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81. 发明授权

US09480409B2 Sensing probe comprising multiple, spatially separate, sensing sites 有权
标题翻译：感测探头包括多个空间分离的感测位置
公开(公告)号：US09480409B2
公开(公告)日：2016-11-01
申请号：US13784200
申请日：2013-03-04
申请人： Drexel University
发明人： Simon F. Giszter
IPC分类号： A61B5/04 , G01D21/00 , A61B5/00
CPC分类号： A61B5/04001 , A61B5/40 , A61B5/6868 , A61B5/72 , G01D21/00
摘要： A single sensing probe comprising multiple, spatially separate, sensing sites is utilized to sense neural activity. The sensing probe includes multiple conductors each with multiple sensing sites in a fixed geometric arrangement. The sensing probe is configured to comprise multiple combined sensing sites in polytrode configuration. By appropriately combining the wire groupings at each combined sensing site, activity sensed from a single wire with multiple sensing sites, can be coupled with other wires to unmix signals from the spatially separate sites and leverage the power of combinatorics to maximize total recording bandwidth and single neuron/unit yield per wire and per probe.
摘要翻译：使用包括多个空间上分离的感测位点的单个感测探头来感测神经活动。感测探头包括多个导体，每个导体具有固定几何布置的多个感测位置。感测探头被配置为包括多重配置中的多个组合的感测位置。通过适当地组合在每个组合的感测位置处的线分组，从具有多个感测位置的单线感测的活动可以与其他线耦合以从空间上分离的位置混合信号，并利用组合的功率来最大化总记录带宽和单个每根线和每个探针的神经元/单位产量。

82. 发明授权

US09469507B2 Modular escalating wheelchair lift 有权
标题翻译：模块化升级轮椅电梯
公开(公告)号：US09469507B2
公开(公告)日：2016-10-18
申请号：US14720828
申请日：2015-05-24
申请人： Drexel University
发明人： Jonathan Awerbuch , Jordan Berman , Steve Eggert , Nicholas Raiser , Giancarlo Migliuolo
IPC分类号： B66B9/08
CPC分类号： B66B9/08 , B66B9/0815 , B66B9/0846
摘要： A modular lift system that can be mounted on a stairway is disclosed. The system includes forks located on a first floor onto which the user rolls their wheelchair. The forks are motor operated to traverse a toothed track between the first floor and a second floor with the wheelchair and the user riding the forks. When the forks reach the second floor, the user rolls the wheelchair off the forks.
摘要翻译：公开了一种可以安装在楼梯上的模块化升降系统。该系统包括位于用户滚动轮椅的一楼的叉。叉子通过轮椅和用户骑叉的方式在一楼和二楼之间穿过齿形轨道。当叉子到达二楼时，用户将轮椅从叉子上滚开。

83. 发明授权

US09464057B2 Anti-malarial agents 有权
标题翻译：抗疟剂
公开(公告)号：US09464057B2
公开(公告)日：2016-10-11
申请号：US14905369
申请日：2014-07-17
申请人： MMV MEDICINES FOR MALARIA VENTURE , DREXEL UNIVERSITY , UNIVERSITY OF WASHINGTON
发明人： Jeremy Burrows , Matthew Wyvratt , Akhil Vaidya , Sandhya Kortagere , Erkang Fan , Arnab Kumar Chatterjee , Advait Suresh Nagle , Tomoyo Kato
IPC分类号： C07D403/12 , C07D231/40 , A61K31/4184 , A61K45/06 , A61K31/415
CPC分类号： C07D231/40 , A61K31/415 , A61K31/4184 , A61K45/06 , C07D403/12
摘要： The present invention is related to a use of pyrazole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrazole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.
摘要翻译：本发明涉及吡唑衍生物在制备用于预防或治疗疟疾的药物中的用途。具体地，本发明涉及可用于制备用于抑制疟疾寄生虫增殖的药物制剂的吡唑衍生物。

84. 发明申请

US20160256417A1 NOVEL TREATMENTS FOR ATTENTION AND COGNITIVE DISORDERS, AND FOR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER 审中-公开
标题翻译：注意和认知障碍的新治疗方法，以及与神经病变疾病有关的疾病
公开(公告)号：US20160256417A1
公开(公告)日：2016-09-08
申请号：US15028654
申请日：2014-10-28
申请人： DREXEL UNIVERSITY
发明人： Sandhya KORTAGERE
IPC分类号： A61K31/137 , A61K31/4184 , A61K31/519 , A61K45/06 , A61K31/4045
CPC分类号： A61K31/137 , A61K31/4045 , A61K31/4184 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method of treating or preventing an attention and/or cognitive disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention. The present invention further provides a method of treating or preventing dementia associated with a neurodegenerative disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention.
摘要翻译：本发明提供了治疗或预防有此需要的受试者的注意和/或认知障碍的方法，包括向受试者施用本发明中有用的化合物。本发明还提供了治疗或预防有此需要的受试者与神经退行性疾病相关的痴呆的方法，其包括向受试者施用本发明中有用的化合物。

85. 发明授权

US09410636B2 Flow control/shut-off valve assembly 有权
公开(公告)号：US09410636B2
公开(公告)日：2016-08-09
申请号：US14659756
申请日：2015-03-17
申请人： Drexel University
发明人： John Older
IPC分类号： F16K17/32 , F16K21/16 , E03B7/07 , F16K17/34 , F16K31/126 , G05B15/02 , G05D7/01
CPC分类号： F16K17/32 , E03B7/071 , E03B7/072 , F16K17/34 , F16K21/16 , F16K31/1262 , G05B15/02 , G05D7/0106 , Y02A20/15 , Y10T137/0324 , Y10T137/7726 , Y10T137/7727 , Y10T137/7759 , Y10T137/7761 , Y10T137/777 , Y10T137/7784 , Y10T137/7785 , Y10T137/7787 , Y10T137/7788 , Y10T137/8158 , Y10T137/87298 , Y10T137/87354 , Y10T137/87507
摘要： A flow valve assembly includes a valve operable between an open position and a closed position and a controller operatively coupled to the valve to operate the valve between the open position and the closed position. A mechanically or electrically operated assembly is provided to determine an amount of fluid flow through the valve when the valve is in the open position. A mechanically or electrically operated mechanism moves the valve from the open position to the closed position when the amount of fluid flow exceeds a predetermined value. A method of operating the valve is also provided.

86. 发明授权

US09394427B2 Toughening cross-linked thermosets 有权
公开(公告)号：US09394427B2
公开(公告)日：2016-07-19
申请号：US14791057
申请日：2015-07-02
申请人： Drexel University , Government of the United States as represented by the Secretary of the Army
发明人： Giuseppe R. Palmese , John J. LaScala , James M. Sands , Xing Geng
IPC分类号： C08K5/15 , C08K5/101 , C08L67/06 , C11C3/04 , C11C3/08 , C08F120/40 , C08K5/1515 , C08L31/02 , C08F222/40 , C08K3/00 , C08F8/44 , C08F269/00
CPC分类号： C08K5/1515 , C08F8/44 , C08F120/40 , C08F222/40 , C08F269/00 , C08K3/013 , C08K5/101 , C08L31/02 , C08L67/06 , C11C3/04 , C11C3/08
摘要： Grafted triglycerides comprising an acrylated triglyceride grafted with a fatty acid residue containing 4 to 28 carbon atoms. Also described are methods for making a grafted triglyceride and for curing a material selected from vinyl esters and unsaturated polyesters and mixtures thereof and optionally a reactive diluent. The method includes the steps of mixing a grafted triglyceride of the present invention with a material selected from vinyl esters, unsaturated polyesters and mixtures thereof to form a mixture, and curing the mixture to form a cured resin system. A cured resin system comprising a cured product obtained by the foregoing method and composites containing the cured product and a filler or reinforcing material are also disclosed. This method also includes use of the grafted triglycerides to make toughened resin and composite systems with reduced hazardous air pollutants without significantly reducing the glass transition temperature and significantly increasing the viscosity.

87. 发明授权

US09375474B2 Compounds useful for inhibiting metastasis from cancer and methods using same 有权
标题翻译：可用于抑制癌症转移的化合物及使用其的方法
公开(公告)号：US09375474B2
公开(公告)日：2016-06-28
申请号：US13776220
申请日：2013-02-25
申请人： Alessandro Fatatis , Joseph M. Salvino , Olimpia Meucci , Whitney L. Gladney
发明人： Alessandro Fatatis , Joseph M. Salvino , Olimpia Meucci , Whitney L. Gladney
IPC分类号： A01N43/58 , A01N43/60 , A61K31/495 , A61K31/50 , A01N43/40 , A61K31/445 , C07D499/26 , A61K39/395 , C07D487/04 , A61K31/451 , A61K31/453 , A61K31/7088 , C07D403/04 , C07K16/28
CPC分类号： C07D487/04 , A61K31/451 , A61K31/453 , A61K31/7088 , A61K39/3955 , C07D403/04 , C07K16/28
摘要： The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or treating metastasis in a subject diagnosed with cancer, wherein the method comprises administering to the subject in need thereof an effective amount of a pharmaceutical formulation comprising at least one pharmaceutically acceptable carrier and at least one CX3CR1 or fractalkine antagonist.
摘要翻译：本发明包括可用于预防或治疗患有癌症的受试者的转移的组合物。本发明还包括预防或治疗患有癌症的受试者的转移的方法，其中所述方法包括向有需要的受试者施用有效量的药物制剂，其包含至少一种药学上可接受的载体和至少一种CX3CR1或fractalkine 拮抗剂。

88. 发明授权

US09359603B2 Modulation of pre-mRNA using splice modulating oligonucleotides as therapeutic agents in the treatment of disease 有权
标题翻译：使用剪接调节寡核苷酸作为治疗疾病的治疗剂调节前mRNA
公开(公告)号：US09359603B2
公开(公告)日：2016-06-07
申请号：US14188168
申请日：2014-02-24
申请人： Drexel University
发明人： Gordon J. Lutz , Melanie K. Tallent , Nicole Michele Lykens
IPC分类号： C12N15/11 , C07H21/04 , A61K48/00 , C12N15/113
CPC分类号： C12N15/1138 , A61K48/005 , C12N15/11 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/11 , C12N2320/33
摘要： The present invention encompasses a class of compounds known as splice modulating oligonucleotides (SMOs) that modulate pre-mRNA splicing, thereby affecting expression and functionality of a specific protein in a cell. The present invention further provides compositions and methods for modulating pre-mRNA splicing using a SMO of the invention to abrogate disease-causing mutations in a protein. Accordingly, the present invention provides compositions and methods of treating a subject at risk of, susceptible to, or having a disease, disorder, or condition associated with aberrant or unwanted target pre-mRNA expression or activity.
摘要翻译：本发明包括称为剪接调节寡核苷酸（SMO）的一类化合物，其调节前mRNA剪接，从而影响细胞中特定蛋白质的表达和功能。本发明还提供了使用本发明的SMO调节前mRNA剪接的组合物和方法，以消除蛋白质中的致病突变。因此，本发明提供了治疗患有与异常或不期望的靶mRNA表达或活性相关的疾病，病症或病症的风险易感或具有疾病，病症或病症的风险的受试者的组合物和方法。

89. 发明申请

US20160051692A1 NOVEL METHODS OF USE OF BIOMIMETIC PROTEOGLYCANS 审中-公开
标题翻译：使用生物保护剂的新方法
公开(公告)号：US20160051692A1
公开(公告)日：2016-02-25
申请号：US14784525
申请日：2014-04-17
申请人： DREXEL UNIVERSITY
发明人： Michele MARCOLONGO , Owen C. MONTGOMERY , Katsiaryna PRUDNIKOVA
IPC分类号： A61K47/48 , A61K9/00 , A61K38/17
CPC分类号： A61K47/48176 , A61K9/0019 , A61K38/1703 , A61K38/1732 , A61K47/58 , A61L27/22 , A61L27/50 , A61L27/52 , A61L2300/252 , A61L2400/06
摘要： In one aspect, the present invention relates to a new method of treating or preventing urinary incontinence in a mammal in need thereof. In certain embodiments, the method comprises contacting a composition comprising at least one biomimetic proteoglycan with the urethral or periurethral tissue of the mammal.
摘要翻译：一方面，本发明涉及在有需要的哺乳动物中治疗或预防尿失禁的新方法。在某些实施方案中，该方法包括将包含至少一种生物模拟蛋白多糖的组合物与哺乳动物的尿道或尿道周围组织接触。

90. 发明申请

US20150375965A1 Modular Escalating Wheelchair Lift 审中-公开
标题翻译：模块式升降轮椅升降机
公开(公告)号：US20150375965A1
公开(公告)日：2015-12-31
申请号：US14720828
申请日：2015-05-24
申请人： DREXEL UNIVERSITY
发明人： Jonathan Awerbuch , Jordan Berman , Steve Eggert , Nicholas Raiser , Giancarlo Migliuolo
IPC分类号： B66B9/08
CPC分类号： B66B9/08 , B66B9/0815 , B66B9/0846
摘要： A modular lift system that can be mounted on a stairway is disclosed. The system includes forks located on a first floor onto which the user rolls their wheelchair. The forks are motor operated to traverse a toothed track between the first floor and a second floor with the wheelchair and the user riding the forks. When the forks reach the second floor, the user rolls the wheelchair off the forks.
摘要翻译：公开了一种可以安装在楼梯上的模块化升降系统。该系统包括位于用户滚动轮椅的一楼的叉。叉子通过轮椅和用户骑叉的方式在一楼和二楼之间穿过齿形轨道。当叉子到达二楼时，用户将轮椅从叉子上滚开。

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