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1. 发明授权

US11881387B2 TOF MS detection system with improved dynamic range 有权
公开(公告)号：US11881387B2
公开(公告)日：2024-01-23
申请号：US17056965
申请日：2019-05-23
申请人： Micromass UK Limited
发明人： Anatoly Verenchikov
IPC分类号： H01J49/40 , H01J49/00 , H01J49/02 , H01J49/06
CPC分类号： H01J49/406 , H01J49/005 , H01J49/0036 , H01J49/025 , H01J49/061 , H01J49/401
摘要： Apparatus and method are proposed for the strong improvement of dynamic range (DR) of detectors and of data systems for time-of-flight mass spectrometers (TOF MS) with periodically repetitive signals. TOF separated ions are converted into secondary particles, primarily electrons, and the flow of secondary particles is controllably attenuated to sustain the data acquisition system in a counting mode above the electronic noise threshold. The acquisition time is split between at least two time segments, characterized by alternated transmission efficiency SE of secondary particles. Using strong electron suppression (SE«1) is employed for recording intense ion peak, while counting ions with either ADC, or TDC, or ADC with extracting peak centroids. A longer time segment employs an efficient electron transfer (SE=1) for detecting weak ion species. In another independent aspect, an ion-optical element is provided upstream of the ion detector and is configured to deflect, reflect or retard ions such that ions that have been scattered or fragmented in the time of flight region do not impact on the ion detector.

2. 发明公开

US20230386817A1 TIME-OF-FLIGHT MASS SPECTROMETER AND TUNING METHOD FOR THE SAME 审中-公开
公开(公告)号：US20230386817A1
公开(公告)日：2023-11-30
申请号：US18295900
申请日：2023-04-05
申请人： Shimadzu Corporation
发明人： Kosuke UCHIYAMA , Tomoyuki OSHIRO
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： In a TOFMS measurement unit, an ion acceleration section accelerates ions to send them into a flight space, within which a flight-field creation section creates, an electric field for causing ions to fly. A controller unit operates the measurement unit so as to repeat a measurement for a predetermined sample while varying a voltage applied to an electrode in the measurement unit, and calculates mass-resolving power based on each measurement result. An approximate function calculator unit finds an approximate function representing a relationship between the voltage and the mass-resolving power, based on data of combinations of the voltage and the mass-resolving power obtained under the control of the controller unit. A voltage determiner unit determines a voltage value corresponding to a target value of the mass-resolving power by the approximate function, and determines the voltage value as a voltage to be applied to the electrode in the TOFMS concerned.

3. 发明授权

US11791147B2 Mass spectrometer and method for analysing a gas by mass spectrometry 有权
公开(公告)号：US11791147B2
公开(公告)日：2023-10-17
申请号：US17280694
申请日：2019-08-12
申请人： Leybold GmbH
发明人： Anthony Hin Yiu Chung , Thorsten Benter , Michel Aliman , Rudiger Reuter , Yessica Brachthaeuser
IPC分类号： H01J49/24 , H01J49/04 , H01J49/40
CPC分类号： H01J49/0468 , H01J49/0422 , H01J49/24 , H01J49/401
摘要： The invention relates to a mass spectrometer for analysing a gas by mass spectrometry, comprising: a controllable inlet system for pulsed feeding of the gas to be analysed from a process region outside the mass spectrometer into an ionisation region, an ionisation device for ionising the gas to be analysed in the ionisation region, an ion transfer device for transferring the ionised gas from a ionisation region via an ion transfer region into an analysis region, and an analyser for detecting the ionised gas in the analysis region. The invention further relates to an associated method for mass spectrometrically analysing a gas.

4. 发明公开

US20230170204A1 ACCELERATOR FOR MULTI-PASS MASS SPECTROMETERS 审中-公开
公开(公告)号：US20230170204A1
公开(公告)日：2023-06-01
申请号：US18159300
申请日：2023-01-25
申请人： Micromass UK Limited
发明人： Anatoly Verenchikov , Mikhail Yavor
IPC分类号： H01J49/40 , H01J49/00 , H01J49/02 , H01J49/06 , H01J49/16 , H01J49/42
CPC分类号： H01J49/406 , H01J49/0031 , H01J49/025 , H01J49/061 , H01J49/164 , H01J49/401 , H01J49/405 , H01J49/4245
摘要： Improved pulsed ion sources and pulsed converters are proposed for multi-pass time-of-flight mass spectrometer, either multi-reflecting (MR) or multi-turn (MT) TOF. A wedge electrostatic field 45 is arranged within a region of small ion energy for electronically controlled tilting of ion packets 54 time front. Tilt angle γ of time front 54 is strongly amplified by a post-acceleration in a flat field 48. Electrostatic deflector 30 downstream of the post-acceleration 48 allows denser folding of ion trajectories, whereas the injection mechanism allows for electronically adjustable mutual compensation of the time front tilt angle, i.e. γ=0 for ion packet in location 55, for curvature of ion packets, and for the angular energy dispersion. The arrangement helps bypassing accelerator 40 rims, adjusting ion packets inclination angles α2, and what is most important, compensating for mechanical misalignments of the optical components.

5. 发明授权

US10020181B2 Time-of-flight mass spectrometer 有权
公开(公告)号：US10020181B2
公开(公告)日：2018-07-10
申请号：US15504541
申请日：2014-08-19
申请人： SHIMADZU CORPORATION
发明人： Daisuke Okumura
IPC分类号： H01J49/40 , H01J49/06
CPC分类号： H01J49/401 , H01J49/0045 , H01J49/062 , H01J49/24 , H01J49/40
摘要： An ion transport optical system is disposed between a collision cell and an orthogonal acceleration unit. When releasing ions that are held in the collision cell, an accelerating electric field in which a large potential difference exists is created between an exit-side end of an ion guide and a first stage of the ion transport optical system, and a decelerating electric field in which a relatively small potential difference exists is created between a final stage of the ion transport optical system and an entrance end of the orthogonal acceleration unit. In the accelerating electric field, the velocity of ions is increased overall by imparting a large amount of energy to the ions, and spreading of ions in the ion travel direction that is caused by differences between the mass-to-charge ratios of the ions is reduced.

6. 发明授权

US09997345B2 Orthogonal acceleration coaxial cylinder mass analyser 有权
公开(公告)号：US09997345B2
公开(公告)日：2018-06-12
申请号：US15301179
申请日：2015-04-01
申请人： MICROMASS UK LIMITED
发明人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/40 , H01J49/42 , H01J49/02
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/025 , H01J49/406 , H01J49/4245 , H01J49/427
摘要： A mass analyzer is disclosed comprising an annular ion guide comprising a first annular ion guide section and a second annular ion guide section, wherein the annular ion guide comprises: (i) an inner cylindrical electrode arrangement which is axially segmented and comprises a plurality of first electrodes and (ii) an outer cylindrical electrode arrangement which is axially segmented and comprises a plurality of second electrodes. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits. Ions are orthogonally accelerated from the first annular ion guide section into the second annular ion guide section and one or more parabolic DC potentials are maintained along a portion of the second annular ion guide section so that ions undergo simple harmonic motion. An inductive ion detector is arranged and adapted to detect ions within the second annular ion guide section.

7. 发明申请

US20180158665A1 APPARATUS FOR DETECTING CONSTITUENTS IN A SAMPLE AND METHOD OF USING THE SAME 审中-公开
公开(公告)号：US20180158665A1
公开(公告)日：2018-06-07
申请号：US15370947
申请日：2016-12-06
申请人： Rapiscan Systems, Inc.
发明人： Gary A. Eiceman , Stephen J. Davila , Stefan R. Lukow , Hartwig Schmidt
IPC分类号： H01J49/40 , G01N27/62 , H01J49/00
CPC分类号： H01J49/401 , G01N27/622 , H01J49/0045
摘要： An apparatus for detecting constituents in a sample includes first and second drift tubes defining first and second drift regions, and a controllable electric field device within a fragmentation region coupled to the first and second drift tubes. The apparatus also includes a first ion shutter positioned between the first drift and fragmentation regions. The apparatus further includes a control system configured to regulate the first ion shutter, thereby facilitating injection of a selected portion of ions from the first drift region into the fragmentation region. The control system is also configured to regulate the controllable device to modify the selected portion of ions to generate predetermined ion fragments within the fragmentation region, thereby facilitating injection of a selected portion of the predetermined fragmented ions into the second drift region. A method of detecting constituents in a sample is facilitated through such an apparatus.

8. 发明授权

US09870905B2 Method of generating electric field for manipulating charged particles 有权
公开(公告)号：US09870905B2
公开(公告)日：2018-01-16
申请号：US14891197
申请日：2014-05-16
申请人： Micromass UK Limited
发明人： John Brian Hoyes
IPC分类号： H01J49/06 , H01J49/40 , H01J49/42
CPC分类号： H01J49/062 , H01J49/401 , H01J49/405 , H01J49/421
摘要： A method of manufacturing a device for manipulating charged particles using an axial electric field as they travel along a longitudinal axis of the device is disclosed. The method comprises providing first electrodes of different lengths, supplying different voltages to these electrodes and arranging grounded electrodes between the first electrodes in order to form the desired axial potential profile.

9. 发明授权

US09627190B2 Energy resolved time-of-flight mass spectrometry 有权
公开(公告)号：US09627190B2
公开(公告)日：2017-04-18
申请号：US14671521
申请日：2015-03-27
申请人： Agilent Technologies, Inc.
发明人： Julia Zaks , Trygve Ristroph
IPC分类号： H01J49/40 , H01J49/06 , H01J49/00
CPC分类号： H01J49/401 , H01J49/0027 , H01J49/06
摘要： A time-of-flight mass spectrometer (TOF-MS) utilizes an ion dispersion device and a position-sensitive ion detector or an energy-sensitive ion detector to enable measurement of time of flight and kinetic energy of ions arriving at the detector. The measurements may be utilized to improve accuracy in calculating ion masses.

10. 发明授权

US09576782B2 Orthogonal acceleration system for time-of-flight mass spectrometer 有权
标题翻译：飞行时间质谱仪的正交加速系统
公开(公告)号：US09576782B2
公开(公告)日：2017-02-21
申请号：US14928793
申请日：2015-10-30
申请人： PerkinElmer Health Sciences, Inc.
发明人： David G. Welkie
IPC分类号： H01J49/40 , H05H5/02 , H05H5/04 , H01J49/00
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/40 , H01J49/403 , H05H5/02 , H05H5/047
摘要： An orthogonal pulse accelerator for a Time-of-Flight mass analyzer includes an electrically-conductive first plate extending in a first plane, and a second plate spaced from the first plate. The second plate includes a grid that defines a plurality of apertures each having a first dimension extending in a first direction and a second dimension orthogonal to the first dimension, the first and second dimensions lying in the second plane and the second dimension begin larger than the first dimension. The first and second plates are positioned in the Time-of-Flight mass analyzer to receive, during operation of the mass analyzer, an ion beam propagating in the first direction in a region between the first and second plates, and the orthogonal pulse accelerator directs ions in the ion beam through the apertures.
摘要翻译：用于飞行时间质量分析器的正交脉冲加速器包括在第一平面中延伸的导电第一板和与第一板间隔开的第二板。第二板包括限定多个孔的栅格，每个孔具有在第一方向上延伸的第一尺寸和与第一尺寸正交的第二尺寸，第一和第二尺寸位于第二平面中，而第二尺寸开始大于第一维度。第一和第二板位于飞行时间质量分析器中，以在质量分析仪的操作期间接收在第一和第二板之间的区域中沿第一方向传播的离子束，并且正交脉冲加速器指示离子束中的离子通过孔。

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