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71. 发明申请

US20150182658A1 EMBOLIZATION 有权
标题翻译：嵌入
公开(公告)号：US20150182658A1
公开(公告)日：2015-07-02
申请号：US14643992
申请日：2015-03-10
申请人： Boston Scientific Scimed, Inc.
发明人： Robert F. RIOUX , Thomas V. CASEY, II , Janel LANPHERE
IPC分类号： A61L24/02 , A61L24/00
CPC分类号： A61L24/02 , A61B18/18 , A61K9/14 , A61K9/1635 , A61K9/1652 , A61K49/0452 , A61K51/1244 , A61L24/0015 , A61L24/0036 , A61L24/0089 , A61L2300/102 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2430/36
摘要： A particle includes a ferromagnetic material, a radiopaque material, and/or an MRI-visible material.
摘要翻译：颗粒包括铁磁材料，不透射线材料和/或MRI可见材料。

72. 发明授权

US08845801B2 Bone cement and method 有权
标题翻译：骨水泥和方法
公开(公告)号：US08845801B2
公开(公告)日：2014-09-30
申请号：US13519822
申请日：2010-12-29
申请人： Wook-Jin Seong , Young Cheul Heo , Hyeon Cheol Kim , Iel Yong Sung , Soo Cheol Jeong
发明人： Wook-Jin Seong , Young Cheul Heo , Hyeon Cheol Kim , Iel Yong Sung , Soo Cheol Jeong
IPC分类号： A61L24/02 , A61F2/28 , C04B7/02 , C04B11/00 , A61L24/08 , A61K6/00 , A61L24/00
CPC分类号： A61K6/0023 , A61L24/0057 , A61L24/02 , A61L24/08 , A61L2430/02 , C08L1/284
摘要： Bone cements and methods provided include a bone cement composition having collective attributes and properties desirable for initial fixation as well as interventional applications. Compositions include an amount of Portland cement and an amount of calcium sulfate.
摘要翻译：所提供的骨水泥和方法包括具有集体属性和初始固定以及介入应用所需的性质的骨水泥组合物。组合物包括一定量的波特兰水泥和一定量的硫酸钙。

73. 发明申请

US20140275287A1 Compositions and Methods for Hemostasis 审中-公开
标题翻译：止血组合物和方法
公开(公告)号：US20140275287A1
公开(公告)日：2014-09-18
申请号：US14354188
申请日：2012-11-01
申请人： ABYRX, INC.
发明人： David Knaack , John Pacifico , Marci Wirtz , Richard L. Kronenthal , Frank Do , Aniq Darr
IPC分类号： A61L24/00 , A61L24/04 , A61L24/02 , A61L24/08
CPC分类号： A61L24/00 , A61L24/001 , A61L24/0089 , A61L24/02 , A61L24/046 , A61L24/08 , A61L27/446 , A61L27/50 , A61L27/56 , A61L2400/04
摘要： The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for use in tamponade hemostasis of bone or cartilage.
摘要翻译：本发明涉及具有蜡或蜡状基质的水溶性和完全可吸收和/或生理可降解的止血组合物，其有效用于骨或软骨的止血止血。

74. 发明授权

US08546462B2 Bone cement system for bone augmentation 有权
标题翻译：用于骨增生的骨水泥系统
公开(公告)号：US08546462B2
公开(公告)日：2013-10-01
申请号：US13173317
申请日：2011-06-30
申请人： Andreas Boger , Christoph Sattig , Stefan Deusser
发明人： Andreas Boger , Christoph Sattig , Stefan Deusser
IPC分类号： A61F2/28 , A61L24/06 , A61L24/02 , A61B17/56
CPC分类号： A61L24/0084 , A61B17/8805 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L33/08 , C08L33/10
摘要： A bone cement is provided that includes a solid component and a liquid component. The solid component and liquid component are mixed together to form the bone cement. After completion of the solid and liquid component mixing, the bone cement has an initial viscosity effective for manual application or manual injection onto or into a targeted anatomical location, e.g., bone, and the cement has stable viscosity range that over both time and temperature is effective for uniformly filling the targeted anatomical location, for example an osteoporotic bone or a fractured vertebral body, with minimal to no leakage of the cement from the targeted anatomical location. Additionally, both the initial viscosity and the stable viscosity of the bone cement are within a range that renders the bone cement effective for injection with a manually operated syringe or multiple syringes.
摘要翻译：提供了包括固体组分和液体组分的骨水泥。将固体组分和液体组分混合在一起形成骨水泥。在固体和液体组分混合完成后，骨水泥具有有效的手动施用或手动注射到目标解剖位置（例如骨）上的初始粘度，并且水泥具有稳定的粘度范围，在时间和温度上均为有效地均匀地填充目标解剖学位置，例如骨质疏松的骨骼或骨折的椎体，其水泥从目标解剖位置的最小到不泄漏。此外，骨水泥的初始粘度和稳定的粘度都在使得骨水泥有效地用手动操作的注射器或多个注射器注射的范围内。

75. 发明授权

US07553362B2 High strength biological cement composition and using the same 有权
标题翻译：高强度生物水泥组合物和使用相同
公开(公告)号：US07553362B2
公开(公告)日：2009-06-30
申请号：US11584132
申请日：2006-10-20
申请人： Donghui Lu , Shuxin Zhou
发明人： Donghui Lu , Shuxin Zhou
IPC分类号： A61K6/06 , A61L24/02 , C04B12/02 , C04B14/00 , C04B14/48 , C04B24/00 , C04B28/02 , C04B28/34 , C04B7/02
CPC分类号： A61L24/02 , A61K6/0038 , A61K6/033 , A61K6/0612 , A61K6/0643 , A61K6/0675 , A61K33/06 , A61K33/42 , A61K45/06 , A61L27/04 , A61L27/12 , A61L27/425 , A61L27/50 , C04B7/345 , C04B12/027 , C04B28/18 , C04B28/34 , C04B28/346 , C04B2103/0067 , C04B2111/00836 , C04B2111/10 , C04B2111/80 , Y02P40/148 , C04B22/16 , C04B12/025 , C04B14/062 , C04B14/308 , C04B14/365 , C04B22/064 , C04B14/306 , C04B14/043
摘要： A hydraulic cement for biomedical applications. The cement sets in-situ, hardening when exposed to water to produce nano-dispersed composite of calcium-silicate-hydrate gel mixed with hydroxyapatite. In comparison with prior cements, the composition provides high biocompatibility, high bioactivity and high biomechanical strength, due to the composite structure of the calcium silicate hydrate reinforced with co-precipitated particles of hydroxyapatite. Biocompatibility is also increased due to an absence of aluminum and magnesium in the composition. The cement is suitable for variety of applications, including dental implants, bone fixation, and bone repair.
摘要翻译：用于生物医学应用的水硬性水泥。水泥原位固化，暴露于水时硬化，生成与羟基磷灰石混合的硅酸钙水合物凝胶纳米分散复合物。与以前的水泥相比，由于由羟基磷灰石的共沉淀颗粒增强的硅酸钙水合物的复合结构，该组合物提供高生物相容性，高生物活性和高生物力学强度。由于组合物中不存在铝和镁，生物相容性也增加。该水泥适用于各种应用，包括牙科植入物，骨固定和骨修复。

76. 发明申请

US20080086143A1 MATERIALS AND APPARATUS FOR IN-SITU BONE REPAIR 失效
标题翻译：用于现场骨修复的材料和装置
公开(公告)号：US20080086143A1
公开(公告)日：2008-04-10
申请号：US11861246
申请日：2007-09-25
申请人： James Seaton , Ralph Carmichael
发明人： James Seaton , Ralph Carmichael
IPC分类号： A61L24/02 , A61B17/58 , A61F2/28
CPC分类号： A61B17/8816 , A61B50/30 , A61B50/33 , A61B2050/0065 , A61B2050/3008 , A61L27/26 , A61L27/50 , C08L83/04
摘要： Compositions for use in treating and repairing orthopedic defects are provided. The compositions are especially useful for performing percutaneous vertebroplasty, percutaneous kyphoplasty and other procedures. When cured, the compositions are relatively solid but compressible, and prior to curing are viscous liquids with a low enough viscosity to fill voids in cavities such as voids within fractured vertebrae. Optionally, the properties of a composition according to the invention can be adjusted taking into account the hardness and density of the orthopedic structure to be repaired. Also disclosed are devices and methods for using the compositions, and a kit containing components for forming and utilizing the composition.
摘要翻译：提供了用于治疗和修复矫形缺陷的组合物。该组合物特别适用于进行经皮椎体成形术，经皮椎体后凸成形术和其他手术。当固化时，组合物相对固体但是可压缩，并且在固化之前是具有足够低粘度的粘性液体，以填充空腔内的空隙，例如在断裂的椎骨内的空隙。任选地，可以考虑到待修复的整形外科结构的硬度和密度来调节根据本发明的组合物的性质。还公开了用于使用组合物的装置和方法，以及包含用于形成和利用组合物的组分的试剂盒。

77. 发明授权

US07115163B2 Magnesium ammonium phosphate cement composition 有权
公开(公告)号：US07115163B2
公开(公告)日：2006-10-03
申请号：US11104392
申请日：2005-04-11
申请人： Michael Zimmermann
发明人： Michael Zimmermann
IPC分类号： A61L24/02 , C04B9/11
CPC分类号： C04B28/34 , A61B17/00491 , A61F2/28 , A61F2002/30062 , A61F2002/30535 , A61F2002/4631 , A61F2210/0004 , A61F2250/0058 , A61K6/0008 , A61K6/033 , A61K6/0643 , A61K6/065 , A61K33/06 , A61K33/42 , A61K45/06 , A61L24/0036 , A61L24/02 , A61L27/12 , A61L27/56 , A61L2430/02 , C04B28/344 , C04B28/346 , C04B28/348 , C04B2103/0009 , C04B2111/00206 , C04B2111/00836 , C04B14/304 , C04B22/062 , C04B12/025 , C04B14/26 , C04B22/064 , C04B22/10 , C04B22/16 , C04B22/126 , C04B22/142 , C04B24/282 , C04B20/008 , C04B22/06 , C04B22/124 , C04B22/143 , C04B14/22 , C04B14/30 , C04B14/366 , C04B24/10
摘要： This invention relates to a cement, which comprises in its main phase of microcrystalline magnesium ammonium phosphate and nanoapatite after hardening and thus at the same time has considerable strength. The material is biologically degradable and is suitable for application in tooth cements, as bone replacement, as bone filler, as bone cement or as bone adhesive.

78. 发明授权

US07094286B2 Inorganic bone adhesion agent and its use in human hard tissue repair 失效
标题翻译：无机骨粘连剂及其在人体硬组织修复中的应用
公开(公告)号：US07094286B2
公开(公告)日：2006-08-22
申请号：US10468648
申请日：2001-02-26
申请人： Changsheng Liu
发明人： Changsheng Liu
IPC分类号： A61L24/02
CPC分类号： G03G15/09 , A61L24/02 , A61L2430/02 , B82Y15/00 , G03G2221/183 , Y10S623/923
摘要： The present invention discloses an inorganic bone adhesive and its use in human hard tissue repairs. The inorganic bone adhesive comprises basic compound, phosphate, calcium phosphate bone cement and retarder with the characteristics of rapid hydration rate and high early strength. Inorganic Bone adhesive can be widely used in the artificial joints fixation, screw fixation as well as comminuted fracture fixation. It is a kind of safe and effective adhesive material and beneficial for the fast postoperative recovery. The final hydration reaction products contains the composition of magnesium phosphate, bio-mineral containing ammonium and apatite-like materials, which has excellent biocompatibility and can be gradually absorbed by surrounding tissues after being implanted in vivo, which benefits the in-growth of the new bone.
摘要翻译：本发明公开了一种无机骨粘合剂及其在人体硬组织修复中的应用。无机骨粘合剂包括碱性化合物，磷酸盐，磷酸钙骨水泥和缓凝剂，具有水化速度快，早期强度高的特点。无机骨粘合剂可广泛用于人造关节固定，螺钉固定以及粉碎骨折固定。它是一种安全有效的粘合剂材料，有利于术后快速恢复。最终的水化反应产物含有磷酸镁，含有矿物质和磷灰石的物质的生物矿物质组成，具有极好的生物相容性，植物体内可被周围组织逐渐吸收，有利于新生物的生长骨。

79. 发明申请

US20050274289A1 Process for affecting the setting and working time of, bioresorbable calcium phosphate cements 失效
标题翻译：影响生物可再吸收的磷酸钙水泥的设定和工作时间的方法
公开(公告)号：US20050274289A1
公开(公告)日：2005-12-15
申请号：US11137695
申请日：2005-05-25
申请人： Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
发明人： Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
IPC分类号： A61L24/02 , C04B12/02 , C04B28/34
CPC分类号： C04B28/346 , A61K6/0643 , A61L24/0063 , A61L24/02 , C04B12/025 , C04B28/34 , C04B2103/10 , C04B2111/00836 , C04B2111/70 , C04B40/0082 , C04B22/064 , C04B2103/0099 , C04B22/062 , C04B22/16 , C04B22/143 , C04B22/165
摘要： A fast-setting, bioresorbable calcium phosphate cement is prepared by a process which can be carried out with a heat treatment up to 1000° C. on a mixture of a wetting solution and a calcium phosphate powder having a Ca to P molar ratio of 0.5-2.5. The wetting solution suitable for use in the process of the present invention includes water, an organic solvent, an acidic and basic solution. A setting solution for mixing with the heated powder to form the fast-setting, bioresorbable calcium phosphate cement may be water, an acidic or basic solution according to the process of the present invention.
摘要翻译：快速凝固的生物可再吸收的磷酸钙水泥通过一种方法制备，该方法可以在加氢溶液和Ca与P摩尔比为0.5的磷酸钙粉末的混合物中进行高达1000℃的热处理 -2.5。适用于本发明方法的润湿溶液包括水，有机溶剂，酸性和碱性溶液。与加热的粉末混合以形成快速凝固的生物可再吸收的磷酸钙水泥的凝固溶液可以是水，根据本发明的方法的酸性或碱性溶液。

80. 发明申请

US20050271741A1 Injectable calcium phosphate cements and the preparation and use thereof 失效
标题翻译：可注射的磷酸钙水泥及其制备和应用
公开(公告)号：US20050271741A1
公开(公告)日：2005-12-08
申请号：US11129063
申请日：2005-05-13
申请人： Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
发明人： Jiin-Huey Lin , Chien-Ping Ju , Wen-Cheng Chen
IPC分类号： A61C5/00 , A61C5/06 , A61K6/033 , A61K33/42 , A61L24/00 , A61L24/02 , A61L27/12 , A61L27/50 , C04B12/02 , C04B14/36 , C04B28/34
CPC分类号： A61L24/02 , A61C5/62 , A61K6/0008 , A61K6/0067 , A61K6/033 , A61K6/0643 , A61K33/42 , A61L24/001 , A61L27/12 , A61L27/50 , C04B12/02 , C04B12/025 , C04B14/366 , C04B28/34 , C04B28/344 , C04B28/346 , C04B2111/00836 , Y10T428/2991 , Y10T428/2993 , C04B20/008 , C04B40/0272 , C04B40/0218 , C04B40/0263 , C04B20/1014 , C04B22/064 , C04B22/126 , C04B20/023 , C04B20/107 , A61K6/087 , C08L89/00
摘要： A calcium phosphate cement suitable for use in dental and bone prosthesis is disclosed, which include calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.
摘要翻译：公开了一种适用于牙齿和骨假体的磷酸钙骨水泥，其包括直径为0.05至100微米的磷酸钙颗粒，其中表面上的所述磷酸钙颗粒具有宽度范围为1至100的晶须或细晶体 nm，长度范围为1〜1000nm。

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