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1. 发明授权

US12064910B2 System for the improved introduction of a separating device and blown film line, as well as a method for the production and supply of at least two plastic film webs in a blown film line 有权
公开(公告)号：US12064910B2
公开(公告)日：2024-08-20
申请号：US17599824
申请日：2020-03-27
申请人： Windmöller & Hölscher KG
发明人： Tim Oberdalhoff , Thomas Sehlleier , Sebastian Martinek , Tim Kirchhoff
IPC分类号： B29C48/00 , B26D1/02 , B29C48/10 , B29C48/25 , B29C48/28 , B29C48/355 , B29C48/92 , B29L23/00
CPC分类号： B29C48/0022 , B26D1/025 , B29C48/0017 , B29C48/0018 , B29C48/0019 , B29C48/10 , B29C48/2528 , B29C48/28 , B29C48/355 , B29C48/92 , B29C2793/0036 , B29C2793/0054 , B29C2793/0063 , B29C2948/92295 , B29C2948/92438 , B29C2948/92447 , B29L2023/001
摘要： The invention relates to a system (10) for improved introduction of a separating device (40) into a flattened film tube (2) of a blown film line (1), with a cutting device (20) for severing only a first tube side (2.1) of the film tube (2), in particular the film tube (2) which has not yet been flattened.
Furthermore, the invention relates to a blown film line (1), as well as a method (100) for producing and providing at least two film webs (6).

2. 发明授权

US12059502B2 Composition and method for pretreating cancer 有权
公开(公告)号：US12059502B2
公开(公告)日：2024-08-13
申请号：US16087034
申请日：2017-04-21
申请人： Valcuria AB
发明人： Johan Drott , Kristina Drott , Stefan Ulvenlund , Catharina Salomonsson
IPC分类号： A61K9/50 , A61K31/19 , A61K31/20 , A61K31/573 , A61K45/06 , A61K47/38 , A61P35/00
CPC分类号： A61K9/5084 , A61K9/5026 , A61K9/5047 , A61K31/19 , A61K31/20 , A61K31/573 , A61K45/06 , A61K47/38 , A61P35/00 , A61K31/19 , A61K2300/00 , A61K31/20 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising an HDAC inhibitor, a pharmaceutically acceptable acid or salt thereof or a mixture of the acid and salt, provided both in a immediate release form and in an extended release form wherein 70-90 weight % of the HDAC inhibitor is provided in the immediate release form and the remainder of the HDAC inhibitor is provided in the extended release form. In further aspects the present invention relates to a kit comprising a number of doses of an HDAC inhibitor, a pharmaceutically acceptable acid or salt thereof or a mixture of the acid and salt thereof provided both in an immediate release form and in an extended release form. In still further aspects the present invention relates to an HDAC inhibitor, a pharmaceutically acceptable acid or salt thereof or a mixture of the acid and salt, provided in both an immediate release form and an extended release form, for use in a method of pretreating cancer, and a method of pretreating cancer using said HDAC inhibitor provided both in said immediate release form and said extended release form. Further aspects relate to combination treatment of cancer and to a dispenser for a blister pack.

3. 发明授权

US12043620B2 Benzazole compounds and methods for making and using the compounds 有权
公开(公告)号：US12043620B2
公开(公告)日：2024-07-23
申请号：US17687826
申请日：2022-03-07
申请人： Rigel Pharmaceuticals, Inc.
发明人： Rose Yen , Yan Chen , Rajinder Singh , Vanessa Taylor
IPC分类号： C07D413/14 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06 , A61P9/00 , A61P11/00 , A61P17/00 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00 , C07D417/14 , C07D471/04
CPC分类号： C07D413/14 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06 , A61P9/00 , A61P11/00 , A61P17/00 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00 , C07D417/14 , C07D471/04
摘要： Disclosed are novel benzazole compounds and compositions comprising the compounds. The compounds are useful as kinase inhibitors including interleukin receptor associated kinases (IRAK) inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

4. 发明授权

US12037595B2 Rust resistance gene 有权
公开(公告)号：US12037595B2
公开(公告)日：2024-07-16
申请号：US17865137
申请日：2022-07-14
申请人： Commonwealth Scientific and Industrial Research Organisation
发明人： Evans Lagudah , John Wallace Moore
IPC分类号： C12N15/82 , A01N65/08 , A01N65/44 , C07K14/415 , C12Q1/54 , C12Q1/6895 , G01N33/50
CPC分类号： C12N15/8282 , A01N65/08 , A01N65/44 , C07K14/415 , C12Q1/54 , C12Q1/6895 , G01N33/5035 , C12Q2600/13 , C12Q2600/158 , G01N2333/415
摘要： The present invention relates to new transporter polypeptides, and genes encoding therefor, which can be used to confer upon a plant resistance to one or more biotrophic fungal pathogens.

5. 发明授权

US12037402B2 Treatment of cancer with dual targeting of CD47 and EGFR 有权
公开(公告)号：US12037402B2
公开(公告)日：2024-07-16
申请号：US17411953
申请日：2021-08-25
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Irving L. Weissman , Stephen Willingham , Doris Po Yi Ho , Piero D. Dalerba , Kelly Marie McKenna , Jens-Peter Volkmer
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , A61K39/00 , C12Q1/6883
CPC分类号： C07K16/2863 , A61K39/39558 , A61P35/00 , C07K16/2803 , C07K16/2839 , A61K2039/507 , C07K2317/76 , C12Q1/6883
摘要： Methods are provided for targeting cells for depletion, including, without limitation, cancer cells, in a regimen comprising contacting the targeted cells with a combination of agents, including (i) an agent that blockades CD47 activity; and (ii) an antibody that specifically binds to EGFR. In some embodiments the cancer cells have a mutated form of one or more of KRAS, NRAS and BRAF. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used.

6. 发明授权

US12036314B2 Compositions and methods for in situ-forming tissue constructs 有权
公开(公告)号：US12036314B2
公开(公告)日：2024-07-16
申请号：US17251605
申请日：2019-06-27
申请人： The Board of Trustees of the Leland Stanford Junior University , The U.S. Government Represented by the Department of Veterans Affairs
发明人： David Myung , Sarah Hull , Sarah Heilshorn , Christopher Lindsay , Christopher Madl , Hyun Jong Lee
IPC分类号： A61K9/00 , A61F2/14 , A61K9/06 , A61K47/10 , A61K47/36 , A61K47/42
CPC分类号： A61K9/0051 , A61F2/142 , A61K9/06 , A61K47/10 , A61K47/36 , A61K47/42 , A61F2210/0076
摘要： Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using biomaterials that form a defined gel structure in situ. Such gels can serve as cellular or acellular lamellar substitutes to reconstruct corneal stroma, facilitate matrix remodeling, and support multilayered re-epithelialization of wounded corneal stromal tissue, as well delivery vehicles for cells, biomolecules, and/or pharmaceutical agents to wound sites throughout the body.

7. 发明授权

US12036033B2 Vaginal drug delivery device and vaginal diagnostic device 有权
公开(公告)号：US12036033B2
公开(公告)日：2024-07-16
申请号：US17155651
申请日：2021-01-22
申请人： LiGalli B.V.
发明人： Wilhelmus Nicolaas Gerardus Maria De Laat
IPC分类号： A61B5/00 , A61B5/145 , A61B10/00 , A61K9/00 , A61M31/00
CPC分类号： A61B5/4337 , A61B5/4325 , A61B5/6875 , A61B10/0012 , A61M31/002 , A61B5/002 , A61B5/14532 , A61B5/14546 , A61B2560/0214 , A61K9/0036 , A61M2205/0216 , A61M2205/3303 , A61M2205/8206 , A61M2210/1475 , A61M2230/201
摘要： The present invention is related to a vaginal drug delivery device and to a vaginal diagnostic device that comprises a first and second rigid member, wherein the first and/or second rigid member comprises a reservoir holding a medicament to be delivered, an opening, and a pump for pumping said medicament out of said opening, and/or wherein the first rigid member and/or second rigid member comprises a diagnostic device for performing an intravaginal diagnosis or measurement therefor.
The device further comprises a first flexible member and flexible part, wherein at least one of the first flexible member and the flexible part is at least partially elastic having an elasticity such that the device can be squeezed from an extended shape to a collapsed shape. The device is pre-biased to assume the extended shape when little to no external force is being applied thereto. Furthermore, the device assumes a shape substantially corresponding to the extended shape when the device is inserted with the squeezed rigid member first, so that these naturally unfold in the formix posterior vaginae.

8. 发明授权

US12031902B2 Method for contactless characterization of a substance 有权
公开(公告)号：US12031902B2
公开(公告)日：2024-07-09
申请号：US17297246
申请日：2020-04-07
申请人： Steinfurth Mess-Systeme GmbH
发明人： Markus Grafen
IPC分类号： G01N21/27 , G01N21/3504 , G01N21/90
CPC分类号： G01N21/274 , G01N21/3504 , G01N21/90
摘要： The invention relates to a method for contactless characterization of a substance (A) using waves (W), wherein the substance (A) comprises a spectral structure (a({tilde over (e)}i)) as a characteristic field (KF) which qualitatively depends on at least one property (ei) of the substance (A), wherein the spectral structure (a({tilde over (e)}i)) is recorded by a measurement (x), and wherein the measurement (x) may comprise an interference structure (s) that depends on the measurement circumstances. According to the invention it is provided that in step 1) at least two different measurements (xj) are carried out under different measurement circumstances, which can have quantitatively and/or qualitatively different interference structures (sj) and/or quantitatively different spectral structures (gj·α), and that in step 2) coefficients (cj) of a linear combination

(

∑

j
=
1

M

⁢

c
j

⁢

x
j

)

of the different measurements (xj) and the value ({tilde over (e)}i) of the at least one property (ei) of the substance (A) are optimized so that the deviation between the linear combination

(

∑

j
=
1

M

⁢

c
j

⁢

x
j

)

and the spectral structure (a({tilde over (e)}i)) is minimized.

9. 发明授权

US12023411B2 Dendritic nanogel carriers and method of production 有权
公开(公告)号：US12023411B2
公开(公告)日：2024-07-02
申请号：US17264716
申请日：2019-08-13
申请人： POLYMER FACTORY SWEDEN AB
发明人： Michael Malkoch , Surinthra Mongkhontreerat , Oliver Andrén , Randi Nordström , Yuning Zhang
IPC分类号： A61K45/06 , A61K9/06 , A61K9/51 , B82Y5/00 , B82Y30/00
CPC分类号： A61K9/5146 , A61K9/06 , A61K45/06 , B82Y5/00 , B82Y30/00
摘要： The present invention relates to a nanogel of nanoparticles. The nanoparticles comprise self-assembled dendritic containing polymers having at least one dendritic hydrophobic segment forming the core and at least one hydrophilic segment forming the shell.

10. 发明授权

US12016682B2 In-vivo monitoring of molecular targets 有权
公开(公告)号：US12016682B2
公开(公告)日：2024-06-25
申请号：US14768134
申请日：2014-01-29
申请人： The Regents of the University Of California
发明人： Brian Scott Ferguson , Hyongsok Tom Soh , David A. Hoggarth
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1473 , A61B5/15 , C12N15/11 , C12N15/115 , C12Q1/6816
CPC分类号： A61B5/14525 , A61B5/14546 , A61B5/1473 , A61B5/14735 , A61B5/150992 , A61B5/4839 , C12N15/111 , C12N15/115 , C12Q1/6816 , A61B2503/40 , A61B2503/42 , C12N2310/16 , C12N2320/10 , C12Q1/6816 , C12Q2525/205 , C12Q2565/629
摘要： The present disclosure provides devices, methods and systems for analyte detection and/or monitoring, e.g., the continuous and/or semi-continuous monitoring of in-vivo analyte concentrations in real time. Generally, the devices, methods and systems of the present disclosure make use of signaling probes; methods or devices for reducing interferent-based fouling of the signaling probes, non-specific binding to the signaling probes and/or occlusion of a sensor surface; and methods and/or devices for providing an adjusted signal based on a detected signal from the signaling probes. Compositions including conformation switching signaling probes are also provided.

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