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1. 发明授权

US08046331B1 Method and apparatus for recreating placeholders 有权
标题翻译：重建占位符的方法和装置
公开(公告)号：US08046331B1
公开(公告)日：2011-10-25
申请号：US11807003
申请日：2007-05-25
申请人： Mugdha Sanghavi , Kishor S. Ghait , Andrew Nash , Laxmikant Vithal Gunda
发明人： Mugdha Sanghavi , Kishor S. Ghait , Andrew Nash , Laxmikant Vithal Gunda
IPC分类号： G06F17/30
CPC分类号： G06F17/30221
摘要： A method and apparatus for recreating placeholders comprising selecting at least one object of information in an archive, determining a source location for the selected at least one object of information, accessing the selected at least one object of information, and recreating a placeholder from the selected at least one object of information.
摘要翻译：一种用于重建占位符的方法和装置，包括选择存档中的至少一个信息对象，确定所选择的至少一个信息对象的源位置，访问所选择的至少一个信息对象，以及从所选择的对象重新创建占位符至少一个信息对象。

2. 发明申请

US20080009444A1 Biologically active complex of NR6 and cardiotrophin-like-cytokine 审中-公开
标题翻译： NR6和心肌营养蛋白样细胞因子的生物活性复合物
公开(公告)号：US20080009444A1
公开(公告)日：2008-01-10
申请号：US11704086
申请日：2007-02-08
申请人： Andrew Nash , Kim Jachno , Louis Fabri , Kate Reid , Perry Bartlett , Douglas Hilton , Yasuhiko Nakata , Masakazu Hasegawa
发明人： Andrew Nash , Kim Jachno , Louis Fabri , Kate Reid , Perry Bartlett , Douglas Hilton , Yasuhiko Nakata , Masakazu Hasegawa
IPC分类号： A61K38/22 , A61K38/02 , A61P43/00 , C07H21/00 , C07K14/00 , C07K14/575 , C07K16/00 , C07K2/00 , C12N15/63 , G01N33/68
CPC分类号： E05B63/06 , E05B17/0012 , E05B17/0062 , E05B17/06 , E05C9/021 , E05C9/1808 , E05C9/185 , Y10T292/0843 , Y10T292/0993 , Y10T292/432
摘要： The present invention relates generally to a biologically active complex comprising at least two heterologous molecules. More particularly, the biologically active complex of the present invention comprises at least two polypeptides or parts, fragments, truncates or protease-activated forms of one or more of the polypeptides wherein the complex alone or in association with a receptor, ligand or other molecule facilitates proliferation, differentiation and/or survival of a cell. The identification of the biologically active complex of the present invention permits the assay for agonists and antagonists of the formation of the biologically active complex as well as therapeutic and diagnostic reagents based on the biologically active complex or interaction between the biologically active complex and a receptor, ligand or other molecule.
摘要翻译：本发明一般涉及包含至少两个异源分子的生物活性复合物。更具体地，本发明的生物活性复合物包含一种或多种多肽的至少两种多肽或部分，片段，截短物或蛋白酶活化形式，其中单独或与受体，配体或其它分子缔合的复合物有助于细胞的增殖，分化和/或存活。本发明的生物活性复合物的鉴定允许激活剂和拮抗剂测定生物活性复合物的形成以及基于生物活性复合物或生物活性复合物与受体之间相互作用的治疗和诊断试剂，配体或其他分子。

3. 发明申请

US20050058645A1 Monoclonal antibody against Interleukin-13 receptor alpha 1 (IL-13Ralpha1) 有权
标题翻译：白细胞介素-13受体α1单克隆抗体（IL-13Rα1）
公开(公告)号：US20050058645A1
公开(公告)日：2005-03-17
申请号：US10850270
申请日：2004-05-20
申请人： Felicity Dunlop , Manuel Baca , Andrew Nash , Louis Fabri , Douglas Hilton , Nicos Nicola
发明人： Felicity Dunlop , Manuel Baca , Andrew Nash , Louis Fabri , Douglas Hilton , Nicos Nicola
IPC分类号： C07K16/28 , C12N5/20 , A61K39/395 , C07K16/24
CPC分类号： C07K16/2866 , C07K2317/24 , C07K2317/55 , C07K2319/00
摘要： The present invention relates generally to antibodies that bind to the Interleukin-13 receptor α1 chain (IL-13Rα1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13Rα1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13Rα1/ligand interaction is also provided.
摘要翻译：本发明一般涉及结合白细胞介素-13受体α1链（IL-13Rα1）并通过IL-13和/或IL-4拮抗IL-13受体介导的信号传导的抗体。更具体地说，本发明为哺乳动物，特别是IL-13Rα1提供人源化或人抗体。这些抗体在治疗或预防IL-13和/或IL-4介导的疾病或病症中具有应用。本发明进一步考虑通过施用受试者抗体调节IL-13和/或IL-4介导的疾病或病症的方法。本发明还提供了可用于鉴定通过IL-13受体复合物调节IL-13和/或IL-4信号传导的抗体或其它试剂的测定系统。因此，还提供了筛选IL-13Rα1/配体相互作用的调节剂的方法。

4. 发明授权

US06696768B1 Arrangement of equipment for a motor vehicle 失效
标题翻译：机动车辆设备安排
公开(公告)号：US06696768B1
公开(公告)日：2004-02-24
申请号：US09959492
申请日：2002-01-28
申请人： Didier Barat , Andrew Nash
发明人： Didier Barat , Andrew Nash
IPC分类号： B60R1602
CPC分类号： B60K37/02 , B60K2350/945
摘要： An arrangement of equipment for a motor vehicle is designed to perform a variable number of functions such as to assist and/or enhance driving. The arrangement comprises at least one plurality of electronic components based equipment elements (1). According to the invention, remote processing members which are common to the entire set of equipment elements are provided. The electronic components have specific functions according to each equipment element and act as additional processing members, whereby it is possible for each equipment element to carry out one or several given functions of the arrangement by combining them with the common processing members. The invention also relate to a dashboard for a motor vehicle which is provided with the arrangement of equipment.
摘要翻译：用于机动车辆的设备的布置被设计成执行可变数量的功能，例如辅助和/或增强驾驶。该装置包括至少多个基于电子元件的设备元件（1）。根据本发明，提供了整套设备元件共同的远程处理构件。电子部件具有根据每个设备元件的特定功能，并且用作附加的处理部件，由此每个设备元件可以通过将其与公共处理部件组合来执行该布置的一个或多个给定的功能。本发明还涉及一种设置有设备布置的机动车辆的仪表板。

5. 发明申请

US20140199361A1 INHIBITORY ANTI-FACTOR XII/XIIA MONOCLONAL ANTIBODIES AND THEIR USES 有权
标题翻译：抑制性抗体XII / XIIA单克隆抗体及其用途
公开(公告)号：US20140199361A1
公开(公告)日：2014-07-17
申请号：US14234021
申请日：2012-07-20
申请人： Con Panousis , Veronika Rayzman , Andrew Nash , Michael Wilson , Stefan Schmidbauer , Marc Nolte
发明人： Con Panousis , Veronika Rayzman , Andrew Nash , Michael Wilson , Stefan Schmidbauer , Marc Nolte
IPC分类号： C07K16/36
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/36 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12Y304/21038
摘要： The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.
摘要翻译：本发明涉及抑制性抗因子XII / FXIIa抗体及其使用方法。

6. 发明授权

US08535669B2 Methods of treating lupus by administering humanized anti-interleukin 3 receptor alpha chain antibodies 有权
标题翻译：通过施用人源化抗白介素3受体α链抗体治疗狼疮的方法
公开(公告)号：US08535669B2
公开(公告)日：2013-09-17
申请号：US13579886
申请日：2011-02-17
申请人： Gino Luigi Vairo , Andrew Nash , Eugene Maraskovsky , Nick Wilson , Samantha Busfield
发明人： Gino Luigi Vairo , Andrew Nash , Eugene Maraskovsky , Nick Wilson , Samantha Busfield
IPC分类号： A61K39/395 , A61K39/44
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/202 , A61K39/3955 , A61K51/1021 , A61K51/1033 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present disclosure provides a method for treating lupus, Sjörgen's syndrome or scleroderma, the method comprising administering to the mammal an immunoglobulin which binds an interleukin 3 receptor α (IL-3Rα) chain and which depletes or at least partly eliminates plasmacytoid dendritic cells (p DCs) and basophils to which it binds.
摘要翻译：本公开提供了一种治疗狼疮，Sjörgen综合征或硬皮病的方法，所述方法包括向哺乳动物施用结合白介素3受体α（IL-3Rα）链的免疫球蛋白，其消耗或至少部分消除浆细胞样树突状细胞（p DCs）和与其结合的嗜碱性粒细胞。

7. 发明申请

US20070128197A1 Immunointeractive molecules 有权
标题翻译：免疫相互作用分子
公开(公告)号：US20070128197A1
公开(公告)日：2007-06-07
申请号：US11652711
申请日：2007-01-12
申请人： Andrew Nash , Giuseppe Maccarone , Pierre Scotney
发明人： Andrew Nash , Giuseppe Maccarone , Pierre Scotney
IPC分类号： A61K39/395 , C12N5/06 , C12P21/04 , A01K67/027
CPC分类号： C07K14/52 , C07K14/71
摘要： The present invention relates generally to immunointeractive molecules and more particularly antibodies which bind to vascular endothelial growth factor-B (VEGF-B) or its functional or structural equivalent and inhibit the biological activity of VEGF-B. In particular, the present invention relates to deimmunized such as humanized or human antibodies that bind to VEGF-B and inhibit the biological activity of VEGF-B. These antibodies have uses in the treatment or prevention of diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling. The present invention further contemplates a method of modulating diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies which bind to VEGF-B and block the biological activity of VEGF-B. Accordingly, a method of screening for inhibitors of the biological activity of VEGF-B is also provided.
摘要翻译：本发明一般涉及免疫相互作用分子，更具体地涉及结合血管内皮生长因子-B（VEGF-B）或其功能或结构等同物并抑制VEGF-B生物学活性的抗体。特别地，本发明涉及与VEGF-B结合并抑制VEGF-B的生物学活性的去免疫化的人源化或人抗体。这些抗体在治疗或预防与正常血管发生或血管生成或血管重构中的扰动相关的疾病中具有用途。本发明进一步考虑了通过施用本发明的抗体调节与正常血管发生或血管发生或血管重构中的扰动有关的疾病的方法。本发明还提供了可用于鉴定结合VEGF-B并阻断VEGF-B的生物学活性的抗体的测定系统。因此，还提供了筛选VEGF-B生物活性抑制剂的方法。

8. 发明申请

US20070111944A1 Purification of vascular endothelial growth factor-B 审中-公开
标题翻译：血管内皮生长因子B的纯化
公开(公告)号：US20070111944A1
公开(公告)日：2007-05-17
申请号：US11541848
申请日：2006-10-02
申请人： Sergio Scrofani , Andrew Nash , Louis Fabri , Andrew Mackenzie , Pierre Scotney
发明人： Sergio Scrofani , Andrew Nash , Louis Fabri , Andrew Mackenzie , Pierre Scotney
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/52 , C07K1/22
摘要： The present invention provides a method for purifying recombinant peptides, polypeptides or proteins away from truncated or other full-length forms of these molecules. In particular the invention contemplates a method of purifying a vascular endothelial growth factor (VEGF) molecule by subjecting a biological sample containing the molecule to be purified to affinity chromatography under conditions sufficient for the full length molecules to bind and not the truncated or clipped forms. In the preferred embodiment there are two columns, the first is based on affinity for a poly his tag, the second column based on heparin binding affinity. Particularly preferred VEGF molecules are untagged VEGF-B167, hexa-His-tagged VEGF-B167, hexa-His-tagged VEGF-B186 and hexa-His-tagged VEGF-B10-108.
摘要翻译：本发明提供了用于从这些分子的截短或其他全长形式纯化重组肽，多肽或蛋白质的方法。特别地，本发明考虑了通过使含有待分子的生物样品在足以使全长分子结合的条件下纯化至亲和层析而不是截短或剪切形式来纯化血管内皮生长因子（VEGF）分子的方法。在优选实施方案中，有两列，第一列是基于对多聚标签的亲和力，第二列基于肝素结合亲和力。特别优选的VEGF分子是未标记的VEGF-B 167，六His标记的VEGF-B 167，六His标记的VEGF-B >和六His标记的VEGF-B 10-108。

9. 发明授权

US06949709B1 Method for making a dashboard subassembly in paticular a motor vehicle dashboard console 失效
标题翻译：在仪表板控制台中制作仪表板组件的方法
公开(公告)号：US06949709B1
公开(公告)日：2005-09-27
申请号：US10019504
申请日：2000-06-30
申请人： Didier Barat , Andrew Nash
发明人： Didier Barat , Andrew Nash
IPC分类号： B60R7/06 , B29C70/70 , B29C70/72 , B60K37/00 , B60R16/02 , H05K1/11 , H05K3/28 , B29C45/14
CPC分类号： B29C70/70 , B29C70/72 , B60K37/00 , B60R16/0215 , H05K1/118 , H05K3/284 , H05K2201/091 , H05K2201/10053 , H05K2203/1327
摘要： The invention concerns a method for making a dashboard subassembly comprising electrical and/or electronic components (1) connected to conductors (2) and attached to a rigid support (3). The invention is characterized in that it consists in: providing a flexible mat (4) provided with said conductors (2); mounting said components (1) on said mat (4), connected to said electrical conductors (2); rigidizing said mat (4) by overmoulding it with a material designed to form said support (3). The invention also concerns a dashboard subassembly, in particular a motor vehicle dashboard console, obtained by said method.
摘要翻译：本发明涉及一种用于制造仪表板子组件的方法，其包括连接到导体（2）并连接到刚性支撑件（3）的电和/或电子部件（1）。本发明的特征在于：提供设置有所述导体（2）的柔性垫（4）; 将所述部件（1）安装在所述垫（4）上，连接到所述电导体（2）; 通过用设计成形成所述支撑件（3）的材料将其模制成硬化所述垫（4）。本发明还涉及通过所述方法获得的仪表板子组件，特别是机动车辆仪表板控制台。

10. 发明申请

US20130084282A1 COMPOSITIONS AND METHODS FOR TARGETING TYPE 1 INTERFERON PRODUCING CELLS 有权
公开(公告)号：US20130084282A1
公开(公告)日：2013-04-04
申请号：US13579886
申请日：2011-02-17
申请人： Gino Luigi Vairo , Andrew Nash , Eugene Maraskovsky , Nick Wilson , Samantha Busfield
发明人： Gino Luigi Vairo , Andrew Nash , Eugene Maraskovsky , Nick Wilson , Samantha Busfield
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/202 , A61K39/3955 , A61K51/1021 , A61K51/1033 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present disclosure provides a method for treating lupus, Sjörgen's syndrome or scleroderma, the method comprising administering to the mammal an immunoglobulin which binds an interleukin 3 receptor α (IL-3Rα) chain and which depletes or at least partly eliminates plasmacytoid dendritic cells (p DCs) and basophils to which it binds.

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