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    • 57. 发明授权
    • Oxyalkylene-substituted aminophenol intermediate
    • 氧亚烷基取代的氨基苯酚中间体
    • US6040482A
    • 2000-03-21
    • US263902
    • 1999-03-05
    • Philip G. HarrisRajnish Batlaw
    • Philip G. HarrisRajnish Batlaw
    • C07C215/76C07C217/42C07D265/38C07D311/82C07D405/04C09B11/14C09B19/00C09B57/02C07C215/00C07C211/00
    • C07D405/04C07C215/76C07C217/42C07D265/38C07D311/82C09B11/14C09B19/00C09B57/02
    • This invention relates to very specific oxyalkylene-substituted aminophenol compounds as intermediates for the production of poly(oxyalkylene)-substituted xanthene (or other type) colorants. Such an inventive intermediate compound is produced in a single step by reacting an oxyalkylene oxide having from 3 to 12 carbon atoms (branched or unbranched), glycidol, or a glycidyl directly with aminophenol without the use of a catalyst and at a relatively low temperature. Propylene oxide and m-aminophenol are the preferred reactants. The propylene oxide selectively reacts with the amine group on the m-aminophenol without propoxylating the phenolic hydroxyl group. Such a specific method thus does not require extra time- and cost-consuming steps of protecting the phenolic hydroxyl group from attack. After production, this intermediate may be reacted with suitable compounds to ultimately form any number of different colorants, including xanthenes, oxazines, coumarins, and the like. The resultant oxypropylene groups may subsequently be reacted with electrophile compounds to produce any number of different colorants. Resultant colorants produced through the reaction of the inventive intermediate are also contemplated within this invention.
    • 本发明涉及作为制备聚(氧化烯)取代呫吨(或其它类型)着色剂的中间体的非常具体的氧化烯取代的氨基苯酚化合物。 这种本发明的中间体化合物是通过使具有3-12个碳原子的氧化烯(支链或非支链),缩水甘油或缩水甘油基直接与氨基苯酚反应而不使用催化剂并在相对较低的温度下在一个步骤中制备的。 环氧丙烷和间氨基苯酚是优选的反应物。 环氧丙烷选择性地与间氨基苯酚上的胺基反应而不丙氧基酚羟基。 因此,这种具体方法不需要额外的时间和成本的步骤来保护酚羟基免受攻击。 生产后,该中间体可以与合适的化合物反应,最终形成任何数量的不同着色剂,包括呫吨,恶嗪,香豆素等。 随后可以将所得的氧亚丙基与亲电子化合物反应以产生任何数量的不同的着色剂。 通过本发明中间体的反应产生的所得着色剂也在本发明范围内。