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1. 发明申请

US20120202196A1 LABELLED NUCLEOTIDES 有权
公开(公告)号：US20120202196A1
公开(公告)日：2012-08-09
申请号：US13432989
申请日：2012-03-28
申请人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , John Milton
发明人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , John Milton
IPC分类号： C12Q1/68 , G01N21/76 , C12P19/34
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20 , C07H21/00 , C12P19/34 , C12Q1/6806 , C12Q1/6818 , C12Q1/6823 , C12Q1/6834 , C12Q1/6874 , C12Q1/6876 , C12Q2525/186
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.

2. 发明授权

US08148064B2 Labelled nucleotides 有权
标题翻译：标记核苷酸
公开(公告)号：US08148064B2
公开(公告)日：2012-04-03
申请号：US12804296
申请日：2010-07-19
申请人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , John Milton
发明人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , John Milton
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/00 , C07H21/02
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20 , C07H21/00 , C12P19/34 , C12Q1/6806 , C12Q1/6818 , C12Q1/6823 , C12Q1/6834 , C12Q1/6874 , C12Q1/6876 , C12Q2525/186
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
摘要翻译：公开了通过可切割连接基团与可检测标记物连接的核苷和核苷酸。

3. 发明授权

US07541444B2 Modified nucleotides 有权
公开(公告)号：US07541444B2
公开(公告)日：2009-06-02
申请号：US10525401
申请日：2003-08-22
申请人： John Milton , Xiaolin Wu , Mark Smith , Joseph Brennan , Colin Barnes , Xiaohai Liu , Silke Ruediger
发明人： John Milton , Xiaolin Wu , Mark Smith , Joseph Brennan , Colin Barnes , Xiaohai Liu , Silke Ruediger
IPC分类号： C07G11/00 , C07H21/02 , C12Q1/68 , C12P19/34 , C07H21/00
CPC分类号： C12Q1/6869 , C07H1/00 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q2525/186 , C12Q2535/113 , Y02P20/55 , C12Q2525/197
摘要： The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O-Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′)2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H.

4. 发明申请

US20060188901A1 Labelled nucleotides 有权
公开(公告)号：US20060188901A1
公开(公告)日：2006-08-24
申请号：US11301578
申请日：2005-12-13
申请人： Colin Barnes , Shankar Balasubramanian , Xiaohai Liu , Harold Swerdlow , John Milton
发明人： Colin Barnes , Shankar Balasubramanian , Xiaohai Liu , Harold Swerdlow , John Milton
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.

5. 发明授权

US08241573B2 Systems and devices for sequence by synthesis analysis 有权
标题翻译：通过合成分析进行序列的系统和装置
公开(公告)号：US08241573B2
公开(公告)日：2012-08-14
申请号：US12295337
申请日：2007-03-30
申请人： Saibal Banerjee , Colin Barnes , Kevin Benson , Jason Bryant , Dale Buermann , Sergey Etchin , Johnny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Mark Reed , Chiara Rodighiero , Subra Sankar , Harold Swerdlow , Eric Vermaas
发明人： Saibal Banerjee , Colin Barnes , Kevin Benson , Jason Bryant , Dale Buermann , Sergey Etchin , Johnny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Mark Reed , Chiara Rodighiero , Subra Sankar , Harold Swerdlow , Eric Vermaas
IPC分类号： G01N21/64 , G06K9/00 , C12M1/36
CPC分类号： C12Q1/6869 , C12Q2535/122 , C12Q2565/60 , G01N21/6456
摘要： The present invention comprises systems and devices for sequencing of nucleic acid, such as short DNA sequences from clonally amplified single-molecule arrays.
摘要翻译：本发明包括用于核酸测序的系统和装置，例如来自克隆扩增的单分子阵列的短DNA序列。

6. 发明授权

US08158346B2 Labelled nucleotides 有权
公开(公告)号：US08158346B2
公开(公告)日：2012-04-17
申请号：US12804025
申请日：2010-07-13
申请人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu
发明人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/00 , C07H21/02
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20 , C07H21/00 , C12P19/34 , C12Q1/6806 , C12Q1/6818 , C12Q1/6823 , C12Q1/6834 , C12Q1/6874 , C12Q1/6876 , C12Q2525/186
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.

7. 发明授权

US08071739B2 Modified nucleotides 有权
标题翻译：修饰的核苷酸
公开(公告)号：US08071739B2
公开(公告)日：2011-12-06
申请号：US12804352
申请日：2010-07-20
申请人： John Milton , Xiaolin Wu , Mark Smith , Joseph Brennan , Colin Barnes , Xiaohai Liu , Silke Ruediger
发明人： John Milton , Xiaolin Wu , Mark Smith , Joseph Brennan , Colin Barnes , Xiaohai Liu , Silke Ruediger
IPC分类号： C07H21/02 , C07H21/04 , C07H19/04 , C12Q1/68
CPC分类号： C12Q1/6869 , C07H1/00 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q2525/186 , C12Q2535/113 , Y02P20/55 , C12Q2525/197
摘要： The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′)2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H.
摘要翻译：本发明提供了修饰的核苷酸或核苷分子，其包含嘌呤或嘧啶碱基和核糖或脱氧核糖糖部分，其具有共价连接到其上的可移除的3'-OH封闭基团，使得3'碳原子连接一组结构-O -Z其中Z是-C（R'）2 -O-R“，-C（R'）2 -N（R”）2，-C（R'）2 -N（H）R“ -C（R'）2 -S-R“和-C（R'）2 -F，其中每个R”为或可移除的保护基团的一部分; 每个R'独立地是氢原子，烷基，取代的烷基，芳基烷基，烯基，炔基，芳基，杂芳基，杂环，酰基，氰基，烷氧基，芳氧基，杂芳氧基或酰氨基，或通过连接基团连接的可检测标记; 或（R'）2表示式≡C（R'“）2的亚烷基，其中每个R”可以相同或不同，并且选自氢和卤素原子和烷基; 并且其中所述分子可以反应以产生其中每个R“被交换为H的中间体，或其中Z是-C（R'）2 -F，F被交换成OH，SH或NH 2，优选OH，其中中间体在水性条件下解离得到具有游离3'OH的分子; 条件是其中Z是-C（R'）2 -S-R“，两个R'基团不是H.

8. 发明授权

US07628982B2 Composition and corresponding method of using spores of Bacillus subtilis to stimulate and/or enhance immune response in mammals 失效
标题翻译：使用枯草芽孢杆菌孢子的组合物和相应方法刺激和/或增强哺乳动物的免疫应答
公开(公告)号：US07628982B2
公开(公告)日：2009-12-08
申请号：US10309635
申请日：2002-12-04
申请人： Linda Sylvia Klaviniskis , Andrew Graham Colin Barnes
发明人： Linda Sylvia Klaviniskis , Andrew Graham Colin Barnes
IPC分类号： A01N63/00 , A01N65/00 , A61K48/00 , A61K39/38 , A61K39/07 , A61K45/00
CPC分类号： A61K35/742 , A61K39/08 , A61K39/39 , A61K2039/522 , A61K2039/523
摘要： Disclosed is a composition for administration to a human or animal subject, the composition containing spores of Bacillus subtilis in an amount effective to stimulate immune responsiveness in the subject. The spores have an adjuvant, immunomodulatory, immune potentiation, or dendritic cell maturation effect, or a combination thereof Also disclosed is a method of boosting an immune response in an animal subject by administering B. subtilis spores to an animal or human subject. Further disclosed is a vaccine containing B. subtilis spores, in the presence or absence of an antigen.
摘要翻译：公开了一种用于向人或动物受试者施用的组合物，所述组合物含有有效刺激受试者的免疫应答的量的枯草芽孢杆菌孢子。孢子具有佐剂，免疫调节，免疫增强或树突细胞成熟作用或其组合。还公开了通过向动物或人受试者施用枯草芽孢杆菌孢子来增强动物受试者的免疫应答的方法。进一步披露的是在存在或不存在抗原的情况下含有枯草芽孢杆菌孢子的疫苗。

9. 发明申请

US20090118128A1 Preparation of templates for nucleic acid sequencing 审中-公开
标题翻译：核酸测序模板的制备
公开(公告)号：US20090118128A1
公开(公告)日：2009-05-07
申请号：US11989169
申请日：2006-07-20
申请人： Xiaohai Liu , John Milton , Geoffrey Paul Smith , Colin Barnes , Isabelle Marie Julia Rasolonjatovo , Roberto Rigatti , Xiaolin Wu , Tobias William Barr Ost , Graham John Worsley , David James Earnshaw , Gerardo Turcatti , Anthony Romieu
发明人： Xiaohai Liu , John Milton , Geoffrey Paul Smith , Colin Barnes , Isabelle Marie Julia Rasolonjatovo , Roberto Rigatti , Xiaolin Wu , Tobias William Barr Ost , Graham John Worsley , David James Earnshaw , Gerardo Turcatti , Anthony Romieu
IPC分类号： C40B20/00 , C07H1/00 , C12P19/34 , C40B50/06
CPC分类号： B01J19/0046 , B01J2219/00596 , B01J2219/00608 , B01J2219/00675 , B01J2219/00722 , C12Q1/6806 , C12Q1/6834 , C12Q1/6874 , C12Q2565/543 , C12Q2535/101 , C12Q2523/113 , C12Q2523/107 , C12Q2521/331 , C12Q2521/307
摘要： The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5′ end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.
摘要翻译：本发明涉及产生用于核酸测序反应的模板的方法，其包括：提供至少一个双链核酸分子，其中双链核酸分子的两条链在5'末端连接到固体支持物上切割双链核酸分子的一条或两条链，并使切割的链进行变性条件以除去未连接到固体支持物上的部分切割的链，从而产生部分或基本上用于核酸测序反应的单链模板。

10. 发明授权

US07057026B2 Labelled nucleotides 有权
公开(公告)号：US07057026B2
公开(公告)日：2006-06-06
申请号：US10227131
申请日：2002-08-23
申请人： Colin Barnes , Shankar Balasubramanian , Xiaohai Liu , Harold Swerdlow , John Milton
发明人： Colin Barnes , Shankar Balasubramanian , Xiaohai Liu , Harold Swerdlow , John Milton
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.

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