专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09035097B2 Aminoethylation process having improved yield of aryloxyalkylene amine compounds and reduced urea by-products 有权
标题翻译：氨基乙基化方法具有提高的芳氧基亚烷基胺化合物的产率和减少的尿素副产物
公开(公告)号：US09035097B2
公开(公告)日：2015-05-19
申请号：US13612595
申请日：2012-09-12
申请人： Patrick J. McDougall , James Saenz , David Lao
发明人： Patrick J. McDougall , James Saenz , David Lao
IPC分类号： C07C215/00 , C07C209/78 , C07C213/08
CPC分类号： C07C209/78 , C07C213/08 , C07C217/16
摘要： Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; wherein R3 is selected from the group consisting of hydrogen or lower alkyl having 1 to 6 carbon atoms, R4 is selected from the group consisting of hydrogen, straight or branched chain alkyl having from one to six carbon atoms, phenyl, alkaryl, or arylalkyl; and b) reacting the intermediate product of step a) with a polyalkylene polyamine.
摘要翻译：公开了通过氨基乙基化反应制备芳氧基亚烷基胺化合物的方法，包括：a）在碱性催化剂存在下使芳族羟基化合物与式II的2-恶唑烷酮化合物反应，形成中间反应产物; 其中R 3选自氢或具有1至6个碳原子的低级烷基，R 4选自氢，具有1至6个碳原子的直链或支链烷基，苯基，烷芳基或芳基烷基; 和b）使步骤a）的中间产物与聚亚烷基多胺反应。

2. 发明授权

US08884061B2 Compositions and methods of use of electron transport system inhibitors 有权
标题翻译：电子传递系统抑制剂的组合物和使用方法
公开(公告)号：US08884061B2
公开(公告)日：2014-11-11
申请号：US12281364
申请日：2007-03-02
申请人： Michio Kurosu , Dean Calvin Crick
发明人： Michio Kurosu , Dean Calvin Crick
IPC分类号： A01N33/02 , A61K31/135 , C07C211/00 , C09B11/02 , C07C215/00 , C07C213/00 , C07C217/00 , C07C321/00 , C07C323/00 , C07C381/00 , C07C217/18
CPC分类号： C07C217/18
摘要： The invention provides compounds of the formula: or a pharmaceutically acceptable salt thereof, where m, n, R1, R2, R3 R4, R5, R6, R7 are those defined herein. The invention also provides pharmaceutical compositions comprising a compound of the invention, methods for using compounds and/or pharmaceutical compositions of the invention, and methods for synthesizing compounds of the invention.
摘要翻译：本发明提供下式的化合物或其药学上可接受的盐，其中m，n，R 1，R 2，R 3，R 4，R 5，R 6，R 7是本文定义的那些。本发明还提供包含本发明化合物的药物组合物，使用本发明化合物和/或药物组合物的方法，以及合成本发明化合物的方法。

3. 发明授权

US08679436B2 Process for working up an exhaust gas from a system for producing hydroxylamine or hydroxylammonium salts 失效
标题翻译：从用于生产羟胺或羟铵盐的系统处理废气的方法
公开(公告)号：US08679436B2
公开(公告)日：2014-03-25
申请号：US13876496
申请日：2011-09-27
申请人： Arnd Garsuch , Alexander Panchenko , Sigmar Bräuninger , Jens Scheidel , Alfred Thome
发明人： Arnd Garsuch , Alexander Panchenko , Sigmar Bräuninger , Jens Scheidel , Alfred Thome
IPC分类号： B01D53/34 , B01D53/46 , C07C215/00
CPC分类号： B01D53/46 , B01D53/229 , B01D53/326 , B01D69/148 , B01D71/024 , B01D71/32 , B01D71/52 , B01D71/62 , B01D71/82 , B01D2257/108 , B01D2313/345 , C01B3/501 , C01B3/503 , C01B21/1418 , C01B2203/0405 , C01B2203/041 , C01B2203/0465 , H01M8/086 , H01M8/1023 , H01M8/1025 , H01M8/106 , H01M8/1246 , Y02E60/525 , Y02P70/56
摘要： Process for working up an exhaust gas from a system for producing hydroxylamine or hydroxylammonium salts by catalytic reduction of nitrogen monoxide with hydrogen, the exhaust gas containing nitrogen monoxide, hydrogen, dinitrogen monoxide, nitrogen and ammonia. At least some of the hydrogen present in the exhaust gas is separated off from the exhaust gas by means of a gas-tight membrane-electrode assembly which comprises at least one selectively proton-conducting membrane, a retentate side, a permeate side, and, on each side of the membrane, at least one electrode catalyst, wherein, on the retentate side of the membrane, at least some of the hydrogen is oxidized to protons at the anode catalyst and the protons, after crossing the membrane, are, on the permeate side, at the cathode catalyst according to (I) reduced to hydrogen and/or (II) reacted with oxygen to form water, the oxygen originating from an oxygen-containing stream which is contacted with the permeate side.
摘要翻译：通过用氢气还原一氧化氮，含有一氧化氮，氢气，一氧化二氮，氮气和氨的废气来处理来自用于生产羟胺或羟铵盐的系统的排气的方法。存在于废气中的至少一部分氢气通过气密膜电极组件与废气分离，所述气 - 气膜 - 电极组件包括至少一个选择性质子传导膜，滞留物侧，渗透侧，在膜的每一侧上，至少一个电极催化剂，其中在膜的截留侧上，至少一些氢被氧化成在阳极催化剂和质子之间的质子，在穿过膜之后，在渗透侧，根据（I）的阴极催化剂还原为氢和/或（II）与氧反应形成水，所述氧来源于与渗透侧接触的含氧流。

4. 发明授权

US08618326B2 Methods of synthesizing 2-substituted-1,4-benzenediamine 有权
公开(公告)号：US08618326B2
公开(公告)日：2013-12-31
申请号：US13016322
申请日：2011-01-28
申请人： John Michael Gardlik , Garry Steven Garrett , Bryan Patrick Murphy , Guiru Zhang , Robert Edward Shumate , James S. Anderson
发明人： John Michael Gardlik , Garry Steven Garrett , Bryan Patrick Murphy , Guiru Zhang , Robert Edward Shumate , James S. Anderson
IPC分类号： C07C215/00 , C07C209/00 , C07C213/00 , C07C217/00 , C07C211/00
CPC分类号： C07C217/84 , C07C209/10 , C07C209/32
摘要： Disclosed is a method of making a 2-substituted-1,4-benzenediamine by nucleophilic aromatic substitution.

5. 发明授权

US08476305B2 Therapeutic agent or prophylactic agent for inflammatory bowel disease comprising amino alcohol derivative as active ingredient 失效
标题翻译：包含氨基醇衍生物作为活性成分的炎性肠病的治疗剂或预防剂
公开(公告)号：US08476305B2
公开(公告)日：2013-07-02
申请号：US12866576
申请日：2009-02-06
申请人： Naoya Yamamuro , Koichi Nakamaru , Tokutarou Yasue
发明人： Naoya Yamamuro , Koichi Nakamaru , Tokutarou Yasue
IPC分类号： C07C215/00 , A61K31/00
CPC分类号： A61K31/133 , A61K31/225 , A61K31/27 , A61K31/4965 , C07D241/08
摘要： A novel therapeutic agent or prophylactic agent for an inflammatory bowel disease is provided. An amino alcohol derivative represented by the general formula (1): which is a sphingosine-1-phosphate receptor agonist or a pharmaceutically acceptable salt or hydrate thereof are a therapeutic agent or prophylactic agent for an inflammatory bowel disease comprises.
摘要翻译：提供了一种用于炎症性肠病的新型治疗剂或预防剂。由通式（1）表示的氨基醇衍生物：其为鞘氨醇-1-磷酸受体激动剂或其药学上可接受的盐或水合物，是炎症性肠病的治疗剂或预防剂。

6. 发明授权

US08344180B2 Hydrazine amide derivative 有权
标题翻译：肼酰胺衍生物
公开(公告)号：US08344180B2
公开(公告)日：2013-01-01
申请号：US12310566
申请日：2007-08-28
申请人： Naoki Kouyama
发明人： Naoki Kouyama
IPC分类号： C07C303/00 , C07C241/00 , C07C215/00 , C07C211/00
CPC分类号： C07D209/08 , A61K9/1623 , A61K9/2018 , A61K9/4858 , C07C311/07 , C07C2601/14 , C07D213/77
摘要： Disclosed are compound having NPY Y5 receptor antagonistic activity of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 is optionally substituted lower alkyl, R2 and R8 are each independently hydrogen or lower alkyl, X is optionally substituted cycloalkylene, or —NR2—X— may be a group of the formula: wherein a group of the formula: is piperidinediyl, piperazinediyl, pyridindiyl, pyrazinediyl, pyrrolidinediyl or pyrrolediyl, U is a bond, lower alkylene or lower alkenylene, Y is —OCONR7—, —CONR7— or —CSNR7—, R7 is hydrogen or lower alkyl, Z is optionally substituted carbocyclyl, or optionally substituted heterocyclyl, W is —S(═O)n-, n is 2, provided that Z is not carbocyclyl substituted with non-halogeno lower alkoxy, and provided that 5-Methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-carboxylic acid [2-[(5-chloro-1H-indole-2-carbonyl)-amino]-5 -(N′,N′-dimethyl-hydrazinocarbonyl)-cyclohexyl]-amide and 5-Methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-carboxylic acid [2-[(5-chloro-4-fluoro-1H-indole-2-carbonyl)-amino]-5-(N′,N′-dimethyl-hydrazinocarbonyl) -cyclohexyl]-amide are excluded.
摘要翻译：公开了具有式（I）的NPY Y5受体拮抗活性的化合物或其药学上可接受的盐，其中R 1为任选取代的低级烷基，R 2和R 8各自独立地为氢或低级烷基，X为任选取代的亚环烷基或-NR 2 -X-可以是下式的基团：其中下式的基团是哌啶二基，哌嗪二基，吡啶二基，吡嗪二基，吡咯烷二基或吡咯二基，U是一个键，低级亚烷基或低级亚烯基，Y是-OCONR7-，-CONR7 - 或-CSNR 7 - ，R 7是氢或低级烷基，Z是任选取代的碳环基或任选取代的杂环基，W是-S（= O）n - ，n是2，条件是Z不是被非卤素取代的碳环基并且条件是5-甲基-4,5,6,7-四氢 - 噻唑并[5,4-c]吡啶-2-甲酸[2 - [（5-氯-1H-吲哚-2-羰基） - 氨基] -5 - （N'，N'-二甲基 - 肼基羰基） - 环己基] - 酰胺和5-甲基-4,5,6,7-四氢 - 噻唑 o [5,4-c]吡啶-2-甲酸[2 - [（5-氯-4-氟-1H-吲哚-2-羰基） - 氨基] -5-（N'，N'-二甲基 - 肼基羰基） - 环己基] - 酰胺。

7. 发明授权

US08242144B2 Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases 有权
标题翻译：用于预防和治疗心血管疾病的Stilbenes和沙洛酮
公开(公告)号：US08242144B2
公开(公告)日：2012-08-14
申请号：US12905500
申请日：2010-10-15
申请人： Norman C. W. Wong , Joseph E. L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
发明人： Norman C. W. Wong , Joseph E. L. Tucker , Henrik C. Hansen , Fabrizio S. Chiacchia , David McCaffrey
IPC分类号： A01N43/40 , A01N33/26 , A61K31/44 , A61K31/655 , C09B29/00 , C07C39/00 , C07C39/12 , C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00 , C07C215/00
CPC分类号： C07D213/64 , A61K31/05 , A61K31/055 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/216 , A61K31/265 , A61K31/352 , A61K31/353 , A61K31/357 , A61K31/382 , A61K31/435 , A61K31/4375 , A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4433 , A61K31/465 , A61K31/47 , A61K31/536 , C07C37/003 , C07C37/055 , C07C37/18 , C07C39/14 , C07C39/15 , C07C39/21 , C07C43/23 , C07C46/00 , C07C49/83 , C07C49/835 , C07C50/32 , C07C205/22 , C07C311/29 , C07C317/22 , C07C327/28 , C07D213/65 , C07D213/80 , C07D213/89 , C07D215/233 , C07D217/16 , C07D217/22 , C07D217/24 , C07D265/22 , C07D311/30 , C07D311/32 , C07D311/36 , C07D311/60 , C07D319/20 , C07D335/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D491/052
摘要： The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
摘要翻译：本公开提供了上调载脂蛋白A-I（ApoA-I）表达的非天然存在的多酚化合物。所公开的组合物和方法可用于治疗和预防心血管疾病和相关疾病状态，包括胆固醇或脂质相关疾病，例如动脉粥样硬化。

8. 发明授权

US08242066B2 Aniline compounds as ashless TBN sources and lubricating oil compositions containing same 有权
公开(公告)号：US08242066B2
公开(公告)日：2012-08-14
申请号：US12342702
申请日：2008-12-23
申请人： Jie Cheng , Jacob Emert
发明人： Jie Cheng , Jacob Emert
IPC分类号： C10M133/12 , C10M133/00 , C07C211/00 , C07C215/00
CPC分类号： C10M133/12 , C10M133/14 , C10M2215/06 , C10M2215/062 , C10N2230/04 , C10N2230/12 , C10N2230/36 , C10N2230/45 , C10N2230/52 , C10N2240/10 , C10N2240/102
摘要： Aniline compounds useful as ashless TBN sources for lubricating oil compositions that are compatible with fluoroelastomeric engine seal materials, and lubricating oil compositions containing such aniline compounds.

9. 发明授权

US08193391B2 Process for preparation of 3-(2-hydroxy-5-substituted phenyl)-N-alkyl-3-phenylpropylamines 有权
标题翻译：制备3-（2-羟基-5-取代苯基）-N-烷基-3-苯基丙胺的方法
公开(公告)号：US08193391B2
公开(公告)日：2012-06-05
申请号：US12305913
申请日：2007-06-18
申请人： Erik Fischer
发明人： Erik Fischer
IPC分类号： C07C215/00
CPC分类号： C07C213/08 , C07B2200/07 , C07C253/30 , C07C215/54 , C07C255/59
摘要： A new process for preparation of 3-(2-hydroxy-5-substituted phenyl)-N,alkyl-3-phenylpropylamines from cinnamyl chloride via N-alkyl-3-phenylprop-2-en-1-amine has been developed.
摘要翻译：已经开发了通过N-烷基-3-苯基丙-2-烯-1-胺从肉桂酰氯制备3-（2-羟基-5-取代的苯基）-N，烷基-3-苯基丙胺的新方法。

10. 发明授权

US07960588B2 Benzyl cycloalkyl sphingosine 1-phosphate receptor modulators 有权
标题翻译：苄基环烷基鞘氨醇1-磷酸受体调节剂
公开(公告)号：US07960588B2
公开(公告)日：2011-06-14
申请号：US12748981
申请日：2010-03-29
申请人： Kevin R. Lynch , Timothy L. Macdonald
发明人： Kevin R. Lynch , Timothy L. Macdonald
IPC分类号： C07C215/00 , C07C229/00 , C07F9/00 , C07D333/00 , C07D307/00 , C07D417/00 , C07D261/00 , C07D231/00 , C07D295/00 , C07D207/00 , A61K31/66 , A61K31/425 , A61K31/42 , A61K31/415 , A61K31/40 , A61K31/38 , A61K31/34
CPC分类号： C07C215/42 , C07C217/52 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07F9/091 , C07F9/301
摘要： Sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type are provided. The disclosed compounds include an optional phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.
摘要翻译：提供了强效的鞘氨醇-1-磷酸类似物和一种或多种S1P受体，特别是S1P1受体类型的选择性激动剂。所公开的化合物包括任选的磷酸酯部分以及具有水解抗性的磷酸酯替代物的化合物，例如膦酸酯，α-取代的膦酸酯和磷酸三乙酯。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式