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31. 发明授权

US10634688B2 Assay and method for identifying compounds that reduce SIL1 expression or activity 有权
公开(公告)号：US10634688B2
公开(公告)日：2020-04-28
申请号：US14773115
申请日：2014-03-06
申请人： Macquarie University
发明人： Lars Matthias Ittner , Janet Van Eersel
IPC分类号： G01N33/68 , C12Q1/6883
CPC分类号： G01N33/6896 , C12Q1/6883 , C12Q2600/136 , G01N2333/4709 , G01N2500/02
摘要： The invention relates to methods and assays for identifying compounds as candidates in the development of a drug for the treatment of various diseases including those associated with pathological Tau. The invention also relates to methods and assays for identifying compounds for the treatment of various diseases including those associated with pathological Tau. The invention also relates to cell lines and constructs for use in an assay of the invention. The methods and assays identify a compound as useful in the treatment of a tauopathy if said compound modulates Sil1 expression or activity.

32. 发明授权

US09816926B2 Multiplex suspension assay/array using lifetime coding 有权
公开(公告)号：US09816926B2
公开(公告)日：2017-11-14
申请号：US14410015
申请日：2013-06-21
申请人： Macquarie University
发明人： Dayong Jin , Yiqing Lu , Jiangbo Zhao
IPC分类号： G01N21/64 , C40B70/00 , C09K11/02 , C09K11/06 , C09D11/50 , C09K11/77 , B42D25/382 , B42D25/387 , G01N33/542 , G01N33/58
CPC分类号： G01N21/6408 , B42D25/382 , B42D25/387 , C09D11/50 , C09K11/02 , C09K11/025 , C09K11/06 , C09K11/7773 , C09K2211/182 , C40B70/00 , G01N21/6428 , G01N33/542 , G01N33/582
摘要： A system, device and/or method for multiplex assays. In a particular, but non-limiting, example there is provided a multiplex array, such as a suspension array. Luminescence decay lifetimes are utilized for probes in a suspension array, and coding/decoding the codes from time-resolved spectra. Lifetime populations can be generated at distinct color bands. A novel temporal technique or dimension is applied over conventional spectral and intensity combinations, thereby expanding the multiplexing capacity of a suspension array. In one example form, the multiplexing capacity of a suspension array can be expanded to the order of about 58. This provides a reliable, high-throughput and relatively inexpensive solution for multiplex assays in various areas of application such as life sciences, data storage and security.

33. 发明授权

US08298783B2 Detecting molecules 失效
标题翻译：检测分子
公开(公告)号：US08298783B2
公开(公告)日：2012-10-30
申请号：US10569107
申请日：2004-08-20
申请人： Mark S. Baker
发明人： Mark S. Baker
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： C07K16/065 , C07K1/22
摘要： Disclosed are processes to increase the relative abundance of a molecule that is present in a test sample at relatively low abundance. The process includes fractionating a sample and immunizing hosts with the fractions. The antibodies produced from the fractionated test sample are directed primarily to molecules that are in relatively high abundance in the test sample fractions. These antibodies are then contacted with the test sample or a test sample to immuno-deplete relatively high abundance molecules from the sample to form a first depleted sample. These steps can be repeated a reiterative process of immuno-subtraction to produce second and third depleted samples where the relative abundance of the “low abundance” molecule is increased.
摘要翻译：公开的是以相对低的丰度增加存在于测试样品中的分子的相对丰度的方法。该方法包括对样品进行分级并用分数免疫宿主。从分级测试样品产生的抗体主要针对测试样品部分中相对较高丰度的分子。然后将这些抗体与测试样品或测试样品接触以从样品中免除耗尽相对高丰度的分子以形成第一个耗尽的样品。这些步骤可以重复免疫减除的重复过程，以产生其中低丰度分子的相对丰度增加的第二和第三贫化样品。

34. 发明申请

US20120214194A1 PROCESS FOR SYNTHESIZING EPICCONONE ANALOGS 有权
标题翻译：合成EPICCONONE ANALOGS的方法
公开(公告)号：US20120214194A1
公开(公告)日：2012-08-23
申请号：US13503880
申请日：2010-10-25
申请人： Xavier Franck , Philippe Peixoto , Peter Helmuth Karuso
发明人： Xavier Franck , Philippe Peixoto , Peter Helmuth Karuso
IPC分类号： G01N21/64 , C07D493/14
CPC分类号： C07D493/04 , C07D307/58 , C07D311/76 , C09B61/00
摘要： The present invention relates to a process for the total synthesis of epicocconone analogs of formula (I): The invention also relates to novel epicocconone analogs.
摘要翻译：本发明涉及一种总体合成式（I）表皮素类似物的方法：本发明还涉及新颖的表皮素类似物。

35. 发明申请

US20110152313A1 SYNTHESIS OF AGELADINE A AND ANALOGS THEREOF 审中-公开
标题翻译： AGELADINE A及其类似物的合成
公开(公告)号：US20110152313A1
公开(公告)日：2011-06-23
申请号：US12999046
申请日：2009-06-19
申请人： Peter Helmuth Karuso , Sudhir Ramnathrao Shengule
发明人： Peter Helmuth Karuso , Sudhir Ramnathrao Shengule
IPC分类号： A61K31/437 , C07D471/02 , A61P35/00 , A61P27/02
CPC分类号： C07D471/04 , A61K31/437
摘要： The invention describes a one pot process for synthesizing a compound of structure (I), or a tautomer thereof. A compound of structure (II), or a tautomer thereof, and an aldehyde of structure RdCHO are condensed to form a condensation product. The resulting condensation product is then oxidized in the same reaction mixture to produce the compound of structure (I) or a tautomer thereof.
摘要翻译：本发明描述了一种用于合成结构（I）化合物或其互变异构体的一锅方法。将结构（II）的化合物或其互变异构体和结构RdCHO的醛缩合形成缩合产物。然后将所得缩合产物在相同的反应混合物中氧化，生成结构（I）化合物或其互变异构体。

36. 发明申请

US20090137061A1 DETECTING MOLECULES 审中-公开
标题翻译：检测分子
公开(公告)号：US20090137061A1
公开(公告)日：2009-05-28
申请号：US11813443
申请日：2006-01-06
申请人： Mark S. Baker
发明人： Mark S. Baker
IPC分类号： G01N1/18
CPC分类号： C07K1/36 , G01N33/5306 , Y10T436/25375
摘要： The invention relates to separating molecules, in particular, to proteins comprised in biological fluid such as serum, to purifying molecules and to producing antisera to molecules.
摘要翻译：本发明涉及分离分子，特别是分离生物流体例如血清中的蛋白质，以分离纯化分子和产生分子的抗血清。

37. 发明授权

US07517685B2 Gene promoters 失效
标题翻译：基因启动子
公开(公告)号：US07517685B2
公开(公告)日：2009-04-14
申请号：US10498549
申请日：2002-12-13
申请人： Helena Nevalainen , Valentino Setoa Junior Te'O , Natalie Curach , Peter Leonard Bergquist
发明人： Helena Nevalainen , Valentino Setoa Junior Te'O , Natalie Curach , Peter Leonard Bergquist
IPC分类号： C12N5/08
CPC分类号： C07K14/37 , C12N15/10 , C12N15/1034 , C12N15/80 , C12Q1/68 , C12Q1/6895 , C12Q2600/158
摘要： The invention is directed to a method for obtaining a promoter from an organism using a proteomics approach, isolated promoters from fungal species and uses of the isolated promoters.
摘要翻译：本发明涉及使用蛋白质组学方法从生物体获得启动子的方法，来自真菌种类的分离的启动子和分离的启动子的用途。

38. 发明申请

US20080265177A1 Fluorescence Detection 失效
标题翻译：荧光检测
公开(公告)号：US20080265177A1
公开(公告)日：2008-10-30
申请号：US11577216
申请日：2005-10-17
申请人： Russell Connally , James Austin Piper
发明人： Russell Connally , James Austin Piper
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G01N21/6408
摘要： A fluorescence detection system comprises a light source (22), dichroic mirror (32), excitation port (16), emission port (14), and a detector. The light source (22) is, for example, a pulsed ultraviolet LED, with a light emission that decays sufficiently rapidly to permit gated detection of fluorescence from a fluorescently-labelled species, at a time when it is distinguishable from autofluorescence. The detector is, for example, an electron multiplying CCD, with high gain on-chip amplification. A circuit (26) may be used to control a repeating cycle of (i) generation of a 20-200 microsecond UV. pulse; (ii) a gate delay of 1-5 microseconds; and (iii) a 10-800 microsecond detection period. This allows time-resolved-fluorescence-microscopy with real time or near real time operation.
摘要翻译：荧光检测系统包括光源（22），分色镜（32），激发端口（16），发射端口（14）和检测器。光源（22）例如是脉冲紫外LED，具有足够快速衰减的光发射，以允许在与自发荧光区分时从荧光标记物质进行门控检测。检测器是例如具有高增益片上放大的电子倍增CCD。电路（26）可用于控制（i）产生20-200微秒UV的重复循环。脉冲; （ii）1-5微秒的门延迟; 和（iii）10-800微秒的检测周期。这允许实时或接近实时操作的时间分辨荧光显微镜。

39. 发明公开

US20230257294A1 ALUMINOSILICATE GLASS 审中-公开
公开(公告)号：US20230257294A1
公开(公告)日：2023-08-17
申请号：US17787007
申请日：2020-12-18
申请人： Macquarie University
发明人： Toney Teddy Fernandez , Simon Gross , Michael Withford
IPC分类号： C03C3/091 , C03C3/087 , G02B6/13 , C03C23/00
CPC分类号： C03C3/091 , C03C3/087 , G02B6/13 , C03C23/0025 , G02B2006/12171
摘要： An aluminosilicate glass having a composition according to the following formula (I):

(100−(1+a1+b1)·x)SiO2·(x)Al2O3·(a1·x)MO·(b1·x)R (wt %) (I)

in which MO is alkaline earth metal oxide, the alkaline earth metal M being one or more of Mg, Ca, Sr, and Ba, R comprises alkali metal oxide, the alkali metal being one or more of Li, Na, and K, x is at least 15, a1 is at least 0.35, b1 is at least 0.55, and wherein the product of a1 and b1 is at least 0.22.

40. 发明授权

US11557985B2 Piezoelectric and magnetostrictive energy harvesting with pipe-in-pipe structure 有权
公开(公告)号：US11557985B2
公开(公告)日：2023-01-17
申请号：US16944775
申请日：2020-07-31
申请人： SAUDI ARABIAN OIL COMPANY , Macquarie University
发明人： Chinthaka Pasan Gooneratne , Subhas Mukhopadhyay , Bodong Li , Guodong Zhan , Arturo Magana-Mora , Timothy Eric Moellendick
IPC分类号： H02N2/18 , E21B17/00 , E21B17/02
摘要： An apparatus includes an outer structure body having an inner surface defining a cavity and an inner structure body rotatably supported within the cavity. The inner structure body has an outer surface in opposing relation to the inner surface and a central bore. Movable elements are positioned along the inner surface and movably coupled to the outer structure body. Ball elements are positioned along the outer surface and coupled to the inner structure body for movement with the inner structure body. The ball elements releasably contact the movable elements and impart motion to the movable elements in response to relative motion between the inner structure body and the outer structure body. Energy harvesters are positioned to generate electrical charges based on piezoelectric effect or magnetostrictive effect when motion is imparted to the movable elements by the ball elements.

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