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1. 发明授权

US10078204B2 Non-destructive 3-dimensional chemical imaging of photo-resist material 有权
公开(公告)号：US10078204B2
公开(公告)日：2018-09-18
申请号：US14229909
申请日：2014-03-29
申请人： Intel Corporation
发明人： Nilanjan Z. Ghosh , Kevin T. McCarthy , Zhiyong Wang , Deepak Goyal , Changhua Liu , Leonel R. Arana
IPC分类号： G01J3/28 , G01J3/04 , G01J3/44 , G02B21/00 , G01N21/65 , G01N21/84 , G01N21/95 , G01N21/21
CPC分类号： G02B21/008 , G01J3/44 , G01N21/21 , G01N21/65 , G01N21/8422 , G01N21/9501 , G01N2021/656 , G02B21/0064
摘要： Embodiments include devices, systems and processes for using a combined confocal Raman microscope for inspecting a photo resist film material layer formed on the top surface of a layer of a substrate package, to detect border defects between regions of light exposed (e.g., cured) and unexposed (e.g., uncured) resist film material. Use of the confocal Raman microscope may provide a 3D photo-resist chemical imaging and characterization technique based on combining (1) Raman spectroscopy to identify the borders between regions of light exposed and unexposed resist along XY planes, with (2) Confocal imaging to select a Z-height of the XY planes scanned. Such detection provides fast, high resolution, non-destructive in-line inspection, and improves technical development of polymerization profiles of the resist film material.

2. 发明授权

US10001443B2 Heroin detection by Raman spectroscopy from impure compositions comprising an interfering fluorescent contaminant 有权
公开(公告)号：US10001443B2
公开(公告)日：2018-06-19
申请号：US14996725
申请日：2016-01-15
申请人： Thermo Scientific Portable Analytical Instruments Inc.
发明人： Craig Morris Gardner , Michael Derek Hargreaves , Peidong Wang , Yu Shen
IPC分类号： G01J3/44 , G01N21/65 , G01N21/94 , G01N33/94 , G01N21/84 , G01N21/64
CPC分类号： G01N21/658 , G01J3/44 , G01N21/65 , G01N21/8483 , G01N21/94 , G01N33/9486 , G01N2021/646 , G01N2021/656 , G01N2201/0221 , G01N2201/06113
摘要： A method of identifying the presence of heroin in an impure heroin composition which contains heroin and at least one fluorescent contaminant which interferes with a Raman signal from the heroin. The method may include contacting the mixture with a solvent such as an alcohol, then contacting the resulting alcohol composition with a SERS surface. The surface may then be exposed to laser light from a hand-held Raman spectrometer to detect a Raman signal from the heroin. An apparatus for performing the method is also provided.

3. 发明授权

US10001442B2 Optical fiber-based hybrid SERS platform for in vivo detection of bio-molecules 有权
公开(公告)号：US10001442B2
公开(公告)日：2018-06-19
申请号：US14304290
申请日：2014-06-13
申请人： The Regents of the University of California
发明人： Ya-Hong Xie , Pu Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , G01N2021/656
摘要： An optical probe includes an optical fiber with a first end and a second end, and an enhanced surface on a portion of the first end of the optical fiber. The enhanced surface includes a patterned base layer including multiple protruding nano-pyramids, an intermediate layer over the patterned base layer, and a graphene layer over the intermediate layer. Using a layer of graphene to cover the enhanced surface increases the sensitivity of a surface-enhanced Raman spectroscopy (SERS) process performed in conjunction with the enhanced surface, and further increases the chemical stability and bio-compatibility of the enhanced surface. Further, placing the enhanced surface at the end of the optical fiber provides a self-contained probe for use with a SERS process, thereby allowing for in-vivo characterization of a sample.

4. 发明申请

US20180164217A1 RAMAN TOPOGRAPHY SYSTEM AND METHODS OF IMAGING 审中-公开
公开(公告)号：US20180164217A1
公开(公告)日：2018-06-14
申请号：US15835582
申请日：2017-12-08
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Cristina Zavaleta , Michael J. Mandella , Zhen Qiu
IPC分类号： G01N21/65 , A61B5/00 , A61B5/15 , A61K49/00
CPC分类号： G01N21/65 , A61B1/043 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/1072 , A61B5/150832 , A61B2562/0257 , A61K49/0002 , G01N21/6456 , G01N21/658 , G01N2021/6439 , G01N2021/656
摘要： The present disclosure describes a Raman topography system, which includes a container with at least one Raman probe positioned within. Also described are methods of imaging which include the Raman topography system.

5. 发明申请

US20160363538A1 OPTICAL MICROSCOPY SYSTEM AND METHOD FOR RAMAN SCATTERING WITH ADAPTIVE OPTICS 审中-公开
标题翻译：具有自适应光学的拉曼散射的光学显微系统和方法
公开(公告)号：US20160363538A1
公开(公告)日：2016-12-15
申请号：US15121632
申请日：2015-02-24
申请人： HORIBA JOBIN YVON SAS
发明人： Bertrand DUTERTRE , Denis CATTELAN , Emmanuel FRETEL
IPC分类号： G01N21/65 , G01J3/02 , G02B27/00 , G02B21/00 , G02B21/16 , G01J3/44 , G02B21/02
CPC分类号： G01N21/65 , G01J3/0205 , G01J3/44 , G01N2021/656 , G01N2201/06113 , G01N2201/063 , G01N2201/068 , G02B21/0048 , G02B21/0064 , G02B21/0076 , G02B21/02 , G02B21/16 , G02B27/0025
摘要： An optical apparatus for Raman scattering microscopy, includes a laser source (10) suitable for emitting a laser beam (11) at an excitation wavelength λ, a microscope objective (14) suitable for receiving the laser beam (11) and focusing the laser beam in an image plane of the microscope objective (14), the focused laser beam (21) being intended to illuminate a sample (20), an optical system suitable for collecting a Raman scattering optical beam (22), and detection elements (16, 17) suitable for detecting the Raman scattering beam (22) collected. More particularly, the Raman scattering microscopy apparatus further includes an adaptive optics system (31, 32, 33) positioned on an optical path of the excitation laser beam (11), on an optical path of the Raman scattering beam (22) or on an optical path common to the excitation laser beam (11) and the Raman scattering beam (22).
摘要翻译：一种用于拉曼散射显微镜的光学装置，包括适于发射激发波长λ的激光束（11）的激光源（10），适于接收激光束（11）并将激光束聚焦的显微镜物镜（14）在显微镜物镜（14）的像平面中，聚焦激光束（21）旨在照射样品（20），适于收集拉曼散射光束（22）的光学系统和检测元件（16， 17）适用于检测所收集的拉曼散射光束（22）。更具体地，拉曼散射显微镜装置还包括位于激光激光束（11）的光路上的自适应光学系统（31,32,33），在拉曼散射光束（22）的光路上，或者在激光激光束（11）和拉曼散射光束（22）共用的光路。

6. 发明授权

US09341515B2 Optical absorbance measurement apparatus, method, and applications 有权
标题翻译：光吸收测定装置，方法及应用
公开(公告)号：US09341515B2
公开(公告)日：2016-05-17
申请号：US13370969
申请日：2012-02-10
申请人： Alfons Schulte , Silki Arora
发明人： Alfons Schulte , Silki Arora
IPC分类号： G01J3/42 , G02B21/00 , G01J3/02 , G01J3/427 , G01N21/03 , G01N21/31 , G02B21/26 , G02B21/36 , G01N21/05 , G01N21/65
CPC分类号： G01J3/42 , G01J3/0208 , G01J3/0229 , G01J3/0289 , G01J3/427 , G01N21/03 , G01N21/31 , G01N21/314 , G01N21/3151 , G01N2021/0346 , G01N2021/058 , G01N2021/651 , G01N2021/656 , G01N2201/0627 , G01N2201/0846 , G02B21/0028 , G02B21/0032 , G02B21/26 , G02B21/367
摘要： Apparatus and method to measure optical absorption spectra with spatial resolution on the micron scale. An exemplary setup combines a continuous white light excitation beam in transmission geometry with a confocal microscope. Spatial resolution better than 1.4 μm in the lateral and 3.6 μm in the axial, directions was obtained. The detection and measurement of the absorption spectrum of hemoglobin in a single red blood cell under physiological conditions on the timescale of seconds was realized. The apparatus and method enables the investigation of spatial variations in the optical density of small samples on the micron scale and the study of biological assemblies at the single cell level, leading to applications in optical diagnostics, microfluidics, and other areas.
摘要翻译：用微米尺度测量空间分辨率的光吸收光谱的装置和方法。示例性设置将透射几何中的连续白光激发光束与共聚焦显微镜组合。获得横向分辨率优于1.4μm，轴向方向为3.6μm。实现了在生理条件下单次红细胞血红蛋白吸收光谱在秒的时间刻度上的检测和测量。该装置和方法能够调查微尺度上小样品的光密度的空间变化以及在单细胞水平上对生物组装的研究，导致在光学诊断，微流体等领域的应用。

7. 发明授权

US09074938B2 Substrate for surface enhanced Raman spectroscopy analysis and manufacturing method of the same, biosensor using the same, and microfluidic device using the same 有权
标题翻译：用于表面增强拉曼光谱分析的基板及其制造方法，使用该基板的生物传感器和使用其的微流体装置
公开(公告)号：US09074938B2
公开(公告)日：2015-07-07
申请号：US13929381
申请日：2013-06-27
申请人： Xiaoyan Liu , Kenji Kitamura , Minoru Osada , Takahiro Nagata , Guozhong Cao
发明人： Xiaoyan Liu , Kenji Kitamura , Minoru Osada , Takahiro Nagata , Guozhong Cao
IPC分类号： G01N21/75 , G01J3/44 , G01J3/02 , G01N21/64 , B01L3/00 , G01N21/65 , G01N21/63 , G01N21/77
CPC分类号： G01J3/44 , B01L3/5027 , B01L2200/10 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , G01J3/0291 , G01N21/63 , G01N21/6452 , G01N21/6454 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2021/7763
摘要： A substrate for surface enhanced Raman spectroscopy analysis (SERS) comprises a ferroelectric single crystal having polarization-inverted patterns of spontaneous polarizations including polarization-inverted portions and non-inverted polarization portions, and metallic dots positioned at only either one polarized surfaces of the polarization-inverted portions and the non-inverted polarization portions. The provided SERS substrate produces a high enhancement effect. A microfluidic device incorporating the SERS substrate is also provided.
摘要翻译：用于表面增强拉曼光谱分析（SERS）的衬底包括具有包括偏振反转部分和非反相偏振部分的自发偏振的偏振反转图案的铁电单晶，以及仅位于偏振反射部分和非反相偏振部分的一个极化表面的金属点，倒置部分和非反相偏振部分。所提供的SERS底物产生高增强效果。还提供了结合SERS衬底的微流体装置。

8. 发明申请

US20140368817A1 OPTICAL FIBER-BASED HYBRID SERS PLATFORM FOR IN VIVO DETECTION OF BIO-MOLECULES 有权
标题翻译：用于体外检测生物分子的基于光纤的混合体平台
公开(公告)号：US20140368817A1
公开(公告)日：2014-12-18
申请号：US14304290
申请日：2014-06-13
申请人： The Regents of the University of California
发明人： Ya-Hong Xie , Pu Wang
IPC分类号： G01N21/65 , G01J3/44
CPC分类号： G01N21/658 , G01N2021/656
摘要： An optical probe includes an optical fiber with a first end and a second end, and an enhanced surface on a portion of the first end of the optical fiber. The enhanced surface includes a patterned base layer including multiple protruding nano-pyramids, an intermediate layer over the patterned base layer, and a graphene layer over the intermediate layer. Using a layer of graphene to cover the enhanced surface increases the sensitivity of a surface-enhanced Raman spectroscopy (SERS) process performed in conjunction with the enhanced surface, and further increases the chemical stability and bio-compatibility of the enhanced surface. Further, placing the enhanced surface at the end of the optical fiber provides a self-contained probe for use with a SERS process, thereby allowing for in-vivo characterization of a sample.
摘要翻译：光学探头包括具有第一端和第二端的光纤，以及在光纤的第一端的一部分上的增强表面。增强表面包括图案化基底层，包括多个突出的纳米金字塔，在图案化基底层上方的中间层，以及中间层之上的石墨烯层。使用一层石墨烯覆盖增强的表面增加了与增强表面结合进行的表面增强拉曼光谱（SERS）工艺的灵敏度，并进一步提高了增强表面的化学稳定性和生物相容性。此外，将增强的表面放置在光纤末端提供了与SERS过程一起使用的独立探针，从而允许样品的体内表征。

9. 发明授权

US08750952B2 Apparatus and method for dating a body sample 有权
标题翻译：用于测量身体样品的装置和方法
公开(公告)号：US08750952B2
公开(公告)日：2014-06-10
申请号：US12988725
申请日：2009-04-21
申请人： Maurice Christian Gerard Aalders
发明人： Maurice Christian Gerard Aalders
IPC分类号： A61B5/1455
CPC分类号： G01N21/31 , A61B5/0059 , G01N21/314 , G01N21/35 , G01N21/64 , G01N21/65 , G01N33/487 , G01N33/49 , G01N2021/3148 , G01N2021/3181 , G01N2021/656
摘要： A method and apparatus for dating a body sample, for example a sample of body fluid involves taking a series of spectroscopic measurements of the sample, each measurement in the series including at least two predetermined positions in the spectrum. The positions have spectral characteristics corresponding to two or more predetermined substances present in the sample that have a time varying relationship with each other. The measurements in the series are spaced in time. A concentration of each of the substances present in the sample is then determined from each of the spectroscopic measurements at each point in time. Next, a ratio of the concentrations of the two predetermined substances at each point in time is determined and then the ratios of the concentrations of the two predetermined substances over time are analyzed to estimate when the concentrations of the two substances were at a limit of their concentrations, thereby providing an indication of the age of the sample. The sample may be blood, which may be either within the body (e.g. as a bruise), or external to the body.
摘要翻译：用于测量身体样品（例如体液样品）的方法和装置包括对样品进行一系列光谱测量，该系列中的每个测量包括光谱中的至少两个预定位置。这些位置具有对应于样品中存在的彼此具有时间变化关系的两种或更多种预定物质的光谱特性。系列中的测量时间间隔。然后从每个时间点的每个光谱测量中确定存在于样品中的每种物质的浓度。接下来，确定每个时间点上两种预定物质的浓度比，然后分析两种预定物质随时间的浓度比，以估算两种物质的浓度在它们浓度，从而提供样品的年龄。样品可以是血液，其可以在体内（例如作为瘀伤）或身体外部。

10. 发明授权

US08718106B2 Nonlinear imaging using passive pulse splitters 有权
标题翻译：使用无源脉冲分离器的非线性成像
公开(公告)号：US08718106B2
公开(公告)日：2014-05-06
申请号：US13099475
申请日：2011-05-03
申请人： Na Ji , Eric Betzig
发明人： Na Ji , Eric Betzig
IPC分类号： H01S3/10
CPC分类号： H01S3/0057 , G01N21/6408 , G01N21/6458 , G01N2021/653 , G01N2021/656 , H01S3/025 , H01S3/1625 , H01S3/1636
摘要： An apparatus includes a pulsed laser source that produces a pulsed laser beam at an input repetition rate and an input pulse power; a passive pulse splitter that receives the pulsed laser beam and outputs a signal including a plurality of sub-pulses for each input pulse of the pulsed laser beam, where the sub-pulses have a repetition rate that is greater than the input repetition rate and at least two of the sub-pulses have power less than the input pulse power; a sample accommodating structure configured to accommodate a sample placed in the path of a sample beam that is formed from the beam that exits the pulse splitter; and a detector that receives a signal of interest emitted from a sample accommodated by the sample accommodating structure based on the incident sample beam.
摘要翻译：一种装置包括脉冲激光源，其以输入重复频率和输入脉冲功率产生脉冲激光束; 被动脉冲分离器，其接收脉冲激光束并输出包括用于脉冲激光束的每个输入脉冲的多个子脉冲的信号，其中子脉冲具有大于输入重复频率的重复率，并且在至少两个子脉冲的功率小于输入脉冲功率; 样品容纳结构，其构造成容纳放置在由离开所述脉冲分离器的光束形成的样品光束的路径中的样品; 以及检测器，其基于所述入射样本光束接收从由所述样本容纳结构容纳的样本发射的感兴趣的信号。

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