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1. 发明授权

US06282448B1 Self applied and self adjusting device and method for prevention of deep vein thrombosis with movement detection 有权
标题翻译：自适应和自动调节装置及预防深静脉血栓形成与运动检测的方法
公开(公告)号：US06282448B1
公开(公告)日：2001-08-28
申请号：US09313806
申请日：1999-05-18
申请人： Amiram Katz , Orly Katz
发明人： Amiram Katz , Orly Katz
IPC分类号： A61N108
CPC分类号： A61N1/321 , A61N1/36003 , Y10S128/15
摘要： An elongated rectangular cuff having electrodes combined with a motion detector for detecting muscle contraction with an attached control unit for providing a predetermined electrical signal to the electrodes. The predetermined electrical signal is substantially a square wave with a duration of between 0.1 and 0.3 milliseconds, a frequency of between 0.1 and 0.5 Hertz, with 5 to 15 repetitions delivered every 5 to 15 minute intervals. The control unit provides a controllable intensity of between 0.20 to 4 milliamperes, and a voltage between 1 and 200 volts at an output resistance of substantially 50 kilo Ohms. The cuff or sleeve, when wrapped around a user's leg and positioned below the knee such that the electrodes contact the calf muscles, causes a muscle and nerve stimulation resulting in contraction of the calf muscle. A motion detector monitors the contraction and provides feedback to the control unit to adjust the signal. Blood flow is therefore increased regardless of body position or movement greatly decreasing the possibility of developing deep vein thrombosis or pulmonary embolism, which may be fatal. In addition it reduces ankle edema and leg discomfort associated with prolonged sitting. In addition it prevents orthostatic hypotension. An applied signal is continuously adjusted resulting in little risk of harm to the user.
摘要翻译：一种细长矩形袖带，其具有与用于检测肌肉收缩的运动检测器的电极，所述运动检测器具有附接的控制单元，用于向电极提供预定的电信号。预定的电信号基本上是持续时间在0.1和0.3毫秒之间，频率在0.1和0.5赫兹之间的方波，每5到15分钟间隔传送5到15次。控制单元在大约50千欧姆的输出电阻下提供0.20至4毫安之间的可控强度和1至200伏特之间的电压。袖口或袖子当缠绕在使用者的腿部并且位于膝盖下方以使得电极与小腿肌肉接触时，引起肌肉和神经刺激，导致小腿肌肉的收缩。运动检测器监视收缩并向控制单元提供反馈以调整信号。因此，无论身体位置或运动如何，血液流量都会增加，大大降低发生深静脉血栓形成或肺栓塞的可能性，这可能是致命的。此外，它减少与长期坐着相关的脚踝水肿和腿部不适。此外，它还能防止体位性低血压。应用信号被连续调整，导致对用户的危害很小。

2. 发明授权

US06002965A Self applied device and method for prevention of deep vein thrombosis 失效
标题翻译：自适应装置及预防深静脉血栓形成的方法
公开(公告)号：US06002965A
公开(公告)日：1999-12-14
申请号：US94512
申请日：1998-06-10
申请人： Amiram Katz , Orly Katz
发明人： Amiram Katz , Orly Katz
IPC分类号： A61N1/32 , A61N1/24 , A61N1/18 , A61N1/22
CPC分类号： A61N1/321 , A61N1/36003 , Y10S128/15
摘要： An elongated rectangular cuff having fasteners and electrodes with an attached control unit for providing a predetermined electrical signal to the electrodes. The predetermined electrical signal is substantially a square wave with a duration of between 0.1 and 0.3 milliseconds, a frequency of between 0.1 and 0.5 Hertz, with 5 to 15 repetitions delivered every 5 to 15 minute intervals. The control unit provides a controllable intensity of between 1 to 20 milliamperes. The cuff or sleeve, when wrapped around a user's leg and positioned below the knee such that the electrodes contact the calf muscles, causes a muscle and nerve stimulation resulting in contraction of the calf muscle. Blood flow is therefore increased regardless of body position or a movement greatly decreasing the possibility of developing deep vein thrombosis or pulmonary embolism, which may be fatal. In addition it reduces ankle edema and leg discomfort associated with prolonged sitting. A predetermined applied signal is safe with little risk of harm to the user. Additionally, preferably the control unit has a single external control for controlling intensity preventing a user from applying an inappropriate signal. A simple to use, compact device and method is disclosed that can safely be used by individuals having no prior knowledge of anatomy, effectively during extended periods of sitting or immobility, such as when traveling.
摘要翻译：具有紧固件和电极的细长矩形箍，其具有附接的控制单元，用于向电极提供预定的电信号。预定的电信号基本上是持续时间在0.1和0.3毫秒之间，频率在0.1和0.5赫兹之间的方波，每5到15分钟间隔传送5到15次。控制单元提供1至20毫安之间的可控强度。袖口或袖子当缠绕在使用者的腿部并且位于膝盖下方以使得电极与小腿肌肉接触时，引起肌肉和神经刺激，导致小腿肌肉的收缩。因此，不管身体位置或运动大大降低发生深静脉血栓形成或肺栓塞的可能性，血液流动可能是致命的。此外，它减少与长期坐着相关的脚踝水肿和腿部不适。预定的应用信号是安全的，对用户几乎没有危害的风险。此外，优选地，控制单元具有用于控制防止用户施加不适当信号的强度的单个外部控制。公开了一种易于使用，紧凑的装置和方法，可以在长时间的坐着或不动时（例如旅行时）有效地安全地使用具有解剖学先验知识的个体。

3. 发明授权

US5643331A Method and device for prevention of deep vein thrombosis 失效
标题翻译：用于预防深静脉血栓形成的方法和装置
公开(公告)号：US5643331A
公开(公告)日：1997-07-01
申请号：US561372
申请日：1995-11-21
申请人： Amiram Katz
发明人： Amiram Katz
IPC分类号： A61N1/36 , A61N1/03 , A61N1/04
CPC分类号： A61N1/36014
摘要： An electrical stimulator and method of prevention of deep vein thrombosis, ankle edema, and venostasis. An electronic circuit that includes a power source and a micro controller for processing the signals generated by a duration control circuit, a frequency control circuit, and an intensity control circuit so as to generate a square wave pattern or wave form having a controllable duration ranging between 0.1 to 0.3 milliseconds, a controllable frequency ranging between 0.001 to 0.1 cycles per seconds, and a controllable intensity ranging between 1 to 20 milliamperes. In application, an electrode portion having an exposed juxtapositioned anode and cathode is secured to the patient externally at or near the tibial nerve at the popliteal fossa, on both legs. The specific wave pattern generated stimulates the nerve causing a muscle contraction, whether passively or actively, of the calves which prevents deep vein thrombosis, ankle edema, and venostasis.
摘要翻译：电刺激剂和预防深静脉血栓形成，踝水肿和静脉血栓的方法。一种电子电路，其包括用于处理由持续时间控制电路，频率控制电路和强度控制电路产生的信号的电源和微控制器，以便产生具有可控持续时间范围的方波模式或波形， 0.1至0.3毫秒，可控频率范围在0.001至0.1个循环/秒之间，可控制的强度范围在1至20毫安之间。在应用中，具有暴露并置的阳极和阴极的电极部分在两条腿上在al窝处的胫神经处或附近被固定到患者身上。所产生的特定波形刺激神经，导致肌肉收缩，无论是被动还是主动的，防止深静脉血栓形成，踝水肿和静脉血栓。

4. 外观设计

USD432240S Electronic cuff for stimulation 失效
公开(公告)号：USD432240S
公开(公告)日：2000-10-17
申请号：US113950
申请日：1999-11-15
申请人： Amiram Katz , Orly Katz
设计人： Amiram Katz , Orly Katz

5. 发明授权

US10420923B1 Method and device for intrathecal administering of immunoglobulin 有权
公开(公告)号：US10420923B1
公开(公告)日：2019-09-24
申请号：US15210076
申请日：2016-07-14
申请人： Amiram Katz
发明人： Amiram Katz
IPC分类号： A61M39/02 , A61M39/04 , C07K16/06 , A61M25/00 , A61M39/22 , A61B17/34
摘要： A device for providing an implanted injection site capable of delivering a therapeutic substance or medication into the subarachnoid space. The receiving compartment is implanted under the skin adjacent the spine. Injections may be made repeatedly into the membrane for delivering the therapeutic substance without the need for repeated spinal taps. Medications such as immunoglobulin may be administered intrathecally directly into the central nervous system bypassing the blood brain barrier providing more concentrated, effective and less costly treatment of diseases such as Alzheimer's disease. Another embodiment is a method of administering an immunoglobulin composition having a four to six percent concentration incrementally over time by alternately removing cerebrospinal fluid and injecting the immunoglobulin composition.

6. 发明授权

US09610336B1 Immunotherapy for lyme disease 有权
公开(公告)号：US09610336B1
公开(公告)日：2017-04-04
申请号：US14799553
申请日：2015-07-14
申请人： Amiram Katz
发明人： Amiram Katz
IPC分类号： A61K39/02 , A61K49/00 , A61K39/395 , C07K16/12 , A61K39/00
CPC分类号： A61K39/0225 , A61K2039/505 , A61K2039/521 , A61K2039/545 , C07K16/1207 , C07K2317/76 , Y02A50/401
摘要： Diseases caused by a spirochete bacteria are treated. Doses of an anti-flagellin monoclonal antibody, spirochetal protein, or Lyme lysate are used in predetermined increasing doses to effectively treat diseases and symptoms caused by spirochete bacteria, and in particular Lyme disease.

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