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81. 发明授权

US10790061B2 Method and system for microbiome-derived diagnostics and therapeutics for mental health associated conditions 有权
公开(公告)号：US10790061B2
公开(公告)日：2020-09-29
申请号：US15668653
申请日：2017-08-03
申请人： PSOMAGEN, INC.
发明人： Zachary Apte , Daniel Almonacid , Jessica Richman
IPC分类号： G01N33/48 , G16H50/20 , G06F19/00 , G16B50/00 , G16H50/70 , C12Q1/04 , C12Q1/24 , G01N33/569 , G16B40/00 , G16H50/50 , G16H10/40 , G16H20/70 , G06G7/58 , C12Q1/00
摘要： A method for at least one of characterizing, diagnosing, and treating a mental health associated condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the mental health associated condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the mental health associated condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

82. 发明授权

US10788478B2 Blood test kit, member thereof, and method for manufacturing the same 有权
公开(公告)号：US10788478B2
公开(公告)日：2020-09-29
申请号：US15861875
申请日：2018-01-04
申请人： FUJIFILM Corporation
发明人： Hikaru Urano , Haruyasu Nakatsugawa , Susumu Osawa , Shinya Sugimoto
IPC分类号： G01N33/49 , A61B5/15 , G01N1/10 , G01N33/96 , G01N33/48 , B01L3/00 , G01N1/38 , G01N33/66
摘要： An object is to perform analysis of a target component contained in a small volume of blood sample at high accuracy using a normal component homeostatically present in blood. Provided is a blood test kit for analyzing a concentration of a target component in a blood sample by using a normal component homeostatically present in blood, the kit including: a diluent solution for diluting a blood sample; and a member selected from the group consisting of a first storing instrument in which the diluent solution is stored, a separating instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separating instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma in the second storing instrument, in which an amount of the normal component which is derived from the member and may be contained in the diluent solution is defined.

83. 发明授权

US10782240B2 Test mass compensation of mass measurement drift in a microcantilever resonator 有权
公开(公告)号：US10782240B2
公开(公告)日：2020-09-22
申请号：US15587284
申请日：2017-05-04
申请人： Applied Invention, LLC
发明人： W. Daniel Hillis
IPC分类号： G01N33/48 , G01N33/50 , G01N21/84 , G01Q10/04 , G02B6/36 , G16C99/00 , G01N9/00 , G01N5/02 , G01N29/30 , G01N29/02 , G01N15/10 , G01N15/00
摘要： The present disclosure provides methods and mechanisms for measuring small masses attached to a substrate within a microcantilever. Specifically, the disclosure describes the measurement of small particles accumulated at a substrate that cannot be flowed through a microchannel within a microcantilever. A resonance measurement is acquired at a first time. A pair resonance measurements is then acquired at a second point in time—one with the test mass at a first position off or along the microcantilever, the second with the test mass at a second position along the microcantilever. Comparing the resonance frequencies determined for the two test mass positions allows for disambiguation of changes in the mass of the particles from changes in the resonant behavior of the microcantilever itself.

84. 发明授权

US10779769B2 Method and system for evaluating a noise level of a biosignal 有权
公开(公告)号：US10779769B2
公开(公告)日：2020-09-22
申请号：US15119940
申请日：2015-02-17
申请人： INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (INRS)
发明人： Tiago Henrique Falk , Diana Patricia Tobon Vallejo , Martin Maier
IPC分类号： G01N33/48 , G01N33/50 , A61B5/00 , A61B5/0205 , A61B5/04 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/0408 , A61B5/11 , A61B5/0245
摘要： There is described a method for evaluating a level of noise in a biosignal, the method comprising: receiving a time signal representative of a biological activity, the time signal comprising a biological activity component and a noise component; determining a modulation spectrum for the time signal, the modulation spectrum representing a signal frequency as a function of a modulation frequency; from the modulation spectrum determining a first amount of modulation energy corresponding to the biological activity component and a second amount of modulation energy corresponding to the noise component determining an indication of the level of noise using the first and second amounts of modulation energy; and outputting the indication of the level of noise.

85. 发明授权

US10766031B2 Microfluidics based analyzer and method for fluid control thereof 有权
公开(公告)号：US10766031B2
公开(公告)日：2020-09-08
申请号：US15970866
申请日：2018-05-03
申请人： Feng Chia University
发明人： Chih-Hsin Shih , Ho-Chin Wu , Yen-Hao Chen
IPC分类号： B01L3/00 , G01N15/06 , G01N33/00 , G01N33/48 , G01N35/00
摘要： The present disclosure relates to a microfluidic-based analyzer, including a drive module and a microfluidic disc. On the microfluidic disk, a capillary is connected between a mixing chamber and a waste chamber. More particularly, the capillary is connected to the mixing chamber through a first access on the first radius of the microfluidic disc, and the capillary is connected to the waste chamber through a second access on the second radius of the microfluidic disk. Specifically, a turn of the capillary is disposed between the first access and the second access, in which a folding is configured on a third radius of the microfluidic disc. Overall, the aforementioned microfluidic-based analyzer is able to be operated in different rotational speeds and is capable of evacuating the mixing chamber and enhancing the washing efficiency.

86. 发明授权

US10754926B2 Data management unit and method operating same 有权
公开(公告)号：US10754926B2
公开(公告)日：2020-08-25
申请号：US15022146
申请日：2014-09-19
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Andrew Tubb
IPC分类号： G01N33/48 , G06F19/00 , G16H40/63 , G16H10/60 , G16H20/17 , G16H50/20 , A61B5/145 , A61B5/00
摘要： The present invention refers to data management unit comprising a data storage (130) adapted to store a plurality of measurement values of the physiological parameter, preferably a blood glucose level, for each measurement value an associated event tag, for each measurement value an associated time stamp, an associated time range for tagging preselection for each of at least two meal events, each time range is preferably user-settable, preferably also for a fasting event an associated time range for tagging preselection, this time range is preferably user-settable, a processor (140) adapted to receive a new measurement value from the data storage (130) or from a measurement unit (110), which is preferably at least shortly connected for data transfer, assign an associated time stamp to the new measurement value, if an associated time stamp does not yet exist with the new measurement value, receive selection data containing the information that the user has selected and/or confirmed one of a “before meal” tag and an “after meal” tag with regard to the new measurement value, automatically select an additional associated tag referring to one of the at least two meal events and preferably also of the fasting event based on the selection data and on a comparison of the time stamp of the new measurement value with the associated time ranges for tagging preselection of the at least two meal events and preferably also with the time range for tagging preselection of the fasting event. The invention further refers to a corresponding medical device (100), a corresponding method and computer program for operating a data management unit as well as to a corresponding computer program product.

87. 发明授权

US10746723B2 Blood test kit and blood analysis method 有权
公开(公告)号：US10746723B2
公开(公告)日：2020-08-18
申请号：US15861353
申请日：2018-01-03
申请人： FUJIFILM Corporation
发明人： Seiji Yamashita , Haruyasu Nakatsugawa , Susumu Osawa , Shinya Sugimoto
IPC分类号： G01N33/48 , A61B5/15 , G01N33/487 , G01N1/28 , G01N33/49 , G01N1/00 , G01N1/38 , G01N33/66 , G01N33/96 , G01N1/10
摘要： An object of the present invention is to provide a blood test kit of which a component in a small volume of blood can be mailed in a safe state by controlling the influence of the outside temperature during the mailing, and a highly accurate blood analysis method in which coefficient of variation of a measurement value is reduced. According to the present invention, a blood test kit including a diluent solution for diluting a blood sample; a separating means for recovering blood plasma components from the diluted blood sample; a container for storing the blood plasma components recovered from the diluted blood sample; and a cold insulation means for cold-insulating the container, is provided.

88. 发明授权

US10739265B2 Solution attachment device and solution attachment method 有权
公开(公告)号：US10739265B2
公开(公告)日：2020-08-11
申请号：US15984443
申请日：2018-05-21
申请人： FUJIFILM Corporation
发明人： Kota Kato
IPC分类号： G01N21/01 , G01N35/00 , G01N33/48 , G01N1/00 , G01N1/10 , G01N21/64 , G01N1/28 , B01L3/02 , G01N21/552 , G01N35/10 , B01L3/00
摘要： A solution attachment device includes: an ejection tool having an ejection opening that ejects a solution in a direction of gravitational force; and a solution attachment control portion for controlling attachment of the solution ejected from the ejection opening to at least one attachment subject region of the solution formed on a substrate in a state in which the at least one attachment subject region is disposed below an end surface including the ejection opening of the ejection tool in the direction of gravitational force, and, in the state, a first projection region obtained by projecting the end surface to a surface perpendicular to the direction of gravitational force substantially overlaps a second projection region obtained by projecting the at least one attachment subject region to the surface.

89. 发明授权

US10732165B2 Infrared analysis of benign tumors 有权
公开(公告)号：US10732165B2
公开(公告)日：2020-08-04
申请号：US15785801
申请日：2017-10-17
申请人： TODOS MEDICAL LTD.
发明人： Joseph Kapelushnik , Shaul Mordechai , Ilana Nathan , Udi Zelig , Rami Zigdon
IPC分类号： G01N33/48 , G01N33/483 , G01N21/3577 , G01N21/359 , G01N21/3563 , G01N21/35
摘要： A method including identifying a subject as possibly having a benign tumor in ovarian tissue and obtaining an infrared spectrum of a PBMC sample of the subject and assessing a characteristic of the sample at at least one wavenumber selected from the group consisting of: 754.0±4 cm-1, 1103.6±4 cm-1, 1121.4±4 cm-1, 1346.1±4 cm-1, 1376.9±4 cm-1, 753.50±4 cm-1, 850.5±4 cm-1, 918.9±4 cm-1, 1058.7±4 cm-1, 1187.9±4 cm-1 and 1651.7±4 cm-1. Using a processor comparing, at the at least one wavenumber, the infrared spectrum to an infrared spectrum obtained from a PBMC sample from a person without a benign tumor, to detect a difference between the infrared spectrum of the PBMC sample of the subject and the infrared spectrum obtained from the PBMC sample from the person without a benign tumor. Other applications are also described.

90. 发明授权

US10726943B2 Clinical decision model 有权
公开(公告)号：US10726943B2
公开(公告)日：2020-07-28
申请号：US13083090
申请日：2011-04-08
申请人： Alexander Stojadinovic , Eric Elster , Doug K. Tadaki , John S. Eberhardt, III , Trevor Brown , Thomas A. Davis , Jonathan Forsberg , Jason Hawksworth
发明人： Alexander Stojadinovic , Eric Elster , Doug K. Tadaki , John S. Eberhardt, III , Trevor Brown , Thomas A. Davis , Jonathan Forsberg , Jason Hawksworth
IPC分类号： G01N33/48 , G16B40/00 , G16B50/00 , G16B25/00
摘要： An embodiment of the invention provides a method for determining a patient-specific probability of disease. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of the healing rate of an acute traumatic wound is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of the healing rate of an acute traumatic wound.

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