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    • 2. 发明授权
    • Image forming apparatus and image forming method
    • 图像形成装置及图像形成方法
    • US08471879B2
    • 2013-06-25
    • US13213266
    • 2011-08-19
    • Ikuko KanazawaHirofumi Nakagawa
    • Ikuko KanazawaHirofumi Nakagawa
    • B41C1/055B41M1/06B41J2/32
    • B41M1/24
    • Disclosed is an image forming method including forming a concave-convex pattern on a surface of a plate by pressing the plate and a mold having the convex-concave pattern on a surface thereof against each other, the plate having the surface made of a material in which a hardness changes reversibly at a transition point temperature, forming a plate image constituted of a concave-convex region having the concave-convex pattern and a smooth region in which the concave-convex pattern is erased on the plate by erasing the concave-convex pattern by selectively heating the surface of the plate to the transfer point temperature or above corresponding to an image signal, and forming an image on a recording medium by forming an ink image on the plate by applying an ink on the plate image and by transferring the ink image on to the recording medium.
    • 公开了一种图像形成方法,包括通过将板压在板的表面上并在其表面上具有凸凹图案的模具彼此相对地形成凹凸图案,该板具有由材料制成的表面 其硬度在转变点温度下可逆地变化,形成由凹凸图案的凹凸区域构成的平板图像和通过擦除凹凸图案而在该板上擦除凹凸图案的平滑区域 通过将所述板的表面选择性地加热到对应于图像信号的转印点温度或高于图像信号的转印点温度,并且通过在平板图像上施加墨水将印刷图像形成在印版上形成图像,并通过转印 油墨图像到记录介质上。
    • 7. 发明授权
    • Macrocyclic peptides as inhibitors of viral replication
    • 大环肽作为病毒复制的抑制剂
    • US08785378B2
    • 2014-07-22
    • US12955413
    • 2010-11-29
    • Avinash PhadkeXiangzhu WangSuoming ZhangAtul Agarwal
    • Avinash PhadkeXiangzhu WangSuoming ZhangAtul Agarwal
    • A61K38/00
    • A61K38/05A61K38/00A61K38/12A61K45/06C07K5/02C07K5/06078C07K5/06139C07K5/06165C07K5/06191C07K5/0808C07K5/12
    • The invention provides 4-amino-4-oxobutanoyl peptide compounds of Formula I and the pharmaceutically salts and hydrates thereof. The variables R1-R9, R16, R18, R19, n, M, n, M, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. Certain 4-amino-4-oxobutanoyl peptide compounds disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptide compounds and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain 4-amino-4-oxobutanoyl peptide compound as the only active agent or may contain a combination of 4-amino-4-oxobutanoyl peptide containing peptides compound and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in mammals.
    • 本发明提供了式I的4-氨基-4-氧代丁酰基肽化合物及其药学上可接受的盐和水合物。 变量R1-R9,R16,R18,R19,n,M,n,M和Z在本文中定义。 某些式I化合物可用作抗病毒剂。 本文公开的某些4-氨基-4-氧代丁酰基肽化合物是病毒复制的有效和/或选择性抑制剂,特别是丙型肝炎病毒复制。 本发明还提供含有一种或多种4-氨基-4-氧代丁酰基肽化合物和一种或多种药学上可接受的载体的药物组合物。 这样的药物组合物可以含有4-氨基-4-氧代丁酰基肽化合物作为唯一的活性剂,或者可以含有含有4-氨基-4-氧代丁酰基肽的肽化合物和一种或多种其它药物活性剂的组合。 本发明还提供了用于治疗哺乳动物中的病毒感染(包括丙型肝炎感染)的方法。