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1. 发明授权

US08466286B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
标题翻译： SMMR（小分子代谢物记者）用作体内葡萄糖生物传感器
公开(公告)号：US08466286B2
公开(公告)日：2013-06-18
申请号：US13215061
申请日：2011-08-22
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： C07F5/02 , A61K49/00 , A61B5/00 , A61B8/00 , A61B10/00 , C07D471/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

2. 发明授权

US07831298B1 Mapping physiological functions of tissues in lungs and other organs 有权
标题翻译：映射肺和其他器官组织的生理功能
公开(公告)号：US07831298B1
公开(公告)日：2010-11-09
申请号：US11747879
申请日：2007-05-11
申请人： Feiling Wang , Alex R. Zelenchuk , Xiao-Li Li
发明人： Feiling Wang , Alex R. Zelenchuk , Xiao-Li Li
IPC分类号： A61B6/00
CPC分类号： A61B1/2676 , A61B5/0059 , A61B5/0066 , A61B5/6852 , A61B18/1492 , A61B18/1815 , A61B18/22 , A61B2017/00057 , A61B2018/00541 , A61B2018/2065 , A61N5/0601
摘要： Systems, apparatus and techniques for non-invasive optical probing of various substances, and systems, apparatus and techniques for detecting, diagnosing and treating a disease in lungs and other organs using the non-invasive optical probing, including mapping physiological functions of tissues in lungs and other organs.
摘要翻译：用于各种物质的非侵入式光学探测的系统，装置和技术以及用于使用非侵入性光学探测来检测，诊断和治疗肺和其他器官中的疾病的系统，装置和技术，包括映射肺中组织的生理功能和其他器官。

3. 发明申请

US20090004108A1 Smmr (Small Molecule Metabolite Reporters) For Use As In Vivo Glucose Biosensors 有权
标题翻译： Smmr（小分子代谢记录）用作体内葡萄糖生物传感器
公开(公告)号：US20090004108A1
公开(公告)日：2009-01-01
申请号：US10584821
申请日：2004-12-23
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00 , C07D311/78
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

4. 发明申请

US20120046554A1 Fluorescent Fiberoptic Probe for Tissue Health Discrimination and Method of Use Thereof 失效
标题翻译：用于组织健康歧视的荧光光纤探针及其使用方法
公开(公告)号：US20120046554A1
公开(公告)日：2012-02-23
申请号：US13215096
申请日：2011-08-22
申请人： Alex R. Zelenchuk
发明人： Alex R. Zelenchuk
IPC分类号： A61B6/00
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0088 , A61B5/4255 , A61B5/4331 , A61B5/7267
摘要： A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, one of which corresponds to an isosbestic point. In one example, the isosbestic point occurs at about 431 nm. The intensities of the observed signals are normalized using the 431 nm intensity. A score is determined using the ratios in a discriminant analysis. The tissue under examination is resected or not, based on the diagnosis of disease or health, according to the outcome of the discriminant analysis.
摘要翻译：用于原位鉴别健康和患病组织的系统和方法。使用基于光纤的探针将紫外线照射引导到组织标本上并收集荧光反应辐射。在三个选择的波长处观察到响应辐射，其中一个对应于等腰点。在一个实例中，等腰点发生在约431nm处。观察信号的强度使用431nm的强度进行归一化。使用判别分析中的比例来确定得分。根据判别分析的结果，根据疾病或健康的诊断，切除或不切除组织。

5. 发明授权

US08029765B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
公开(公告)号：US08029765B2
公开(公告)日：2011-10-04
申请号：US10584821
申请日：2004-12-23
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

6. 发明授权

US08311607B2 Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof 失效
标题翻译：用于组织健康鉴别的荧光光纤探针及其使用方法
公开(公告)号：US08311607B2
公开(公告)日：2012-11-13
申请号：US13215096
申请日：2011-08-22
申请人： Alex R. Zelenchuk
发明人： Alex R. Zelenchuk
IPC分类号： A61B5/00
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0088 , A61B5/4255 , A61B5/4331 , A61B5/7267
摘要： A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, one of which corresponds to an isosbestic point. In one example, the isosbestic point occurs at about 431 nm. The intensities of the observed signals are normalized using the 431 nm intensity. A score is determined using the ratios in a discriminant analysis. The tissue under examination is resected or not, based on the diagnosis of disease or health, according to the outcome of the discriminant analysis.
摘要翻译：用于原位鉴别健康和患病组织的系统和方法。使用基于光纤的探针将紫外线照射引导到组织标本上并收集荧光反应辐射。在三个选择的波长处观察到响应辐射，其中一个对应于等腰点。在一个实例中，等腰点发生在约431nm处。观察信号的强度使用431nm的强度进行归一化。使用判别分析中的比例来确定得分。根据判别分析的结果，根据疾病或健康的诊断，切除或不切除组织。

7. 发明授权

US07310547B2 Fluorescent fiberoptic probe for tissue health discrimination 失效
标题翻译：荧光光纤探针用于组织健康辨别
公开(公告)号：US07310547B2
公开(公告)日：2007-12-18
申请号：US10894356
申请日：2004-07-19
申请人： Alex R. Zelenchuk
发明人： Alex R. Zelenchuk
IPC分类号： A61B6/00
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0088 , A61B5/4255 , A61B5/4331 , A61B5/7267
摘要： A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, one of which corresponds to an isosbestic point. In one example, the isosbestic point occurs at about 431 nm. The intensities of the observed signals are normalized using the 431 nm intensity. A score is determined using the ratios in a discriminant analysis. The tissue under examination is resected or not, based on the diagnosis of disease or health, according to the outcome of the discriminant analysis.
摘要翻译：用于原位鉴别健康和患病组织的系统和方法。使用基于光纤的探针将紫外线照射引导到组织标本上并收集荧光反应辐射。在三个选择的波长处观察到响应辐射，其中一个对应于等腰点。在一个实例中，等腰点发生在约431nm处。观察信号的强度使用431nm的强度进行归一化。使用判别分析中的比例来确定得分。根据判别分析的结果，根据疾病或健康的诊断，切除或不切除组织。

8. 发明授权

US07225005B2 Optical determination of in vivo properties 失效
标题翻译：光学测定体内特性
公开(公告)号：US07225005B2
公开(公告)日：2007-05-29
申请号：US11011714
申请日：2004-12-14
申请人： Howard B. Kaufman , Alex R. Zelenchuk
发明人： Howard B. Kaufman , Alex R. Zelenchuk
IPC分类号： A61B5/00
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/489 , A61B5/681 , A61B5/6824 , A61B5/742
摘要： A system and method for determining an in vivo property of a tissue or blood is described. The in vivo property may be a hematocrit value, a hemoglobin concentration, or a combination thereof. The system can automatically determine a location of a subcutaneous blood vessel. Based on the automatically determined location, the system illuminates the blood vessel with a light beam and detects light resulting from the illumination. The system determines the in vivo property based on the detected light. Alternatively, or in combination, the system displays an image corresponding to a spatial relationship between a subcutaneous blood vessel and a light beam. Based on the image, an operator can adjust the light beam with respect to the blood vessel to have a selected spatial relationship. The system determines an in vivo property based on the illumination of the blood vessel when the light beam has the selected spatial relationship.
摘要翻译：描述了用于确定组织或血液的体内特性的系统和方法。体内性质可以是血细胞比容值，血红蛋白浓度或其组合。系统可以自动确定皮下血管的位置。基于自动确定的位置，系统用光束照射血管并检测照明产生的光。该系统基于检测到的光来确定体内特性。或者或组合地，系统显示对应于皮下血管和光束之间的空间关系的图像。基于图像，操作者可以相对于血管调节光束以具有选定的空间关系。当光束具有选择的空间关系时，该系统基于血管的照明确定体内特性。

9. 发明授权

US06768918B2 Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof 有权
公开(公告)号：US06768918B2
公开(公告)日：2004-07-27
申请号：US10192836
申请日：2002-07-10
申请人： Alex R. Zelenchuk
发明人： Alex R. Zelenchuk
IPC分类号： A61B600
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0088 , A61B5/4255 , A61B5/4331 , A61B5/7267
摘要： A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, one of which corresponds to an isosbestic point. In one example, the isosbestic point occurs at about 431 nm. The intensities of the observed signals are normalized using the 431 nm intensity. A score is determined using the ratios in a discriminant analysis. The tissue under examination is resected or not, based on the diagnosis of disease or health, according to the outcome of the discriminant analysis.

10. 发明申请

US20120052018A1 SMMR (SMALL MOLECULE METABOLITE REPORTERS) FOR USE AS IN VIVO GLUCOSE BIOSENSORS 有权
标题翻译：用于葡萄糖生物传感器的SMMR（小分子代谢报告物）
公开(公告)号：US20120052018A1
公开(公告)日：2012-03-01
申请号：US13215061
申请日：2011-08-22
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00 , C07F5/02
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

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