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51. 发明申请

US20080194630A1 LTA4H modulators and uses thereof 审中-公开
标题翻译： LTA4H调节剂及其用途
公开(公告)号：US20080194630A1
公开(公告)日：2008-08-14
申请号：US12069943
申请日：2008-02-14
申请人： William T. Barchuk , Paul J. Dunford , James P. Edwards , Anne M. Fourie , Lars Karlsson , Joanne M. Quan
发明人： William T. Barchuk , Paul J. Dunford , James P. Edwards , Anne M. Fourie , Lars Karlsson , Joanne M. Quan
IPC分类号： A61K31/4535 , A61K31/426 , A61K31/423 , A61P43/00
CPC分类号： A61K31/423 , A61K31/426 , A61K31/4535
摘要： Leukotriene A4 hydrolase (LTA4H) inhibitors, compositions containing them, and methods of use for the inhibition of LTA4H enzyme activity and the treatment, prevention or inhibition of inflammation and/or conditions associated with inflammation.
摘要翻译：白细胞三烯A4水解酶（LTA4H）抑制剂，含有它们的组合物，以及用于抑制LTA4H酶活性以及治疗，预防或抑制与炎症相关的炎症和/或病症的方法。

52. 发明授权

US07402430B2 MHC class II antigen-presenting systems and methods for activating CD4+ T cells 有权
公开(公告)号：US07402430B2
公开(公告)日：2008-07-22
申请号：US10903213
申请日：2004-07-29
申请人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
发明人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
IPC分类号： C12N5/16 , G01N33/53 , A01N63/00
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.

53. 发明申请

US20080117993A1 Method and Apparatus for Enhancing the Speed of Wideband Signal Search Systems 失效
标题翻译：用于提高宽带信号搜索系统速度的方法和装置
公开(公告)号：US20080117993A1
公开(公告)日：2008-05-22
申请号：US12023162
申请日：2008-01-31
申请人： Lars Karlsson
发明人： Lars Karlsson
IPC分类号： H04L27/00 , H04B1/18
CPC分类号： H03J1/0091 , H03J1/005
摘要： A Method and Apparatus for Enhancing the Speed of Wideband Signal Search Systems provides a system that can perform hyper fast scanning for signals while at the same time provide very good phase noise performance. The method and apparatus provide a way to reduce costs by avoiding the expensive solutions employed by the unmodified prior systems. The method and apparatus have all of the abilities of standard wideband signal collection systems. Secondly the method and apparatus are able to automatically, and extremely quickly, control multiple VCO's in a finely coordinated tuning process. Thirdly, the method and apparatus still have very good phase noise performance, even though it has hyper fast tuning speeds. Fourthly, the preferred method and apparatus pipeline the digitization and tuning phases of the collection process. Finally, the method and apparatus provide real-time control logic to accurately synchronize all events and make them work in the specific procedure at their respective specific microseconds in time.
摘要翻译：用于提高宽带信号搜索速度的方法和装置提供了一种可以对信号执行超快扫描的系统，同时提供非常好的相位噪声性能。该方法和装置提供了一种通过避免未修改的现有系统所采用的昂贵解决方案来降低成本的方法。该方法和装置具有标准宽带信号采集系统的所有能力。其次，该方法和装置能够在精细协调的调谐过程中自动且非常快速地控制多个VCO。第三，该方法和装置仍然具有非常好的相位噪声性能，即使它具有超快的调谐速度。第四，优选的方法和设备管理收集过程的数字化和调整阶段。最后，该方法和装置提供实时控制逻辑以准确地同步所有事件，并使它们在具体过程中在其相应的特定微秒时间内工作。

54. 发明申请

US20080102476A1 Analyzing Histamine H4 Receptor-Mediated Effects In Whole Blood 审中-公开
标题翻译：分析组胺H4受体介导的全血中的作用
公开(公告)号：US20080102476A1
公开(公告)日：2008-05-01
申请号：US10572985
申请日：2004-09-24
申请人： Lars Karlsson , Wai-Ping Leung , Ping Ling , Robin Thurmond
发明人： Lars Karlsson , Wai-Ping Leung , Ping Ling , Robin Thurmond
IPC分类号： G01N33/53
CPC分类号： G01N33/566 , G01N2500/04
摘要： Assay methods for analyzing whole blood to detect histamine H4 receptor-mediated effects, such as eosinophil shape change, cytoskeletal change, adhesion molecule up-regulation, or calcium flux are described. Such methods are useful in clinical and diagnostic applications.
摘要翻译：描述了用于分析全血以检测组胺H 4受体介导的作用的测定方法，例如嗜酸性粒细胞形状变化，细胞骨架变化，粘附分子上调或钙通量。这些方法在临床和诊断应用中是有用的。

55. 发明申请

US20080049106A1 NIGHT VISION DEVICE FOR A VEHICLE 有权
公开(公告)号：US20080049106A1
公开(公告)日：2008-02-28
申请号：US11837370
申请日：2007-08-10
申请人： Jan-Erik Kallhammer , Dick Eriksson , Lars Karlsson , Staffan Straat
发明人： Jan-Erik Kallhammer , Dick Eriksson , Lars Karlsson , Staffan Straat
IPC分类号： H04N5/33
CPC分类号： H04N5/33 , B60R1/00 , B60R2300/106 , B60R2300/205 , B60R2300/301 , B60R2300/302 , B60R2300/306 , B60R2300/804 , B60R2300/8053
摘要： In a night vision arrangement for a motor vehicle in which a camera captures an infra-red image of the roadway in front of the vehicle, a video signal generated by the camera is processed by a signal processor so that the field of view of the image displayed by a display unit is selected in accordance with a control signal. The control signal is generated by a signal generator which is responsive to one or more parameters of the movement of the vehicle. The width of the field of view may be decreased with increasing speed. The axial direction of the field of view may be adjusted depending upon the nature of a turning movement of the vehicle.

56. 发明授权

US07312045B2 Aggrecanase-1 and -2 peptide substrates and methods 有权
标题翻译：聚集蛋白酶-1和-2肽底物和方法
公开(公告)号：US07312045B2
公开(公告)日：2007-12-25
申请号：US11012797
申请日：2004-12-15
申请人： Anne M. Fourie , Lars Karlsson , Fawn Coles
发明人： Anne M. Fourie , Lars Karlsson , Fawn Coles
IPC分类号： C12Q1/37 , C12N9/64 , A61K38/00 , A61K38/04
CPC分类号： C12N9/6421
摘要： The present invention describes synthetic peptide substrates of the metalloproteases, aggrecanase-1 and/or -2 suitable for assays of enzyme activity. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases.
摘要翻译：本发明描述了适用于酶活性测定的金属蛋白酶合用肽底物，聚集蛋白聚糖蛋白聚糖酶-1和/或-22。本发明还描述了使用这些肽发现调节这些蛋白酶的药剂的方法。

57. 发明授权

US07223204B2 Method and system for automatic freewheeling of vehicle 有权
标题翻译：车辆自动续航方法及系统
公开(公告)号：US07223204B2
公开(公告)日：2007-05-29
申请号：US11463601
申请日：2006-08-10
申请人： Marcus Steen , Lars Karlsson , Sixten Berglund
发明人： Marcus Steen , Lars Karlsson , Sixten Berglund
IPC分类号： F16H59/60 , F16H59/62 , B60T8/24 , G05D1/00 , G06F7/00
CPC分类号： F16H61/21 , B60K17/26 , B60W10/115 , B60W10/184 , B60W2030/1809 , B60W2520/10 , B60W2540/103 , B60W2550/142 , B60W2550/402 , F16H2059/663 , F16H2059/666 , F16H2061/0234 , F16H2061/0237 , Y10T477/65
摘要： A method and a system for automatic freewheeling of a vehicle, where in the vehicle is arranged a speed-lowering arrangement, including an engine, a wheel driven by the engine via an automated stage-geared gearbox, a gas pedal for regulating the driving torque of the engine, and a control unit. The control unit is arranged to, when the freewheel function is activated and in the presence of an input signal indicating that a predetermined vehicle speed limit is exceeded, to automatically deactivate the freewheel function and brake the vehicle with the speed lowering arrangement. The control unit is arranged to reactivate the freewheel function in the presence of an input signal indicating that the vehicle speed has fallen to close to the predetermined vehicle speed limit. The future progression of the vehicle may be simulated with a view to optimizing the freewheel function in terms of good fuel economy and/or increased comfort.
摘要翻译：一种用于车辆自动续飞的方法和系统，其中在车辆中布置有降速装置，包括发动机，经由自动化齿轮齿轮箱由发动机驱动的车轮，用于调节驱动扭矩的油门踏板的发动机，以及控制单元。控制单元被布置成当飞轮功能被激活并且在存在指示超过预定车速限制的输入信号的情况下，自动停用续流功能并且以降速装置制动车辆。控制单元被布置成在存在指示车速已经下降到接近预定车速极限的输入信号的情况下重新启动续流功能。可以模拟车辆的未来进展，以便在良好的燃料经济性和/或增加的舒适性方面优化飞轮功能。

58. 发明申请

US20070117785A1 Substituted pyrazoles and methods of treatment with substituted pyrazoles 审中-公开
标题翻译：取代的吡唑和用取代的吡唑处理的方法
公开(公告)号：US20070117785A1
公开(公告)日：2007-05-24
申请号：US11542838
申请日：2006-10-04
申请人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Joanne Quan , Clark Sehon , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei , Ann Welton
发明人： Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Joanne Quan , Clark Sehon , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei , Ann Welton
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/416
CPC分类号： A61K31/416 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases or allergic conditions, including atopic allergic conditions, mediated by cathepsin S are described.
摘要翻译：描述了取代的吡唑，其制备方法，含有它们的组合物，以及使用它们来治疗例如自身免疫性疾病或过敏性疾病（包括由组织蛋白酶S介导的特应性过敏性病症）的方法。

59. 发明申请

US20070105841A1 Method for treating allergies using substituted pyrazoles 审中-公开
标题翻译：使用取代的吡唑治疗过敏症的方法
公开(公告)号：US20070105841A1
公开(公告)日：2007-05-10
申请号：US11590900
申请日：2006-10-31
申请人： J. Breitenbucher , Hui Cai , James Edwards , Cheryl Grice , Yin Gu , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei
发明人： J. Breitenbucher , Hui Cai , James Edwards , Cheryl Grice , Yin Gu , Darin Gustin , Lars Karlsson , Haripada Khatuya , Steven Meduna , Barbara Pio , Siquan Sun , Kevin Tays , Robin Thurmond , Jianmei Wei
IPC分类号： A61K31/551 , A61K31/53 , A61K31/501 , A61K31/496
CPC分类号： A61K31/496 , A61K31/501 , A61K31/53 , A61K31/551
摘要： A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
摘要翻译：一种使用取代的吡唑治疗过敏性疾病（包括特应性过敏症状）的方法。

60. 发明授权

US07126979B2 System and method to autonomously and selectively jam frequency hopping signals in near real-time 失效
标题翻译：系统和方法可以实时自动地选择性地阻止跳频信号
公开(公告)号：US07126979B2
公开(公告)日：2006-10-24
申请号：US10912976
申请日：2004-08-06
申请人： Lars Karlsson
发明人： Lars Karlsson
IPC分类号： H04B1/69 , H04K3/00 , H04K1/10
CPC分类号： H04K3/45 , H04K3/42 , H04K3/68
摘要： The system and method autonomously and selectively jams frequency-hopping signals in near real-time by incorporating a fundamental change in the detection and reaction technology, to provide a reaction time that is short enough, within milliseconds or less, to capture and then jam even the fastest frequency hopping radios in use today, without relying on prior art methods of using standard CPU driven technology.The system automatically determines if detected signal(s) should be jammed, and subsequently to automatically end extremely quickly activates the jamming transmitter on the frequency-hopper transmitter's frequency. Finally, the system provides a programmable user interface so that operators can set up the system to act autonomously as intended, such that operator intervention is unnecessary when the system is placed in jamming operation mode.
摘要翻译：该系统和方法通过在检测和反应技术中引入根本性的变化来自主选择接近实时的跳频信号，以提供足够短的反应时间，在几毫秒或更短的时间内捕获甚至阻塞甚至是目前使用最快的跳频无线电，而不依赖于使用标准CPU驱动技术的现有技术方法。系统自动确定检测到的信号是否卡住，然后自动结束极快地启动频率料斗变送器频率上的干扰变送器。最后，该系统提供可编程的用户界面，使得操作者可以将系统设置为按预期的方式自主行动，使得当系统处于干扰操作模式时不需要操作员干预。

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