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1. 发明申请

US20230036774A1 NON-MECHANICAL MULTI-MODE MCF/CF 有权
公开(公告)号：US20230036774A1
公开(公告)日：2023-02-02
申请号：US17813392
申请日：2022-07-19
申请人： ChemImage Corporation
发明人： Lei SHI , George VENTOURIS
IPC分类号： G02F1/1347 , G02B5/20
摘要： A non-mechanical liquid crystal tunable filter (LCTF) assembly capable of switching between a multi-conjugate filter mode and a conformal filter mode is described. The non-mechanical LCTF architecture can include a plurality of LCTF components that each comprises a first optical filter comprising a first optical axis, a second optical filter comprising a second optical axis, wherein the second optical axis is rotated 90° relative to the first optical axis, and a first twisted nematic cell positioned between the first optical filter and the second optical filter, the first twisted nematic cell configured to polarize received light by 90° when a voltage is not applied and not polarize the received light when the voltage is applied. The non-mechanical LCTF assembly is configured to switch between a conformal filter mode and a multi-conjugate filter mode based on whether the voltage is applied to each of the plurality of LCTF components.

2. 发明申请

US20220018714A1 SYSTEMS AND METHODS FOR SPECTRAL PROCESSING IMPROVEMENTS IN SPATIAL HETERODYNE SPECTROSCOPY 有权
公开(公告)号：US20220018714A1
公开(公告)日：2022-01-20
申请号：US17379616
申请日：2021-07-19
申请人： CHEMIMAGE CORPORATION
发明人： Nathaniel GOMER , Heather E. GOMER
IPC分类号： G01J3/44 , G01J3/28
摘要： Raman spectroscopy data is collected using a Spatial Heterodyne Spectrometer and processed in order to reduce signal noise. The processing of the Raman spectroscopy data includes segmenting generating an interferogram from the Raman spectroscopy data, segmenting the interferogram, determining an estimate of power spectrum density, and averaging the estimates of power spectrum density for each segment to provide an output spectrum. The output spectrum has greatly reduced variance of the individual power measurements, and allows the length of segments to be optimized to balance noise reduction operations and the loss of frequency resolution.

3. 发明申请

US20210353225A1 SYSTEMS AND METHODS FOR DETECTING ORAL CANCER USING MOLECULAR CHEMICAL IMAGING 有权
公开(公告)号：US20210353225A1
公开(公告)日：2021-11-18
申请号：US17323462
申请日：2021-05-18
申请人： CHEMIMAGE CORPORATION
发明人： Shona STEWART , Aaron SMITH , Patrick J. TREADO
IPC分类号： A61B5/00 , A61B1/07 , A61B1/06 , A61B1/05 , A61B1/04 , A61B1/24
摘要： Methods and systems of identifying oral cancer in vivo are disclosed. An oral cavity of a patient is illuminated with a plurality of illuminating photons. A plurality of interacted photos are received from the oral cavity. The interacted photons may have been absorbed, reflected, scattered or emitted by the oral cavity. The interacted photons are filtered into first and second polarized multi-passband wavelengths using first and second tunable conformal filters, respectively. A detector captures the first and second polarized multi-passband wavelengths. A processor automatically discriminates between cancerous tissue and non-cancerous tissue in an image resolved from the first and second polarized multi-passband wavelengths.

4. 发明申请

US20140043488A1 System and Method for Drug Detection Using SWIR 审中-公开
标题翻译：使用SWIR进行药物检测的系统和方法
公开(公告)号：US20140043488A1
公开(公告)日：2014-02-13
申请号：US14055509
申请日：2013-10-16
申请人： ChemImage Corporation
发明人： Patrick Treado , Matthew Nelson , Charles Gardner
IPC分类号： G01N33/15
CPC分类号： G01N33/15 , G01J3/02 , G01J3/0218 , G01J3/027 , G01J3/0278 , G01J3/44 , G01N21/359 , G01N33/0057
摘要： A method for detecting unknown materials, such as drugs. A first location is surveyed using a video capture device to identify a second location comprising an unknown material. The second location is interrogated using SWIR spectroscopic and/or imaging methods to generate a SWIR hyperspectral image. The SWIR hyperspectral image is analyzed to associate the unknown material with a known drug material. A system for detecting unknown materials, such as drugs comprising a first collection lens for collecting interacted photons from a first location and a visible imaging device for generating a visible image. A second collection lens may collect a plurality of interacted photons from a second location and a tunable filter may filter the interacted photons. A spectroscopic imaging device may detect the interacted photons and generate a SWIR hyperspectral image. A processor may analyze the SWIR hypespectral image to associate an unknown material with a known material.
摘要翻译：检测未知物质如药物的方法。使用视频捕获设备来测量第一位置以识别包括未知材料的第二位置。使用SWIR光谱和/或成像方法询问第二个位置以产生SWIR高光谱图像。分析SWIR高光谱图像以将未知材料与已知药物材料相关联。一种用于检测未知材料的系统，例如药物，其包括用于从第一位置收集相互作用的光子的第一收集透镜和用于产生可见图像的可见成像装置。第二采集透镜可以从第二位置收集多个相互作用的光子，并且可调谐滤光器可以过滤相互作用的光子。光谱成像装置可以检测相互作用的光子并产生SWIR高光谱图像。处理器可以分析SWIR超光谱图像以将未知材料与已知材料相关联。

5. 发明授权

US08440959B2 Method and apparatus for automated spectral calibration 有权
标题翻译：用于自动光谱校准的方法和装置
公开(公告)号：US08440959B2
公开(公告)日：2013-05-14
申请号：US12897376
申请日：2010-10-04
申请人： Matthew Nelson , Patrick Treado
发明人： Matthew Nelson , Patrick Treado
IPC分类号： G01D18/00
CPC分类号： A61B5/0059 , A61B2560/0223 , G01J3/28 , G01J3/42
摘要： A method and apparatus for automated spectral calibration of a spectroscopy device. A method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum.
摘要翻译：一种用于光谱装置的自动光谱校准的方法和装置。一种通过以下步骤同时校准和光谱成像的方法：同时用多个照明光子照射样品和校准物; 在光谱仪处接收从样品收集的第一组多个光子和从校准物收集的第二组多个光子; 从所述第一多个收集的光子形成校准谱，以及来自所述第二多个收集的光子的样品光谱; 将校准谱与校准物的参考光谱进行比较，以确定校准谱中的波长漂移; 将波长偏移应用于样本光谱以获得校准的样本光谱。

6. 发明授权

US08416405B2 Raman chemical imaging of implantable drug delivery devices 有权
标题翻译：可植入药物递送装置的拉曼化学成像
公开(公告)号：US08416405B2
公开(公告)日：2013-04-09
申请号：US12537671
申请日：2009-08-07
申请人： Janice Panza , John Maier
发明人： Janice Panza , John Maier
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01N21/65 , G01N2201/129
摘要： A system and method of determining an attribute of a biological tissue sample or a drug delivery device. A sample is illuminated with substantially monochromatic light to thereby generate Raman scattered photons. The Raman scattered photons are assessed to thereby generate a spectroscopic data set wherein said spectroscopic data set comprises at least one of: a Raman spectra and a spatially accurate wavelength resolved image. The spectroscopic data set is evaluated to determine at least one of: an attribute of a biological tissue sample and a drug delivery device. In one embodiment, the biological tissue comprises arterial tissue. In another embodiment, the drug delivery device is a drug-eluting stent. In another embodiment, Raman chemical imaging can be used to evaluate a sample and identify at least one of: the tissue, a drug, a drug delivery device, and a matrix associated with a drug delivery device.
摘要翻译：一种确定生物组织样品或药物递送装置的属性的系统和方法。用基本单色光照射样品，从而产生拉曼散射光子。评估拉曼散射光子，从而产生光谱数据集，其中所述光谱数据集包括拉曼光谱和空间上准确的波长分辨图像中的至少一个。评估光谱数据集以确定生物组织样品和药物递送装置的属性中的至少一个。在一个实施方案中，生物组织包含动脉组织。在另一个实施方案中，药物递送装置是药物洗脱支架。在另一个实施方案中，拉曼化学成像可用于评估样品并鉴定组织，药物，药物递送装置和与药物递送装置相关联的基质中的至少一种。

7. 发明授权

US08289513B2 System and method for component discrimination enhancement based on multispectral addition imaging 有权
标题翻译：基于多光谱加法成像的组件鉴别增强的系统和方法
公开(公告)号：US08289513B2
公开(公告)日：2012-10-16
申请号：US12799779
申请日：2010-04-30
申请人： Matthew Nelson , Patrick Treado , Charles W. Gardner, Jr.
发明人： Matthew Nelson , Patrick Treado , Charles W. Gardner, Jr.
IPC分类号： G01J3/28
CPC分类号： G01J3/02 , G01J3/0224 , G01J3/32 , G01J3/44 , G01N21/314 , G01N21/33 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/65 , G02B21/16 , G02B21/361
摘要： A system and method for performing multispectral color addition imaging. An optical image is obtained for a sample scene comprising one or more target materials. Spectroscopic data is obtained for one or more target materials. A first and second waveband of interest are obtained for one or more target materials. A ratio of the first and second wavebands of interest is obtained and compared to one or more ranges of threshold values. Based on this comparison, a result is displayed wherein this result comprises a pseudo color overlay on said optical image. The pseudo color image may comprise one or more pseudo colors assigned to one or more target materials so as to differentiate and identify the target materials present in the sample scene.
摘要翻译：用于执行多光谱彩色加成成像的系统和方法。获得包含一个或多个目标材料的样本场景的光学图像。获得一种或多种目标材料的光谱数据。获得针对一种或多种目标材料的第一和第二感兴趣波段。获得感兴趣的第一和第二波段的比率并将其与一个或多个阈值范围进行比较。基于该比较，显示结果，其中该结果包括所述光学图像上的伪颜色覆盖。伪彩色图像可以包括分配给一个或多个目标材料的一种或多种伪颜色，以便区分和识别存在于样本场景中的目标材料。

8. 发明授权

US08289503B2 System and method for classifying a disease state using representative data sets 有权
标题翻译：使用代表性数据集分类疾病状态的系统和方法
公开(公告)号：US08289503B2
公开(公告)日：2012-10-16
申请号：US12762609
申请日：2010-04-19
申请人： Jeffrey Cohen , John Maier
发明人： Jeffrey Cohen , John Maier
IPC分类号： G01N21/00
CPC分类号： G01J3/02 , G01J3/0264 , G01J3/0289 , G01J3/0291 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： System and method for determining a disease state of a sample. A sample is positioned in a field of view and a first spectroscopic data set is obtained. The positional information is stored and the sample is treated with a contrast enhancing agent. The sample is repositioned in the field of view and a digital image is obtained. The spectroscopic data is linked with the digital image and a database comprising representative spectroscopic data sets is searched to classify the disease state of the sample. The disclosure also provides for the step of obtaining a processed derivative image and searching a database comprising representative processed derivative images to classify a disease state of the sample.
摘要翻译：用于确定样品的疾病状态的系统和方法。将样品放置在视场中，并获得第一光谱数据组。存储位置信息，并用对比度增强剂处理样品。样本在视野中重新定位，并获得数字图像。光谱数据与数字图像相关联，并且搜索包含代表性光谱数据集的数据库以分类样品的疾病状态。本公开还提供了获得经处理的衍生图像并搜索包括代表性处理的衍生图像的数据库以分类样本的疾病状态的步骤。

9. 发明申请

US20120252058A1 System and Method for the Assessment of Biological Particles in Exhaled Air 审中-公开
标题翻译：呼吸空气中生物颗粒评估系统和方法
公开(公告)号：US20120252058A1
公开(公告)日：2012-10-04
申请号：US13432938
申请日：2012-03-28
申请人： Jeffrey Cohen , Shona Stewart , Oksana Klueva
发明人： Jeffrey Cohen , Shona Stewart , Oksana Klueva
IPC分类号： G01N21/64 , C12M1/34
CPC分类号： G01N21/6456 , G01N21/359 , G01N21/65 , G01N2021/6423 , G01N2021/6484
摘要： A system and method for the deposition and analysis of a sample comprising exhaled particles. The sample may be deposited on a substrate and regions of interest comprising exhaled particles may be targeted using autofluorescence. Regions of interest comprising exhaled particles may then be interrogated to thereby generate a spectroscopic data set. This spectroscopic data set may be compared to a reference data set associated with at least one of the following: a known disease state, a known metabolic state, a known inflammatory state, a known immunologic state, a known infectious state, and combinations thereof.
摘要翻译：用于沉积和分析包含呼出颗粒的样品的系统和方法。可以将样品沉积在基底上，并且可以使用自发荧光靶向包含呼出颗粒的感兴趣区域。然后可以询问包括呼出颗粒的感兴趣区域，从而产生光谱数据集。该光谱数据集可以与与以下至少一个相关联的参考数据集进行比较：已知的疾病状态，已知的代谢状态，已知的炎性状态，已知的免疫学状态，已知的感染状态及其组合。

10. 发明申请

US20120154792A1 Portable system for detecting hazardous agents using SWIR and method for use thereof 审中-公开
标题翻译：使用SWIR检测危险品的便携式系统及其使用方法
公开(公告)号：US20120154792A1
公开(公告)日：2012-06-21
申请号：US13068542
申请日：2011-05-12
申请人： Patrick J. Treado , Matthew Nelson , Charles W. Gardner, JR. , Thomas Voigt , Jeffrey Beckstead
发明人： Patrick J. Treado , Matthew Nelson , Charles W. Gardner, JR. , Thomas Voigt , Jeffrey Beckstead
IPC分类号： G01J3/00
CPC分类号： G01J3/0208 , G01J3/0224 , G01J3/0248 , G01J3/0264 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0289 , G01J3/0291 , G01J3/1256 , G01J3/26 , G01J3/2823
摘要： The disclosure provides for a portable device for detecting hazardous agents, including explosives using SWIR hyperspectral imaging. The device may comprise a collection optics, a SWIR multi-conjugate filter, a SWIR camera, and a display. The device may also comprise an RGB camera. The disclosure also provides for a method of using said portable device wherein interacted photons are collected and passed through a SWIR multi-conjugate filter. The interacted photons are detected to generate at least one SWIR hyperspectral image. The SWIR hyperspectral image may be analyzed to determine the presence or absence of a hazardous agent on a target. An RGB image of a target may also be generated and analyzed to survey a sample scene.
摘要翻译：本公开提供了用于检测危险剂的便携式装置，包括使用SWIR高光谱成像的爆炸物。该装置可以包括收集光学器件，SWIR多共轭滤光器，SWIR相机和显示器。该设备还可以包括RGB相机。本公开还提供了使用所述便携式设备的方法，其中相互作用的光子被收集并通过SWIR多重共轭滤波器。检测相互作用的光子以产生至少一个SWIR高光谱图像。可以分析SWIR高光谱图像以确定目标上是否存在危险剂。还可以生成和分析目标的RGB图像以对样本场景进行调查。

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