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1. 发明授权

US11597842B2 Labeling dye and kit including same 有权
公开(公告)号：US11597842B2
公开(公告)日：2023-03-07
申请号：US16860982
申请日：2020-04-28
申请人： SFC CO., LTD.
发明人： Bong-Ki Shin , Tae-Young Kim , Ju-Man Song , Hee-Jung Yang , Jong-Tae Je
IPC分类号： C09B23/00 , C09B57/02 , C09B23/01 , G01N33/58
摘要： The present invention relates to: a labeling dye having excellent fluorescent intensity and photostability; and a kit.

2. 发明授权

US10573839B2 Organic light-emitting device 有权
公开(公告)号：US10573839B2
公开(公告)日：2020-02-25
申请号：US16030692
申请日：2018-07-09
申请人： SAMSUNG DISPLAY CO., LTD.
发明人： Naoyuki Ito , Seul-Ong Kim , Youn-Sun Kim , Dong-Woo Shin , Jung-Sub Lee
IPC分类号： C09B57/00 , H01L51/50 , H01L51/00 , C09K11/06 , H05B33/14 , H05B33/18 , C09B23/14 , C09B57/02 , C09B57/10 , C09B1/00
摘要： An organic light-emitting device includes: a first electrode, a second electrode facing the first electrode, and an organic layer between the first electrode and the second electrode, the organic layer including: an emission layer, an electron transport region between the second electrode and the emission layer, and a mixed layer between the emission layer and the electron transport region, the mixed layer including a first material and a second material, the first material and the second material being selected from a pyrrolidine-based compound and a C10-C30 polycyclicaromatic hydrocarbon-based compound, and a triplet energy EgT1 of at least one selected from the first material and the second material being 2.2 eV or greater.

3. 发明授权

US10344165B2 2,7-disubstituted cephalosporin derivatives as β-lactamase substrates and methods for their use for the diagnosis of tuberculosis 有权
公开(公告)号：US10344165B2
公开(公告)日：2019-07-09
申请号：US15831266
申请日：2017-12-04
申请人： The Texas A&M University System , The Board of Trustees of the Leland Stanford Junior University
发明人： Jianghong Rao , Hexin Xie , Yunfeng Cheng , Jeffrey D. Cirillo
IPC分类号： C07D501/52 , C09B11/24 , C09B57/02 , C07D501/62 , C12Q1/04 , C12Q1/18 , C12Q1/34
摘要： β-Lactamase substrates and methods for using the substrates to detect β-lactamase and to diagnose tuberculosis.

4. 发明授权

US10222390B2 Near-infrared fluorescent sensors for biological amines 有权
公开(公告)号：US10222390B2
公开(公告)日：2019-03-05
申请号：US15229716
申请日：2016-08-05
申请人： The Curators of the University of Missouri
发明人： Timothy Glass , Kenneth Hettie
IPC分类号： C09K11/07 , G01N33/94 , C09B57/02 , G01N33/58 , C09K11/06
摘要： A fluorescence sensing compound for separately detecting and visualizing one or more monoamine neurotransmitters in cells, the fluorescence sensing compound having the following formula: wherein R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkylene, aryl, cycloalkyl; wherein R3 is selected from the group consisting of hydrogen, alkyl, alkylene, aryl, cycloalkyl, cyano, azido; and wherein R4 is selected from the group consisting of (CH3)2Si, O, N, S, and CH2.

5. 发明申请

US20180196033A1 CELL TRACKING REAGENTS AND THEIR METHODS OF USE 审中-公开
公开(公告)号：US20180196033A1
公开(公告)日：2018-07-12
申请号：US15738069
申请日：2016-06-20
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Penny MELQUIST , Kyle GEE
IPC分类号： G01N33/50 , C09B57/02
CPC分类号： G01N33/5005 , C09B57/02 , G01N33/582
摘要： Described herein are compounds, methods, and kits for short- and long-term tracking of cell proliferation, differentiation, and/or function. The compounds disclosed herein are coumarin-based cell-tracking reagents that fluoresce in the blue portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, good retention within cells and low toxicity toward cells.

6. 发明授权

US09896711B2 Fluorogenic or fluorophoric compounds and uses thereof 有权
公开(公告)号：US09896711B2
公开(公告)日：2018-02-20
申请号：US15226096
申请日：2016-08-02
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： Stephen B. Roscoe , Shih-Hung Chou , Stephanie J. Moeller , Jesse D. Miller , Kurt J. Halverson , Jason W. Bjork
IPC分类号： C07D405/04 , C12Q1/04 , C07D311/16 , C07D409/04 , C07H17/075 , G01N33/52 , G01N33/58 , C09B57/02
CPC分类号： C12Q1/04 , C07D311/16 , C07D405/04 , C07D409/04 , C07H17/075 , C09B57/02 , C12Q1/045 , G01N33/525 , G01N33/582
摘要： Compounds are provided that are either fluorogenic or fluorophoric. Compositions and articles that include the compounds are also provided. Additionally, methods of detecting a microorganism using the compounds are provided. The compounds are fluorinated and can be used advantageously under acidic conditions.

7. 发明授权

US09834681B2 2,7-disubstituted cephalosporin derivatives as beta-lactamase substrates and methods for their use for the diagnosis of tuberculosis 有权
公开(公告)号：US09834681B2
公开(公告)日：2017-12-05
申请号：US14613214
申请日：2015-02-03
申请人： The Texas A&M University System , The Board of Trustees of the Leland Stanford Junior University
发明人： Jianghong Rao , Hexin Xie , Yunfeng Cheng , Jeffrey D. Cirillo
IPC分类号： C07D501/52 , C07D501/62 , C09B11/24 , C09B57/02 , C12Q1/04 , C12Q1/18 , C12Q1/34
CPC分类号： C09B11/24 , C07D501/52 , C07D501/62 , C09B57/02 , C12Q1/04 , C12Q1/18 , C12Q1/34 , G01N2333/30 , G01N2333/986 , G01N2800/12 , G01N2800/52
摘要： β-Lactamase substrates and methods for using the substrates to detect β-lactamase and to diagnose tuberculosis.

8. 发明授权

US09441261B2 Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics 有权
标题翻译：使用细菌β-内酰胺酶进行体外诊断和体内成像，诊断和治疗
公开(公告)号：US09441261B2
公开(公告)日：2016-09-13
申请号：US14044825
申请日：2013-10-02
申请人： Jeffrey D Cirillo , Jianghong Rao
发明人： Jeffrey D Cirillo , Jianghong Rao
IPC分类号： C12Q1/34 , C12Q1/66 , A61K49/00 , C12Q1/04 , C09B57/02
CPC分类号： C12Q1/18 , A61K49/0013 , A61K49/0021 , A61K49/0028 , A61K49/0032 , A61K49/0041 , A61K49/0052 , C09B57/02 , C12Q1/04 , C12Q1/34 , C12Q1/66 , G01N21/6408 , G01N21/6428 , G01N21/78 , G01N2021/6417 , G01N2201/061 , G01N2333/986
摘要： Provided herein are assays and in vitro methods to determine susceptibility to a drug effective against a pathogenic bacteria, for example, a pathogenic Mycobacteria, that has a beta-lactamase activity. An excitation wavelength is delivered to a biological sample obtained from a subject having an infection from the pathogenic bacteria in the presence of a beta-lactamase substrate. The intensity of a signal, such as a fluorescent, luminescent or colorimetric signal, at an emission wavelength of a product of the beta-lactamase on the subject is correlated to drug susceptibility. Also provided is an assay system for monitoring drug susceptibility of a pathogenic bacteria comprising color-producing substrates for a beta-lactamase of the pathogenic bacteria, an assay device for visibly detecting a product of the beta-lactamase on the substrate thereof and a reader configured to quantify the visibly detected product.
摘要翻译：本文提供了测定和体外方法以确定对具有β-内酰胺酶活性的致病细菌例如致病性分枝杆菌有效的药物的易感性。在β-内酰胺酶底物的存在下，将激发波长输送到从具有病原菌感染的受试者获得的生物样品。在受试者的β-内酰胺酶的产物的发射波长处的信号强度，例如荧光，发光或比色信号与药物敏感性相关。还提供了用于监测病原细菌的药物敏感性的测定系统，其包括致病细菌的β-内酰胺酶的着色产生底物，用于可见地检测其底物上的β-内酰胺酶的产物的测定装置和配置量化可见的产品。

9. 发明授权

US09128097B2 Method and kit for assessing viable cells 有权
标题翻译：用于评估活细胞的方法和试剂盒
公开(公告)号：US09128097B2
公开(公告)日：2015-09-08
申请号：US13003943
申请日：2009-07-13
申请人： Mette Elena Skindersø , Helle Frobøse Sørensen , Søren Kjærulff
发明人： Mette Elena Skindersø , Helle Frobøse Sørensen , Søren Kjærulff
IPC分类号： C12Q1/02 , G01N33/58 , C09B15/00 , C09B57/00 , C09B57/02 , G01N33/50
CPC分类号： G01N33/582 , C09B15/00 , C09B57/00 , C09B57/02 , G01N21/6428 , G01N33/502 , G01N33/583 , G01N2021/6439 , G01N2201/06113 , G01N2201/062 , G01N2510/00
摘要： The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells, such as viability. The present invention relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with thiol-containing species present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead, stressed and apoptotic) cells. The present invention also relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of various optionally substituted reporter compounds. The invention further relates to compositions used in methods for analyzing cells, such as a composition comprising N-(7-dimethylamino-4-methyl-3-coumarinyl)-maleimide (DACM).
摘要翻译：本发明提供用于分析细胞的简单，快速的方法和程序，在此对细胞进行定量和定性评估，例如活力。本发明涉及各种任选取代的报告化合物在完整（例如，活的）细胞中与在非完整（例如死亡，应激和凋亡）细胞中比较高的浓度存在的硫醇类物质反应时特别可检测的用途）。本发明还涉及各种任选取代的报告化合物在与完整和/或未完整细胞中存在的物质反应时特别可检测的用途。此外，本发明涉及与使用各种任选取代的报告化合物的测量技术和/或仪器的用途。本发明还涉及用于分析细胞的方法中使用的组合物，例如包含N-（7-二甲基氨基-4-甲基-3-香豆素基） - 马来酰亚胺（DACM）的组合物。

10. 发明申请

US20150241440A1 METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS 有权
标题翻译：肽和蛋白质的特异性标记的方法和组合物
公开(公告)号：US20150241440A1
公开(公告)日：2015-08-27
申请号：US14426599
申请日：2013-09-05
申请人： UNIVERSITY OF ROCHESTER
发明人： Rudi Fasan , John R. Frost
IPC分类号： G01N33/58 , C07D495/04 , C12N9/42 , C09B57/02
CPC分类号： C07K1/13 , A61K47/65 , A61K49/0039 , A61K49/0054 , C07C323/58 , C07C323/59 , C07C323/60 , C07D249/04 , C07D311/16 , C07D495/04 , C07K1/1072 , C07K14/35 , C07K2319/20 , C07K2319/21 , C07K2319/50 , C07K2319/60 , C07K2319/92 , C09B57/02 , C12N9/2442 , C12Y302/01014 , G01N33/582 , G01N33/6803
摘要： Methods and compositions are provided for covalently linking a chemical species to a recombinant or synthetic polypeptide. The methods involve the reaction of a thioester-comprising polypeptide with a reagent comprising a reactive amino-thiol group connected to the chemical species which is to be covalently linked to the polypeptide, via a linker. Such chemical species can be a functional group, a label or tag molecule, a biological molecule, a ligand, or a solid support. Efficient and catalyst-free methods for C-terminal protein labeling are also provided. The methods expand current capabilities in the area of protein functionalization, providing useful and complementary tools for the isolation, detection, characterization, and analysis of proteins in a variety of in vitro and in vivo applications.
摘要翻译：提供方法和组合物以共价连接化学物质与重组或合成的多肽。该方法涉及含硫酯的多肽与包含通过连接体共价连接至多肽的化学物质连接的反应性氨基硫醇基团的试剂的反应。这种化学物质可以是官能团，标记物或标签分子，生物分子，配体或固体支持物。还提供了有效和无催化剂的C-末端蛋白标记方法。该方法扩展了蛋白质功能化领域的当前能力，为各种体外和体内应用中蛋白质的分离，检测，表征和分析提供了有用和互补的工具。

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