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1. 发明申请

US20180112192A1 PINK1 C-TERMINAL DOMAIN POLYPEPTIDE AND METHODS USING THE SAME IN CANCER TREATMENT 审中-公开
公开(公告)号：US20180112192A1
公开(公告)日：2018-04-26
申请号：US15571249
申请日：2016-05-02
申请人： Andrew Man Chung Wo , National Taiwan University , Academia Sinica
发明人： Pan-Chyr Yang , Pei-Ying Lin , Bo-Tsang Huang
IPC分类号： C12N9/12 , A61P35/00 , A61K38/45 , A61K45/06
CPC分类号： C12N9/12 , A61K31/517 , A61K31/5377 , A61K38/179 , A61K38/45 , A61K39/395 , A61K45/06 , A61P35/00 , C07K14/00 , C07K14/71 , C07K2319/10 , C07K2319/41 , C07K2319/43 , C12Y207/11001 , A61K2300/00
摘要： The present disclosure includes a PINK1-C-terminal domain (PINK1-CTD) polypeptide that binds to ERBB tyrosine kinase domain (ERBB-TKD) and therefore impedes ERBB from dimerization and activation. The PINK1-CTD polypeptide inhibits, prevents and/or treats ERBB-expressing cancers. The disclosure demonstrates the anti-tumor function of the PINK1-CTD, which provides a new direction for ERBB-expressing cancer therapy.

2. 发明授权

US08524169B2 Disk-based fluid sample collection device 有权
标题翻译：基于磁盘的流体样品采集装置
公开(公告)号：US08524169B2
公开(公告)日：2013-09-03
申请号：US13104307
申请日：2011-05-10
申请人： Andrew Man Chung Wo , Chen-Lin Chen , Cheng-Wei Yang , Yu-Cheng Pan
发明人： Andrew Man Chung Wo , Chen-Lin Chen , Cheng-Wei Yang , Yu-Cheng Pan
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L2200/027 , B01L2300/045 , B01L2300/048 , B01L2300/0803 , B01L2400/0409 , B01L2400/0644 , G01N35/00069 , G01N2035/0449 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A fluid sample collection device for a disk-based fluid separation system is disclosed. The disk-based separation system includes a compact microfluidic disk with at least one flow channel pattern formed on a side surface of the disk. At least one orifice is formed on an outflow boundary of the disk and is designed in fluid communication with the flow channel pattern through a communication channel. The fluid sample collection device includes at least one collection tube having an open end serving as a fluid receiving end and corresponding to the orifice of the disk with a distance. When the disk is rotated, at least a portion of fluid sample in a sample processing reservoir formed on the disk is delivered by centripetal force through the communication channel and the orifice, and finally the expelling fluid sample is collected in the collection tube.
摘要翻译：公开了一种用于基于盘的流体分离系统的流体样品收集装置。基于盘的分离系统包括紧凑的微流体盘，其具有形成在盘的侧表面上的至少一个流动通道图案。在盘的流出边界上形成至少一个孔，并且通过通信通道设计成与流动通道图案流体连通。流体样品收集装置包括至少一个收集管，该收集管的开口端用作流体接收端并对应于具有一定距离的盘的孔口。当盘旋转时，形成在盘上的样品处理容器中的流体样品的至少一部分通过向心力传递通过连通通道和孔口，最后将排出流体样品收集在收集管中。

3. 发明申请

US20180230435A1 CANCER-ASSOCIATED FIBROBLASTS IN MAINTAINING STEMNESS OF CANCER STEM CELLS 审中-公开
公开(公告)号：US20180230435A1
公开(公告)日：2018-08-16
申请号：US15513804
申请日：2014-09-24
申请人： Andrew Man Chung WO , National Taiwan University
发明人： Pan-Chyr Yang , Huei-Wen Chen , Wan-Jiun Chen
IPC分类号： C12N5/095 , C12N5/09 , G01N33/50 , G01N33/574
CPC分类号： C12N5/0695 , C12N5/0693 , C12N2501/605 , C12N2502/30 , G01N33/5011 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N33/57496 , G01N2333/4706 , G01N2333/475 , G01N2333/4753 , G01N2333/52 , G01N2333/71 , G01N2333/715 , G01N2333/7158 , G01N2800/52
摘要： An in vitro co-culture system comprising cancer-associated fibroblasts (CAFs) and cancer cells for producing and maintaining cancer stem cells and uses thereof for identifying agents capable of reducing cancer cell stemness. Also disclosed herein are a paracrine network through which CAFs facilitate production and/or maintenance of cancer stem cells and the use of components of such a paracrine network for prognosis purposes and for identifying cancer patients who are likely to respond to certain treatment.

4. 发明申请

US20120024083A1 DISK-BASED FLUID SAMPLE SEPARATION DEVICE 审中-公开
标题翻译：基于磁盘的流体样品分离装置
公开(公告)号：US20120024083A1
公开(公告)日：2012-02-02
申请号：US13104289
申请日：2011-05-10
申请人： ANDREW MAN CHUNG WO , CHEN-LIN CHEN , CHENG WEI YANG
发明人： ANDREW MAN CHUNG WO , CHEN-LIN CHEN , CHENG WEI YANG
IPC分类号： G01N1/10
CPC分类号： G01N35/00069 , B01L3/502738 , B01L3/502753 , B01L2200/0668 , B01L2400/0409 , B01L2400/043 , B01L2400/0694 , G01N21/07
摘要： A disk-based fluid sample separation device including at least one air vent forming a part of a flow channel pattern on a microfluidic disk is disclosed. The fluid sample separation device is provided with an air vent sealing cover having at least through hole and is placed on the top surface of the disk. The air vent sealing cover is rotated with respect to the disk either at a first position or a second position. At the first position, the hole of the air vent sealing cover is in correspondence to the air vent of the flow channel pattern to control the sample liquid delivery. At the second position, the air vent of the flow channel pattern is closed. The flow channel pattern includes at least one sample storage reservoir, at least one sample processing reservoir, and at least one communication channel which is in fluid communication between the sample storage reservoir and the sample processing reservoir. In alternative, the status of the hole of the air vent sealing cover is controlled by a control unit.
摘要翻译：公开了一种基于盘的流体样品分离装置，其包括在微流体盘上形成流路图案的一部分的至少一个排气口。流体样品分离装置设置有至少具有通孔的排气密封盖，并且放置在盘的顶表面上。排气密封盖在第一位置或第二位置处相对于盘旋转。在第一位置，排气孔密封盖的孔对应于流动通道图案的排气口，以控制样品液体输送。在第二位置，流路图案的排气口关闭。流动通道图案包括至少一个样品储存储存器，至少一个样品处理储存器以及在样品储存储存器和样品处理储存器之间流体连通的至少一个通信通道。另外，排气密封盖的孔的状态由控制单元控制。

5. 发明申请

US20120039769A1 DISK-BASED FLUID SAMPLE COLLECTION DEVICE 有权
标题翻译：基于盘的液体样品收集装置
公开(公告)号：US20120039769A1
公开(公告)日：2012-02-16
申请号：US13104307
申请日：2011-05-10
申请人： ANDREW MAN CHUNG WO , CHEN-LIN CHEN , CHENG WEI YANG , YU-CHENG PAN
发明人： ANDREW MAN CHUNG WO , CHEN-LIN CHEN , CHENG WEI YANG , YU-CHENG PAN
IPC分类号： G01N1/10
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L2200/027 , B01L2300/045 , B01L2300/048 , B01L2300/0803 , B01L2400/0409 , B01L2400/0644 , G01N35/00069 , G01N2035/0449 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A fluid sample collection device for a disk-based fluid separation system is disclosed. The disk-based separation system includes a compact microfluidic disk with at least one flow channel pattern formed on a side surface of the disk. At least one orifice is formed on an outflow boundary of the disk and is designed in fluid communication with the flow channel pattern through a communication channel. The fluid sample collection device includes at least one collection tube having an open end serving as a fluid receiving end and corresponding to the orifice of the disk with a distance. When the disk is rotated, at least a portion of fluid sample in a sample processing reservoir formed on the disk is delivered by centripetal force through the communication channel and the orifice, and finally the expelling fluid sample is collected in the collection tube.
摘要翻译：公开了一种用于基于盘的流体分离系统的流体样品收集装置。基于盘的分离系统包括紧凑的微流体盘，其具有形成在盘的侧表面上的至少一个流动通道图案。在盘的流出边界上形成至少一个孔，并且通过通信通道设计成与流动通道图案流体连通。流体样品收集装置包括至少一个收集管，该收集管的开口端用作流体接收端并对应于具有一定距离的盘的孔口。当盘旋转时，形成在盘上的样品处理容器中的流体样品的至少一部分通过向心力传递通过连通通道和孔口，最后将排出流体样品收集在收集管中。

6. 发明授权

US11214774B2 PINK1 C-terminal domain polypeptide and methods using the same in cancer treatment 有权
公开(公告)号：US11214774B2
公开(公告)日：2022-01-04
申请号：US15571249
申请日：2016-05-02
申请人： Andrew Man Chung Wo , National Taiwan University , Academia Sinica
发明人： Pan-Chyr Yang , Pei-Ying Lin , Bo-Tsang Huang
IPC分类号： C07K5/00 , C12N9/12 , A61K45/06 , C07K14/00 , A61K39/395 , C07K14/71 , A61K31/517 , A61K38/17 , A61K31/5377 , A61P35/00 , A61K38/45
摘要： The present disclosure includes a PINK1-C-terminal domain (PINK1-CTD) polypeptide that binds to ERBB tyrosine kinase domain (ERBB-TKD) and therefore impedes ERBB from dimerization and activation. The PINK1-CTD polypeptide inhibits, prevents and/or treats ERBB-expressing cancers. The disclosure demonstrates the anti-tumor function of the PINK1-CTD, which provides a new direction for ERBB-expressing cancer therapy.

7. 发明授权

US10172699B2 Implants for pelvic organ prolapse support 有权
公开(公告)号：US10172699B2
公开(公告)日：2019-01-08
申请号：US15304988
申请日：2014-12-02
申请人： National Taiwan University , National Taiwan University Hospital , Andrew Man Chung Wo
发明人： Ho-Hsiung Lin , Ting-Chen Chang
IPC分类号： A61F2/00 , A61F6/08
摘要： The present invention provides an implant for pelvic organ prolapse support, comprising an implant for anterior vaginal wall prolapse support which comprises first body having a first angle and a second angle, a pair of first arms and a pair of second arms. The implant for pelvic organ prolapse support of the present invention can treat cystocele and stress urinary incontinence simultaneously, and can optionally combine with an implant for posterior vaginal wall prolapse support and an auxiliary supporter to treat cystocele, stress urinary incontinence, enterocele, uterine prolapse, rectocele prolapse, anal prolapse, and vaginal vault prolapse at one time.

8. 发明申请

US20170273921A1 3,5,N-TRIHYDROXY-ALKANAMIDE OR 3,5,N-TRIHYDROXY-6-ALKENAMIDE DERIVATIVE ALONE OR IN COMBINATION WITH CHEMOTHERAPEUTIC AGENT FOR TREATING CANCER 审中-公开
公开(公告)号：US20170273921A1
公开(公告)日：2017-09-28
申请号：US15507075
申请日：2015-08-14
申请人： Andrew Man Chung WO , National Taiwan University
发明人： Ching-Chow Chen
IPC分类号： A61K31/16 , A61K31/22 , C07C259/06 , A61K31/4418 , C07D239/42 , A61K31/505 , A61K31/402
CPC分类号： A61K31/16 , A61K31/22 , A61K31/40 , A61K31/402 , A61K31/4418 , A61K31/4745 , A61K31/505 , A61K31/555 , A61K31/7068 , A61K33/24 , A61K45/06 , C07C259/06 , C07D207/22 , C07D239/42 , A61K2300/00
摘要： The present invention provides a novel method for treating cancer that comprises administering a compound represented by formula (I) and/or a chemotherapeutic agent to a subject. The present invention further provides a novel kit that comprises a compound represented by formula (I) and a chemotherapeutic agent for treating cancer.

9. 发明申请

US20170181823A1 IMPLANTS FOR PELVIC ORGAN PROLAPSE SUPPORT 审中-公开
公开(公告)号：US20170181823A1
公开(公告)日：2017-06-29
申请号：US15304988
申请日：2014-12-02
申请人： Andrew Man Chung WO , NATIONAL TAIWAN UNIVERSITY , NATIONAL TAIWAN UNIVERSITY HOSPITAL
发明人： Ho-Hsiung LIN , Ting-Chen CHANG
IPC分类号： A61F2/00 , A61F6/08
CPC分类号： A61F2/0045 , A61F2/0063 , A61F6/08
摘要： The present invention provides an implant for pelvic organ prolapse support, comprising an implant for anterior vaginal wall prolapse support which comprises first body having a first angle and a second angle, a pair of first arms and a pair of second arms. The implant for pelvic organ prolapse support of the present invention can treat cystocele and stress urinary incontinence simultaneously, and can optionally combine with an implant for posterior vaginal wall prolapse support and an auxiliary supporter to treat cystocele, stress urinary incontinence, enterocele, uterine prolapse, rectocele prolapse, anal prolapse, and vaginal vault prolapse at one time.

10. 发明授权

US08535541B2 Method for separating immunomagnetic bead labeled particulates 有权
标题翻译：分离免疫磁珠标记微粒的方法
公开(公告)号：US08535541B2
公开(公告)日：2013-09-17
申请号：US12861989
申请日：2010-08-24
申请人： Andrew Man Chung Wo , Yu-Cheng Pan , Ken-Chao Chen , Chen-Lin Chen
发明人： Andrew Man Chung Wo , Yu-Cheng Pan , Ken-Chao Chen , Chen-Lin Chen
IPC分类号： B01D21/26 , B01D35/06 , G01N33/543
CPC分类号： C12N13/00 , G01N33/54326
摘要： Disclosed is a method for separating immunomagnetic bead labeled particulates. A carrier board is formed with at least one flow channel structure, which includes an inner reservoir, an outer reservoir, and at least one micro flow channel in communication with the inner reservoir and the outer reservoir. The method includes labeling target particulates with immunomagnetic bead, introducing a sample fluid into the inner reservoir, and applying a magnetic force and a driving force, wherein the driving force drives the particulates not labeled with immunomagnetic bead to flow through the micro flow channel to the outer reservoir, while the magnetic force attracts the particulates labeled with the immunomagnetic bead to retain in the inner reservoir. The driving force may be centrifugal force, pressure, or surface tension.
摘要翻译：公开了分离免疫磁珠标记的微粒的方法。载体板形成有至少一个流动通道结构，其包括内部储存器，外部储存器和与内部储存器和外部储存器连通的至少一个微流动通道。该方法包括用免疫磁珠标记目标颗粒，将样品流体引入内部储存器中，以及施加磁力和驱动力，其中驱动力驱动未标记有免疫磁珠的微粒流过微流通道至外部储存器，而磁力吸引用免疫磁珠标记的微粒保留在内部储存器中。驱动力可以是离心力，压力或表面张力。

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