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    • 48. 发明申请
    • Bipodal-Peptide Binder
    • 双峰肽粘合剂
    • US20110152500A1
    • 2011-06-23
    • US12999717
    • 2009-10-20
    • Sang Yong JonSung Hyun KimSe Ho Park
    • Sang Yong JonSung Hyun KimSe Ho Park
    • C07K14/00C40B30/04
    • C07K14/001A61K49/0032A61K49/0056
    • The present invention deals with a bipodal-peptide binder that specifically binds with a target including (a) a structure stabilizing region that includes parallel, antiparallel or parallel and antiparallel amino acid strands wherein interstrand non-covalent bonds are formed; and (b) a target binding region I and a target binding region II that are bonded at both terminals of said structure stabilizing region and respectively include n and m amino acids, and a method of preparing same; the bipodal-peptide binder of the present invention exhibits the KD value (dissociation constant) of a very low level (for example, nM level) and, therefore, exhibits very high affinity toward a target. The bipodal-peptide binder of the present invention has applications not only in pharmaceuticals but also in in-vivo imaging, in vitro cell imaging, and drug delivery targeting, and can be very usefully employed as an escort molecule.
    • 本发明涉及与靶标特异性结合的双齿肽粘合剂,包括(a)结构稳定区,其包含平行,反向平行或平行和反平行的氨基酸链,其中形成了链间非共价键; 和(b)在所述结构稳定区的两端键合并分别包含n和m个氨基酸的靶结合区I和靶结合区II及其制备方法。 本发明的双齿 - 肽结合物表现出非常低水平(例如,nM水平)的KD值(解离常数),因此对目标表现出非常高的亲和力。 本发明的双齿肽粘合剂不仅在药物中也具有体内成像,体外细胞成像和药物递送靶向的用途,并且可以非常有用地用作护送分子。