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1. 发明申请

US20230036774A1 NON-MECHANICAL MULTI-MODE MCF/CF 有权
公开(公告)号：US20230036774A1
公开(公告)日：2023-02-02
申请号：US17813392
申请日：2022-07-19
申请人： ChemImage Corporation
发明人： Lei SHI , George VENTOURIS
IPC分类号： G02F1/1347 , G02B5/20
摘要： A non-mechanical liquid crystal tunable filter (LCTF) assembly capable of switching between a multi-conjugate filter mode and a conformal filter mode is described. The non-mechanical LCTF architecture can include a plurality of LCTF components that each comprises a first optical filter comprising a first optical axis, a second optical filter comprising a second optical axis, wherein the second optical axis is rotated 90° relative to the first optical axis, and a first twisted nematic cell positioned between the first optical filter and the second optical filter, the first twisted nematic cell configured to polarize received light by 90° when a voltage is not applied and not polarize the received light when the voltage is applied. The non-mechanical LCTF assembly is configured to switch between a conformal filter mode and a multi-conjugate filter mode based on whether the voltage is applied to each of the plurality of LCTF components.

2. 发明申请

US20220018714A1 SYSTEMS AND METHODS FOR SPECTRAL PROCESSING IMPROVEMENTS IN SPATIAL HETERODYNE SPECTROSCOPY 有权
公开(公告)号：US20220018714A1
公开(公告)日：2022-01-20
申请号：US17379616
申请日：2021-07-19
申请人： CHEMIMAGE CORPORATION
发明人： Nathaniel GOMER , Heather E. GOMER
IPC分类号： G01J3/44 , G01J3/28
摘要： Raman spectroscopy data is collected using a Spatial Heterodyne Spectrometer and processed in order to reduce signal noise. The processing of the Raman spectroscopy data includes segmenting generating an interferogram from the Raman spectroscopy data, segmenting the interferogram, determining an estimate of power spectrum density, and averaging the estimates of power spectrum density for each segment to provide an output spectrum. The output spectrum has greatly reduced variance of the individual power measurements, and allows the length of segments to be optimized to balance noise reduction operations and the loss of frequency resolution.

3. 发明申请

US20210353225A1 SYSTEMS AND METHODS FOR DETECTING ORAL CANCER USING MOLECULAR CHEMICAL IMAGING 有权
公开(公告)号：US20210353225A1
公开(公告)日：2021-11-18
申请号：US17323462
申请日：2021-05-18
申请人： CHEMIMAGE CORPORATION
发明人： Shona STEWART , Aaron SMITH , Patrick J. TREADO
IPC分类号： A61B5/00 , A61B1/07 , A61B1/06 , A61B1/05 , A61B1/04 , A61B1/24
摘要： Methods and systems of identifying oral cancer in vivo are disclosed. An oral cavity of a patient is illuminated with a plurality of illuminating photons. A plurality of interacted photos are received from the oral cavity. The interacted photons may have been absorbed, reflected, scattered or emitted by the oral cavity. The interacted photons are filtered into first and second polarized multi-passband wavelengths using first and second tunable conformal filters, respectively. A detector captures the first and second polarized multi-passband wavelengths. A processor automatically discriminates between cancerous tissue and non-cancerous tissue in an image resolved from the first and second polarized multi-passband wavelengths.

4. 发明申请

US20200327349A1 EXTENDED PARTICLE SWARM BAND SELECTION 审中-公开
公开(公告)号：US20200327349A1
公开(公告)日：2020-10-15
申请号：US16791634
申请日：2020-02-14
申请人： ChemImage Corporation
发明人： Shashank R. DESHPANDE , Lucas P. ZBUR , Christopher D. ANDERSON , Patrick J. TREADO
IPC分类号： G06K9/20 , G16C20/20 , G06K9/00 , G06T7/20
摘要： The disclosure provides methods, systems, and computer program products for detecting compounds of interest that are deposited on or associated with objects of interest. The compounds of interest are not limited and include drugs, alcohol, cannabis, narcotics, controlled substances as defined by state, federal, or international law, ammonium-based explosives, MGE-based explosives, toxic compounds, organic compounds, inorganic compounds, nerve agents, or biological compounds. The disclosure increases the speed and efficiency of processing hyperspectral images, especially on low-power or portable devices.

5. 发明申请

US20140118722A1 SYSTEM AND METHOD FOR SAFER DETECTION OF UNKNOWN MATERIALS USING DUAL POLARIZED HYPERSPECTRAL IMAGING AND RAMAN SPECTROSCOPY 有权
公开(公告)号：US20140118722A1
公开(公告)日：2014-05-01
申请号：US13842098
申请日：2013-03-15
申请人： Chemimage Corporation
发明人： Patrick J. Treado , Matthew Nelson , Charles Gardner
IPC分类号： G01N21/65 , G01N21/17
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0221 , G01J3/0224 , G01J3/32 , G01J3/44 , G01N21/17 , G01N21/21 , G01N21/314 , G01N21/33 , G01N21/35 , G01N21/3581 , G01N21/359 , G02B21/0092 , G02B21/16 , G02B21/361
摘要： A first location comprising an unknown material may be scanned using SWIR hyperspectral imaging in a dual polarization configuration. Surveying may also be applied to thereby determine whether or not a human is present. This surveying may be achieved my assessing LWIR data, data acquired from motion sensors, and combinations thereof. If no human is present, a second location may be interrogated using Raman spectroscopic techniques to thereby obtain a Raman data set representative of the region of interest. This Raman data set may be assessed to associate an unknown material with a known material. This assessment may be achieved by comparing the Raman data set to one or more reference data sets in a reference database, where each reference data set is associated with a known material.

6. 发明申请

US20140043488A1 System and Method for Drug Detection Using SWIR 审中-公开
标题翻译：使用SWIR进行药物检测的系统和方法
公开(公告)号：US20140043488A1
公开(公告)日：2014-02-13
申请号：US14055509
申请日：2013-10-16
申请人： ChemImage Corporation
发明人： Patrick Treado , Matthew Nelson , Charles Gardner
IPC分类号： G01N33/15
CPC分类号： G01N33/15 , G01J3/02 , G01J3/0218 , G01J3/027 , G01J3/0278 , G01J3/44 , G01N21/359 , G01N33/0057
摘要： A method for detecting unknown materials, such as drugs. A first location is surveyed using a video capture device to identify a second location comprising an unknown material. The second location is interrogated using SWIR spectroscopic and/or imaging methods to generate a SWIR hyperspectral image. The SWIR hyperspectral image is analyzed to associate the unknown material with a known drug material. A system for detecting unknown materials, such as drugs comprising a first collection lens for collecting interacted photons from a first location and a visible imaging device for generating a visible image. A second collection lens may collect a plurality of interacted photons from a second location and a tunable filter may filter the interacted photons. A spectroscopic imaging device may detect the interacted photons and generate a SWIR hyperspectral image. A processor may analyze the SWIR hypespectral image to associate an unknown material with a known material.
摘要翻译：检测未知物质如药物的方法。使用视频捕获设备来测量第一位置以识别包括未知材料的第二位置。使用SWIR光谱和/或成像方法询问第二个位置以产生SWIR高光谱图像。分析SWIR高光谱图像以将未知材料与已知药物材料相关联。一种用于检测未知材料的系统，例如药物，其包括用于从第一位置收集相互作用的光子的第一收集透镜和用于产生可见图像的可见成像装置。第二采集透镜可以从第二位置收集多个相互作用的光子，并且可调谐滤光器可以过滤相互作用的光子。光谱成像装置可以检测相互作用的光子并产生SWIR高光谱图像。处理器可以分析SWIR超光谱图像以将未知材料与已知材料相关联。

7. 发明授权

US11525733B2 Systems and methods of conformal spectral library training 有权
公开(公告)号：US11525733B2
公开(公告)日：2022-12-13
申请号：US17379588
申请日：2021-07-19
申请人： CHEMIMAGE CORPORATION
发明人： Patrick J. Treado , Matthew P. Nelson , Shawna Tazik , Robert C. Schweitzer
IPC分类号： G01J3/28 , G01N21/31
摘要： The conformal spectral library training method (CSLTM) of the disclosure allows sets of voltages for an optical filter to be calculated by way of a direct calculation without processing large amounts of spectral information, which significantly increases the speed of processing spectral information.

8. 发明授权

US11120288B2 Extended particle swarm band selection 有权
公开(公告)号：US11120288B2
公开(公告)日：2021-09-14
申请号：US16791634
申请日：2020-02-14
申请人： ChemImage Corporation
发明人： Shashank R. Deshpande , Lucas P. Zbur , Christopher D. Anderson , Patrick J. Treado
IPC分类号： G06K9/00 , B07C5/00 , G06K9/20 , G06T7/20 , G16C20/20
摘要： The disclosure provides methods, systems, and computer program products for detecting compounds of interest that are deposited on or associated with objects of interest. The compounds of interest are not limited and include drugs, alcohol, cannabis, narcotics, controlled substances as defined by state, federal, or international law, ammonium-based explosives, MGE-based explosives, toxic compounds, organic compounds, inorganic compounds, nerve agents, or biological compounds. The disclosure increases the speed and efficiency of processing hyperspectral images, especially on low-power or portable devices.

9. 发明申请

US20210104028A1 FUSION OF MOLECULAR CHEMICAL IMAGING WITH RGB IMAGING 有权
公开(公告)号：US20210104028A1
公开(公告)日：2021-04-08
申请号：US17061686
申请日：2020-10-02
申请人： CHEMIMAGE CORPORATION
发明人： Heather GOMER , Patrick TREADO , Jihang WANG
IPC分类号： G06T5/50 , H04N5/225 , H04N5/265 , G06T5/00 , H04N5/247 , H04N5/232 , G01N33/483
摘要： Methods, systems, and computer program products of fusing Molecular Chemical Imaging (MCI) and Red Green Blue (RGB) images are disclosed herein. A sample is illuminated with illuminating photons which interact with the sample and are used to form MCI and RGB images. The MCI and RGB images are fused by way of mathematical operations to generate a RGB image with a detection overlay.

10. 发明授权

US10779713B2 Molecular chemical imaging endoscopic imaging systems 有权
公开(公告)号：US10779713B2
公开(公告)日：2020-09-22
申请号：US15932435
申请日：2015-12-09
申请人： ChemImage Corporation
发明人： Patrick Treado , Matthew Nelson , Shona Stewart
IPC分类号： A61B1/07 , A61B1/04 , A61B1/06 , A61B1/307 , A61B1/00
摘要： The instant disclosure provides for medical imaging systems that may be used in conjunction with an intraoperative medical device, such as an endoscope. Generally, the disclosed medical imaging systems include an illumination source configured to generate illuminating photons for illuminating a biological sample. An optical signal modulator is configured to separate one or more of the illuminating photons and photons that have interacted with the biological sample into a first optical signal having first multi-passband wavelengths and a second optical signal having second multi-passband wavelengths. At least one detector is configured to detect one or more of the first optical signal and the second optical signal and generate at least one image data set. A processor is configured to analyze the at least one image data set. In some embodiments, the processor is configured to differentiate between structures of the biological sample, such as between an ureter and surrounding tissue.

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