疗，远程病理学，显微镜教育等理想应用中的应用，以及组织阵列等高价值标本的分析。

33. 发明申请

US20120113242A1 Data Management in a Linear-Array-Based Microscope Slide Scanner 有权
标题翻译：基于线性阵列的显微镜幻灯片扫描仪中的数据管理
公开(公告)号：US20120113242A1
公开(公告)日：2012-05-10
申请号：US13347077
申请日：2012-01-10
申请人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
发明人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays.
摘要翻译：提供了用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速生成的超大图像数据的系统和方法。该系统接收，处理和存储由线性扫描仪产生的图像数据作为一系列重叠的图像条纹，并将数据组合成无缝和连续的基线图像。基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。该系统能够在扫描和捕获新的图像条纹时消除与存储未压缩图像条纹相关的开销的动态图像数据压缩。该系统还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。该系统有助于虚拟幻灯片在诸如远程医疗，远程病理学，显微镜教育等应用中的使用，以及对组织阵列等高价值标本的分析。

34. 发明授权

US08116547B2 Signal to noise ratio in digital pathology image analysis 有权
标题翻译：数字病理图像分析中的信噪比
公开(公告)号：US08116547B2
公开(公告)日：2012-02-14
申请号：US13259562
申请日：2010-12-10
申请人： Allen Olson , Ole Eichhorn
发明人： Allen Olson , Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G06T2207/10056 , G06T2207/30024
摘要： A digital slide analysis system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slide images. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. Prior to the application of selected routine, the system employs a digital pre-processing module to create a metadata mask that reduces undesirable image data such that the image data processed by the selected routine has an improved signal to noise ratio. The pre-processing module uses a classifier that may be implemented as a pattern recognition module, for example. Undesirable image data is therefore excluded from the image data that is processed by the digital pathology image processing and analysis routine, which significantly improves the digital pathology image analysis.
摘要翻译：数字幻灯片分析系统包括维护或者可以访问多个图像处理和分析程序的算法服务器。算法服务器还可以访问多个数字幻灯片图像。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。在应用所选程序之前，系统采用数字预处理模块来创建一个减少不需要的图像数据的元数据掩码，使得由所选程序处理的图像数据具有改善的信噪比。预处理模块使用例如可以被实现为模式识别模块的分类器。因此，不希望的图像数据被排除在由数字病理图像处理和分析程序处理的图像数据中，这显着地改善了数字病理图像分析。

35. 发明授权

US08059336B2 Rapid microscope scanner for volume image acquisition 有权
标题翻译：用于体积图像采集的快速显微镜扫描仪
公开(公告)号：US08059336B2
公开(公告)日：2011-11-15
申请号：US12114611
申请日：2008-05-02
申请人： Nikolai Ptitsyn , Ole Eichhorn
发明人： Nikolai Ptitsyn , Ole Eichhorn
IPC分类号： G02B21/00
CPC分类号： G01B9/04 , G02B21/367 , G06K9/00134
摘要： Apparatus for and method of rapid three dimensional scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a tilted sensor synchronized with a positioning stage. The system also provides a method for interpolating tilted image layers into a orthogonal tree dimensional array or into its two dimensional projection as well as a method for composing the volume strips obtained from successive scans of the sample into a single continuous digital image or volume.
摘要翻译：使用与定位台同步的倾斜传感器，对整个显微镜样品或显微镜样品的大部分进行快速三维扫描和数字化的装置和方法。该系统还提供了一种用于将倾斜图像层内插到正交树尺寸阵列或其二维投影中的方法，以及用于组合从样本连续扫描到单个连续数字图像或体积中获得的体积条带的方法。

36. 发明授权

US08010555B2 System and method for managing images over a network 有权
标题翻译：通过网络管理图像的系统和方法
公开(公告)号：US08010555B2
公开(公告)日：2011-08-30
申请号：US11770499
申请日：2007-06-28
申请人： Ole Eichhorn
发明人： Ole Eichhorn
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30277 , G06F17/30106 , G06F17/3028 , Y10S707/915 , Y10S707/966
摘要： Images created by one or more image acquisition devices are initially stored in remote data bases at one or more remote or satellite locations and copies of the images are subsequently transferred to a central server at a central storage location over a network and stored in a central data base. A common catalog listing local image files stored at the central data base and remote image files stored at one or more remote data bases is stored at the central location and is accessed by users to search for images. User requests for images associated with local image files result in transfer of the requested images by the central server to the user. User requests for images associated with remote image files are relayed by the central server to the associated remote location, and the requested images are then relayed to the user from the remote location via the central server.
摘要翻译：由一个或多个图像采集设备创建的图像最初存储在一个或多个远程或卫星位置的远程数据库中，并且图像的副本随后通过网络传输到中央存储位置的中央服务器并存储在中央数据基础。列出存储在中央数据库的本地图像文件和存储在一个或多个远程数据库中的远程图像文件的公共目录存储在中央位置，并被用户访问以搜索图像。对与本地图像文件相关联的图像的用户请求导致中央服务器向用户传送所请求的图像。对与远程图像文件相关联的图像的用户请求由中央服务器中继到相关联的远程位置，然后所请求的图像经由中央服务器从远程位置中继给用户。

37. 发明申请

US20100321387A1 Viewing Three Dimensional Digital Slides 有权
标题翻译：查看三维数字幻灯片
公开(公告)号：US20100321387A1
公开(公告)日：2010-12-23
申请号：US12871676
申请日：2010-08-30
申请人： Ole Eichhorn
发明人： Ole Eichhorn
IPC分类号： G06T17/00
CPC分类号： G06T15/00 , G02B21/34 , G02B21/367 , G06T5/50 , G06T15/08 , G06T15/10 , G06T2207/20212 , G06T2207/20224 , G06T2207/30024 , G06T2207/30056
摘要： Systems and methods for retrieving, manipulating, and viewing 3D image objects from 3D virtual microscope slide images (“3D digital slides”) are provided. An image library module provides access to the imagery data in a 3D digital slide and constructs 3D image objects that are coextensive with the 3D digital slide or a 3D sub-portion thereof. From within the 3D image object, cross layer planar views spanning various depths of the 3D digital slide are constructed as well as 3D prisms and other shaped image areas. The image library module allows a 3D image object to be sliced into horizontal and vertical views, skewed cross layer views and regular and irregular shaped 3D image areas for viewing by a user.
摘要翻译：提供了从3D虚拟显微镜幻灯片图像（“3D数字幻灯片”）中检索，操纵和查看3D图像对象的系统和方法。图像库模块提供对3D数字幻灯片中的图像数据的访问，并且构建与3D数字幻灯片或其3D子部分共同延伸的3D图像对象。从3D图像对象中，构建跨越3D数字幻灯片的各种深度的跨层平面视图以及3D棱镜和其他形状图像区域。图像库模块允许3D图像对象被切割成水平和垂直视图，倾斜的交叉层视图和规则和不规则形状的3D图像区域以供用户观看。

38. 发明申请

US20100260407A1 Viewing Digital Slides 审中-公开
标题翻译：观看数字幻灯片
公开(公告)号：US20100260407A1
公开(公告)日：2010-10-14
申请号：US12814611
申请日：2010-06-14
申请人： Ole Eichhorn , Anne Brumme
发明人： Ole Eichhorn , Anne Brumme
IPC分类号： G06K9/00
CPC分类号： H04L65/403 , G02B21/26 , G02B21/32 , G06F3/1454 , G06F16/9577 , G06F17/241 , G06F19/321 , G06Q50/24
摘要： Virtual slide image data and corresponding information are stored in a data storage area on a virtual slide image server. A client viewer requests image data at a particular resolution. The image server obtains corresponding image data from the data storage area at a resolution nearest to the requested resolution. The image data is then sent to the client viewer. The client viewer receives the image data and scales the image data to the requested resolution prior to displaying the image data.
摘要翻译：虚拟幻灯片图像数据和相应的信息存储在虚拟幻灯片服务器上的数据存储区域中。客户端查看器以特定分辨率请求图像数据。图像服务器以最接近请求的分辨率的分辨率从数据存储区域获取相应的图像数据。然后将图像数据发送到客户端查看器。在显示图像数据之前，客户端查看器接收图像数据并将图像数据缩放到所请求的分辨率。

39. 发明申请

US20090208134A1 Image Processing and Analysis Framework 有权
标题翻译：图像处理与分析框架
公开(公告)号：US20090208134A1
公开(公告)日：2009-08-20
申请号：US12428394
申请日：2009-04-22
申请人： Ole Eichhorn , Allen Olson
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06K9/36
CPC分类号： G06K9/46 , G06T1/00
摘要： A system and method for processing and analyzing virtual microscopy digital images (“digital slides”) is provided. The system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slides. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. The digital slide can be accessed locally or remotely across a network. Similarly, the image processing routines can be obtained from local storage or across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely obtained routines. Access to image processing and analysis may be restricted through a monitor process that authenticates requests to process or view digital slides. Variations in restrictions to images provide a rich diversity in access levels that allow sharing of digital slides and demonstrations of image processing algorithms.
摘要翻译：提供了一种用于处理和分析虚拟显微数字图像（“数字幻灯片”）的系统和方法。该系统包括维护或访问多个图像处理和分析例程的算法服务器。算法服务器还可以访问多个数字幻灯片。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。数字幻灯片可以在本地或通过网络远程访问。类似地，图像处理例程可以从本地存储器或网络或两者获得。有利地，某些公共子例程可以被本地存储以包含在其他本地或远程获得的例程中。对图像处理和分析的访问可以通过认证要处理或查看数字幻灯片的监视进程来限制。对图像限制的变化提供了访问级别丰富的多样性，允许共享数字幻灯片和图像处理算法的演示。

40. 发明授权

US07502519B2 Systems and methods for image pattern recognition 有权
标题翻译：图像模式识别的系统和方法
公开(公告)号：US07502519B2
公开(公告)日：2009-03-10
申请号：US11836713
申请日：2007-08-09
申请人： Ole Eichhorn , Dirk G. Soenksen
发明人： Ole Eichhorn , Dirk G. Soenksen
IPC分类号： G06K9/36 , G06K9/00
CPC分类号： G06K9/6218 , G06K9/00147 , G06T9/008 , G06T9/40 , H04N19/94 , H04N19/96
摘要： Systems and methods for image pattern recognition comprise digital image capture and encoding using vector quantization (“VQ”) of the image. A vocabulary of vectors is built by segmenting images into kernels and creating vectors corresponding to each kernel. Images are encoded by creating a vector index file having indices that point to the vectors stored in the vocabulary. The vector index file can be used to reconstruct an image by looking up vectors stored in the vocabulary. Pattern recognition of candidate regions of images can be accomplished by correlating image vectors to a pre-trained vocabulary of vector sets comprising vectors that correlate with particular image characteristics. In virtual microscopy, the systems and methods are suitable for rare-event finding, such as detection of micrometastasis clusters, tissue identification, such as locating regions of analysis for immunohistochemical assays, and rapid screening of tissue samples, such as histology sections arranged as tissue microarrays (TMAs).
摘要翻译：用于图像模式识别的系统和方法包括使用图像的矢量量化（“VQ”）的数字图像捕获和编码。通过将图像分割为内核并创建与每个内核相对应的向量来构建向量的词汇表。通过创建具有指向存储在词汇表中的向量的索引的向量索引文件对图像进行编码。向量索引文件可用于通过查找存储在词汇表中的向量来重建图像。可以通过将图像向量与包括与特定图像特征相关的向量的预先训练的矢量集合的词汇相关联来实现图像候选区域的模式识别。在虚拟显微镜中，系统和方法适用于罕见事件发现，例如检测微转移簇，组织鉴定，例如免疫组织化学测定的分析区域以及组织样品的快速筛选，例如排列成组织的组织切片微阵列（TMA）。

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