会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 72. 发明授权
    • Substituted amide beta secretase inhibitors
    • 取代的酰胺β分泌酶抑制剂
    • US08367712B2
    • 2013-02-05
    • US12861347
    • 2010-08-23
    • Ying HuangGuoqing LiAndrew W. Stamford
    • Ying HuangGuoqing LiAndrew W. Stamford
    • A01N43/50A61K31/415
    • C07D401/12C07D241/04C07D241/08C07D401/10C07D403/12C07D405/12C07D413/12C07D417/12
    • Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R4 and X are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I.Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease.Also disclosed are methods of treating a cognitive or neurodegenerative disease comprising administering to a patient I need of such treatment a combination of at least one compound of formula I and at least one compound selected from the group consisting of β-secretase inhibitors other than those of formula I, HMG-CoA reductase inhibitors, gamma-secretase inhibitors, non-steroidal anti-inflammatory agents, N-methyl-D-aspartate receptor antagonists, cholinesterase inhibitors and anti-amyloid antibodies.
    • 公开了下式的新化合物或其药学上可接受的盐或溶剂化物,其中R1,R2,R3,R4和X如说明书中所定义。 还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。 还公开了治疗认知或神经退行性疾病的方法,包括向需要这种治疗的患者施用至少一种式I化合物和至少一种选自除了那些的那些之外的其他化合物 式I,HMG-CoA还原酶抑制剂,γ-分泌酶抑制剂,非甾体抗炎剂,N-甲基-D-天冬氨酸受体拮抗剂,胆碱酯酶抑制剂和抗淀粉样蛋白抗体。
    • 73. 发明申请
    • DATA TRANSMISSION METHOD, SYSTEM AND DEVICE IN MULTI-CARRIER SYSTEM
    • 数据传输方法,多载波系统中的系统和设备
    • US20120327877A1
    • 2012-12-27
    • US13578234
    • 2011-01-30
    • Yali ZhaoGuoqing LiFangli Xu
    • Yali ZhaoGuoqing LiFangli Xu
    • H04W72/04
    • H04W72/1252H04L5/001
    • A data transmission method, system and device in multi-carrier system, which relate to wireless communication field, are provided for solving the problem, that is, when the scheduling methods for same time unit in the network side of multi-carrier system include Semi-Persistent Scheduling (SPS) and dynamic scheduling at the same time, how the terminal transmits data in said time unit. Before transmitting the uplink data by using the time unit, the terminal determines that the network side schedules the terminal to implement SPS uplink transmission and dynamic scheduling uplink transmission in the time unit by using the uplink component carrier and the number of uplink component carriers which can be used to implement uplink transmission by the terminal is more than one; the terminal selects parts or all of multiple available uplink component carriers, and implements SPS uplink transmission and/or dynamic scheduling uplink transmission in the time unit by using the selected uplink component carriers.
    • 提供了与无线通信领域相关的多载波系统中的数据传输方法,系统和装置,用于解决问题,即当多载波系统的网络侧的同一时间单元的调度方法包括半 - 一致性调度(SPS)和动态调度的同时,终端如何在所述时间单元中传输数据。 在通过使用时间单元发送上行链路数据之前,终端确定网络侧通过使用上行链路分量载波和上行链路分量载波的数量来确定网络侧在时间单位中执行SPS上行链路传输和动态调度上行链路传输, 用于实现上行传输的终端是多个; 终端选择多个可用上行链路分量载波的部分或全部,并且通过使用所选择的上行链路分量载波,在时间单元中实现SPS上行链路传输和/或动态调度上行链路传输。
    • 78. 发明申请
    • METHOD, SYSTEM AND DEVICE FOR INDICATING TRANSMISSION AND TRANSMITTING PREAMBLE
    • 用于指示传输和传输前缀的方法,系统和设备
    • US20110294513A1
    • 2011-12-01
    • US13057363
    • 2009-08-07
    • Guoqing LiLi ChenJiayi Fang
    • Guoqing LiLi ChenJiayi Fang
    • H04W72/04
    • H04W74/008H04W74/0833H04W74/0866
    • A method, a system and a device for indicating and transmitting the preamble are used to solve the problem existing in the prior art, which reduces the resource utilization efficiency due to that the user equipment (UE) sends the preamble to the evolution base station through the physical random access channel (PRACH) selected by itself in the present random access. The method includes: determining the channel signature associated with the PRACH assigned to the terminal side; sending the determined channel signature to the terminal side, and indicating the terminal side to transmit the preamble using the PRACH associated with the channel signature. Adopting said method can improve the resource utilization efficiency.
    • 用于指示和发送前同步码的方法,系统和装置用于解决现有技术中存在的问题,这降低了资源利用效率,这是由于用户设备(UE)将前导码发送到演进基站,通过 在当前随机接入中自身选择的物理随机接入信道(PRACH)。 该方法包括:确定与分配给终端侧的PRACH相关联的信道签名; 将确定的信道签名发送到终端侧,并且指示终端侧使用与频道签名相关联的PRACH来发送前导码。 采用该方法可以提高资源利用效率。
    • 79. 发明授权
    • Macrocyclic beta-secretase inhibitors
    • 大环β-分泌酶抑制剂
    • US08012953B2
    • 2011-09-06
    • US12571840
    • 2009-10-01
    • Andrew W. StamfordYing HuangGuoqing LiCorey O. StricklandJohannes H. Voigt
    • Andrew W. StamfordYing HuangGuoqing LiCorey O. StricklandJohannes H. Voigt
    • A61K31/33C07D513/00
    • C07D498/04C07D413/06
    • Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, n and X are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are methods of treating a cognitive or neurodegenerative disease comprising administering to a patient I need of such treatment a combination of at least one compound of formula I and at least one compound selected from the group consisting of β-secretase inhibitors other than those of formula I, HMG-CoA reductase inhibitors, gamma-secretase inhibitors, non-steroidal anti-inflammatory agents, N-methyl-D-aspartate receptor antagonists, cholinesterase inhibitors and anti-amyloid antibodies.
    • 公开了下式的新化合物或其药学上可接受的盐或溶剂化物,其中R1,R2,R3,n和X如说明书中所定义。 还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。 还公开了治疗认知或神经退行性疾病的方法,包括向需要这种治疗的患者施用至少一种式I化合物和至少一种选自除了那些的那些之外的其他化合物 式I,HMG-CoA还原酶抑制剂,γ-分泌酶抑制剂,非甾体抗炎剂,N-甲基-D-天冬氨酸受体拮抗剂,胆碱酯酶抑制剂和抗淀粉样蛋白抗体。