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1. 发明申请

US20110152500A1 Bipodal-Peptide Binder 审中-公开
标题翻译：双峰肽粘合剂
公开(公告)号：US20110152500A1
公开(公告)日：2011-06-23
申请号：US12999717
申请日：2009-10-20
申请人： Sang Yong Jon , Sung Hyun Kim , Se Ho Park
发明人： Sang Yong Jon , Sung Hyun Kim , Se Ho Park
IPC分类号： C07K14/00 , C40B30/04
CPC分类号： C07K14/001 , A61K49/0032 , A61K49/0056
摘要： The present invention deals with a bipodal-peptide binder that specifically binds with a target including (a) a structure stabilizing region that includes parallel, antiparallel or parallel and antiparallel amino acid strands wherein interstrand non-covalent bonds are formed; and (b) a target binding region I and a target binding region II that are bonded at both terminals of said structure stabilizing region and respectively include n and m amino acids, and a method of preparing same; the bipodal-peptide binder of the present invention exhibits the KD value (dissociation constant) of a very low level (for example, nM level) and, therefore, exhibits very high affinity toward a target. The bipodal-peptide binder of the present invention has applications not only in pharmaceuticals but also in in-vivo imaging, in vitro cell imaging, and drug delivery targeting, and can be very usefully employed as an escort molecule.
摘要翻译：本发明涉及与靶标特异性结合的双齿肽粘合剂，包括（a）结构稳定区，其包含平行，反向平行或平行和反平行的氨基酸链，其中形成了链间非共价键; 和（b）在所述结构稳定区的两端键合并分别包含n和m个氨基酸的靶结合区I和靶结合区II及其制备方法。本发明的双齿 - 肽结合物表现出非常低水平（例如，nM水平）的KD值（解离常数），因此对目标表现出非常高的亲和力。本发明的双齿肽粘合剂不仅在药物中也具有体内成像，体外细胞成像和药物递送靶向的用途，并且可以非常有用地用作护送分子。

2. 发明授权

US10131693B2 Bipodal-peptide binder 有权
公开(公告)号：US10131693B2
公开(公告)日：2018-11-20
申请号：US12999717
申请日：2009-10-20
申请人： Sang Yong Jon , Sung Hyun Kim , Se Ho Park
发明人： Sang Yong Jon , Sung Hyun Kim , Se Ho Park
IPC分类号： C07K14/00 , A61K49/00
摘要： The present invention deals with a bipodal-peptide binder that specifically binds with a target including (a) a structure stabilizing region that includes parallel, antiparallel or parallel and antiparallel amino acid strands wherein interstrand non-covalent bonds are formed; and (b) a target binding region I and a target binding region II that are bonded at both terminals of said structure stabilizing region and respectively include n and m amino acids, and a method of preparing same; the bipodal-peptide binder of the present invention exhibits the KD value (dissociation constant) of a very low level (for example, nM level) and, therefore, exhibits very high affinity toward a target. The bipodal-peptide binder of the present invention has applications not only in pharmaceuticals but also in in-vivo imaging, in vitro cell imaging, and drug delivery targeting, and can be very usefully employed as an escort molecule.

3. 发明申请

US20120321697A1 BPB-BASED CARGO DELIVERY SYSTEM 审中-公开
标题翻译：基于BPB的货物运输系统
公开(公告)号：US20120321697A1
公开(公告)日：2012-12-20
申请号：US13515163
申请日：2010-12-03
申请人： Sang Yong Jon , Sung Hyun Kim , Seho Park , Dongkyu Kim , Jinho Park , Phei Er Saw
发明人： Sang Yong Jon , Sung Hyun Kim , Seho Park , Dongkyu Kim , Jinho Park , Phei Er Saw
IPC分类号： A61K38/02 , A61K9/127 , C07K19/00 , C07K17/10 , B82Y5/00
CPC分类号： C07K19/00
摘要： Disclosed are bipodal peptide binder (BPB) based cargo delivery systems wherein cargo is linked to a BPB for delivery into cells or to cell surfaces using target binding ability and specificity of the BPB. The BPB has a structure stabilizing region of parallel or antiparallel amino acid strands or a combination of these strands to induce interstrand non-covalent bonds. The BPB also has target binding regions I and II, each binding to each of both termini of the structure stabilizing region. The number of amino acid residues of regions I and II, respectively, are n and m. The BPB exhibits the KD value (dissociation constant) of a very low level (for example, nM level) and, therefore, exhibits very high affinity toward a biological target molecule. The BPB based cargo delivery system has applications in drugs, in vivo molecular imaging, in vitro cell imaging, drug delivery targeting and escort molecules.
摘要翻译：公开了基于双齿肽粘合剂（BPB）的货物运输系统，其中货物与BPB连接以使用BPB的靶结合能力和特异性递送至细胞或细胞表面。 BPB具有平行或反平行氨基酸链的结构稳定区或这些链的组合以诱导链间非共价键。 BPB还具有靶结合区域I和II，其各自结合结构稳定区域的两个末端中的每一个。区域I和II的氨基酸残基数分别为n和m。 BPB显示非常低水平（例如，nM水平）的KD值（解离常数），因此对生物靶分子表现出非常高的亲和力。基于BPB的货物运输系统在药物，体内分子成像，体外细胞成像，药物递送靶向和护送分子中都有应用。

4. 发明申请

US20120309934A1 INTRACELLUAR TARGETING BIPODAL PEPTIDE BINDER 审中-公开
标题翻译：腹腔内定向双功能胶原蛋白BINDER BINDER
公开(公告)号：US20120309934A1
公开(公告)日：2012-12-06
申请号：US13515026
申请日：2010-12-03
申请人： Sang Yong Jon , Sung Hyun Kim , Daejin Kim
发明人： Sang Yong Jon , Sung Hyun Kim , Daejin Kim
IPC分类号： C07K19/00
CPC分类号： C07K19/00 , A61K38/00
摘要： An intracellular targeting bipodal-peptide binder specifically binding to an intracellular target molecule, comprising: (a) a structure-stabilizing region comprising a parallel amino acid strand, an antiparallel amino acid strand or parallel and antiparallel amino acid strands to induce interstrand non-covalent bonds; (b) target binding regions I and II each binding to each of both termini of the structure-stabilizing region, wherein the number of amino acid residues of the target binding region I is n and the number of amino acid residues of the target binding region II is m; and (c) a cell-penetrating peptide (CPP) linked to the structure-stabilizing region, the target binding region I or the target binding region II. Also contemplated is a method for preparing an intracellular targeting bipodal-peptide binder. The bipodal-peptide binder capable of binding to intracellular targets has applications to drugs, in vivo molecular imaging, in vitro cell imaging, drug delivery targeting and escort molecules.
摘要翻译：特异性结合细胞内靶分子的细胞内靶向双齿肽结合物，其包含：（a）包含平行氨基酸链，反平行氨基酸链或平行和反平行氨基酸链的结构稳定区，以诱导链间非共价键债券（b）靶结合区域I和II各自与结构稳定区域的两个末端各自结合，其中靶结合区域I的氨基酸残基数目为n，靶结合区域的氨基酸残基数二是m 和（c）与结构稳定区域连接的细胞穿透肽（CPP），靶结合区域I或靶结合区域II。还考虑了制备细胞内靶向双齿肽粘合剂的方法。能够结合细胞内靶标的双峰肽结合物可用于药物，体内分子成像，体外细胞成像，药物递送靶向和护送分子。

5. 发明授权

US09152041B2 Display panel including patterned spacer 有权
标题翻译：显示面板包括图案间隔
公开(公告)号：US09152041B2
公开(公告)日：2015-10-06
申请号：US11629476
申请日：2005-07-05
申请人： Sung Hyun Kim , Jin Suek Kim , Kyung Jun Kim , Seung Hee Lee , Il Eok Kwon , Jeong Ae Yoon
发明人： Sung Hyun Kim , Jin Suek Kim , Kyung Jun Kim , Seung Hee Lee , Il Eok Kwon , Jeong Ae Yoon
IPC分类号： C09K19/00 , G03F7/00 , G03F7/029
CPC分类号： G03F7/0007 , G03F7/0295 , Y10T428/10 , Y10T428/1073
摘要： Disclosed is a display panel including a lower substrate, upper substrate, and a patterned spacer that causes the lower substrate and upper substrate to be spaced apart from each other by a predetermined distance, wherein the patterned spacer is obtained from a photosensitive resin composition comprising: (a) a triazine-based photopolymerization initiator represented by the following formula 1; (b) an alkali-soluble photo polymerizable reactive resin binder; and (c) a polymerizable compound: (wherein each of R1-R5 has the same meaning as defined herein). A photosensitive resin composition for use in a patterned spacer is also disclosed, the composition comprising: (a) a triazine-based photopolymerization initiator represented by the following formula 1; (b) an alkali-soluble photopolymerizable reactive resin binder; (c) a polymerizable compound; and (d) a solvent. The photosensitive resin composition shows high sensitivity and excellent properties related with development, and provides a patterned spacer having excellent strength, sensitivity, residue characteristics, film uniformity, residual film ratio, etc.
摘要翻译：公开了一种显示面板，其包括下基板，上基板和图案化间隔件，其使得下基板和上基板彼此间隔开预定距离，其中图案化间隔件由感光树脂组合物获得，包括：（a）由下式1表示的三嗪系光聚合引发剂; （b）碱溶性光聚合反应性树脂粘合剂; 和（c）可聚合化合物：（其中R 1 -R 5各自具有与本文所定义的相同的含义）。还公开了用于图案化间隔物的感光性树脂组合物，该组合物包含：（a）由下式1表示的三嗪系光聚合引发剂; （b）碱溶性光聚合反应性树脂粘合剂; （c）可聚合化合物; 和（d）溶剂。感光性树脂组合物显示出高的敏感性和与显影相关的优异性能，并且提供了具有优异的强度，灵敏度，残留特性，膜均匀性，残留膜比等的图案化间隔物。

6. 发明授权

US08813229B2 Apparatus, system, and method for preventing infection by malicious code 有权
标题翻译：用于防止恶意代码感染的装置，系统和方法
公开(公告)号：US08813229B2
公开(公告)日：2014-08-19
申请号：US13574346
申请日：2011-01-20
申请人： Jae Han Lee , Jeong Hun Kim , Sung Hyun Kim
发明人： Jae Han Lee , Jeong Hun Kim , Sung Hyun Kim
IPC分类号： G08B23/00
CPC分类号： G06F21/564 , G06F21/567
摘要： The invention relates to an apparatus for preventing infection by malicious code, comprising: a database in which files installed in an agent system, DNA values for each part of the files, and index information for indicating whether each file is normal or malicious are stored; a calculation unit which calculates a DNA value for a part of a file for which an execution is requested in the agent system; and a file inspection unit which searches the database to extract, in a group, files having the DNA value calculated by the calculation unit, inspects whether an object file is normal or malicious on the basis of the index information on the files extracted in a group, and allows the execution of the object file or makes a request for the calculation of DNA values of other parts which selectively include one part of the object file.
摘要翻译：本发明涉及一种防止恶意代码感染的装置，包括：数据库，其中安装在代理系统中的文件，文件的每个部分的DNA值，以及用于指示每个文件是正常还是恶意的索引信息; 计算单元，其计算在代理系统中请求执行的文件的一部分的DNA值; 以及文件检查单元，其搜索数据库以提取具有由计算单元计算出的DNA值的文件，根据关于在组中提取的文件的索引信息来检查对象文件是正常还是恶意的，并且允许执行目标文件或者请求计算选择性地包括目标文件的一部分的其他部分的DNA值。

7. 发明授权

US08497797B2 Two-dimensional array antenna and device for detecting internal object using the same 有权
标题翻译：二维阵列天线和用于检测内部物体的装置
公开(公告)号：US08497797B2
公开(公告)日：2013-07-30
申请号：US12878618
申请日：2010-09-09
申请人： Dae Heon Lee , Sung Hyun Kim , Sang Woo Cho , Ji Eun Choi
发明人： Dae Heon Lee , Sung Hyun Kim , Sang Woo Cho , Ji Eun Choi
IPC分类号： G01S13/00
CPC分类号： G01S13/888 , G01S7/41 , G01S13/06 , H01Q3/08 , H01Q21/06
摘要： Provided are a two-dimensional array antenna and a device for detecting an internal object using the same. The device includes a plurality of unit antennas in a two-dimensional array of m columns and n rows on a board (where m and n are integers greater than 1), a first switch selecting one or more transmitting antenna to radiate a pulse signal onto an internal object in a structure from among the unit antennas; a second switch selecting one or more receiving antenna to collect a signal reflected from the internal object from among the unit antennas, and a transceiving analysis module analyzing information about the position and shape of the internal object.
摘要翻译：提供了一种二维阵列天线和用于检测使用该天线的内部物体的装置。该装置包括在板上的m列和n行的二维阵列中的多个单位天线（其中m和n是大于1的整数），第一开关选择一个或多个发射天线以将脉冲信号辐射到单元天线中的结构中的内部对象; 选择一个或多个接收天线以从所述单元天线收集从所述内部对象反射的信号的第二开关，以及分析关于所述内部对象的位置和形状的信息的收发分析模块。

8. 发明授权

US08487363B2 Method for manufacturing semiconductor device 失效
标题翻译：制造半导体器件的方法
公开(公告)号：US08487363B2
公开(公告)日：2013-07-16
申请号：US13305463
申请日：2011-11-28
申请人： Sung Hyun Kim
发明人： Sung Hyun Kim
IPC分类号： H01L29/78
CPC分类号： H01L21/28525 , H01L29/78
摘要： The present invention relates to a method for manufacturing a semiconductor device, and provides to reduce a contact resistance of a landing plug by forming the landing plug in such a manner that a polysilicon layer is deposited only on the surface of a landing plug contact hole, and a metal layer is buried in the rest of the landing plug contact hole in the process of forming a storage node contact or a bit line contact.
摘要翻译：本发明涉及一种制造半导体器件的方法，并且通过以仅将多晶硅层沉积在着陆插头接触孔的表面上的方式，通过形成着陆塞来提供降低着陆塞的接触电阻，并且在形成存储节点接触或位线接触的过程中，金属层被埋在着陆插头接触孔的其余部分中。

9. 发明申请

US20130000965A1 DIELECTRIC COMPOSITION, MULTILAYERED PRINTED CIRCUIT BOARD COMPRISING DIELECTRIC LAYER MANUFACTURED THEREOF, AND METHOD FOR PREPARING THE MULTILAYERED PRINTED CIRCUIT BOARD 审中-公开
标题翻译：电介质组合物，包含其制造的电介质层的多层印刷电路板以及制备多层印刷电路板的方法
公开(公告)号：US20130000965A1
公开(公告)日：2013-01-03
申请号：US13469614
申请日：2012-05-11
申请人： Dong Joo SHIN , Seong Min Chin , Moon Soo Park , Sung Taek Lim , Sung Hyun Kim , Choon Keun Lee
发明人： Dong Joo SHIN , Seong Min Chin , Moon Soo Park , Sung Taek Lim , Sung Hyun Kim , Choon Keun Lee
IPC分类号： H05K1/00 , C08K3/26 , C08K3/36 , H01B19/04
CPC分类号： H05K3/4676 , H01B3/40 , H05K1/0373 , H05K3/38 , H05K2201/0209 , H05K2203/0773
摘要： Disclosed herein are a dielectric composition of a multilayered circuit board including two types of inorganic fillers of 10 to 60 parts by weight with respect to an epoxy resin of 100 parts by weight, a multilayered printed circuit board including a dielectric layer manufactured of the dielectric composition, and a method for preparing the multilayered printed circuit board.According to the present invention, by mixing two types of inorganic fillers such as SiO2 and CaCO3 in manufacturing the dielectric layer of the multilayered circuit board, a high adhesive strength to a plating layer can be achieved without using a fluoride-based solution including 3NH4HF2 as an oxidant while etching the dielectric layer and furthermore, an environmentally hazardous substance can be prevented from being discharged.
摘要翻译：本文公开了一种多层电路板的电介质组合物，其包含相对于100重量份的环氧树脂为10至60重量份的两种类型的无机填料，包括由电介质组合物制成的电介质层的多层印刷电路板以及制备多层印刷电路板的方法。根据本发明，通过在制造多层电路板的电介质层中混合两种无机填料如SiO 2和CaCO 3，可以在不使用包含3NH 4 HF 2的氟化物溶液作为氧化剂，同时蚀刻电介质层，此外，可以防止对环境有害的物质的排出。

10. 发明授权

US08168369B2 Photoactive compound and photosensitive resin composition containing the same 有权
标题翻译：光敏化合物和含有它的感光性树脂组合物
公开(公告)号：US08168369B2
公开(公告)日：2012-05-01
申请号：US13147342
申请日：2010-02-12
申请人： Chang Ho Cho , Sung Hyun Kim , Raisa Kharbash , Keon Woo Lee , Dong Kung Oh , Won Jin Chung , Sang Kyu Kwak , Chang Soon Lee
发明人： Chang Ho Cho , Sung Hyun Kim , Raisa Kharbash , Keon Woo Lee , Dong Kung Oh , Won Jin Chung , Sang Kyu Kwak , Chang Soon Lee
IPC分类号： G03F7/00 , G03F7/004 , G03F7/028 , C07D209/82
CPC分类号： C07F9/5728 , C07D209/88 , C08F2/50 , G03F7/031 , Y10S430/106 , Y10S430/127
摘要： The present invention relates to a photoactive compound of a novel structure represented by Chemical Formula 1 below In Chemical Formula 1, R1 and R2, R3, and A are as defined in the specification, and a photosensitive resin composition comprising the same. The photoactive compound of the present invention comprises a nitro group and a phosphonate structure and thus exhibits excellent sensitivity through efficient absorption for UV light, excellent compatibility between the photoactive compound and the alkali-soluble binder resin, and an improved solubility of the photosensitive resin composition. Furthermore, the photosensitive resin composition of the present invention has excellent residual film thickness and mechanical strength characteristics and heat-resistant, chemical-resistant, and development-resistant properties. Accordingly, the photosensitive resin composition of the present invention is advantageous in hardening the column spacers of liquid crystal displays, an overcoat, and passivation materials and also advantageous in a high-temperature process characteristic.
摘要翻译：本发明涉及由化学式1化学式1表示的新结构的光敏化合物，其中R1，R2，R3，A如说明书中所定义，和含有该化合物的感光性树脂组合物。本发明的光活性化合物包括硝基和膦酸酯结构，因此通过有效吸收UV光，光活性化合物和碱溶性粘合剂树脂之间的相容性优异，并且改善了感光性树脂组合物的溶解性而显示出极好的灵敏度。此外，本发明的感光性树脂组合物具有优异的残留膜厚度和机械强度特性以及耐热，耐化学腐蚀和耐开发性能。因此，本发明的感光性树脂组合物有利于硬化液晶显示器的列间隔物，外涂层和钝化材料，并且在高温工艺特性中也是有利的。

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