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51. 发明申请

US20110090223A1 CREATING AND VIEWING THREE DIMENSIONAL VIRTUAL SLIDES 有权
标题翻译：创建和查看三维虚拟幻灯片
公开(公告)号：US20110090223A1
公开(公告)日：2011-04-21
申请号：US12979996
申请日：2010-12-28
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G06T15/40
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional digital slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. These two dimensional digital slide images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维数字幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。这些二维数字幻灯片图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像，并且选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

52. 发明授权

US07860292B2 Creating and viewing three dimensional virtual slides 有权
标题翻译：创建和查看三维虚拟幻灯片
公开(公告)号：US07860292B2
公开(公告)日：2010-12-28
申请号：US12731083
申请日：2010-03-24
申请人： Ole Eichhorn , Greg Crandall , Dirk Soenksen , Steven Hashagen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Dirk Soenksen , Steven Hashagen , Mark Wrenn
IPC分类号： G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

53. 发明授权

US07787674B2 Systems and methods for viewing three dimensional virtual slides 有权
标题翻译：用于查看三维虚拟幻灯片的系统和方法
公开(公告)号：US07787674B2
公开(公告)日：2010-08-31
申请号：US11341097
申请日：2006-01-27
申请人： Ole Eichhorn
发明人： Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06T15/00 , G02B21/34 , G02B21/367 , G06T5/50 , G06T15/08 , G06T15/10 , G06T2207/20212 , G06T2207/20224 , G06T2207/30024 , G06T2207/30056
摘要： Systems and methods for retrieving, manipulating, and viewing 3D image objects from 3D virtual microscope slide images are provided. An image library module provides access to the imagery data in a 3D virtual slide and constructs 3D image objects that are coextensive with the 3D virtual slide or a 3D sub-portion thereof. From within the 3D image object, cross layer planar views spanning various depths of the 3D virtual slide are constructed as well as 3D prisms and other shaped image areas. The image library module allows a 3D image object to be sliced into horizontal and vertical views, skewed cross layer views and regular and irregular shaped 3D image areas for viewing by a user.
摘要翻译：提供了从3D虚拟显微镜幻灯片图像检索，操作和查看3D图像对象的系统和方法。图像库模块提供对3D虚拟幻灯片中的图像数据的访问，并且构造与3D虚拟幻灯片或其3D子部分共同延伸的3D图像对象。从3D图像对象中，构建跨越3D虚拟幻灯片的各种深度的跨层平面视图以及3D棱镜和其他形状的图像区域。图像库模块允许3D图像对象被切割成水平和垂直视图，倾斜的交叉层视图和规则和不规则形状的3D图像区域以供用户观看。

54. 发明申请

US20100177166A1 Creating and Viewing Three Dimensional Virtual Slides 有权
标题翻译：创建和查看三维虚拟幻灯片
公开(公告)号：US20100177166A1
公开(公告)日：2010-07-15
申请号：US12731083
申请日：2010-03-24
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： H04N13/02 , H04N7/18
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

55. 发明申请

US20080292159A1 Second Opinion Network 有权
标题翻译：第二意见网
公开(公告)号：US20080292159A1
公开(公告)日：2008-11-27
申请号：US12110185
申请日：2008-04-25
申请人： Dirk G. Soenksen , Kathy Zirker-Smith , Ole Eichhorn
发明人： Dirk G. Soenksen , Kathy Zirker-Smith , Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G16H80/00 , G06F19/00 , G06F19/321 , G16H50/50
摘要： Systems and methods are provided to facilitate consultations between a referral source (e.g., labs, pathologists and patients) and a consultant (e.g., pathologist, radiologist, or other digital image analyst). Links between the various referral sources and consultants are established through a scanning center via a data communication network such as the Internet. The referral source sends a slide to the scanning center where the corresponding digital slide is posted for review and analysis by the consultant. Upon completion of the analysis and report, a digital slide conference is conducted through the scanning center that provides a venue for direct communication regarding the consultation. The scanning center may also facilitate payment from the referral source to the consultant.
摘要翻译：提供系统和方法以便于转介来源（例如，实验室，病理学家和患者之间）和顾问（例如病理学家，放射科医师或其他数字图像分析者）之间的协商。通过扫描中心通过数据通信网络（如互联网）建立各种转介来源和顾问之间的联系。推荐来源将幻灯片发送到扫描中心，其中相应的数字幻灯片发布供顾问进行审查和分析。完成分析报告后，通过扫描中心进行数字幻灯片会议，为会议提供直接沟通的场所。扫描中心也可以方便从推荐来源向顾问付款。

56. 发明申请

US20080124002A1 Method for Storing and Retrieving Large Images Via DICOM 有权
标题翻译：通过DICOM存储和检索大图像的方法
公开(公告)号：US20080124002A1
公开(公告)日：2008-05-29
申请号：US11771612
申请日：2007-06-29
申请人： Ole Eichhorn
发明人： Ole Eichhorn
IPC分类号： G06K9/54
CPC分类号： G06F17/30244 , G06F17/3028 , G06F19/00 , G06F19/321 , G06T3/40 , G06T7/0012 , G06T7/30 , G06T2207/20021 , G06T2207/30004
摘要： Systems and methods that acquire digital slides and other large images and store these images into commercially available PACS systems using DICOM-standard messaging are provided. A digital slide or other large two-dimensional image is acquired and each separate resolution level of the digital slide or large image is divided into a series of regions that are each identified as a DICOM image. All of the regions at the same resolution in the digital slide or other large image are collectively identified as a DICOM series. A plurality of DICOM series, representing multiple resolution levels in a digital slide are collectively identified and stored as a DICOM study.
摘要翻译：提供了获取数字幻灯片和其他大图像并将这些图像存储到使用DICOM标准消息传递的市售PACS系统中的系统和方法。获取数字幻灯片或其他大的二维图像，并且将数字幻灯片或大图像的每个单独的分辨率级别划分为每个被识别为DICOM图像的一系列区域。数字幻灯片或其他大图像中相同分辨率的所有区域被统称为DICOM系列。在数字幻灯片中表示多个分辨率级别的多个DICOM系列被集体地识别并存储为DICOM研究。

57. 发明授权

US07257268B2 Systems and methods for image pattern recognition 有权
标题翻译：图像模式识别的系统和方法
公开(公告)号：US07257268B2
公开(公告)日：2007-08-14
申请号：US10774971
申请日：2004-02-09
申请人： Ole Eichhorn , Dirk G. Soenksen
发明人： Ole Eichhorn , Dirk G. Soenksen
IPC分类号： G06K9/36
CPC分类号： G06K9/6218 , G06K9/00147 , G06T9/008 , G06T9/40 , H04N19/94 , H04N19/96
摘要： Systems and methods for image pattern recognition comprise digital image capture and encoding using vector quantization (“VQ”) of the image. A vocabulary of vectors is built by segmenting images into kernels and creating vectors corresponding to each kernel. Images are encoded by creating a vector index file having indices that point to the vectors stored in the vocabulary. The vector index file can be used to reconstruct an image by looking up vectors stored in the vocabulary. Pattern recognition of candidate regions of images can be accomplished by correlating image vectors to a pre-trained vocabulary of vector sets comprising vectors that correlate with particular image characteristics. In virtual microscopy, the systems and methods are suitable for rare-event finding, such as detection of micrometastasis clusters, tissue identification, such as locating regions of analysis for immunohistochemical assays, and rapid screening of tissue samples, such as histology sections arranged as tissue microarrays (TMAs).
摘要翻译：用于图像模式识别的系统和方法包括使用图像的矢量量化（“VQ”）的数字图像捕获和编码。通过将图像分割为内核并创建与每个内核相对应的向量来构建向量的词汇表。通过创建具有指向存储在词汇表中的向量的索引的向量索引文件对图像进行编码。向量索引文件可用于通过查找存储在词汇表中的向量来重建图像。可以通过将图像向量与包括与特定图像特征相关的向量的预先训练的矢量集合的词汇相关联来实现图像候选区域的模式识别。在虚拟显微镜中，系统和方法适用于罕见事件发现，例如检测微转移簇，组织鉴定，例如免疫组织化学测定的分析区域以及组织样品的快速筛选，例如排列成组织的组织切片微阵列（TMA）。

58. 发明授权

US07116440B2 Image processing and analysis framework 有权
公开(公告)号：US07116440B2
公开(公告)日：2006-10-03
申请号：US10787330
申请日：2004-02-26
申请人： Ole Eichhorn , Allen Olson
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06F15/00
CPC分类号： G06K9/46 , G06T1/00
摘要： A system and method for processing and analyzing virtual microscopy digital images (“virtual slides”) is provided. The system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of virtual slides. The algorithm server executes a selected routine on an identified virtual slide and provides the resulting data. The virtual slide can be accessed locally or remotely across a network. Similarly, the image processing routines can be obtained from local storage or across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely obtained routines. Access to image processing and analysis may be restricted through a monitor process that authenticates requests to process or view virtual slides. Variations in restrictions to images provide a rich diversity in access levels that allow sharing of virtual slides and demonstrations of image processing algorithms.

59. 发明申请

US20060007533A1 Systems and methods for creating and viewing three dimensional virtual slides 有权
标题翻译：用于创建和查看三维虚拟幻灯片的系统和方法
公开(公告)号：US20060007533A1
公开(公告)日：2006-01-12
申请号：US11140265
申请日：2005-05-27
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G02B21/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

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