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81. 发明授权

US07825237B2 Oligonucleotides and analogs labeled with energy transfer dyes 有权
标题翻译：用能量转移染料标记的寡核苷酸和类似物
公开(公告)号：US07825237B2
公开(公告)日：2010-11-02
申请号：US12554845
申请日：2009-09-04
申请人： Linda Lee , Sandra Spurgeon , Barnett Rosenblum
发明人： Linda Lee , Sandra Spurgeon , Barnett Rosenblum
IPC分类号： C07H19/04 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07H21/04 , C07D311/90
摘要： Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.
摘要翻译：提供了用于将供体染料与能量转移荧光染料中的受体染料连接的新型接头。这些接头促进能量转移染料中供体和受体染料之间的能量的有效转移。用于将供体染料与能量转移荧光染料中的受体染料连接的这些接头之一具有通式结构R21Z1C（O）R22R28，其中R21是与供体染料连接的C 1-5烷基，C（O）是羰基 Z1是NH，硫或氧，R22是包含烯烃，二烯烃，炔烃，具有至少一个不饱和键的五元和六元环或连接到羰基碳上的稠环结构的取代基，R28 包括将接头连接到受体染料的官能团。

82. 发明授权

US07816501B2 Compositions comprising a linked acceptor moiety 有权
标题翻译：包含连接的受体部分的组合物
公开(公告)号：US07816501B2
公开(公告)日：2010-10-19
申请号：US10610338
申请日：2003-06-30
申请人： James M. Coull , Brian D. Gildea , Jens J. Hyldig-Nielsen
发明人： James M. Coull , Brian D. Gildea , Jens J. Hyldig-Nielsen
IPC分类号： C07H21/02 , C07H21/00 , C07H19/04 , C12Q1/68
CPC分类号： C12Q1/6851 , C07K14/003 , C12Q1/6818 , C12Q1/686 , C12Q2565/101 , C12Q2561/113 , C12Q2525/107
摘要： This invention is directed to compositions comprising a linked acceptor moiety.
摘要翻译：本发明涉及包含连接的受体部分的组合物。

83. 发明授权

US07785796B2 Labelled nucleotides 有权
公开(公告)号：US07785796B2
公开(公告)日：2010-08-31
申请号：US12460741
申请日：2009-07-23
申请人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , John Milton
发明人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , John Milton
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04 , C07H19/04
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.

84. 发明授权

US07772384B2 Labelled nucleotides 有权
公开(公告)号：US07772384B2
公开(公告)日：2010-08-10
申请号：US12283285
申请日：2008-09-09
申请人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu
发明人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu
IPC分类号： C07H21/04 , C07H19/04 , C12Q1/68
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20 , C07H21/00 , C12P19/34 , C12Q1/6806 , C12Q1/6818 , C12Q1/6823 , C12Q1/6834 , C12Q1/6874 , C12Q1/6876 , C12Q2525/186
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.

85. 发明授权

US07759470B2 Labeling reagent 有权
标题翻译：标记试剂
公开(公告)号：US07759470B2
公开(公告)日：2010-07-20
申请号：US11707399
申请日：2007-02-16
申请人： Dieter Heindl , Frank Bergmann , Hans-Peter Josel , Dirk Kessler , Gunter Lampert , Christian Weilke
发明人： Dieter Heindl , Frank Bergmann , Hans-Peter Josel , Dirk Kessler , Gunter Lampert , Christian Weilke
IPC分类号： C07G3/00 , C07H21/02 , C07H21/04 , C07H19/04 , C12Q1/68
CPC分类号： C07H19/23 , C07H19/04 , C07H21/00 , C07H21/04 , Y02P20/55
摘要： The current invention restates substituted indole nucleosides as both terminal as well as internal building blocks of labeled oligonucleotide probes for the detection, analysis and quantitation of nucleic acids. The substituent comprises a linker and a detectable group or a linker and a reactive group for post synthesis coupling. These modified nucleosides grant access to a wide application area. These new substituted indole nucleosides can be used as labeling reagents for the facile preparation of e.g. optimized hybridization probes, Taqman-probes, or molecular beacon probes.
摘要翻译：本发明将取代的吲哚核苷作为两个末端以及用于核酸检测，分析和定量的标记的寡核苷酸探针的内部构建块重述。取代基包括接头和可检测的基团或接头以及用于后合成偶联的反应性基团。这些修饰的核苷允许进入广泛的应用领域。这些新的取代的吲哚核苷可以用作标记试剂，用于容易地制备例如优化的杂交探针，Taqman探针或分子信标探针。

86. 发明授权

US07759061B2 2′-nitrobenzyl-modified ribonucleotides 有权
标题翻译： 2'-硝基苄基修饰的核糖核苷酸
公开(公告)号：US07759061B2
公开(公告)日：2010-07-20
申请号：US11628343
申请日：2005-06-02
申请人： Olaf Piepenburg , Derek L. Stemple , Niall A. Armes
发明人： Olaf Piepenburg , Derek L. Stemple , Niall A. Armes
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04 , C07H19/04
CPC分类号： C07H19/10 , C07H19/04 , C07H19/20
摘要： This disclosure provides novel reversibly terminated ribonucleotides which can be used as a reagent for DNA sequencing reactions. Methods of sequencing nucleic acids using the disclosed nucleotides are also provided.
摘要翻译：本公开提供了可用作DNA测序反应试剂的新型可逆终止的核糖核苷酸。还提供了使用公开的核苷酸测序核酸的方法。

87. 发明申请

US20100093609A1 PRODRUGS OF TRICIRIBINE AND TRICIRIBINE PHOSPHATE 审中-公开
标题翻译：焦磷酸和磷酸三苯酯的制备
公开(公告)号：US20100093609A1
公开(公告)日：2010-04-15
申请号：US12593709
申请日：2008-03-31
申请人： John Hilfinger , Wei Shen
发明人： John Hilfinger , Wei Shen
IPC分类号： A61K38/14 , C07H19/04 , C07K9/00 , A61K31/706 , A61P35/00
CPC分类号： A61K31/7064 , C07H19/23
摘要： A prodrug composition is provided which includes a pharmaceutical species and an amino acid having a covalent bond to the pharmaceutical species. Particular pharmaceutical species are 6-amino-4-methyl-8-(beta.-D-ribofuranosyl)pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine, also known as TCN and by the trade name triciribine; as well as the 5′phosphate of triciribine. TCN and TCNP prodrugs of the present invention have increased bioavailability compared to the parent TCN and TCNP. The inventive prodrug is transported from the gastrointestinal lumen by a specific transporter and is enzymatically cleaved to yield TCN or TCNP, such that TCN or TCNP is delivered to the individual.
摘要翻译：提供了前药组合物，其包含药物物质和与药物物质具有共价键的氨基酸。特定的药物种类是6-氨基-4-甲基-8-（β-D-呋喃核糖基）吡咯并[4,3,2-de]嘧啶并[4,5-c]哒嗪，也称为TCN和贸易名称triciribine; 以及三唑来膦酸的5磷酸盐。与母体TCN和TCNP相比，本发明的TCN和TCNP前药具有增加的生物利用度。本发明的前药通过特异的转运蛋白从胃肠腔输送，并被酶切割以产生TCN或TCNP，使得TCN或TCNP被递送给个体。

88. 发明授权

US07678894B2 Nucleotide analogs 有权
标题翻译：核苷酸类似物
公开(公告)号：US07678894B2
公开(公告)日：2010-03-16
申请号：US11804591
申请日：2007-05-18
申请人： Suhaib Siddiqi
发明人： Suhaib Siddiqi
IPC分类号： C07H21/04 , C12Q1/68 , C07H19/04
CPC分类号： C07H19/06 , A61K49/0052 , C07H19/16 , C12Q1/6874 , C12Q2525/101 , C12Q2525/197 , C12Q2563/107
摘要： The disclosure provides nucleotide analogs and methods of their use. Analogs of the invention comprise a reporter molecule (label) attached via the N4, N6, O4, or O6 position of the nitrogenous base portion of the analog. In a preferred embodiment, nucleotide analogs of the invention comprise a label attached to the nitrogenous base portion of the analog via a cleavable linker at the N4, O4, N6 or O6 position.
摘要翻译：本公开提供其使用的核苷酸类似物和方法。本发明的类似物包含通过类似物的含氮碱部分的N4，N6，O4或O6位置连接的报道分子（标记）。在优选的实施方案中，本发明的核苷酸类似物包含在N4，O4，N6或O6位置经由可切割接头连接到类似物的含氮碱部分的标记。

89. 发明授权

US07655409B2 Cyanine dye compounds 有权
标题翻译：花青染料化合物
公开(公告)号：US07655409B2
公开(公告)日：2010-02-02
申请号：US12240218
申请日：2008-09-29
申请人： Jason Dallwig , David Hagen , Shih-Jung Huang , Gerald Thomas , Stephen Yue
发明人： Jason Dallwig , David Hagen , Shih-Jung Huang , Gerald Thomas , Stephen Yue
IPC分类号： C12Q1/68 , C07H21/04 , C07H19/04
CPC分类号： C09B23/02 , C12Q1/6827 , G01N33/582 , Y10T436/143333 , C12Q2527/125 , C12Q2563/107
摘要： Cyanine dye compounds having a negatively charged substituent that are nucleic acid stains, particularly for fluorescent staining of DNA, including compounds having the formula wherein W forms one or two fused 5- or 6-membered aromatic rings, α has a value of 0 or 1, n has a value of 0, or 1, X is O, S, or Se, and D is a pyridinium, or quinolinium moiety, provided that the compound has at least one negatively charged substituent.
摘要翻译：具有带负电荷的取代基的花青染料化合物，特别是用于DNA的荧光染色的带负电荷的取代基，包括具有下式的化合物，其中W形成一个或两个稠合的5-或6-元芳环，α具有0或1的值，n为0或1，X为O，S或Se，D为吡啶鎓或喹啉鎓部分，条件是该化合物具有至少一个带负电荷的取代基。

90. 发明授权

US07645872B2 Compounds and methods for labeling oligonucleotides 有权
公开(公告)号：US07645872B2
公开(公告)日：2010-01-12
申请号：US12535220
申请日：2009-08-04
申请人： Andrei Laikhter , Joseph A. Walder , Mark Behlke , Mikhail Podyminogin , Yawfui Yong
发明人： Andrei Laikhter , Joseph A. Walder , Mark Behlke , Mikhail Podyminogin , Yawfui Yong
IPC分类号： C07H19/04 , C07H21/04 , B01L3/00 , C07J21/00 , C07D225/02 , C12Q1/68 , G01N33/53
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.

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