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1. 发明申请

US20110192969A1 METHOD AND APPARATUS FOR ION MANIPULATION USING MESH IN A RADIO FREQUENCY FIELD 有权
标题翻译：使用无线电频域中的网络进行离子控制的方法和装置
公开(公告)号：US20110192969A1
公开(公告)日：2011-08-11
申请号：US13056167
申请日：2008-07-28
申请人： Anatoli N. Verentchikov
发明人： Anatoli N. Verentchikov
IPC分类号： H01J49/26 , H01J49/36
CPC分类号： H01J49/062
摘要： Ion manipulation systems include ion repulsion by an RF field penetrating through a mesh. Another comprises trapping ions in a symmetric RF field around a mesh. The system uses macroscopic parts, or readily available fine meshes, or miniaturized devices made by MEMS, or flexible PCB methods. One application is ion transfer from gaseous ion sources with focusing at intermediate and elevated gas pressures. Another application is the formation of pulsed ion packets for TOF MS within trap array. Such trapping is preferably accompanied by pulsed switching of RF field and by gas pulses, preferably formed by pulsed vapor desorption. Ion guidance, ion flow manipulation, trapping, preparation of pulsed ion packets, confining ions during fragmentation or exposure to ion to particle reactions and for mass separation are disclosed. Ion chromatography employs an ion passage within a gas flow and through a set of multiple traps with a mass dependent well depth.
摘要翻译：离子操纵系统包括穿过网状物的RF场的离子斥力。另一种方法包括在一个网格周围的一个对称的RF场中捕获离子。该系统使用宏观部件或易于获得的精细网格，或由MEMS制造的小型化设备或柔性PCB方法。一种应用是来自气体离子源的离子传递，在中等和高气体压力下聚焦。另一个应用是在陷阱阵列内形成用于TOF MS的脉冲离子包。这种捕获优选伴随着RF场和气体脉冲的脉冲切换，优选通过脉冲蒸汽解吸形成。公开了离子引导，离子流动操作，捕获，脉冲离子包的制备，分裂期间的限制离子或暴露于离子到颗粒反应和质量分离。离子色谱法在气流中使用离子通道，并通过一组具有质量依赖阱深度的多个阱。

2. 发明授权

US07326925B2 Multi-reflecting time-of-flight mass spectrometer with isochronous curved ion interface 有权
标题翻译：具有同步弯曲离子界面的多反射飞行时间质谱仪
公开(公告)号：US07326925B2
公开(公告)日：2008-02-05
申请号：US11277181
申请日：2006-03-22
申请人： Anatoli N. Verentchikov , Mikhail Yavor
发明人： Anatoli N. Verentchikov , Mikhail Yavor
IPC分类号： H01J49/40
CPC分类号： H01J49/408 , H01J49/406 , H01J49/48
摘要： The present invention relates generally to a multi-reflecting time-of-flight mass spectrometer (MR TOF MS). To improve mass resolving power of a planar MR TOF MS, a spatially isochronous and curved interface may be used for ion transfer in and out of the MR TOF analyzer. One embodiment comprises a planar grid-free MR TOF MS with periodic lenses in the field-free space, a linear ion trap for converting ion flow into pulses and a C-shaped isochronous interface made of electrostatic sectors. The interface allows transferring ions around the edges and fringing fields of the ion mirrors without introducing significant time spread. The interface may also provide energy filtering of ion packets. The non-correlated turn-around time of ion trap converter may be reduced by using a delayed ion extraction from the ion trap and excessive ion energy is filtered in the curved interface.
摘要翻译：本发明一般涉及多反射飞行时间质谱仪（MR TOF MS）。为了提高平面MR TOF MS的质量分辨能力，可以使用空间等时和弯曲界面来进出MR TOF分析仪的离子传输。一个实施例包括在无场空间中具有周期性透镜的平面无栅MR TOF MS，用于将离子流转换成脉冲的线性离子阱和由静电扇区构成的C形等时接口。该界面允许在离子镜的边缘和边缘场附近转移离子，而不会引入显着的时间扩散。界面还可以提供离子包的能量过滤。离子阱转换器的非相关周转时间可以通过使用来自离子阱的延迟离子提取而减少，并且过多的离子能量在弯曲界面中被过滤。

3. 发明授权

US07196324B2 Tandem time of flight mass spectrometer and method of use 有权
标题翻译：串联飞行时间质谱仪和使用方法
公开(公告)号：US07196324B2
公开(公告)日：2007-03-27
申请号：US10520871
申请日：2003-04-29
申请人： Anatoli N. Verentchikov
发明人： Anatoli N. Verentchikov
IPC分类号： H01J49/40
CPC分类号： H01J49/40 , H01J49/004
摘要： To provide comprehensive MS—MS analysis, a time-nested separation is employed using two time-of-flight (TOF) mass spectrometers. Parent ions are separated in a slow and long TOF1, operating at low ion energy (1 to 100eV), and fragment ions are mass analyzed in a fast and short TOF2, operating at much higher keV energy. A low energy fragmentation cell between TOF1 and TOF2 is tailored to accelerate fragmentation and dampening steps, mostly by shortening the cell and employing higher gas pressure. Slow separation in TOF1 becomes possible with an introduction of novel TOF1 analyzers. Higher performance is expected with the use of novel hybrid TOF1 analyzers, combining radio frequency (RF) and quadratic DC fields. An RF field retains low-energy ions within a TOF1 analyzer, while a quadratic DC field improves resolution by compensating for a large relative energy spread.
摘要翻译：为了提供综合的MS-MS分析，使用两个飞行时间（TOF）质谱仪进行时间嵌套分离。母体离子在慢和长的TOF 1中分离，以低离子能（1至100eV）运行，碎片离子在快和短的TOF 2中进行质量分析，操作在高得多的keV能量。 TOF 1和TOF 2之间的低能量破碎细胞被定制以加速碎裂和阻尼步骤，主要是通过缩短电池并采用更高的气体压力。使用新型TOF 1分析仪引入TOF 1中的慢速分离。通过使用新型混合TOF 1分析仪，结合射频（RF）和二次直流场，可以期待更高的性能。 RF场保持TOF 1分析仪内的低能离子，而二次DC场通过补偿大的相对能量扩展来提高分辨率。

4. 发明授权

US06504150B1 Method and apparatus for determining molecular weight of labile molecules 有权
标题翻译：确定不稳定分子的分子量的方法和装置
公开(公告)号：US06504150B1
公开(公告)日：2003-01-07
申请号：US09579989
申请日：2000-05-26
申请人： Anatoli N. Verentchikov , Marvin L. Vestal , Igor P. Smirnov
发明人： Anatoli N. Verentchikov , Marvin L. Vestal , Igor P. Smirnov
IPC分类号： H01J4940
CPC分类号： H01J49/164
摘要： A mass spectrometer instrument for determining the molecular weight of labile molecules of biological importance, in particular heavy molecules, such as proteins, peptides or DNA oligomers, is disclosed. The instrument includes a MALDI ion source that is enclosed in a chamber with an inlet for admitting a gas and an ion sampling aperture for limiting gas flow from the chamber. The elevated pressure of the source in the range from 0.1 to 10 torr causes low energy collisions between the gas and the ions that can cause rapid collisional cooling of the excited ions, thereby improving the stability of the produced ions. The formation of clusters of ions (e.g., protein ions) with matrix materials is broken without fragmenting the ions by increasing the downstream gas temperature to between 150 and 250° C. Operating the source at laser energy at least two times higher than the threshold value of ion formation and using a high repetition rate laser significantly improves sensitivity of analysis and speed of data acquisition.
摘要翻译：公开了用于确定生物重要性的不稳定分子的分子量的质谱仪，特别是重分子，例如蛋白质，肽或DNA寡聚体。仪器包括一个MALDI离子源，该离子源封闭在具有用于允许气体的入口和用于限制来自腔室的气体流的离子采样孔的腔室中。源极的高压在0.1至10托的范围内导致气体和离子之间的低能量碰撞，其可引起被激发的离子的快速碰撞冷却，从而提高所产生的离子的稳定性。通过将下游气体温度升高到150和250℃之间，使用基质材料形成离子簇（例如，蛋白质离子）而不破坏离子，将激光能量的操作比阈值至少高两倍的离子形成和使用高重复率激光器显着提高了分析的灵敏度和数据采集的速度。

5. 发明授权

US06483109B1 Multiple stage mass spectrometer 失效
标题翻译：多级质谱仪
公开(公告)号：US06483109B1
公开(公告)日：2002-11-19
申请号：US09648643
申请日：2000-08-25
申请人： Bruce B. Reinhold , Anatoli N. Verentchikov
发明人： Bruce B. Reinhold , Anatoli N. Verentchikov
IPC分类号： B01D5944
CPC分类号： H01J49/424 , H01J49/004 , H01J49/422
摘要： A highly sensitive multiple stage (MSn) mass spectrometer is disclosed, capable of eliminating losses of ions during the isolation stage. Ions of interest are isolated (by m/z value) without rejecting ions of other m/z values, permitting the selected ions to be dissociated, while the rest of the ion population is available for subsequent isolation, dissociation and analysis of fragment ions. One preferred instrument includes a pulsed ion source coupled with a linear array of mass selective ion trap devices, at least one trap being coupled to an external ion detector. Each ion trap is configured with a storing cell for ion trapping interspersed between a pair of guarding cells, all aligned along their z axis. Radio frequency (RF) and direct current (DC) voltages are applied to electrodes of the ion trap device to retain ions within the storing cells. Each trapping cell has a sub-region in which the dynamical motion of the ion exhibits m/z-dependent resonance frequencies along the z direction, allowing the ion motion to be selectively excited by m/z value. The AC voltages can be combined with time-resolved changes in the applied DC voltages to enable individual trapping cell to be switched between ion trapping, mass selecting and ion fragmenting modes. Ions may be selectively transferred between ions traps, and selectively dissociated within each trap to enable a higher sensitivity MSn operation. Various ion trapping devices are disclosed, namely, harmonic linear traps, Paul traps, and quadrupole traps.
摘要翻译：公开了一种高灵敏度的多级（MSn）质谱仪，能够消除隔离阶段的离子损失。感兴趣的离子被隔离（通过m / z值），而不排除其他m / z值的离子，允许选择的离子解离，而剩余的离子群可用于碎片离子的随后的分离，解离和分析。一个优选的仪器包括与质量选择性离子阱装置的线性阵列耦合的脉冲离子源，至少一个陷阱耦合到外部离子检测器。每个离子阱配置有一个存储单元，用于散布在一对保护单元之间的离子阱，所有保护单元都沿其z轴排列。将射频（RF）和直流（DC）电压施加到离子阱装置的电极以将离子保持在存储单元内。每个俘获池具有其中离子的动态运动沿z方向显示m / z相关共振频率的子区域，允许离子运动由m / z值选择性地激发。 AC电压可以与所施加的直流电压中的时间分辨变化相结合，以使各个陷阱单元在离子捕获，质量选择和离子分割模式之间切换。离子可以在离子阱之间选择性地转移，并且在每个阱内选择性地分离，以实现更高的灵敏度MSn操作。公开了各种离子捕获装置，即谐波线性阱，保护阱和四极阱。

6. 发明授权

US09425034B2 Quasi-planar multi-reflecting time-of-flight mass spectrometer 有权
标题翻译：准平面多反射飞行时间质谱仪
公开(公告)号：US09425034B2
公开(公告)日：2016-08-23
申请号：US13054728
申请日：2008-07-16
申请人： Anatoli N. Verentchikov , Mikhail I. Yavor
发明人： Anatoli N. Verentchikov , Mikhail I. Yavor
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/406 , H01J49/0031 , H01J49/22
摘要： A multi-reflecting time-of-flight (MR-TOF) mass spectrometer, which includes two quasi-planar electrostatic ion mirrors extended along drift direction (Z) and is formed of parallel electrodes, separated by a field-free region. The MR-TOF includes a pulsed ion source to release ion packets at a small angle to X-direction which is orthogonal to the drift direction Z. Ion packets are reflected between ion mirrors and drift along the drift direction. The mirrors are arranged to provide time-of-flight focusing ion packets on the receiver. The MR-TOF mirrors provide spatial focusing in the Y-direction orthogonal to both drift direction Z and ion injection direction X. In a preferred embodiment, at least one mirror has a feature providing periodic spatial focusing of ion packets in the drift Z-direction.
摘要翻译：多反射飞行时间（MR-TOF）质谱仪，其包括沿着漂移方向（Z）延伸的两个准平面静电离子反射镜，并且由平行电极形成，由无场区域分开。 MR-TOF包括脉冲离子源，以与漂移方向Z正交的X方向以小角度释放离子包。离子包在离子反射镜之间反射并沿着漂移方向漂移。这些反射镜被设置成在接收器上提供飞行时间聚焦离子包。 MR-TOF反射镜在与漂移方向Z和离子注射方向X正交的Y方向上提供空间聚焦。在优选实施例中，至少一个反射镜具有提供离子包在漂移Z方向上的周期性空间聚焦的特征。

7. 发明授权

US07772547B2 Multi-reflecting time-of-flight mass spectrometer with orthogonal acceleration 有权
标题翻译：具有正交加速度的多反射飞行时间质谱仪
公开(公告)号：US07772547B2
公开(公告)日：2010-08-10
申请号：US11548556
申请日：2006-10-11
申请人： Anatoli N. Verentchikov
发明人： Anatoli N. Verentchikov
IPC分类号： B01D59/44
CPC分类号： H01J49/401 , H01J49/406
摘要： The disclosed apparatus includes a multi-reflecting time-of-flight mass spectrometer (MR-TOF MS) and an orthogonal accelerator. To improve the duty cycle of the ion injection at a low repetition rate dictated by a long flight in the MR-TOF MS, multiple measures may be taken. The incoming ion beam and the accelerator may be oriented substantially transverse to the ion path in the MR-TOF, while the initial velocity of the ion beam is compensated by tilting the accelerator and steering the beam for the same angle. To further improve the duty cycle of any multi-reflecting or multi-turn mass spectrometer, the beam may be time-compressed by modulating the axial ion velocity with an ion guide. The residence time of the ions in the accelerator may be improved by trapping the beam within an electrostatic trap. Apparatuses with a prolonged residence time in the accelerator provide improvements in both sensitivity and resolution.
摘要翻译：所公开的装置包括多反射飞行时间质谱仪（MR-TOF MS）和正交加速器。为了在MR-TOF MS中以长飞行所指示的低重复率提高离子注入的占空比，可以采取多种措施。入射离子束和加速器可以基本上横向于MR-TOF中的离子路径定向，同时离子束的初始速度通过倾斜加速器并以相同的角度转向束来补偿。为了进一步改善任何多反射或多圈质谱仪的占空比，可以通过用离子导向器调节轴向离子速度来对束进行时间压缩。离子在促进剂中的停留时间可以通过将光束捕获在静电捕获器中来改善。在加速器中延长停留时间的装置提高了灵敏度和分辨率。

8. 发明授权

US08373120B2 Method and apparatus for ion manipulation using mesh in a radio frequency field 有权
标题翻译：在射频场中使用网格进行离子操作的方法和装置
公开(公告)号：US08373120B2
公开(公告)日：2013-02-12
申请号：US13056167
申请日：2008-07-28
申请人： Anatoli N. Verentchikov
发明人： Anatoli N. Verentchikov
IPC分类号： H01J49/26 , B01D59/44
CPC分类号： H01J49/062
摘要： Ion manipulation systems include ion repulsion by an RF field penetrating through a mesh. Another comprises trapping ions in a symmetric RF field around a mesh. The system uses macroscopic parts, or readily available fine meshes, or miniaturized devices made by MEMS, or flexible PCB methods. One application is ion transfer from gaseous ion sources with focusing at intermediate and elevated gas pressures. Another application is the formation of pulsed ion packets for TOF MS within trap array. Such trapping is preferably accompanied by pulsed switching of RF field and by gas pulses, preferably formed by pulsed vapor desorption. Ion guidance, ion flow manipulation, trapping, preparation of pulsed ion packets, confining ions during fragmentation or exposure to ion to particle reactions and for mass separation are disclosed. Ion chromatography employs an ion passage within a gas flow and through a set of multiple traps with a mass dependent well depth.
摘要翻译：离子操纵系统包括穿过网状物的RF场的离子斥力。另一种方法包括在一个网格周围的一个对称的RF场中捕获离子。该系统使用宏观部件或易于获得的精细网格，或由MEMS制造的小型化设备或柔性PCB方法。一种应用是来自气体离子源的离子传递，在中等和高气体压力下聚焦。另一个应用是在陷阱阵列内形成用于TOF MS的脉冲离子包。这种捕获优选伴随着RF场和气体脉冲的脉冲切换，优选通过脉冲蒸汽解吸形成。公开了离子引导，离子流动操作，捕获，脉冲离子包的制备，分裂期间的限制离子或暴露于离子到颗粒反应和质量分离。离子色谱法在气流中使用离子通道，并通过一组具有质量依赖阱深度的多个阱。

9. 发明申请

US20110186729A1 QUASI-PLANAR MULTI-REFLECTING TIME-OF-FLIGHT MASS SPECTROMETER 有权
标题翻译： QUASI-PLANAR多重反射飞行时间质谱仪
公开(公告)号：US20110186729A1
公开(公告)日：2011-08-04
申请号：US13054728
申请日：2008-07-16
申请人： Anatoli N. Verentchikov , Mikhail I. Yavor
发明人： Anatoli N. Verentchikov , Mikhail I. Yavor
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/0031 , H01J49/22
摘要： A multi-reflecting time-of-flight (MR-TOF) mass spectrometer, which includes two quasi-planar electrostatic ion mirrors extended along drift direction (Z) and is formed of parallel electrodes, separated by a field-free region. The MR-TOF includes a pulsed ion source to release ion packets at a small angle to X-direction which is orthogonal to the drift direction Z. Ion packets are reflected between ion mirrors and drift along the drift direction. The mirrors are arranged to provide time-of-flight focusing ion packets on the receiver. The MR-TOF mirrors provide spatial focusing in the Y-direction orthogonal to both drift direction Z and ion injection direction X. In a preferred embodiment, at least one mirror has a feature providing periodic spatial focusing of ion packets in the drift Z-direction.
摘要翻译：多反射飞行时间（MR-TOF）质谱仪，其包括沿着漂移方向（Z）延伸的两个准平面静电离子反射镜，并且由平行电极形成，由无场区域分开。 MR-TOF包括脉冲离子源，以与漂移方向Z正交的X方向以小角度释放离子包。离子包在离子反射镜之间反射并沿着漂移方向漂移。这些反射镜被设置成在接收器上提供飞行时间聚焦离子包。 MR-TOF反射镜在与漂移方向Z和离子注射方向X正交的Y方向上提供空间聚焦。在优选实施例中，至少一个反射镜具有提供离子包在漂移Z方向上的周期性空间聚焦的特征。

10. 发明授权

US07582864B2 Linear ion trap with an imbalanced radio frequency field 有权
标题翻译：具有不平衡射频场的线性离子阱
公开(公告)号：US07582864B2
公开(公告)日：2009-09-01
申请号：US11614287
申请日：2006-12-21
申请人： Anatoli N. Verentchikov
发明人： Anatoli N. Verentchikov
IPC分类号： B01D59/44 , H01J49/42
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/427
摘要： An imbalanced radio frequency (RF) field creates a retarding barrier near the exit aperture of a multipole ion guide, in combination with the extracting DC field such that the barrier provides an m/z dependent cut of ion sampling. Contrary to the prior art, the mass dependent sampling provides a well-conditioned ion beam suitable for other mass spectrometric devices. The mass selective sampling is suggested for improving duty cycle of o-TOF MS, for injecting ions into a multi-reflecting TOF MS in a zoom mode, for parallel MS-MS analysis in a trap-TOF MS, as well as for moderate mass filtering in fragmentation cells and ion reactors. With the aid of resonant excitation, the mass selective ion sampling is suggested for mass analysis.
摘要翻译：不平衡射频（RF）场在多极离子导向器的出口孔附近产生延迟屏障，结合提取DC场，使得势垒提供离子采样的m / z依赖切割。与现有技术相反，质量依赖取样提供了适合于其它质谱装置的良好条件的离子束。建议质量选择性采样用于改善o-TOF MS的占空比，用于以缩放模式将离子注入到多反射TOF MS中，用于捕获TOF MS中的并行MS-MS分析，以及中等质量在碎裂细胞和离子反应器中过滤。在谐振激励的帮助下，质量选择离子采样建议用于质量分析。

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