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51. 发明申请

US20100240964A1 SYSTEM AND METHOD FOR DETERMINING A TREATMENT DOSE FOR A PATIENT 有权
标题翻译：用于确定患者治疗剂量的系统和方法
公开(公告)号：US20100240964A1
公开(公告)日：2010-09-23
申请号：US12702196
申请日：2010-02-08
申请人： Bernhard B. Sterling , James R. Braig , Peter Rule , Richard A. King
发明人： Bernhard B. Sterling , James R. Braig , Peter Rule , Richard A. King
IPC分类号： A61B5/00
CPC分类号： A61B5/150992 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1486 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150854 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N21/274 , G01N21/35 , G01N2201/1293 , G06F19/00 , G06F19/3468 , G16H10/40 , G16H20/17
摘要： In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.
摘要翻译：在某些实施例中，维持患者健康的方法使用分析物检测系统。分析物检测系统耦合到患者，使得患者的体液可被分析物检测系统访问。该方法包括使用分析物检测系统自动启动和进行体液中的分析物的测量。该方法还包括基于使用分析物检测系统的测量确定患者的治疗剂量。

52. 发明授权

US07674396B2 Method and system for treatment of eating disorders 有权
标题翻译：饮食失调的治疗方法和系统
公开(公告)号：US07674396B2
公开(公告)日：2010-03-09
申请号：US11270397
申请日：2005-11-08
申请人： Bernhard B. Sterling , Alexander K. Mills
发明人： Bernhard B. Sterling , Alexander K. Mills
IPC分类号： C09K3/00 , A61K9/12 , A61K33/10
CPC分类号： A61F2/04 , A61F2002/044 , A61K9/0007 , A61K9/0065 , A61K9/2086
摘要： The invention comprises a gastric device having an outer region and a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.
摘要翻译：本发明包括具有外部区域和气体产生材料的胃装置。胃装置中的胃装置在患者的胃中水化，并且气体生成材料将装置扩大到更大的体积。因此，水合，扩张的胃装置的体积占据胃腔中的空间，并减少患者在达到饱腹感之前摄取的食物量。优选地，胃装置由食品级材料制成。胃装置被配置为扩张到期望的体积，然后在停留时间后降解，允许装置通过患者的正常消化过程。

53. 发明申请

US20090187110A1 Method for determining a cardiac function 有权
标题翻译：确定心脏功能的方法
公开(公告)号：US20090187110A1
公开(公告)日：2009-07-23
申请号：US12011122
申请日：2008-01-23
申请人： Gregory I. Voss , James M. Perry , Rankin A. Clinton, III , Bernhard B. Sterling , Andrew R. Lawrence
发明人： Gregory I. Voss , James M. Perry , Rankin A. Clinton, III , Bernhard B. Sterling , Andrew R. Lawrence
IPC分类号： A61B5/024
CPC分类号： A61B5/026 , A61B5/02125
摘要： A method for determining a cardiac function, comprising (i) determining base anatomical characteristics associated with the subject, (ii) determining pulse delay to a first body site (PD01) and a second body site (PD02) as a function of the anatomical characteristics, wherein the distance via the arterial tree from the aortic valve to the first body site (PD01) is different than the arterial tree distance from the aortic valve to the second body site (PD02), (iii) determining pulse wave velocity between the first body site and the second body site (PWV12), (iv) determining pulse wave velocity between the aortic valve and the first body site (PWV01) as a function of PWV12, and the anatomical characteristics; and (v) determining the pre-ejection period (PEP) as a function of PD01 and PWV01.
摘要翻译：一种用于确定心脏功能的方法，包括（i）确定与受试者相关联的基础解剖特征，（ii）根据解剖特征确定到第一身体部位（PD01）和第二身体部位（PD02）的脉冲延迟，其中经由动脉树从主动脉瓣到第一身体部位（PD01）的距离不同于从主动脉瓣到第二身体部位（PD02）的动脉树距离，（iii）确定第一（PWV12），（iv）确定作为PWV12的函数的主动脉瓣与第一个体部位（PWV01）之间的脉搏波速度及其解剖特征; 和（v）确定作为PD01和PWV01的函数的预喷射周期（PEP）。

54. 发明申请

US20090030296A1 Predictive oximetry model and method 审中-公开
标题翻译：预测血氧仪模型及方法
公开(公告)号：US20090030296A1
公开(公告)日：2009-01-29
申请号：US11881103
申请日：2007-07-24
申请人： Bernhard B. Sterling
发明人： Bernhard B. Sterling
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551
摘要： The invention comprises a method for determining oxygen saturation in a subject, comprising the steps of compiling a data base of measured spectral data that includes pulsatile AC and non-pulsatile DC components, and spectral values of oxyhemoglobin (oxyHb) and deoxyhemoglobin (deoxyHb); determining absorbed pulsatile components and non-pulsatile components as a function of the oxyHb and deoxyHb values; determining total pulsatile and non-pulsatile optical density as a function of the absorbed pulsatile and non-pulsatile components; determining a mathematical relationship between at least one pulsatile AC parameter and at least one non-pulsatile DC parameter; and estimating oxygen saturation based on the mathematical relationship.
摘要翻译：本发明包括用于确定受试者的氧饱和度的方法，包括以下步骤：编译包括脉动AC和非脉动DC分量的测量光谱数据的数据库，以及氧合血红蛋白（oxyHb）和脱氧血红蛋白（脱氧Hb）的光谱值; 确定吸收的脉动组分和非脉动组分作为oxyHb和脱氧Hb值的函数; 确定作为吸收的脉动和非脉动组件的函数的总搏动和非脉动光密度; 确定至少一个脉冲AC参数与至少一个非脉动DC参数之间的数学关系; 并根据数学关系估算氧饱和度。

55. 发明申请

US20080269616A1 MIR SPECTROSCOPY OF TISSUE 审中-公开
标题翻译：组织的MIR光谱
公开(公告)号：US20080269616A1
公开(公告)日：2008-10-30
申请号：US11941816
申请日：2007-11-16
申请人： Matthew M. Bloom , Bernhard B. Sterling
发明人： Matthew M. Bloom , Bernhard B. Sterling
IPC分类号： A61B5/1455
CPC分类号： A61B5/0075 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/444 , A61B5/445 , A61B5/7275 , G01N21/35
摘要： Disclosed are methods of determining long-term deposition pattern of a compound in tissue. The following steps can be followed: placing tissue against a receptor; directing mid-infrared electromagnetic radiation onto the tissue; quantifying the electromagnetic radiation that is reflected from the tissue to obtain a reflected amount; using a calibration equation to calculate the concentration of a compound from the reflected amount; and using the concentration of the compound to evaluate presence of a clinical condition in the tissue.
摘要翻译：公开了确定组织中化合物的长期沉积模式的方法。可以遵循以下步骤：将组织置于受体上; 将中红外电磁辐射引导到组织上; 量化从组织反射的电磁辐射以得到反射量; 使用校正方程从反射量计算化合物的浓度; 并使用化合物的浓度来评估组织中临床状况的存在。

56. 发明授权

US07388202B2 Method and apparatus for determining an analyte concentration in a sample having interferents 有权
标题翻译：用于确定具有干扰物的样品中的分析物浓度的方法和装置
公开(公告)号：US07388202B2
公开(公告)日：2008-06-17
申请号：US11256656
申请日：2005-10-21
申请人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Bernhard B. Sterling , W. Dale Hall , Kenneth G. Witte , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： G01J1/00 , G01N21/35
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
摘要翻译：描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。该方法减少了在存在干扰物的情况下分析物浓度的误差。该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

57. 发明授权

US07271912B2 Method of determining analyte concentration in a sample using infrared transmission data 有权
标题翻译：使用红外线传输数据确定样品中分析物浓度的方法
公开(公告)号：US07271912B2
公开(公告)日：2007-09-18
申请号：US10825085
申请日：2004-04-15
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
IPC分类号： G01N21/00 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , G01N21/03 , G01N21/314 , G01N21/35
摘要： A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.
摘要翻译：一种方法确定样品中的分析物浓度。样品包括分析物和物质。该方法包括提供样品的吸收数据。该方法还包括提供该物质的参考吸收数据。该方法还包括计算吸收数据的物质贡献。该方法还包括从吸收数据中减去物质贡献，由此提供基本上不含该物质贡献的校正吸收数据。

58. 发明授权

US07050157B2 Reagent-less whole-blood glucose meter 有权
公开(公告)号：US07050157B2
公开(公告)日：2006-05-23
申请号：US10200384
申请日：2002-07-19
申请人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
发明人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
IPC分类号： G01N33/48
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150213 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150755 , A61B5/15087 , A61B5/151 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

59. 发明授权

US06862534B2 Method of determining an analyte concentration in a sample from an absorption spectrum 有权
公开(公告)号：US06862534B2
公开(公告)日：2005-03-01
申请号：US10366540
申请日：2003-02-12
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
IPC分类号： A61B5/00 , G01N21/27 , G01N21/31 , G01N21/35 , G01N33/487 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B2562/0295 , G01N21/274 , G01N21/314 , G01N21/35 , G01N27/3271
摘要： A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.

60. 发明授权

US06694157B1 Method and apparatus for determination of pH pCO2, hemoglobin, and hemoglobin oxygen saturation 失效
标题翻译：用于测定pH pCO2，血红蛋白和血红蛋白氧饱和度的方法和装置
公开(公告)号：US06694157B1
公开(公告)日：2004-02-17
申请号：US09247681
申请日：1999-02-09
申请人： Robert T. Stone , Bernhard B. Sterling
发明人： Robert T. Stone , Bernhard B. Sterling
IPC分类号： A61B500
CPC分类号： A61B5/14539 , A61B5/14557
摘要： This invention relates to a method and apparatus for in-vivo, real time measurement of pH, pCO2, base excess, hemoglobin, and hemoglobin oxygen saturation. Specifically, the invention relates to an apparatus placed in-line with an existing invasive patient access line to provide continuous, semi-continuous, or non-continuous monitoring of blood pH, pCO2, base excess, hemoglobin, and hemoglobin oxygen saturation in a manner which is relatively non-invasive. Further, the device and apparatus allows monitoring of the listed parameters in a non-destructive manner such that the blood sample under analysis can be returned to the patient.
摘要翻译：本发明涉及用于体内，实时测量pH，pCO 2，碱过量，血红蛋白和血红蛋白氧饱和度的方法和装置。具体地，本发明涉及一种与现有入侵患者接入线一致放置的装置，以提供对血液pH，pCO 2，碱基过量，血红蛋白和血红蛋白氧饱和度的连续，半连续或不连续监测这是相对无创的。此外，该装置和装置允许以非破坏性的方式监视列出的参数，使得被分析的血液样品可以返回给患者。

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