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1. 外观设计

USD939706S1 Brachytherapy applicator 有权
公开(公告)号：USD939706S1
公开(公告)日：2021-12-28
申请号：US29725824
申请日：2020-02-27
申请人： NUCLETRON OPERATIONS B.V.
设计人： Jan Willem Van Manen

2. 发明申请

US20180008163A1 METHOD AND APPARATUS FOR DETERMINING THE POSITION OF A SURGICAL TOOL RELATIVE TO A TARGET VOLUME INSIDE AN ANIMAL BODY 审中-公开
公开(公告)号：US20180008163A1
公开(公告)日：2018-01-11
申请号：US15646033
申请日：2017-07-10
申请人： Nucletron Operations B.V.
发明人： Wilco VAN DER LUGT , Jeroen SCHUURMAN , Johan HENNING , Stefan KWA , Johann KINDLEIN
IPC分类号： A61B5/055 , G06T11/00 , A61N5/10 , A61B17/00 , A61B18/00 , A61B8/00 , A61B8/12 , A61B6/06 , A61B8/08
CPC分类号： A61B5/055 , A61B6/06 , A61B8/12 , A61B8/4461 , A61B8/483 , A61B90/36 , A61B2017/00274 , A61B2018/00547 , A61N5/1027 , A61N5/1049 , A61N2005/1011 , G06T11/008 , G06T2211/428
摘要： The invention relates to a method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan comprising the steps of i) obtaining a plurality of two-dimensional images of said target volume using imaging means, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using transformation means, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using displaying means.

3. 发明授权

US09795804B2 Afterloading device, and use thereof 有权
公开(公告)号：US09795804B2
公开(公告)日：2017-10-24
申请号：US14283470
申请日：2014-05-21
申请人： Nucletron Operations B.V.
发明人： Adriaan Van Appeldoorn , Jeroen Schuurman , Martin Van Beek , Finn Sollen , Johan Henning , Arie Luite Visscher
IPC分类号： A61N5/10 , G01T1/02
CPC分类号： A61N5/1007 , A61N5/1048 , A61N5/1049 , A61N5/1064 , A61N5/1071 , A61N5/1075 , A61N2005/1008 , A61N2005/1024 , G01T1/02
摘要： An afterloading device for effectuating a brachytherapy treatment, comprising a first elongated flexible transport element, arranged to maneuver a radiation source between a storage position inside the afterloading device and a treatment position outside the afterloading device, the afterloading device further comprising a second elongated flexible transport element, having at least one transducer, the second transport element being arranged to move the at least one transducer between a first transducer position and a second transducer position.

4. 发明授权

US09381377B2 Real time radiation treatment planning system 有权
标题翻译：实时辐射治疗计划系统
公开(公告)号：US09381377B2
公开(公告)日：2016-07-05
申请号：US14260009
申请日：2014-04-23
申请人： Nucletron Operations B.V.
发明人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
IPC分类号： A61B5/05 , A61N5/10
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.
摘要翻译：本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间在职位。为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

5. 发明授权

US08995616B2 Mobile X-ray unit 有权
标题翻译：移动X射线单元
公开(公告)号：US08995616B2
公开(公告)日：2015-03-31
申请号：US13335712
申请日：2011-12-22
申请人： Johannes Simon van der Veen , Bas Woudstra , Johan Henning
发明人： Johannes Simon van der Veen , Bas Woudstra , Johan Henning
IPC分类号： A61N5/10 , H05G1/28 , A61N5/00 , H01J35/00
CPC分类号： A61N5/1071 , A61B6/08 , A61N5/1048 , A61N5/1049 , A61N5/1075 , A61N5/1083 , A61N2005/005 , A61N2005/105 , A61N2005/1056 , A61N2005/1091 , H01J35/00 , H01J35/02 , H01J35/16 , H01J35/32 , H05G1/04
摘要： One embodiment of the present disclosure is directed to a mobile X-ray unit. The mobile X-ray unit may include a base for accommodating a control unit for controlling an X-ray applicator and a power supply for supplying power to the X-ray applicator. The mobile X-ray unit may further include an articulated arm associated with the base and coupled to the X-ray applicator. The X-ray applicator may have an X-ray tube configured to emit an X-ray beam through an exit window to irradiate an object. The mobile X-ray unit may further include a dosimetry system adapted for real time dosimetry.
摘要翻译：本公开的一个实施例涉及移动X射线单元。移动X射线单元可以包括用于容纳用于控制X射线施加器的控制单元的基座和用于向X射线施加器供电的电源。移动X射线单元还可以包括与基座相关联并且联接到X射线施加器的铰接臂。 X射线施加器可以具有被配置为通过出射窗口发射X射线束以照射物体的X射线管。移动X射线单元还可以包括适于实时剂量测定的剂量测定系统。

6. 发明申请

US20140121444A1 MODULAR APPLICATOR FOR BRACHYTHERAPY 有权
标题翻译：用于BRACHYTHERAPY的模块化应用程序
公开(公告)号：US20140121444A1
公开(公告)日：2014-05-01
申请号：US14063527
申请日：2013-10-25
申请人： Nucletron Operations B.V.
发明人： Wilhelmus Petrus Martinus Maria van Erp , Tommy Robert Oscar Martens , Gaetan Stephan Marie van Wijck , Cor van de Wardt
IPC分类号： A61N5/10
CPC分类号： A61N5/1016 , A61M2025/028 , A61N5/1007 , A61N5/1014 , A61N5/1015 , A61N5/1027 , A61N2005/1008 , A61N2005/1009 , A61N2005/1018
摘要： A modular applicator for enabling a brachytherapy treatment comprising a central element and one or more of peripheral elements, wherein the central element is adapted with a fixation mechanism having a core for affixing the said peripheral elements thereto, wherein the fixation mechanism prevents a rotational displacement of the peripheral elements attached to the core of the fixation element with respect to the central element.
摘要翻译：一种用于实现包括中心元件和一个或多个周边元件的近距离放射线治疗的模块化施加器，其中所述中心元件适于具有用于将所述周边元件固定到其上的芯的固定机构，其中所述固定机构防止周边元件相对于中心元件附接到固定元件的芯部。

7. 发明申请

US20130204070A1 Brachytherapy applicator device for insertion in a body cavity 有权
公开(公告)号：US20130204070A1
公开(公告)日：2013-08-08
申请号：US13807552
申请日：2011-06-30
申请人： René Gerard Willem Mäkel , Pieter Morssink , Hendrik Steller , Arie Luite Visscher , Cor van de Wardt , Franciscus Antonius Maria Kuipers
发明人： René Gerard Willem Mäkel , Pieter Morssink , Hendrik Steller , Arie Luite Visscher , Cor van de Wardt , Franciscus Antonius Maria Kuipers
IPC分类号： A61N5/10
CPC分类号： A61N5/1014 , A61N5/1016 , A61N2005/1094
摘要： The invention relates to a brachytherapy applicator device for insertion in a body cavity. The applicator device comprises an applicator shaped for insertion in the body cavity; the applicator comprising connectable segments; at least one connectable part having a form following wall surface shaped to follow the body cavity, the wall surface having a multichannel groove structure, so as to guide a plurality of catheters along the grooves in the groove structure along the wall surface.

8. 发明授权

US10758745B2 Methods and systems for brachytherapy planning based on imaging data 有权
公开(公告)号：US10758745B2
公开(公告)日：2020-09-01
申请号：US15312978
申请日：2015-05-28
申请人： NUCLETRON OPERATIONS B.V.
发明人： Cor Van de Wardt , Paulus Cornelis Hendrikus Maria Krechting , Jan Frans Lodewijk De Becker , Nicole Nesvacil , Christian Kirisits , Richard Pötter , Maximilian Paul Schmid
IPC分类号： A61N5/10 , A61B6/00 , A61B8/12 , A61B8/00 , A61B6/12 , A61B8/08 , A61B34/20 , A61B90/00 , A61B18/00 , A61B17/00
摘要： Systems and methods for generating a radiation therapy treatment plan by using ultrasound images are disclosed. The method includes obtaining a first set of image data representing a first image of an anatomical region that includes a treatment applicator inserted into the anatomical region. The method further includes receiving tracking information indicating a position of the treatment applicator as represented in the first set of image data, obtaining a second set of image data representing a second image of the anatomical region, and combining at least a portion of the first set of image data with the second set of image data. One of the first set and the second set of image data is used to identify a target tissue portion in the anatomical region. The method further includes generating, based on the combined image data, treatment plan information for treating the target tissue portion in the anatomical region.

9. 发明授权

US10596390B2 Advanced applicator systems and methods 有权
公开(公告)号：US10596390B2
公开(公告)日：2020-03-24
申请号：US15532050
申请日：2015-12-04
申请人： NUCLETRON OPERATIONS B.V.
发明人： Hendrik Steller , Wilhelmus Van Erp , Jan Willem Van Manen , Norbert Johan Lukas Geheniau
IPC分类号： A61N5/10 , A61B1/303 , A61B17/02
摘要： Systems, methods, and apparatuses are provided for an advanced gynecological applicator. In accordance with some embodiments, a brachytherapy applicator head and assembly is provided. The assembly may include two ovoid tubes configured to receive radiation sources, the two ovoid tubes combining to form a rounded applicator having a middle opening and comprising a plurality of needle holes to guide interstitial needles. The assembly may also include a central applicator tube configured to receive a radiation source that is located within the middle opening. Additionally, the assembly may include a vaginal cap that includes a tool-free connection to the two ovoid tubes and includes needle guides that align with the needle holes of the two ovoid tubes. The assembly may include a one-piece template for securing interstitial needles. The assembly may further include a tool-free connector to secure the two ovoid tubes to the central applicator tube.

10. 发明授权

US09370670B2 Gamma source tracking system 有权
标题翻译：伽马源跟踪系统
公开(公告)号：US09370670B2
公开(公告)日：2016-06-21
申请号：US14158568
申请日：2012-07-19
申请人： Johan Henning , Bas Woudstra , Jeroen Schuurman
发明人： Johan Henning , Bas Woudstra , Jeroen Schuurman
IPC分类号： G01T1/16 , A61N5/10 , G01T1/164
CPC分类号： A61N5/1001 , A61N5/1027 , A61N5/1048 , A61N2005/1052 , G01T1/1644
摘要： An embodiment of the present disclosure is directed to a radioactive source tracking system adapted to determine in real time a spatial position of a gamma source in a volume, including a set of spatially distributed position sensitive detectors operable in real time arranged about the volume. The system includes a real time computer system adapted to calculate the spatial position per time stamp of the gamma source in the volume based on respective signals generated by the position sensitive detectors. In addition, the radioactive source is represented by a 3D or 4D data stream in real time. Other embodiments of the present disclosure are directed to a method for tracking a radioactive gamma source and a computer program product for causing a processor to determine a real time 3D or a 4D spatial position of a gamma source.
摘要翻译：本公开的实施例涉及一种放射源跟踪系统，其适于实时地确定体积中的伽马源的空间位置，包括一组空间分布的位置敏感检测器，其可实时地布置在体积周围。该系统包括实时计算机系统，其适于基于由位置敏感检测器产生的相应信号计算体积中伽马源的每个时间戳的空间位置。此外，放射源由3D或4D数据流实时表示。本公开的其他实施例涉及用于跟踪放射性伽马源的方法和用于使处理器确定伽马源的实时3D或4D空间位置的计算机程序产品的方法。

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