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1. 发明授权

US09899201B1 High dynamic range ion detector for mass spectrometers 有权
公开(公告)号：US09899201B1
公开(公告)日：2018-02-20
申请号：US15346977
申请日：2016-11-09
申请人： Bruker Daltonics, Inc.
发明人： Melvin Andrew Park
IPC分类号： H01J49/40 , H01J49/06 , H01J49/08 , H01J49/02
CPC分类号： H01J49/08 , H01J43/246 , H01J49/025 , H01J49/027 , H01J49/40
摘要： The invention relates to the linear dynamic range of ion abundance measurement devices in mass spectrometers, such as time-of-flight mass spectrometers. The invention solves the problem of ion current peak saturation by producing a second ion measurement signal at an intermediate stage of amplification in a secondary electron multiplier, e.g. a signal generated between the two multichannel plates in chevron arrangement. Because saturation effects are observed only in later stages of amplification, the signal from the intermediate stage of amplification will remain linear even at high ion intensities and will remain outside saturation. In the case of a discrete dynode detector this could encompass, for example, placement of a detection grid between two dynodes near the middle of the amplification chain. The invention uses detection of the image current generated by the passing electrons.

2. 发明申请

US20170315092A1 ION STORAGE FOR A MOBILITY SEPARATOR OF A MASS SPECTROMETRIC SYSTEM 审中-公开
公开(公告)号：US20170315092A1
公开(公告)日：2017-11-02
申请号：US15140554
申请日：2016-04-28
申请人： Bruker Daltonics, Inc.
发明人： Joshua SILVEIRA
IPC分类号： G01N27/62 , H01J49/06 , H01J49/00
CPC分类号： G01N27/622 , H01J49/0031 , H01J49/062
摘要： The invention relates to methods and instruments for combined separation of ions according to mobility and mass to charge ratio. The mass spectrometric system comprises an ion source, a mobility separator and a mass analyzer wherein the mobility separator comprises (i) a gas filled drift region with a substantially constant electric DC field or a traveling electric field and (ii) an ion storage located adjacent to the entrance or inside the drift region. The ion storage comprises an electric field gradient and a gas flow wherein the electric field gradient and gas flow provide opposing forces on ions in the ion storage such that they are trapped at mobility dependent positions inside the ion storage.

3. 发明授权

US09741552B2 Triple quadrupole mass spectrometry coupled to trapped ion mobility separation 有权
公开(公告)号：US09741552B2
公开(公告)日：2017-08-22
申请号：US14978508
申请日：2015-12-22
申请人： Bruker Daltonics, Inc.
发明人： Melvin Andrew Park , Mark Ridgeway , Desmond Allen Kaplan , Felician Muntean
IPC分类号： H01J49/42 , H01J49/10
CPC分类号： H01J49/4225 , G01N27/622 , H01J49/0045 , H01J49/066 , H01J49/10
摘要： The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer (“TIMS”) is used as the ion mobility separation device coupled to a triple quadrupole mass filter assembly. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with upstream substance separator. TIMS, in particular equipped with parallel accumulation, provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species such as to improve the quality of the fragment ion spectra.

4. 发明授权

US10060879B2 Ion storage for a mobility separator of a mass spectrometric system 有权
公开(公告)号：US10060879B2
公开(公告)日：2018-08-28
申请号：US15140554
申请日：2016-04-28
申请人： Bruker Daltonics, Inc.
发明人： Joshua Silveira
IPC分类号： G01N27/62 , H01J49/00 , H01J49/06
CPC分类号： G01N27/622 , H01J49/0031 , H01J49/062
摘要： The invention relates to methods and instruments for combined separation of ions according to mobility and mass to charge ratio. The mass spectrometric system comprises an ion source, a mobility separator and a mass analyzer wherein the mobility separator comprises (i) a gas filled drift region with a substantially constant electric DC field or a traveling electric field and (ii) an ion storage located adjacent to the entrance or inside the drift region. The ion storage comprises an electric field gradient and a gas flow wherein the electric field gradient and gas flow provide opposing forces on ions in the ion storage such that they are trapped at mobility dependent positions inside the ion storage.

5. 发明申请

US20180233346A1 MASS SPECTROMETER USING GASTIGHT RADIO FREQUENCY ION GUIDE 审中-公开
公开(公告)号：US20180233346A1
公开(公告)日：2018-08-16
申请号：US15434233
申请日：2017-02-16
申请人： Bruker Daltonics, Inc.
发明人： Felician MUNTEAN , Stephen ZANON
IPC分类号： H01J49/42 , H01J49/24 , H01J49/06 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/0045 , H01J49/062 , H01J49/24
摘要： The disclosure relates to a mass spectrometer, comprising (a) a vacuum recipient containing ion handling elements of the mass spectrometer, the vacuum recipient having a plurality of walls which define a gastight volume and comprise at least one of an entrance and exit, wherein different portions of an ion path pass at least one of the entrance and exit and run through the gastight volume; and (b) a gastight radio frequency ion guide having an ion passage along an axis and being mounted gastight to at least one of the entrance and exit as to continue the ion path in its ion passage outside the gastight volume. Embodiments of the disclosure facilitate, in particular, reducing pumping volumes in the mass spectrometer and corresponding pumping requirements as well as lowering the size and weight of such an assembly.

6. 发明申请

US20160163528A1 INTERFACE FOR AN ATMOSPHERIC PRESSURE ION SOURCE IN A MASS SPECTROMETER 审中-公开
标题翻译：大气压力离子源大气界面
公开(公告)号：US20160163528A1
公开(公告)日：2016-06-09
申请号：US14558801
申请日：2014-12-03
申请人： Bruker Daltonics, Inc.
发明人： Maurizio SPLENDORE , Stephen ZANON
IPC分类号： H01J49/24 , H01J49/16
CPC分类号： H01J49/24 , H01J49/04 , H01J49/165
摘要： The invention relates to a mass spectrometer having an ion source region at substantially atmospheric pressure in which ions are formed from a liquid sample. The mass spectrometer further has an interface for transmitting the formed ions from the ion source region into a vacuum region which is held at a pressure level substantially below the atmospheric pressure and where the formed ions are further processed. The interface comprises a wall dividing the ion source region and the vacuum region and has a central orifice formed therein for letting pass gaseous and particulate matter from the ion source region into the vacuum region following the pressure gradient, wherein the central orifice is surrounded at least section-wise by a plurality of lateral orifices.
摘要翻译：本发明涉及一种质谱仪，其具有基本上大气压的离子源区域，其中离子由液体样品形成。质谱仪还具有用于将形成的离子从离子源区域传输到保持在基本上低于大气压力的压力水平并且形成的离子被进一步处理的真空区域的界面。该界面包括分隔离子源区域和真空区域的壁，并且具有形成在其中的中心孔口，用于使气态和颗粒物质从离子源区域传递到跟随压力梯度的真空区域中，其中中心孔口至少包围通过多个侧向孔分段。

7. 发明申请

US20150348769A1 ABRIDGED MULTIPOLE STRUCTURE FOR THE TRANSPORT, SELECTION AND TRAPPING OF IONS IN A VACUUM SYSTEM 审中-公开
标题翻译：用于真空系统中运输，选择和捕获离子的多重结构
公开(公告)号：US20150348769A1
公开(公告)日：2015-12-03
申请号：US14589598
申请日：2015-01-05
申请人： Bruker Daltonics, Inc.
发明人： Melvin Andrew Park
IPC分类号： H01J49/06 , H01J49/42
CPC分类号： H01J49/063 , H01J49/421 , H01J49/4235 , H01J49/424
摘要： An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. Additional embodiments can act as linear ion traps or Paul ion traps.
摘要翻译：用于在真空系统中沿着中心轴输送和选择离子的简单多极结构由多个直线电极结构构成，每个直线电极结构具有基本平坦的面，其具有垂直于第一维度的第一尺寸和第二尺寸。当跨越第二维度施加电压时，在平面处产生电位，其幅度是沿着第二维度的位置的线性函数。两个电极结构可以彼此平行地布置，其中第一尺寸沿着中心轴延伸，或者更多的电极结构可被布置成形成具有各种多边形横截面的多极结构。另外的实施例可以用作线性离子阱或保护离子阱。

8. 发明授权

US08921770B1 Reduction of cross-talk between RF components in a mass spectrometer 有权
标题翻译：降低质谱仪中RF分量之间的串扰
公开(公告)号：US08921770B1
公开(公告)日：2014-12-30
申请号：US13935732
申请日：2013-07-05
申请人： Bruker Daltonics, Inc.
发明人： Felician Muntean , Roy Moeller , Stephen Zanon
IPC分类号： H01J49/42 , H01J49/06
CPC分类号： H01J49/06 , H01J49/063 , H01J49/4215
摘要： The invention generally relates to an assembly of a first RF component and a second RF component in a mass spectrometer, the first RF component comprising a first set of electrodes and the second RF component comprising a second set of electrodes, wherein the RF components are located and aligned end-to-end to one another, and wherein a transverse dimension of the electrodes of the first set is smaller than that of the electrodes of the second set. The assembly further comprises a conductive electric field screen located at an outer periphery of the first set of electrodes and facing the electrodes of the second set as to reduce RF electric field cross-talk between the electrodes of the first set and those of the second set. The invention affords for technically simple and economic means to reduce cross-talk or capacitive coupling between adjacent RF components in a mass spectrometer.
摘要翻译：本发明一般涉及质谱仪中的第一RF部件和第二RF部件的组件，所述第一RF部件包括第一组电极，所述第二RF部件包括第二组电极，其中RF部件位于并且彼此端对端对齐，并且其中第一组的电极的横向尺寸小于第二组的电极的横向尺寸。组件还包括位于第一组电极的外周边并面向第二组电极的导电电场屏，以减少第一组电极与第二组电极之间的RF电场串扰。本发明提供技术上简单且经济的手段来减少质谱仪中相邻RF部件之间的串扰或电容耦合。

9. 发明授权

US08809769B2 Apparatus and method for cross-flow ion mobility spectrometry 有权
标题翻译：交叉流离子迁移谱法的装置和方法
公开(公告)号：US08809769B2
公开(公告)日：2014-08-19
申请号：US13688594
申请日：2012-11-29
申请人： Bruker Daltonics, Inc.
发明人： Melvin Andrew Park
IPC分类号： H01J49/00
CPC分类号： G01N27/622 , H01J49/004 , H01J49/36
摘要： A cross-flow ion mobility spectrometer consists of two parallel plates defining a volume between them. Analyte ions flow along an axis from an entrance end to an exit end through the volume. An RF confining field tends to guide ions along the axis. An analytical gas flow is established orthogonal to the axis. A DC electrostatic analytical field is oriented in opposition to the analytical gas flow such that the “drag force” on ions of the selected mobility due to the analytical gas flow is balanced by the force on the ions due to the electrostatic analytical field. The selected ions are thereby able to follow a stable path to the exit end of the cross-flow mobility analyzer. However, the force on ions of other than the selected mobility is unbalanced and these ions are deflected and lost.
摘要翻译：交叉流离子迁移谱仪由两个平行的板组成，在它们之间限定体积。分析离子沿着一个轴线从入口端到出口端流过体积。 RF限制场趋向于沿着轴引导离子。建立与轴正交的分析气流。 DC静电分析场与分析气体流动相对取向，使得由于分析气体流动而选择的迁移率的离子上的“阻力”由于静电分析场而由离子上的力平衡。所选择的离子因此能够遵循到交叉流动迁移率分析仪的出口端的稳定路径。然而，除选择的迁移率之外的离子力是不平衡的，并且这些离子被偏转和损失。

10. 发明授权

US09401266B2 Filament for mass spectrometric electron impact ion source 有权
标题翻译：质谱仪用于质谱电子轰击离子源
公开(公告)号：US09401266B2
公开(公告)日：2016-07-26
申请号：US14341076
申请日：2014-07-25
申请人： Bruker Daltonics, Inc.
发明人： Maurizio Splendore , Felician Muntean , Roy P. Moeller
IPC分类号： H01J49/00 , H01J49/14 , H01J27/20
CPC分类号： H01J49/147 , H01J27/205
摘要： The invention provides a cathode system for an Electron Ionization (EI) source comprising a filament and current supply posts, the current supply posts dividing the filament into segments and each current supply post supplying or returning the current for at least two segments of the filament. Each filament segment is connected, for instance by spot welding, to the supply posts delivering the heating current. The filament segments may be arranged in a row, or substantially parallel to each other. Filament segments arranged in a row may form a closed loop, for instance, a ring. Other embodiments encompass the filament shape of a helical coil.
摘要翻译：本发明提供了一种用于电离电离（EI）源的阴极系统，其包括灯丝和电流供应柱，电流供应柱将灯丝分成段，每个电流供应柱供应或返回灯丝的至少两个段的电流。每个细丝段例如通过点焊连接到供给点，从而传递加热电流。灯丝段可以排列成一排或基本上彼此平行。排列成一行的细丝片可以形成闭环，例如环。其他实施例包括螺旋线圈的丝状。

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