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1. 发明授权

US11129676B2 Device and method for vessel treatment 有权
公开(公告)号：US11129676B2
公开(公告)日：2021-09-28
申请号：US13574476
申请日：2011-01-20
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/22 , A61B18/00 , A61B18/20 , A61B18/18
摘要： An endoluminal lasing system for treating vascular disorders is disclosed. Treatment comprises an elongated member that conveys laser radiation to tissue and a motorized mechanism, through which elongated member is rotated. As motor drives, its movement spins elongated member leading to a spiral movement as physician manually moves member in a longitudinal direction. In a preferred embodiment, elongated member is an optical fiber for endoluminal vessel treatment. In another preferred embodiment optical fiber comprises an off-axis firing distal end or side-firing distal end. Optical fiber can be a radial emitting fiber. Spin velocity can be varied according to treatment needs, i.e., pathology, type of vessel, energy source, vessel diameter, etc. One advantage, spiral movement prevents adherence to vessel wall in treatments. Another advantage is that radiation is applied more uniformly along vessel wall. The vessel wall is, thus more evenly treated under most conditions. Treatment velocity and reproducibility are enhanced with this procedure, and human errors are minimized.

2. 发明授权

US10716624B2 Minimally invasive contraception method and device 有权
公开(公告)号：US10716624B2
公开(公告)日：2020-07-21
申请号：US13101873
申请日：2011-05-05
申请人： Martin Sabado , Wolfgang Neuberger
发明人： Martin Sabado , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61B18/20 , A61B18/22 , A61B18/24 , A61B18/00 , A61B90/00
摘要： Minimally invasive methods and devices for endoluminally treating female fallopian tubes or male vas deferens of mammals are presented as a permanent method of contraception. In preferred embodiments, medical devices for male and female sterilization comprise laser radiation source operating at one or more preselected wavelengths between about 980 nm and about 1950 nm, preferably at least one of 980 nm, 1470 nm and 1950 nm; treatment waveguide with a radial or cylindrical radiation emitting tip; viewing scope; and a temperature sensor. In another preferred embodiment, a minimally-invasive permanent contraception method for males and females comprises the steps of introducing at least one treatment waveguide in a body cavity; positioning the treatment waveguide inside a body cavity; irradiating; and repeating the procedure in companion body cavity to inhibit fertilization. In another embodiment, fluids are infused and/or extracted after, before or during the procedure to enhance laser energy absorption and enhance efficiency of laser treatment.

3. 发明授权

US10456375B2 Specifically meso-substituted porphyrins and chlorins for photodynamic therapy 有权
公开(公告)号：US10456375B2
公开(公告)日：2019-10-29
申请号：US15515950
申请日：2015-09-30
申请人： biolitec Untemehmensbeteiligungs II AG , FREIE UNIVERSITÄT BERLIN
发明人： Hartwig Richard Arthur Golf , Arno Wiehe , Susanna Graefe , Volker Albrecht , Hans-Ulrich Reißig
IPC分类号： C07D403/14 , A61K31/4025 , A61K31/409 , C07D487/22 , C07F5/02 , A61K31/03
摘要： Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, opthamological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. One embodiment consists of a method to synthesize a porphyrin with a defined arrangement of meso-substituents and then converting this porphyrin system to a chlorin system by dihydroxylation or reduction, and if more than one isomer is formed separate them by chromatography either on normal or reversed phase silica. In another embodiment the substituents on the porphyrin are selected to direct the reduction or dihydroxylation to the chlorin so that a certain isomer is selectively formed. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT-efficacy. In other embodiments the nucleophilic substitution on pentafluorophenyl-substituted tetrapyrroles is used to obtain compounds with a high PDT-efficacy. In another embodiment substituents are identified that via their steric and/or electronic influence direct the dihydroxylation or reduction with diimine so that one isomer is favored. Another embodiment consists of formulating the desired tetrapyrrole photosensitizer into a pharmaceutical formulation to be injected into the body avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.

4. 发明授权

US09034023B2 Dynamic colorectal PDT application 有权
标题翻译：动态结直肠PDT应用
公开(公告)号：US09034023B2
公开(公告)日：2015-05-19
申请号：US13357319
申请日：2012-01-24
申请人： Bastiaan Kruijt , Eric M van der Snoek , Henricus J. C. M. Sterenborg , Arjen Amelink , Dominic J. Robinson , Wolfgang Neuberger
发明人： Bastiaan Kruijt , Eric M van der Snoek , Henricus J. C. M. Sterenborg , Arjen Amelink , Dominic J. Robinson , Wolfgang Neuberger
IPC分类号： A61N5/06 , A61K31/409 , A61P35/00 , A61B5/02 , A61M5/00 , A61B6/00 , A61B5/1455 , A61B5/00
CPC分类号： A61N5/062 , A61B5/0071 , A61B5/0084 , A61B5/4255 , A61K31/409 , A61N2005/0608 , A61N2005/0628 , A61N2005/063 , A61N2005/0662
摘要： Dynamic colorectal PDT methods, devices and photosensitizer compositions to treat abnormal cell growth in anal tissue such as perianal and intra-anal intraepithelial neoplasia grade III are presented. Dynamic colorectal PDT method comprises the steps of administering topically, intravenously or orally a photosensitizer composition; irradiating; monitoring treatment parameters before, during and/or after irradiation. Photosensitizer composition comprises Temoporfin and excipients/carriers, appropriate for the application method. An applicator is provided for colorectal PDT treatments enhancing irradiation delivery and monitoring treatment parameters. Preferably, applicator is made of a material, used to monitor the fluence rate simultaneously while doing optical spectroscopy. Measurement probe devices are provided for monitoring PDT treatment parameters in-vivo. A device for colorectal PDT treatment is also provided, comprising laser radiation source operating at about 400 and 800 nm; excitation laser radiation source operating at about 650 nm for fluorescence measurements; multichannel dosimetry device; long pass filter; waveguides and measurement probes.
摘要翻译：动态结直肠PDT方法，装置和光敏剂组合物用于治疗肛门组织中异常细胞生长，如肛周和肛门内上皮内瘤变III级。动态结肠直肠PDT方法包括以下步骤：局部给药，静脉内或口服光敏剂组合物; 照射; 在照射之前，期间和/或之后监测治疗参数。光敏剂组合物包含适于施用方法的Temoporfin和赋形剂/载体。提供用于结肠直肠PDT治疗的施用器，其增强辐射递送和监测治疗参数。优选地，施加器由材料制成，用于在进行光学光谱时同时监测注量率。提供测量探针装置用于在体内监测PDT治疗参数。还提供了用于结肠直肠PDT治疗的装置，其包括在约400和800nm下操作的激光辐射源; 用于荧光测量的约650nm的激发激光辐射源; 多通道剂量测定装置; 长通滤波器波导和测量探针。

5. 发明授权

US08906079B2 Method/device for transdermal vascular treatment 有权
标题翻译：用于透皮血管治疗的方法/装置
公开(公告)号：US08906079B2
公开(公告)日：2014-12-09
申请号：US12992533
申请日：2009-05-15
申请人： Jorge O. López D'Ambola , Jorge E. Soracco , Wolfgang Neuberger
发明人： Jorge O. López D'Ambola , Jorge E. Soracco , Wolfgang Neuberger
IPC分类号： A61N5/06 , A61B18/20 , A61B18/22 , A61B18/00 , A61N5/00 , A61B17/00
CPC分类号： A61B18/203 , A61B18/20 , A61B18/22 , A61B2017/00765 , A61B2018/00452 , A61B2018/00458 , A61B2018/202 , A61B2018/2065 , A61N5/062 , A61N2005/007 , A61N2005/0651 , A61N2005/0659
摘要： Devices and transdermal methods are provided for safe and effective therapeutic treatment of the venous system, such as varicose veins. Present invention provides non-invasive and minimally invasive transdermal methods for treating varicose and spider veins, comprising the use of a radiation source in combination with a chemical fluid/composition to safely and more effectively close or shrink vein walls, providing a transdermal therapeutic method for varicose veins until now only treated with surgery or endovascular laser treatments. In a preferred embodiment a device comprises a radiation source, preferably of wavelength between about 980 and 1940 nm, being effective in causing shrinkage of the vein treated. In other preferred embodiments methods comprise the transdermal delivery of a chemical composition through a patch or gel or the injection of a chemical fluid, preferably a hypertonic solution, to the vein under treatment; and simultaneously or after a dwell time, irradiating with a radiation source transdermally. The treatment performed with the present invention results in blood vessel wall damaged, eventually closing the vein, in lesser time with practically no pain or discomfort to the patient during and after the therapy.
摘要翻译：提供装置和透皮方法用于对静脉系统进行安全和有效的治疗，例如静脉曲张。本发明提供用于治疗静脉曲张和蜘蛛静脉的非侵入性和微创透皮方法，其包括使用辐射源与化学液体/组合物组合以安全且更有效地闭合或收缩静脉壁，提供透皮治疗方法静脉曲张直到目前为止只用手术或血管内激光治疗。在优选实施例中，装置包括辐射源，优选波长在约980和1940nm之间，有效地引起所治疗静脉的收缩。在其它优选实施方案中，方法包括通过贴剂或凝胶将化学组合物透皮递送或将化学流体（优选高渗溶液）注射至处理的静脉; 并且在停留时间之后或之后，经皮肤照射辐射源。用本发明进行的治疗导致血管壁受损，最终在较短的时间内关闭静脉，实际上在治疗期间和之后患者没有疼痛或不适。

6. 发明授权

US08257411B2 Method for treatment of varices 失效
标题翻译：治疗静脉曲张的方法
公开(公告)号：US08257411B2
公开(公告)日：2012-09-04
申请号：US11637377
申请日：2006-12-12
申请人： Franco Maglione , Tiziano Caldera , Fabio Coluccia
发明人： Franco Maglione , Tiziano Caldera , Fabio Coluccia
IPC分类号： A61B18/18
CPC分类号： A61B18/24
摘要： A minimally invasive method for treating varices including pelvic varices in females, varicoceles, and also oesophageal varices is disclosed. The method comprises the steps of inserting a catheter device into the blood vessels of a patient and advancing the distal end of the catheter to reach the varix or varices. The insertion may be made in the femoral vein or in other vessels as appropriate. Preferably, x-ray, angiography, or other imaging techniques are used to visualize and position the catheter. An optical fiber or optical fiber bundle is then inserted into the catheter and the distal end is advanced to a predetermined point near the varix or varices. Laser energy of preferably 980 nm is then transmitted to the varix to close the blood vessel. Imaging techniques such as angiographies may again be performed to confirm closure of the vein. The method is an out-patient procedure that requires no incision or general anesthesia, requires no recovery time, and does not require that any foreign objects be left in the body. This method has been shown to have a higher success rate than previous embolization and surgical procedures.
摘要翻译：公开了一种用于治疗静脉曲张的微创方法，包括女性，精索静脉曲张以及食管静脉曲张中的盆腔静脉曲张。该方法包括以下步骤：将导管装置插入患者的血管并使导管的远端前进到达静脉曲张或静脉曲张。插入可以在股静脉或适当的其他血管中进行。优选地，使用x射线，血管造影术或其它成像技术来可视化和定位导管。然后将光纤或光纤束插入导管中，并且远端前进到靠近静脉曲张或静脉曲张的预定点。然后将优选980nm的激光能量传递到静脉曲张以关闭血管。可以再次进行诸如血管造影术的成像技术以确认静脉闭合。该方法是不需要切口或全身麻醉的门诊手术，不需要恢复时间，并且不要求任何异物留在体内。该方法已被证明具有比以前的栓塞和外科手术更高的成功率。

7. 发明授权

US08257347B2 Vein treatment device and method 失效
标题翻译：静脉治疗装置及方法
公开(公告)号：US08257347B2
公开(公告)日：2012-09-04
申请号：US11900248
申请日：2007-09-11
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/22
CPC分类号： A61B18/22 , A61B2018/00404 , A61B2018/00452 , A61B2018/00458 , A61B2018/00702 , A61B2018/00761 , A61B2018/207 , A61B2018/2261
摘要： Device/system and treatment method of varicose veins and other vein abnormalities are presented. Treatment A comprises combining two wavelengths to occlude abnormal veins. Wavelengths are chosen as effective absorption peaks of hemoglobin and/or water, e.g. 980 nm and 1460 nm. Irradiations of blood, collagen and water in the vessel cause occlusion/shrinkage. Constant power-density is used based on fiber withdrawal speed and structural vein parameters. Treatments employ dual laser wavelengths or highly-controlled vein-wall damage wavelengths. Monitored control parameters and predetermined vein structural parameters. Alternatively, 1460+60 nm laser energy is employed, having high absorption in the vein wall, creating little thermal stress outside the vein, and being effective in initiating damage reaction response. Treating at 1460+60 nm has benefits of high vein closure rates and favorable post-operative results, i.e., little post-operative pain/discomfort, brusing/inflammatory reactions, due to their very high absorption in small volumes of the collagen/water in vein walls.
摘要翻译：提出静脉曲张静脉异常的装置/系统及治疗方法。治疗A包括组合两个波长以阻塞异常静脉。选择波长作为血红蛋白和/或水的有效吸收峰，例如， 980nm和1460nm。血管，胶原蛋白和水在血管中的辐射引起闭塞/收缩。基于纤维抽出速度和结构静脉参数使用恒定功率密度。治疗采用双激光波长或高度控制的静脉壁损伤波长。监测控制参数和预定静脉结构参数。或者，使用1460 + 60nm激光能量，在静脉壁中具有高吸收，在静脉外部产生很少的热应激，并且有效起始损伤反应响应。在1460±60nm处治疗具有高静脉闭塞率和良好的术后结果的好处，即手术后疼痛/不适，引起/炎症反应，由于它们在小体积胶原/水中的吸收非常高静脉壁。

8. 发明授权

US07976571B2 Photodynamic therapy irradiation system for the treatment of superficial hyperproliferative tissue growth 失效
标题翻译：光动力疗法照射系统治疗浅表过度增生组织生长
公开(公告)号：US07976571B2
公开(公告)日：2011-07-12
申请号：US11195106
申请日：2005-08-02
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61N5/067
CPC分类号： A61N5/0601 , A61B2018/208 , A61N5/062 , A61N2005/0645 , A61N2005/067
摘要： A device and method is described for photodynamic therapy (PDT) to treat hyperproliferative tissue growth in an underskin area within a few centimeters of the skin surface that is not accessible by conventional topical irradiation. The device comprises a plate having an array of openings with hollow micro-needles mounted therein that extend to a specified length on each side. Optical fibers are individually threaded through the micro-needles from the side opposite the treatment area and may be kept together as a bundle for attachment to a laser radiation source. The optical fibers have output ends made to provide a uniform radiation pattern to the underlying tissue. A photosensitizer is administered either systemically or locally and allowed a sufficient time to diffuse into the area of treatment. The laser of selected wavelength is coupled to the fiber bundle which then directs the radiation through the optical fibers to the treatment site.
摘要翻译：描述了一种用于光动力治疗（PDT）的装置和方法，用于治疗皮肤表面几厘米以内的无法通过常规局部照射进入的下层区域中的过度增生组织生长。该装置包括具有安装在其中的具有中空微针的开口阵列的板，其在每侧延伸到指定的长度。光纤从处理区域的相对侧分别穿过微针，并且可以作为束保持在一起，以附着到激光辐射源。光纤的输出端被制成以向下面的组织提供均匀的辐射图案。光敏剂全身或局部施用，并允许足够的时间扩散到治疗区域。所选波长的激光器耦合到纤维束，然后纤维束将辐射通过光纤引导到处理部位。

9. 发明授权

US10765479B2 Method for treatment of varicocele 有权
公开(公告)号：US10765479B2
公开(公告)日：2020-09-08
申请号：US15438471
申请日：2017-02-21
申请人： biolitec Unternehmensbeteiligungs II AG
发明人： Fabio Coluccia
IPC分类号： A61B6/00 , A61B18/24 , A61B8/08 , A61B6/12 , A61B18/00 , A61B90/00
摘要： A minimally invasive method for treating varices in especially sensitive areas, including pelvic varices in females, varicoceles, and also oesophageal varices is presented. The method comprises the steps of making a micro incision into the blood vessels of a patient, endoscopically inserting a catheter device into the blood vessel of a patient and advancing the distal end of the catheter to reach the varix or varices. Insertion can be made in the femoral vein and advanced using a catheter. A first localizer is placed on the distal end of said catheter to allow use of x-ray, angiography, or other imaging techniques to visualize and position the catheter. An optical fiber is then inserted into the catheter and the distal end is advanced to a predetermined point near the varix or varices. A second localizer is present on the distal end of said optical fiber to allow use of x-ray, angiography, or other imaging techniques to visualize and position the optical fiber as well. Optical fiber distal end is preferably a slim, radial 360 degree emitting fiber end. Laser energy of preferably 1470±30 nm is then transmitted to the varix to close the blood vessel. Other wavelengths with similar or greater absorption in blood/water than at 1470 nm are also effective. Imaging techniques such as angiographies may again be performed to confirm closure of the vein. The laser source linked to a radial emitting fiber allows for thermo occlusion of varicoceles using about 2-3 W of emitting power with little or no pain or discomfort for patient. The present invention is an out-patient procedure that requires no anesthesia and minimal recovery time, and does not require that any foreign objects be left in the body. This method has been shown to have a high success rate and minimum pain or side effects for the patient.

10. 发明授权

US10687894B2 Vaginal remodeling/rejuvenation device and method 有权
公开(公告)号：US10687894B2
公开(公告)日：2020-06-23
申请号：US13997554
申请日：2011-12-29
申请人： Gabriel Femopase
发明人： Gabriel Femopase
IPC分类号： A61B18/22 , A61B18/20 , A61B18/00
摘要： A device and method for treating a vagina's anatomic, functional and aesthetic conditions are disclosed. Device comprises a laser energy source which conveys laser energy through an optical fiber handpiece. A cylindrical/penis shaped device/applicator is specially designed for safe and accurate irradiation of determined parts of vaginal mucosa. Applicator has an inner hollow path through which optical fiber is inserted to irradiate interior vaginal tissue. Irradiated mucous tissue contracts, reducing vaginal radius and during penetration in sexual intercourse it embraces penis more tightly. Sensitivity is substantially improved and sexual intercourse is more pleasurable for both partners. In one embodiment, a 1470 nm diode laser source is used. In another embodiment, a vagina's outer dimensions are accurately measured and surgery is performed to achieve dimensions according to certain aesthetic and functional criteria. Minimum pain and risk of side effects are experienced with this ambulatory procedure performable in a physician's office.

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