专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110152500A1 Bipodal-Peptide Binder 审中-公开
标题翻译：双峰肽粘合剂
公开(公告)号：US20110152500A1
公开(公告)日：2011-06-23
申请号：US12999717
申请日：2009-10-20
申请人： Sang Yong Jon , Sung Hyun Kim , Se Ho Park
发明人： Sang Yong Jon , Sung Hyun Kim , Se Ho Park
IPC分类号： C07K14/00 , C40B30/04
CPC分类号： C07K14/001 , A61K49/0032 , A61K49/0056
摘要： The present invention deals with a bipodal-peptide binder that specifically binds with a target including (a) a structure stabilizing region that includes parallel, antiparallel or parallel and antiparallel amino acid strands wherein interstrand non-covalent bonds are formed; and (b) a target binding region I and a target binding region II that are bonded at both terminals of said structure stabilizing region and respectively include n and m amino acids, and a method of preparing same; the bipodal-peptide binder of the present invention exhibits the KD value (dissociation constant) of a very low level (for example, nM level) and, therefore, exhibits very high affinity toward a target. The bipodal-peptide binder of the present invention has applications not only in pharmaceuticals but also in in-vivo imaging, in vitro cell imaging, and drug delivery targeting, and can be very usefully employed as an escort molecule.
摘要翻译：本发明涉及与靶标特异性结合的双齿肽粘合剂，包括（a）结构稳定区，其包含平行，反向平行或平行和反平行的氨基酸链，其中形成了链间非共价键; 和（b）在所述结构稳定区的两端键合并分别包含n和m个氨基酸的靶结合区I和靶结合区II及其制备方法。本发明的双齿 - 肽结合物表现出非常低水平（例如，nM水平）的KD值（解离常数），因此对目标表现出非常高的亲和力。本发明的双齿肽粘合剂不仅在药物中也具有体内成像，体外细胞成像和药物递送靶向的用途，并且可以非常有用地用作护送分子。

2. 发明授权

US10131693B2 Bipodal-peptide binder 有权
公开(公告)号：US10131693B2
公开(公告)日：2018-11-20
申请号：US12999717
申请日：2009-10-20
申请人： Sang Yong Jon , Sung Hyun Kim , Se Ho Park
发明人： Sang Yong Jon , Sung Hyun Kim , Se Ho Park
IPC分类号： C07K14/00 , A61K49/00
摘要： The present invention deals with a bipodal-peptide binder that specifically binds with a target including (a) a structure stabilizing region that includes parallel, antiparallel or parallel and antiparallel amino acid strands wherein interstrand non-covalent bonds are formed; and (b) a target binding region I and a target binding region II that are bonded at both terminals of said structure stabilizing region and respectively include n and m amino acids, and a method of preparing same; the bipodal-peptide binder of the present invention exhibits the KD value (dissociation constant) of a very low level (for example, nM level) and, therefore, exhibits very high affinity toward a target. The bipodal-peptide binder of the present invention has applications not only in pharmaceuticals but also in in-vivo imaging, in vitro cell imaging, and drug delivery targeting, and can be very usefully employed as an escort molecule.

3. 发明授权

US08474135B2 Method for fabricating printed circuit board 有权
标题翻译：印刷电路板的制造方法
公开(公告)号：US08474135B2
公开(公告)日：2013-07-02
申请号：US12504339
申请日：2009-07-16
申请人： Ki-Hyun Kim , Se Ho Park , Seok-Myong Kang , Young-Min Lee
发明人： Ki-Hyun Kim , Se Ho Park , Seok-Myong Kang , Young-Min Lee
IPC分类号： H01K3/10
CPC分类号： H05K3/4069 , H05K1/0393 , H05K1/095 , H05K3/12 , H05K3/246 , H05K2201/0347 , H05K2201/0352 , H05K2201/09981 , Y10T29/49155 , Y10T29/49165
摘要： A method for fabricating a printed circuit board is provided. The method includes manufacturing a base film including a first side and a second side opposite to the first side; printing a first wiring on the first side with a high-viscosity conductive material having a viscosity of 5,000 to 300,000 centipoise (CPS); forming a via-hole that passes through both sides of the base film, and passes by the first wiring; and printing a second wiring on the second side with a low-viscosity conductive material having a viscosity of 100 to 5,000 CPS. The low-viscosity conductive material is applied to an inner wall of the via-hole to conductively connect the first wiring to the second wiring.
摘要翻译：提供一种制造印刷电路板的方法。该方法包括制造包括第一侧和与第一侧相对的第二侧的基膜; 用粘度为5000至300,000厘泊（CPS）的高粘度导电材料在第一侧印刷第一布线; 形成穿过基膜的两侧的通孔，并通过第一布线; 以及使用粘度为100-5,000CPS的低粘度导电材料在第二侧上印刷第二布线。将低粘度导电材料施加到通孔的内壁，以将第一布线导电连接到第二布线。

4. 发明授权

US07398015B2 Apparatus for controlling fluid-heating using polymer disk 失效
标题翻译：使用聚合物盘控制流体加热的装置
公开(公告)号：US07398015B2
公开(公告)日：2008-07-08
申请号：US11188911
申请日：2005-07-25
申请人： Kwang Hyo Chung , Se Ho Park , Dae Sik Lee , Hyeon Bong Pyo , Chang Auck Choi
发明人： Kwang Hyo Chung , Se Ho Park , Dae Sik Lee , Hyeon Bong Pyo , Chang Auck Choi
IPC分类号： F24F1/10 , C12M1/00
CPC分类号： F24H1/162 , B33Y80/00
摘要： Provided is an apparatus for controlling fluid-heating using a polymer disk, which includes: a pump for discharging fluid at a uniform flow rate; a fluid-heating module including a polymer disk to convey the fluid discharged from the pump to allow a temperature of the fluid to periodically vary; and a controller for controlling the temperature of the fluid-heating module, whereby it is possible to be adapted to a fluid device for biochemical reaction such as DNA amplification, and simply used as a disposable device, which is low cost and readily manufactured in a multiple manner.
摘要翻译：提供了一种使用聚合物盘来控制流体加热的装置，其包括：用于以均匀流量排出流体的泵; 流体加热模块，包括聚合物盘，以输送从泵排出的流体，以允许流体的温度周期性地变化; 以及用于控制流体加热模块的温度的控制器，由此可以适用于用于诸如DNA扩增的生物化学反应的流体装置，并且简单地用作一次性装置，其成本低并且易于在多种方式。

5. 发明授权

US06987923B2 Amplifying optical fiber and method for fabricating the same 失效
标题翻译：放大光纤及其制造方法
公开(公告)号：US06987923B2
公开(公告)日：2006-01-17
申请号：US10638985
申请日：2003-08-12
申请人： Se Ho Park , Jin-Seong Yang , Mun-Hyun Do
发明人： Se Ho Park , Jin-Seong Yang , Mun-Hyun Do
IPC分类号： G02B6/00
CPC分类号： H01S3/06708 , C03C13/044 , C03C13/046
摘要： Disclosed is an amplifying optical fiber for amplifying optical signal transmitted therethrough by stimulated emission, the amplifying optical fiber comprising: an inner core disposed at a center of said optical fiber and containing MX, GaS3/2 and RE; an outer core surrounding said inner core and containing SiO2; and a cladding surrounding said outer core and containing SiO2, wherein said M contained in MX is one component selected from the group consisting of Na, K, Rb and Cs; said X contained in MX is one component selected from the group consisting of F, Cl, Br, and I; and said RE is one component selected from the group consisting of Ce, Pr, Pm, Nd, Sm, Eu, Gd, Tb, Ho, Dy, Er, Tm and Yb.
摘要翻译：公开了一种放大光纤，用于通过受激发射放大透过其的光信号，放大光纤包括：设置在所述光纤中心并包含MX，GaS 3/2和RE的内核 ; 围绕所述内芯并包含SiO 2的外核; 以及围绕所述外芯并包含SiO 2的包层，其中MX中所含的M是选自Na，K，Rb和Cs中的一种成分; MX中所含的X是选自F，Cl，Br和I的一个组分; 所述RE为选自Ce，Pr，Pm，Nd，Sm，Eu，Gd，Tb，Ho，Dy，Er，Tm和Yb中的一种成分。

6. 发明授权

US06521526B2 Method of manufacturing flash memory 失效
公开(公告)号：US06521526B2
公开(公告)日：2003-02-18
申请号：US09998339
申请日：2001-12-03
申请人： Cha Deok Dong , Sang Wook Park , Se Ho Park
发明人： Cha Deok Dong , Sang Wook Park , Se Ho Park
IPC分类号： H01L214763
CPC分类号： H01L29/66825 , H01L21/76849 , H01L21/7685 , H01L27/11521
摘要： The present invention forms a protection layer of doped amorphous silicon or amorphous silicon on a semiconductor substrate in which a control gate is formed in a stack structure of doped poly Si and etches only a given portion of the protection layer in a subsequent process to form a contact hole. Therefore, the present invention can prevent oxidization of a given portion of WSix due to exposed WSix.

7. 发明授权

US07652370B2 Plastic microfabricated structure for biochip, microfabricated thermal device, microfabricated reactor, microfabricated reactor array, and micro array using the same 有权
标题翻译：用于生物芯片，微制造热装置，微制造反应堆，微制造反应堆阵列和使用其的微阵列的塑料微制造结构
公开(公告)号：US07652370B2
公开(公告)日：2010-01-26
申请号：US10899177
申请日：2004-07-27
申请人： Dae Sik Lee , Hae Sik Yang , Yong Taik Lim , Kwang Hyo Chung , Sung Jin Kim , Se Ho Park , Kyu Won Kim , Yun Tae Kim
发明人： Dae Sik Lee , Hae Sik Yang , Yong Taik Lim , Kwang Hyo Chung , Sung Jin Kim , Se Ho Park , Kyu Won Kim , Yun Tae Kim
IPC分类号： H01L29/06
CPC分类号： B01J19/0093 , B01J2219/00495 , B01J2219/00605 , B01J2219/0061 , B01J2219/00619 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00783 , B01J2219/00804 , B01J2219/00833 , B01J2219/00853 , B01J2219/00858 , B01J2219/00873 , B01J2219/00961 , B01L3/502707 , B01L3/50851 , B01L2200/12 , B01L2200/147 , B01L2300/0819 , B01L2300/12 , B01L2300/1827 , B33Y80/00 , C40B60/14 , G01N27/128
摘要： Provided are a plastic microfabricated structure, and a microfabricated thermal device, a microfabricated reactor, a microfabricated reactor array and a micro array using the same, which may be applied to a bio chip, and the present invention may fabricate the plastic microfabricated structure for providing a heating region by means of insulating plastic, which has a thin thickness, flatness enough to allow a photolithography process to be performed, thermal isolation in its some or total area, and a small thermal mass, and on top of the heating region of the plastic microfabricated structure, a heater, a temperature sensor for sensing a temperature, an electrode, and an electrode pad are formed to thereby fabricate the microfabricated heating device, whereby element may be readily fabricated at a low cost, and the heating region is formed of a plastic thin layer, so that uniform temperature control is possible even with a low power, and various samples may be thermally treated at a fast speed to obtain their reaction and analysis.
摘要翻译：本发明提供一种塑料微制造结构，微制造热装置，微制造反应器，微制造反应器阵列和使用其的微阵列，其可以应用于生物芯片，并且本发明可以制造塑料微制造结构以提供通过绝缘塑料的加热区域，其具有薄的厚度，足够的平坦度，以允许执行光刻工艺，其一些或总面积的热隔离和小的热质量，以及在形成塑料微加工结构，加热器，用于感测温度的温度传感器，电极和电极焊盘，从而制造微制造加热装置，从而可以以低成本容易地制造元件，并且加热区域由塑料薄层，使得即使在低功率下也能进行均匀的温度控制，并且各种样品可以在fa处进行热处理速度获得反应和分析。

8. 发明申请

US20080273128A1 Programmable mask and method of fabricating biomolecule array using the same 失效
标题翻译：可编程掩模和使用其制造生物分子阵列的方法
公开(公告)号：US20080273128A1
公开(公告)日：2008-11-06
申请号：US12213244
申请日：2008-06-17
申请人： Moon Youn Jung , Dong Ho Shin , Young Jun Kim , Se Ho Park , Hyeon Bong Pyo , Chang Auck Choi
发明人： Moon Youn Jung , Dong Ho Shin , Young Jun Kim , Se Ho Park , Hyeon Bong Pyo , Chang Auck Choi
IPC分类号： G02F1/13
CPC分类号： G03F7/70291 , G02F1/1393 , G03F7/70566
摘要： The present invention relates to a programmable mask used in a photolithography process for fabricating a biomolecule array and a method of fabricating a biomolecule array using the same and, more particularly, to a programmable mask which can increase a contrast ratio of transmittance versus shielding of light incident to a liquid crystal which constitutes each pixel by irradiating parallel ultraviolet (“UV”) light generated from an external parallel light exposure device to a certain cell and using a vertically aligned liquid crystal panel or an LC panel having no spacer, and a method of fabricating a biomolecule array using the same.
摘要翻译：本发明涉及用于制造生物分子阵列的光刻工艺中使用的可编程掩模，以及使用该可编程掩模制造生物分子阵列的方法，更具体地说，涉及一种可增加透射率对光屏蔽对比度的可编程掩模通过将从外部平行曝光装置产生的平行紫外线（“UV”）光照射到某个单元并使用垂直取向的液晶面板或不具有间隔物的LC面板，对构成每个像素的液晶进行入射，以及方法制造使用其的生物分子阵列。

9. 发明授权

US07183056B2 Method for performing multiplex PCR with cyclic changes of PCR parameters 失效
标题翻译：用PCR参数循环变化进行多重PCR的方法
公开(公告)号：US07183056B2
公开(公告)日：2007-02-27
申请号：US10697295
申请日：2003-10-31
申请人： Se Ho Park , Hae Sik Yang , Dae Sik Lee , Yong Beom Shin , Kyu Won Kim , Tae Hwan Yoon , Sung Jin Kim , Yun Tae Kim
发明人： Se Ho Park , Hae Sik Yang , Dae Sik Lee , Yong Beom Shin , Kyu Won Kim , Tae Hwan Yoon , Sung Jin Kim , Yun Tae Kim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q2537/143 , C12Q2527/113 , C12Q2527/101
摘要： The present invention is directed to an improved multiplex PCR method for obtaining at least two PCR products from one PCR solution. In the multiplex PCR method for having at least two DNA amplified products from a sample positioned in a PCR equipment, the object of the present invention is to provide a novel multiplex PCR method characterized in that a primer annealing temperature and an extension time be changed per cycle with constant periods. When a multiplex PCR is performed in accordance with the present invention, limitations in determining PCR conditions due to a various sizes of PCR products or dimers caused by primers can be eliminated, and time and efforts required for determining the PCR conditions to various samples can also be reduced. Further, not only refined DNAs like cDNA, genomic DNA, vector, etc, but blood can be directly used as a multiplex PCR sample, and PCR amplification reaction can be performed even with a sample having the smallest amounts.
摘要翻译：本发明涉及一种用于从一种PCR溶液获得至少两种PCR产物的改进的多重PCR方法。本发明的目的是提供一种新的多重PCR方法，其特征在于，引物退火温度和延长时间根据周期不变的周期。当根据本发明进行多重PCR时，可以消除由于由引物引起的各种大小的PCR产物或二聚体导致的PCR条件的限制的限制，并且确定各种样品的PCR条件所需的时间和努力也可以减少此外，不仅可以将cDNA，基因组DNA，载体等精制DNA与血液直接用作多重PCR样品，即使使用量少的样品也能进行PCR扩增反应。

10. 发明授权

US07948564B2 Programmable mask and method of fabricating biomolecule array using the same 失效
标题翻译：可编程掩模和使用其制造生物分子阵列的方法
公开(公告)号：US07948564B2
公开(公告)日：2011-05-24
申请号：US12213244
申请日：2008-06-17
申请人： Moon Youn Jung , Dong Ho Shin , Young Jun Kim , Se Ho Park , Hyeon Bong Pyo , Chang Auck Choi
发明人： Moon Youn Jung , Dong Ho Shin , Young Jun Kim , Se Ho Park , Hyeon Bong Pyo , Chang Auck Choi
IPC分类号： G02F1/1335
CPC分类号： G03F7/70291 , G02F1/1393 , G03F7/70566
摘要： The present invention relates to a programmable mask used in a photolithography process for fabricating a biomolecule array and a method of fabricating a biomolecule array using the same and, more particularly, to a programmable mask which can increase a contrast ratio of transmittance versus shielding of light incident to a liquid crystal which constitutes each pixel by irradiating parallel ultraviolet (“UV”) light generated from an external parallel light exposure device to a certain cell and using a vertically aligned liquid crystal panel or an LC panel having no spacer, and a method of fabricating a biomolecule array using the same.
摘要翻译：本发明涉及用于制造生物分子阵列的光刻工艺中使用的可编程掩模，以及使用该可编程掩模制造生物分子阵列的方法，更具体地说，涉及一种可增加透射率对光屏蔽对比度的可编程掩模通过将从外部平行曝光装置产生的平行紫外线（“UV”）光照射到某个单元并使用垂直取向的液晶面板或不具有间隔物的LC面板，对构成每个像素的液晶进行入射;以及方法制造使用其的生物分子阵列。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式