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1. 发明申请

US20120280120A1 METHOD AND SYSTEM FOR VACUUM DRIVEN MASS SPECTROMETER INTERFACE WITH ADJUSTABLE RESOLUTION AND SELECTIVITY 有权
标题翻译：具有可调分辨率和选择性的真空驱动质谱仪接口的方法和系统
公开(公告)号：US20120280120A1
公开(公告)日：2012-11-08
申请号：US13541414
申请日：2012-07-03
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： H01J49/26 , H01J49/24
CPC分类号： H01J49/26 , G01N27/622 , H01J49/004 , H01J49/0404 , H01J49/0468 , H01J49/24
摘要： A mass spectrometer system and method of operating same are provided. The system comprises an ion conduit for receiving ions; a boundary member defining a curtain gas chamber containing the ion conduit; a curtain gas supply for providing a curtain gas to an inlet of the ion conduit to provide a gas flow into the conduit, and a curtain gas outflow out of a curtain gas chamber inlet; a mass spectrometer at least partially sealed to, and in fluid communication with, the conduit for receiving the ions from the conduit; a vacuum chamber surrounding the mass spectrometer operable to draw the gas flow including the ions through the conduit and into the vacuum chamber; and, a gas outlet for drawing a gas outflow from the gas flow located between the conduit and the mass spectrometer to increase the gas flow rate through the conduit.
摘要翻译：提供了质谱仪系统及其操作方法。该系统包括用于接收离子的离子导管; 限定包含离子导管的帘式气室的边界构件; 用于向离子管道的入口提供帘式气体以提供气体流入管道中的帘式气体供应，以及帘式气体从帘式气体室入口流出; 至少部分地密封并与导管流体连通的用于从导管接收离子的质谱仪; 围绕质谱仪的真空室可操作以将包括离子的气流通过导管抽入真空室; 以及气体出口，用于从位于导管和质谱仪之间的气流拉出气体流出，以增加通过导管的气体流速。

2. 发明申请

US20070187614A1 Radio frequency ion guide 有权
标题翻译：射频离子导向
公开(公告)号：US20070187614A1
公开(公告)日：2007-08-16
申请号：US11703756
申请日：2007-02-08
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： H01J3/14
CPC分类号： H01J49/062
摘要： An ion guide with two or more ion focusing elements and a gas channeling sleeve is described. An ion transport space within the gas channeling sleeve is in fluid communication with a pumping port. A suction device is used to suction gas out of the ion transport space through the pumping port establishing a gas flow. Ions in the ion transport space are transported from an ion entry end to an ion exit end of the ion guide by the gas flow. Several examples include a multipole ion guide in which rods are used as ion focusing elements. The gas channeling sleeve is fitted about the rods. In another example, toroidal or ring shaped ion focusing elements are used as ion focusing elements. In another example, a set of ion focusing rings are mounted between insulators to form a cylinder with a gas impermeable side wall. The cylinder is itself used as the gas channeling sleeve.
摘要翻译：描述了具有两个或更多离子聚焦元件和气体导引套筒的离子导向器。气体通道套管内的离子传输空间与泵送口流体连通。抽吸装置用于通过建立气流的泵送端口将气体排出离子传输空间。离子传输空间中的离子通过气流从离子入口端输送到离子导向器的离子出口端。几个实例包括其中杆用作离子聚焦元件的多极离子导向器。气体通道套筒围绕杆安装。在另一示例中，使用环形或环形离子聚焦元件作为离子聚焦元件。在另一示例中，一组离子聚焦环安装在绝缘体之间以形成具有不透气侧壁的圆筒。气缸本身用作气体导引套筒。

3. 发明申请

US20060226354A1 Atmospheric pressure charged particle discriminator for mass spectrometry 有权
公开(公告)号：US20060226354A1
公开(公告)日：2006-10-12
申请号：US11447785
申请日：2006-06-06
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： H01J49/00
CPC分类号： H01J49/06 , H01J49/044
摘要： An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

4. 发明授权

US07098452B2 Atmospheric pressure charged particle discriminator for mass spectrometry 有权
公开(公告)号：US07098452B2
公开(公告)日：2006-08-29
申请号：US10778424
申请日：2004-02-13
申请人： Bradley Schneider , Thomas R. Covey
发明人： Bradley Schneider , Thomas R. Covey
IPC分类号： H01J49/04
CPC分类号： H01J49/06 , H01J49/044
摘要： An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

5. 发明申请

US20060169891A1 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US20060169891A1
公开(公告)日：2006-08-03
申请号：US11315788
申请日：2005-12-22
申请人： Bruce Collings , Thomas Covey , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bradley Schneider , Bruce Thomson
发明人： Bruce Collings , Thomas Covey , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bradley Schneider , Bruce Thomson
IPC分类号： B01D59/44
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

6. 发明申请

US20050285031A1 Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring 有权
标题翻译：使用激光解吸和多反应监测的高通量定量方法和系统
公开(公告)号：US20050285031A1
公开(公告)日：2005-12-29
申请号：US11173291
申请日：2005-06-30
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： B01D59/44 , H01J49/00 , H01J49/40
CPC分类号： H01J49/164 , H01J49/004 , H01J49/0481 , H01J49/4215
摘要： A mass spectrometry quantitation technique enables high-throughput quantitation of small molecules using a laser-desorption (e.g., MALDI) ion source coupled to a triple-quadrupole mass analyzer. The ions generated from the ion source are collisionally damped/cooled, and then quantitatively analyzed using the triple-quadrupole analyzer operated in the multiple-reaction-monitoring (MRM) mode. Significantly improved measurement throughput is obtained by applying the laser to each sample spot on the target for an irradiation duration significantly shorter than the time required to deplete the sample material in the sample spot. The irradiation duration may be set based on a determination of the MRM peak broadening caused by the ion optics. This allows significantly reduced widths of the MRM peaks while maintaining good signal to noise ratios and provides a significantly improved throughput of the quantitation analyses as well as improved reproducibility of the MRM peaks and reduced compound dependence of the MRM peak widths.
摘要翻译：使用耦合到三重四极杆质谱仪的激光解吸（例如MALDI）离子源，质谱定量技术可实现小分子的高通量定量。从离子源产生的离子被碰撞阻尼/冷却，然后使用在多反应监测（MRM）模式中操作的三重四极杆分析器进行定量分析。通过将激光施加到目标上的每个样品点上的照射时间显着短于在样品斑点中耗尽样品材料所需的时间，获得显着改善的测量通量。可以基于由离子光学器件引起的MRM峰扩展的确定来设定照射持续时间。这允许显着降低MRM峰的宽度，同时保持良好的信噪比，并且提供定量分析的显着改善的产量以及MRM峰的再现性以及MRM峰宽的复合依赖性。

7. 发明授权

US08084736B2 Method and system for vacuum driven differential mobility spectrometer/mass spectrometer interface with adjustable resolution and selectivity 有权
标题翻译：真空驱动差动迁移谱仪/质谱仪界面的方法和系统，分辨率和选择性可调
公开(公告)号：US08084736B2
公开(公告)日：2011-12-27
申请号：US12473859
申请日：2009-05-28
申请人： Bradley Schneider , Tom Covey , Erkin Nazarov
发明人： Bradley Schneider , Tom Covey , Erkin Nazarov
IPC分类号： H01J49/24 , B01D59/44
CPC分类号： H01J49/004 , G01N27/624
摘要： A mass spectrometer system including a differential mobility spectrometer and a mass spectrometer at least partially sealed to, and in fluid communication, with, the differential mobility spectrometer, together with a related method, are provided. The mass spectrometer system can be operable to, and method can comprise, a) maintaining the differential mobility spectrometer at an internal operating pressure; b) providing ions to the differential mobility spectrometer; c) maintaining the mass spectrometer at a vacuum pressure lower than the internal operating pressure to draw a gas flow including the ions through the differential mobility spectrometer and into the vacuum chamber; and, d) modifying the gas flow between the differential mobility spectrometer and the mass spectrometer to change a gas flow rate through the differential mobility spectrometer.
摘要翻译：提供了一种包括差速迁移谱仪和质谱仪的质谱仪系统以及相关方法，所述质谱仪至少部分地密封到差速迁移率光谱仪并与流体连通。质谱仪系统可以操作，并且方法可以包括：a）将差动迁移谱仪维持在内部操作压力; b）向差示迁移率光谱仪提供离子; c）将质谱仪保持在低于内部操作压力的真空压力下，以将包含离子的气流通过差速迁移谱仪吸入真空室中; 和d）改变差示迁移率光谱仪和质谱仪之间的气流，以改变通过差动迁移谱仪的气体流速。

8. 发明申请

US20090294650A1 Method And System For Vacuum Driven Differential Mobility Spectrometer/Mass Spectrometer Interface With Adjustable Resolution And Selectivity 有权
标题翻译：用于真空驱动的差分移动光谱仪/质谱仪界面的可调分辨率和选择性的方法和系统
公开(公告)号：US20090294650A1
公开(公告)日：2009-12-03
申请号：US12473859
申请日：2009-05-28
申请人： Bradley Schneider , Tom Covey , Erkin Nazarov
发明人： Bradley Schneider , Tom Covey , Erkin Nazarov
IPC分类号： H01J49/26
CPC分类号： H01J49/004 , G01N27/624
摘要： A mass spectrometer system including a differential mobility spectrometer and a mass spectrometer at least partially sealed to, and in fluid communication, with, the differential mobility spectrometer, together with a related method, are provided. The mass spectrometer system can be operable to, and method can comprise, a) maintaining the differential mobility spectrometer at an internal operating pressure; b) providing ions to the differential mobility spectrometer; c) maintaining the mass spectrometer at a vacuum pressure lower than the internal operating pressure to draw a gas flow including the ions through the differential mobility spectrometer and into the vacuum chamber; and, d) modifying the gas flow between the differential mobility spectrometer and the mass spectrometer to change a gas flow rate through the differential mobility spectrometer.
摘要翻译：提供了一种包括差速迁移谱仪和质谱仪的质谱仪系统以及相关方法，所述质谱仪至少部分地密封到差速迁移率光谱仪并与流体连通。质谱仪系统可以操作，并且方法可以包括：a）将差动迁移谱仪维持在内部操作压力; b）向差示迁移率光谱仪提供离子; c）将质谱仪保持在低于内部操作压力的真空压力下，以将包含离子的气流通过差速迁移谱仪吸入真空室中; 和d）改变差示迁移率光谱仪和质谱仪之间的气流，以改变通过差动迁移谱仪的气体流速。

9. 发明授权

US07388194B2 Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring 有权
标题翻译：使用激光解吸和多反应监测的高通量定量方法和系统
公开(公告)号：US07388194B2
公开(公告)日：2008-06-17
申请号：US11173291
申请日：2005-06-30
申请人： Bradley Schneider , Thomas R. Covey
发明人： Bradley Schneider , Thomas R. Covey
IPC分类号： B01D59/44 , H01J49/40
CPC分类号： H01J49/164 , H01J49/004 , H01J49/0481 , H01J49/4215
摘要： A mass spectrometry quantitation technique enables high-throughput quantitation of small molecules using a laser-desorption (e.g., MALDI) ion source coupled to a triple-quadrupole mass analyzer. The ions generated from the ion source are collisionally damped/cooled, and then quantitatively analyzed using the triple-quadrupole analyzer operated in the multiple-reaction-monitoring (MRM) mode. Significantly improved measurement throughput is obtained by applying the laser to each sample spot on the target for an irradiation duration significantly shorter than the time required to deplete the sample material in the sample spot. The irradiation duration may be set based on a determination of the MRM peak broadening caused by the ion optics. This allows significantly reduced widths of the MRM peaks while maintaining good signal to noise ratios and provides a significantly improved throughput of the quantitation analyses as well as improved reproducibility of the MRM peaks and reduced compound dependence of the MRM peak widths.
摘要翻译：使用耦合到三重四极杆质谱仪的激光解吸（例如MALDI）离子源，质谱定量技术可实现小分子的高通量定量。从离子源产生的离子被碰撞阻尼/冷却，然后使用在多反应监测（MRM）模式中操作的三重四极杆分析器进行定量分析。通过将激光施加到目标上的每个样品点上的照射时间显着短于在样品斑点中耗尽样品材料所需的时间，获得显着改善的测量通量。可以基于由离子光学器件引起的MRM峰扩展的确定来设定照射持续时间。这允许显着降低MRM峰的宽度，同时保持良好的信噪比，并且提供定量分析的显着改善的产量以及MRM峰的再现性以及MRM峰宽的复合依赖性。

10. 发明申请

US20080073502A1 MULTIPLE SAMPLE SOURCES FOR USE WITH MASS SPECTROMETERS, AND APPARATUS, DEVICES, AND METHODS THEREFOR 有权
标题翻译：用于质谱仪的多个样品来源及其设备及其方法
公开(公告)号：US20080073502A1
公开(公告)日：2008-03-27
申请号：US11860899
申请日：2007-09-25
申请人： Bradley SCHNEIDER , Thomas Covey
发明人： Bradley SCHNEIDER , Thomas Covey
IPC分类号： H01J49/26
CPC分类号： H01J49/107 , H01J49/0009 , H01J49/0095 , H01J49/067 , H01J49/165
摘要： A method for introducing samples through a boundary member partially defining a chamber at an entrance point coaxial to a sampling inlet of a mass spectrometer is described. Field-free conditions can be established in at least one region of the chamber. The sample can be introduced adjacent to the sampling inlet, and introducing at least a second sample can be introduced through at least one other entrance point in the chamber not adjacent to the sampling inlet. An apparatus having a sampling inlet and a boundary member partially defining a chamber is also described. Field-free conditions can be established in at least one region of the chamber, and there can be a first aperture in the boundary member through which a source emits sample. Related devices, uses and mass spectrometers are also described.
摘要翻译：描述了通过在与质谱仪的取样入口同轴的入口处部分地限定腔室的边界构件引入样品的方法。可以在室的至少一个区域建立无场的条件。可以将样品引入到采样入口附近，并且引入至少第二样品可以通过不与采样入口相邻的室中的至少一个其它入口引入。还描述了具有采样入口和部分地限定腔室的边界构件的装置。可以在室的至少一个区域中建立无场条件，并且在边界构件中可以有一个第一孔，源通过该孔发射样品。还描述了相关的装置，用途和质谱仪。

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