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1. 发明申请

US20170199166A1 METHODS FOR DETERMINING RELATIVE RESPONSE FACTORS FOR IMPURITY ANALYSIS USING LIQUID CHROMATOGRAPHY WITH ABSORBANCE AND EVAPORATIVE LIGHT SCATTERING DETECTION 有权
公开(公告)号：US20170199166A1
公开(公告)日：2017-07-13
申请号：US15404851
申请日：2017-01-12
申请人： Waters Technologies Corporation
发明人： Paula Hong , Michael D. Jones
IPC分类号： G01N30/06 , G01N30/74 , G01N33/15
摘要： Methods and systems for determining relative response factors for liquid chromatography using both molar concentration-based detection and mass concentration-based detection are described herein. A method includes determining a relative response factor for a compound based on the ratio of a molar-based peak area for the compound to the logarithm of the mass-based peak area for the compound and based on the ratio of a molar-based peak area for a reference compound divided by the logarithm of the mass-based peak area for the reference compound.

2. 发明申请

US20200309743A1 DUAL MODE SAMPLE MANAGER 审中-公开
公开(公告)号：US20200309743A1
公开(公告)日：2020-10-01
申请号：US16826667
申请日：2020-03-23
申请人： Waters Technologies Corporation
发明人： Sylvain Gilles Cormier , Joseph D. Michienzi
IPC分类号： G01N30/20 , G01N30/38 , G01N30/32
摘要： Described is a dual mode sample manager for a liquid chromatography system. The dual mode sample manager includes a sample needle, a sample loop, a metering pump, a needle seat and first and second valves. Each valve is configurable in two valve states to enable two modes of operation. In one mode, sample acquired and stored in the sample needle is injected into a chromatography system flow and, in the other mode, sample acquired through the sample needle and stored in the sample loop is injected into the chromatography system flow. The automated switching of the sample manager between the two modes of operation avoids the need for maintaining two separate liquid chromatography systems or manual reconfiguration of a chromatography system for users desiring the capability of both modes of operation.

3. 发明申请

US20160136544A1 METHODOLOGY FOR SCALING METHODS BETWEEN SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEMS 审中-公开
标题翻译：超临界流体色谱系统之间缩放方法的方法
公开(公告)号：US20160136544A1
公开(公告)日：2016-05-19
申请号：US14898014
申请日：2014-06-12
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： Christopher Hudalla
IPC分类号： B01D15/40 , G01N30/32 , B01D15/16
CPC分类号： B01D15/40 , B01D15/16 , B01D15/163 , B01J3/02 , G01N30/32 , G01N30/8658 , G01N2030/326
摘要： A methodology scales supercritical fluid chromatography (SFC) and/or carbon dioxide based chromatography methods between different system and/or column configurations. The methodology includes measuring an average mobile phase density during a first separation utilizing CO2 as a mo bile phase component and substantially duplicating the average density profile for a second separation. Substantial duplication of the average mobile phase density (e.g., within about 10%, 5%, 2.5%, 1%, 0.5%, 0.1 %, 0.05%) results in chromatography for both system and/or column configurations having similar selectivity and retention factors. Average mobile phase density may be, either measured directly, calculated, or approximated using average pressure or density measurements. The average pressure profile may be used as a close approximation to duplicate average density profiles between separations.
摘要翻译： A方法在不同系统和/或柱构型之间进行超临界流体色谱（SFC）和/或基于二氧化碳的色谱法的比较。该方法包括在利用CO 2作为微量相分量的第一分离期间测量平均流动相密度，并基本上复制用于第二分离的平均密度分布。平均流动相密度的显着重复（例如，在约10％，5％，2.5％，1％，0.5％，0.1％，0.05％之内）导致具有相似选择性和保留性的系统和/或柱构型的色谱法因素可以使用平均压力或密度测量直接测量，计算或近似平均流动相密度。平均压力分布可以用于近似分离之间的重复平均密度分布。

4. 发明申请

US20230136953A1 CHEMICAL DENATURATION FOR OLIGONUCLEOTIDE ANALYSIS 有权
公开(公告)号：US20230136953A1
公开(公告)日：2023-05-04
申请号：US17976030
申请日：2022-10-28
申请人： Waters Technologies Corporation
发明人： Matthew A. Lauber , Jennifer M. Nguyen , Xiaoxiao Liu , Michael Donegan
IPC分类号： G01N33/53 , G01N33/92 , C12Q1/6806
摘要： The present disclosure provides compositions and methods for sample processing, particularly for oligonucleotide analysis e.g. analysis of formulated nucleic acid drugs. A composition for pretreating at least one target nucleic acid in a biological mixture provided herein includes a chaotropic agent selected from a substituted guanidine, a substituted amidine, a substituted quaternary amine, or a combination thereof, an optional protease, and/or an optional disulfide-reducing agent. Methods of analyzing at least one target nucleic acid in a biological mixture is also provided herein. Furthermore, the present disclosure provides methods for quantifying at least one target cationic lipid interacting with a nucleic acid.

5. 发明申请

US20230126856A1 REAGENTS FOR RAPID CHIRAL LABELING AND ANALYSIS OF AMINE CONTAINING ENANTIOMERS 有权
公开(公告)号：US20230126856A1
公开(公告)日：2023-04-27
申请号：US17970962
申请日：2022-10-21
申请人： Waters Technologies Corporation
发明人： Matthew A. Lauber , Darryl W. Brousmiche , Jun Yang , Weiqiang Gu , Mingcheng Xu , Peng Chen
IPC分类号： G01N33/68 , C07D207/46
摘要： Provided herein chiral derivatization reagents for use in separating and detecting of amine containing enantiomers. The said chiral derivatization reagents provide a combination of improved detectable properties to facilitate various downstream analyses. In particular, the chiral derivatization reagents include at least one chiral carbon atom; at least one strongly basic moiety; at least one chromophore moiety or at least one fluorophore moiety; and at least one reactive group. The present disclosure further provides methods for analyzing amine-containing enantiomeric isomers using a chromatographic separation device and a mass spectroscopy.

6. 发明申请

US20230111049A1 SAMPLE PREPARATION FOR LC-MS BASED SEQUENCE MAPPING OF NUCLEIC ACIDS 有权
公开(公告)号：US20230111049A1
公开(公告)日：2023-04-13
申请号：US17961061
申请日：2022-10-06
申请人： Waters Technologies Corporation
发明人： Matthew A. Lauber , Xiaoxiao Liu
IPC分类号： C12Q1/6872
摘要： Methods for quenching a nuclease digestion of a target nucleic acid prior to downstream analysis of the target nucleic acid are disclosed herein. Particularly, methods for controlling the end point of a nuclease digestion prior to sequence analysis of a target nucleic acid is provided. Quenching of a nuclease digestion in the present disclosure employs at least one non-ionic or anionic denaturant combined with an optional reducing agent. The methods presented in this disclosure aids preserving the sample comprising the target nucleic acid or fragments thereof for long term storage and ensures that the effect of contaminating nucleases is eliminated during pretreatment step.

7. 发明申请

US20220404299A1 HIGH SAMPLE THROUGHPUT DIFFERENTIAL SCANNING CALORIMETER 有权
公开(公告)号：US20220404299A1
公开(公告)日：2022-12-22
申请号：US17893786
申请日：2022-08-23
申请人： Waters Technologies Corporation
发明人： Donald J. Russell , David Serrell , Anthony E. Arnerich
IPC分类号： G01N25/02 , G01K7/00 , G01K17/00
摘要： Described is a differential scanning calorimeter (DSC) instrument capable of performing analyses of multiple samples at the same time. Some embodiments of DSC instruments described herein include a thermal substrate that provides a substantially uniform temperature across a surface of the substrate. A plurality of DSC units is in thermal communication with the substrate, for example, by mounting the units directly to the surface of the substrate. Each DSC unit includes a second thermal substrate for further thermal isolation, and a reference platform and sample platform to receive a reference cell and a sample cell, respectively. A thermoelectric device is disposed between each platform and the second thermal substrate. Optionally, the reference and sample cells may be disposable chips that can be discarded after measurement are performed, thereby reducing or eliminating the need to clean instrument components to prevent cross-contamination for subsequent instrument operation.

8. 发明授权

US11530966B2 Methods to increase sensitivity of LC/MS analysis 有权
公开(公告)号：US11530966B2
公开(公告)日：2022-12-20
申请号：US17150793
申请日：2021-01-15
申请人： Waters Technologies Corporation
发明人： Paul Rainville , Kerri Smith
IPC分类号： G01N30/72 , G01N1/40 , G01N30/86 , G01N30/02
摘要： The present disclosure discusses a method of separating a sample (e.g., pharmaceutical drug, genotoxic impurity, biomarker, and/or biological metabolite) including coating a metallic flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample using mass spectroscopy. In some examples, the coating applied to the surfaces defining the flow path is non-binding with respect to the sample—and the separated sample. Consequently, the sample does not bind to the low-binding surface of the coating of the flow path. The applied coating can increase the chromatographic peak area for the sample of the chromatographic system.

9. 发明申请

US20220389480A1 SEPARATION OF NUCLEIC ACID COMPONENT COMPOUNDS ON ZWITTERIONIC STATIONARY PHASES 有权
公开(公告)号：US20220389480A1
公开(公告)日：2022-12-08
申请号：US17831641
申请日：2022-06-03
申请人： Waters Technologies Corporation
发明人： Kenneth Berthelette
IPC分类号： C12Q1/68 , C12Q1/6806 , G01N30/72
摘要： The present disclosure pertains to methods of separating nucleic acid component compounds from one another. In some embodiments, the methods comprise: (a) loading a sample fluid comprising a plurality of nucleic acid component compounds onto a chromatographic column comprising a zwitterionic stationary phase contained inside the column; (b) flowing a mobile phase through the chromatographic column over a time period thereby forming an eluent in which at least some of the plurality of the nucleic acid component compounds are separated from each other, the mobile phase comprising a polar aprotic solvent, a protic solvent, and a volatile buffer salt, wherein flowing the mobile phase comprises varying a ratio of the protic solvent to the polar aprotic solvent over at least a portion of the time period and varying an ionic strength of the volatile buffer salt over at least a portion of the time period.

10. 发明授权

US11506641B2 Rotary valve having bypass state 有权
公开(公告)号：US11506641B2
公开(公告)日：2022-11-22
申请号：US17583559
申请日：2022-01-25
申请人： Waters Technologies Corporation
发明人： Sylvain Gilles Cormier , Charles T. Murphy , Joseph D. Michienzi
IPC分类号： G01N30/20
摘要： A rotary valve that includes a stator, a rotor and a plurality of sample channels. The stator includes a stator surface having an inlet port, an outlet port and a plurality of selectable ports. The rotor includes a rotor surface having a first rotor channel and a second rotor channel. The rotor is configurable in a plurality of rotor positions, each of which couples the inlet port to one of the selectable ports through the first rotor channel and couples the outlet port to another one of the selectable ports through the second rotor channel. The two selectable ports are coupled to each other through one of the sample channels. The rotor has a bypass state defined by a rotor position, or angular range of rotor positions, at which the inlet port is coupled to the outlet port through the second rotor channel.

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