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1. 发明申请

US20100093016A1 MICROFLUIDIC APPARATUS AND METHOD FOR PREPARING CYTOLOGICAL SPECIMENS 有权
标题翻译：微流感装置及其制备方法
公开(公告)号：US20100093016A1
公开(公告)日：2010-04-15
申请号：US12574554
申请日：2009-10-06
申请人： Howard B. Kaufman , Tuan Ha
发明人： Howard B. Kaufman , Tuan Ha
IPC分类号： C12Q1/02 , C12M1/26
CPC分类号： G01N1/2813 , G01N15/1484
摘要： An apparatus for processing a specimen from a fluid sample includes a first set of one or more microfluidic channels configured to deliver the sample fluid to a filter disposed on an inflatable bladder configured to transfer the specimen from the filter to a slide. The apparatus is configured to collect an approximate monolayer of particles and includes a second set of one or more microfluidic channels configured to remove fluid flowing through the filter disposed on the inflatable bladder. The apparatus also includes a pressure source, a sample container connected to the pressure source and the first set of one or more microfluidic channels, a fluid flow gauge configured to measure a fluid flow rate through the filter, and a stain source connected to the first set of one or more microfluidic channels.
摘要翻译：用于从流体样品处理样本的装置包括第一组一个或多个微流体通道，其被配置为将样品流体递送到布置在可膨胀囊上的过滤器，所述过滤器构造成将样品从过滤器转移到载玻片。该装置被配置为收集大致单层的颗粒，并且包括第二组一个或多个微流体通道，其被配置为去除流过设置在可充气囊上的过滤器的流体。该装置还包括压力源，连接到压力源的样品容器和第一组一个或多个微流体通道，流量计，其配置成测量通过过滤器的流体流速，以及污染源，连接到第一一组或多个微流体通道。

2. 发明授权

US08983166B2 Method for automatically seeding previously-classified images among images of objects of interest from a specimen 有权
标题翻译：用于在来自样本的感兴趣对象的图像之间自动播种先前分类的图像的方法
公开(公告)号：US08983166B2
公开(公告)日：2015-03-17
申请号：US13427251
申请日：2012-03-22
申请人： Howard B. Kaufman
发明人： Howard B. Kaufman
IPC分类号： G06K9/00 , G06K9/62 , G06F19/00 , G06K9/03
CPC分类号： G06F19/321 , G06F19/00 , G06K9/00127 , G06K9/033 , G06K9/6263 , G16H10/40 , G16H40/20 , G16H50/20
摘要： A computer-assisted method of classifying cytological samples, includes using a processor to analyze images of cytological samples and identify cytological objects of interest within the sample images, wherein the processor (i) displays images of identified cytological objects of interest from the sample images to a reviewer, (ii) accesses a database of images of previously classified cytological objects, and (iii) displays to the reviewer, interspersed with the displayed images of the identified objects of interest from the sample images, one or more images obtained from the database of images of previously-classified objects.
摘要翻译：用于分类细胞学样品的计算机辅助方法包括使用处理器分析细胞学样品的图像并鉴定样品图像内感兴趣的细胞学物体，其中处理器（i）从所述样品图像显示所识别的感兴趣的细胞学对象的图像，（ii）访问先前分类的细胞学对象的图像的数据库，以及（iii）向所述审阅者显示，从所述样本图像散布所识别的感兴趣对象的显示图像，从所述数据库获得的一个或多个图像先前分类对象的图像。

3. 发明申请

US20120243755A1 METHOD FOR AUTOMATICALLY SEEDING PREVIOUSLY-CLASSIFIED IMAGES AMONG IMAGES OF OBJECTS OF INTEREST FROM A SPECIMEN 有权
标题翻译：在样本图像中自动选择先前分类图像的方法
公开(公告)号：US20120243755A1
公开(公告)日：2012-09-27
申请号：US13427251
申请日：2012-03-22
申请人： Howard B. Kaufman
发明人： Howard B. Kaufman
IPC分类号： G06K9/00
CPC分类号： G06F19/321 , G06F19/00 , G06K9/00127 , G06K9/033 , G06K9/6263 , G16H10/40 , G16H40/20 , G16H50/20
摘要： A computer-assisted method of classifying cytological samples, includes using a processor to analyze images of cytological samples and identify cytological objects of interest within the sample images, wherein the processor (i) displays images of identified cytological objects of interest from the sample images to a reviewer, (ii) accesses a database of images of previously classified cytological objects, and (iii) displays to the reviewer, interspersed with the displayed images of the identified objects of interest from the sample images, one or more images obtained from the database of images of previously-classified objects.
摘要翻译：用于分类细胞学样品的计算机辅助方法包括使用处理器分析细胞学样品的图像并鉴定样品图像内感兴趣的细胞学物体，其中处理器（i）从所述样品图像显示所识别的感兴趣的细胞学对象的图像，（ii）访问先前分类的细胞学对象的图像的数据库，以及（iii）向所述审阅者显示，从所述样本图像散布所识别的感兴趣对象的显示图像，从所述数据库获得的一个或多个图像的先前分类对象的图像。

4. 发明授权

US08329121B2 Apparatus for preparing cytological specimens 有权
标题翻译：用于制备细胞学标本的装置
公开(公告)号：US08329121B2
公开(公告)日：2012-12-11
申请号：US13032517
申请日：2011-02-22
申请人： Howard B. Kaufman , Tuan Ha
发明人： Howard B. Kaufman , Tuan Ha
IPC分类号： A61B10/00
CPC分类号： G01N1/2813 , Y10T436/2575
摘要： A handheld apparatus for preparing a specimen slide includes a handle, a filter holder assembly coupled to and extending from the handle; and a slide holder assembly coupled to and extending from the handle spaced apart from the filter holder assembly, wherein the slide holder assembly comprises a plurality of positioning members movably coupled to one another, and a slide holder movably coupled to one of the positioning members to allow a slide mounted on the slide holder to make rolling contact with an outward facing surface of a filter mounted on the filter holder assembly.
摘要翻译：一种用于准备试样滑块的手持式装置，包括手柄，耦合到手柄并从手柄延伸的过滤器支架组件; 以及滑架保持器组件，其联接到从所述手柄与所述过滤器保持器组件间隔开并且从所述手柄延伸，其中所述滑动保持器组件包括彼此可移动地联接的多个定位构件，以及滑动保持器，其可移动地联接到所述定位构件中的一个，允许安装在滑架上的滑块与安装在过滤器保持器组件上的过滤器的面向外的表面滚动接触。

5. 发明申请

US20120214227A1 APPARATUS FOR PREPARING CYTOLOGICAL SPECIMENS 有权
标题翻译：准备细胞学样本的装置
公开(公告)号：US20120214227A1
公开(公告)日：2012-08-23
申请号：US13032517
申请日：2011-02-22
申请人： Howard B. Kaufman , Tuan Ha
发明人： Howard B. Kaufman , Tuan Ha
IPC分类号： C12M1/26
CPC分类号： G01N1/2813 , Y10T436/2575
摘要： A handheld apparatus for preparing a specimen slide includes a handle, a filter holder assembly coupled to and extending from the handle; and a slide holder assembly coupled to and extending from the handle spaced apart from the filter holder assembly, wherein the slide holder assembly comprises a plurality of positioning members movably coupled to one another, and a slide holder movably coupled to one of the positioning members to allow a slide mounted on the slide holder to make rolling contact with an outward facing surface of a filter mounted on the filter holder assembly.
摘要翻译：一种用于准备试样滑块的手持式装置，包括手柄，耦合到手柄并从手柄延伸的过滤器支架组件; 以及滑架保持器组件，其联接到从所述手柄与所述过滤器保持器组件间隔开并且从所述手柄延伸，其中所述滑动保持器组件包括彼此可移动地联接的多个定位构件，以及滑动保持器，其可移动地联接到所述定位构件中的一个，允许安装在滑架上的滑块与安装在过滤器保持器组件上的过滤器的面向外的表面滚动接触。

6. 发明申请

US20110062087A1 METHODS AND SYSTEMS FOR COLLECTING CELLS OF A BIOLOGICAL SPECIMEN 有权
标题翻译：收集生物样本细胞的方法和系统
公开(公告)号：US20110062087A1
公开(公告)日：2011-03-17
申请号：US12558400
申请日：2009-09-11
申请人： Howard B. Kaufman , Barry Hunt
发明人： Howard B. Kaufman , Barry Hunt
IPC分类号： B01D29/60
CPC分类号： G01N1/2813 , G01N1/4077 , G01N2001/4088
摘要： Methods and systems for collecting cells on a filter disposed in a specimen fluid containing suspended cells of a biological specimen. A short vacuum pulse is applied across a filter to sip specimen fluid. A percentage or portion of the filter surface area covered by cells is determined is representative of or correlates to the density of cells in the specimen fluid. A maximum vacuum amplitude and/or duration are determined utilizing the determined filter coverage. A longer, continuous vacuum or slurp is applied across the filter to collect cells on the filter while limiting the amplitude and/or duration of the slurp based at least in part upon the determined maximum vacuum amplitude and/or duration.
摘要翻译：用于在设置在含有生物样本的悬浮细胞的样本液中的过滤器上收集细胞的方法和系统。在过滤器上施加短的真空脉冲以汲取样品流体。由细胞覆盖的过滤器表面积的百分比或部分被确定为样品流体中的细胞的密度或与之相关。使用确定的滤波器覆盖来确定最大真空振幅和/或持续时间。至少部分地基于所确定的最大真空振幅和/或持续时间，在过滤器上施加更长的连续真空或絮凝物以收集过滤器上的细胞，同时限制浆液的幅度和/或持续时间。

7. 发明授权

US08669118B2 Methods and systems for collecting cells of a biological specimen 有权
标题翻译：用于收集生物样本细胞的方法和系统
公开(公告)号：US08669118B2
公开(公告)日：2014-03-11
申请号：US12558400
申请日：2009-09-11
申请人： Howard B. Kaufman , Barry Hunt
发明人： Howard B. Kaufman , Barry Hunt
IPC分类号： G01N1/10
CPC分类号： G01N1/2813 , G01N1/4077 , G01N2001/4088
摘要： Methods and systems for collecting cells on a filter disposed in a specimen fluid containing suspended cells of a biological specimen. A short vacuum pulse is applied across a filter to sip specimen fluid. A percentage or portion of the filter surface area covered by cells is determined is representative of or correlates to the density of cells in the specimen fluid. A maximum vacuum amplitude and/or duration are determined utilizing the determined filter coverage. A longer, continuous vacuum or slurp is applied across the filter to collect cells on the filter while limiting the amplitude and/or duration of the slurp based at least in part upon the determined maximum vacuum amplitude and/or duration.
摘要翻译：用于在设置在含有生物样本的悬浮细胞的样本液中的过滤器上收集细胞的方法和系统。在过滤器上施加短的真空脉冲以汲取样品流体。由细胞覆盖的过滤器表面积的百分比或部分被确定为样品流体中的细胞的密度或与之相关。使用确定的滤波器覆盖来确定最大真空振幅和/或持续时间。至少部分地基于所确定的最大真空振幅和/或持续时间，在过滤器上施加更长的连续真空或絮凝物以收集过滤器上的细胞，同时限制浆液的幅度和/或持续时间。

8. 发明授权

US08460619B2 Microfluidic apparatus and method for preparing cytological specimens 有权
标题翻译：微流控装置及其制备方法
公开(公告)号：US08460619B2
公开(公告)日：2013-06-11
申请号：US12574554
申请日：2009-10-06
申请人： Howard B. Kaufman , Tuan Ha
发明人： Howard B. Kaufman , Tuan Ha
IPC分类号： A61B10/00
CPC分类号： G01N1/2813 , G01N15/1484
摘要： An apparatus for processing a specimen from a fluid sample includes a first set of one or more microfluidic channels configured to deliver the sample fluid to a filter disposed on an inflatable bladder configured to transfer the specimen from the filter to a slide. The apparatus is configured to collect an approximate monolayer of particles and includes a second set of one or more microfluidic channels configured to remove fluid flowing through the filter disposed on the inflatable bladder. The apparatus also includes a pressure source, a sample container connected to the pressure source and the first set of one or more microfluidic channels, a fluid flow gauge configured to measure a fluid flow rate through the filter, and a stain source connected to the first set of one or more microfluidic channels.
摘要翻译：用于从流体样品处理样本的装置包括第一组一个或多个微流体通道，其被配置为将样品流体递送到布置在可膨胀囊上的过滤器，所述过滤器构造成将样品从过滤器转移到载玻片。该装置被配置为收集大致单层的颗粒，并且包括第二组一个或多个微流体通道，其被配置为去除流过设置在可充气囊上的过滤器的流体。该装置还包括压力源，连接到压力源的样品容器和第一组一个或多个微流体通道，流量计，其配置成测量通过过滤器的流体流速，以及污染源，连接到第一一组或多个微流体通道。

9. 发明授权

US07225005B2 Optical determination of in vivo properties 失效
标题翻译：光学测定体内特性
公开(公告)号：US07225005B2
公开(公告)日：2007-05-29
申请号：US11011714
申请日：2004-12-14
申请人： Howard B. Kaufman , Alex R. Zelenchuk
发明人： Howard B. Kaufman , Alex R. Zelenchuk
IPC分类号： A61B5/00
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/489 , A61B5/681 , A61B5/6824 , A61B5/742
摘要： A system and method for determining an in vivo property of a tissue or blood is described. The in vivo property may be a hematocrit value, a hemoglobin concentration, or a combination thereof. The system can automatically determine a location of a subcutaneous blood vessel. Based on the automatically determined location, the system illuminates the blood vessel with a light beam and detects light resulting from the illumination. The system determines the in vivo property based on the detected light. Alternatively, or in combination, the system displays an image corresponding to a spatial relationship between a subcutaneous blood vessel and a light beam. Based on the image, an operator can adjust the light beam with respect to the blood vessel to have a selected spatial relationship. The system determines an in vivo property based on the illumination of the blood vessel when the light beam has the selected spatial relationship.
摘要翻译：描述了用于确定组织或血液的体内特性的系统和方法。体内性质可以是血细胞比容值，血红蛋白浓度或其组合。系统可以自动确定皮下血管的位置。基于自动确定的位置，系统用光束照射血管并检测照明产生的光。该系统基于检测到的光来确定体内特性。或者或组合地，系统显示对应于皮下血管和光束之间的空间关系的图像。基于图像，操作者可以相对于血管调节光束以具有选定的空间关系。当光束具有选择的空间关系时，该系统基于血管的照明确定体内特性。

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