专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20220373575A1 ATOMIC FORCE MICROSCOPE USING ARTIFICIAL INTELLIGENCE OBJECT RECOGNITION TECHNOLOGY AND OPERATION METHOD THEREOF 有权
公开(公告)号：US20220373575A1
公开(公告)日：2022-11-24
申请号：US17772267
申请日：2021-05-11
申请人： CHUNGBUK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Man Hee LEE , Seong Seok KANG , Jun Hong PARK
IPC分类号： G01Q20/02 , G01Q10/04 , G06T7/70
摘要： An atomic force microscope includes a sample stage on which a sample is placed, a cantilever including a probe tip, a laser radiating a laser beam to the cantilever, a photodetector receiving a laser beam reflected from the cantilever, a first camera photographing the sample and the cantilever, a second camera photographing the cantilever and the spot of the laser beam, and a processor electrically connected to the first and second cameras and the photodetector to process data acquired by the first and second cameras and the photodetector. An operation method of the atomic force microscope includes detecting the positions of the cantilever and the sample using the first camera, adjusting the position of the sample, detecting the positions of the laser and the cantilever using the second camera, aligning the laser, detecting the position of the laser beam using the photodetector, and aligning the position of the photodetector.

2. 发明授权

US10891229B2 Multi-level caching method and multi-level caching system for enhancing graph processing performance 有权
公开(公告)号：US10891229B2
公开(公告)日：2021-01-12
申请号：US16221286
申请日：2018-12-14
申请人： Chungbuk National University Industry-Academic Cooperation Foundation
发明人： Seunghun Yoo , Dojin Choi , Jongtae Lim , Kyoungsoo Bok , Jaesoo Yoo
IPC分类号： G06F12/00 , G06F12/0811 , G06F12/128 , G06F16/901 , G06F12/0891
摘要： A multi-level caching method and a multi-level caching system for enhancing a graph processing performance are provided. The multi-level caching method includes searching for graph data associated with a query from a first cache memory in which data output in response to a previous query request is stored, when a query request for the query is received, re-searching for the graph data from a second cache memory in which neighboring data with a history of an access to each of data stored in the first cache memory is stored, when the graph data is not found in the first cache memory, and outputting first neighboring data found by the re-searching as the graph data when a response to the query request is output.

3. 发明申请

US20180133168A1 PHARMACEUTICAL COMPOSITION FOR TREATING CANCER INCLUDING 2-METHOXY-4-(3-(4-METHOXYPHENYL)PROP-1-EN-1-YL)PHENOL AS ACTIVE INGREDIENT 审中-公开
公开(公告)号：US20180133168A1
公开(公告)日：2018-05-17
申请号：US15564027
申请日：2016-04-08
申请人： CHUNGBUK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Jin-Tae HONG , Hee-Pom LEE , Young-Wan HAM , Chun-Sik KIM , Heon-Sang JUNG
IPC分类号： A61K31/05 , A61P35/00
CPC分类号： A61K31/05 , A61K9/0019 , A61K9/08 , A61K31/09 , A61K47/24 , A61P35/00
摘要： The present disclosure relates to an anticancer use of a novel compound, i.e., 2-methoxy-4-(3-(4-methoxyphenyl)propyl-1-en-1-yl)phenol. The compound of the present disclosure effectively inhibits the growth of cancer cells and tumors in vitro and in a xenograft animal model. The compound of the present disclosure illustrates an anticancer activity by inhibiting a DNA binding activity of transcription factor STAT 3 in cancer cells, inducing apoptosis of cancer cells, and reducing the expression of a cell cycle regulatory protein. The compound of the present disclosure can be developed as an active ingredient of a strong anticancer drug.

4. 发明申请

US20180044275A1 2-METHOXY-4-(3-(4-METHOXYPHENYL)PROP-1-EN-1-YL)PHENOL AND PREPARATION METHOD THEREFOR 审中-公开
公开(公告)号：US20180044275A1
公开(公告)日：2018-02-15
申请号：US15556060
申请日：2016-03-03
申请人： CHUNGBUK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Jin Tae HONG , Hee Pom LEE , Young Wan HAM , Chun Sik KIM , Heon Sang JUNG
IPC分类号： C07C43/23 , C07C41/30
CPC分类号： C07C43/23 , C07C41/30
摘要： Provided herein are 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol having a novel structure capable of being used to prevent or treat all diseases associated with NF-κB, IKK and STAT3, and a method of preparing the same.

5. 发明申请

US20170058352A1 DIAGNOSTIC USE OF VIRUS-ENCODED MICRO RNA HSV1-MIR-H18 AND HSV2-MIR-H9-5P ON PROSTATE CANCER 审中-公开
标题翻译：病毒编码的微RNA HSV1-MIR-H18和HSV2-MIR-H9-5P对前列腺癌的诊断用途
公开(公告)号：US20170058352A1
公开(公告)日：2017-03-02
申请号：US15112641
申请日：2015-03-17
申请人： CHUNGBUK NATIONAL UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
发明人： Wun-Jae KIM , Seok Joong YUN , Pil Du JEONG , Jung Min KIM
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/701 , C12Q1/705 , C12Q2600/158 , C12Q2600/178
摘要： The present invention provides a novel use of hsvI-miR-H18 or hsv2-miR-H9-5p, which is microRNA, for the diagnosis of prostate cancer. According to hsvI-miR-H18 or hsv2-miR-H9-5p of the present invention, it is possible to accurately diagnose even a subject in the PSA gray zone in which accurate diagnosis though PSA is difficult. The present invention can be applied to various biological samples, and exerts accurate diagnostic ability even when a supernatant of the solution excluding, particularly, cell-derived materials is used, and thus a diagnostic procedure is simple and convenient. According to the present invention, the prostate cancer can be accurately and promptly diagnosed at low costs.
摘要翻译：本发明提供了用于诊断前列腺癌的hsvI-miR-H18或hsv2-miR-H9-5p（其是微小RNA）的新用途。根据本发明的hsvI-miR-H18或hsv2-miR-H9-5p，可以准确地诊断PSA难以进行精确诊断的PSA灰色区域的受试者。即使使用除了特别是细胞来源的材料以外的溶液的上清液，本发明也可以应用于各种生物样品，并且即使是诊断程序简单方便，也能发挥准确的诊断能力。根据本发明，可以以低成本准确且及时地诊断前列腺癌。

6. 发明授权

US09476952B2 Structure of measuring iron loss of motor stator core 有权
标题翻译：电机定子铁心损耗测量结构
公开(公告)号：US09476952B2
公开(公告)日：2016-10-25
申请号：US14338204
申请日：2014-07-22
申请人： Hyundai Motor Company , Kia Motors Corporation , Chungbuk National University Industry-Academic Cooperation Foundation
发明人： Young Jin Seo , Myeong Kyu Jung , Dongyeon Han , Shin Gyu Kim , Chang-Seop Koh , Kwang-Young Jeong , Chan-Hyuk Park , Hee-Sung Yoon
IPC分类号： G01R33/14 , G01R33/12 , G01R31/34
CPC分类号： G01R33/123 , G01R31/34 , H02K11/20
摘要： A structure for measuring iron loss of a motor stator core is provided. The structure includes an auxiliary core whose both end surfaces in a longitudinal direction come in contact with inner end surfaces of two adjacent stator teeth among a plurality of stator teeth in a radial direction in order to measure iron loss of a stator core in which a plurality of slots and the plurality of stator teeth are alternately formed on an inner circumferential surface of a stator yoke in a circumferential direction. A pair of excitation windings is provided at portions of the auxiliary core in the longitudinal direction spaced-apart from each other. A B-coil that is a sensor coil is provided at the auxiliary core so as to be positioned inside any one excitation winding of the pair of excitation windings. Fixing protrusions protrude from the both end surfaces of the auxiliary core to extend in the longitudinal direction, and inserted into the slot between the two adjacent stator teeth to be fitted and fixed in the circumferential direction. Accordingly, it is possible to quantitatively and accurately measure iron loss of the motor stator core for each manufacturing process.
摘要翻译：提供了一种用于测量电动机定子铁心的铁损的结构。该结构包括辅助芯，其纵向方向上的两个端面与径向上的多个定子齿中的两个相邻的定子齿的内端表面接触，以便测量定子芯的铁损，其中多个的槽和多个定子齿沿圆周方向交替地形成在定子磁轭的内周面上。辅助铁芯的纵向间隔开的部分设有一对励磁绕组。作为传感器线圈的B线圈设置在辅助铁芯上，以便位于该对励磁绕组的任何一个励磁绕组内。固定突起从辅助芯的两个端面突出，以沿纵向方向延伸，并且插入两个相邻的定子齿之间的狭槽中，以在圆周方向上装配和固定。因此，可以对每个制造工序定量地，精确地测定电动机定子铁心的铁损。

7. 发明授权

US09050301B2 Pharmaceutical composition for treatment of corneal endothelial wounds containing angiogenin 有权
标题翻译：用于治疗含有血管生成素的角膜内皮创伤的药物组合物
公开(公告)号：US09050301B2
公开(公告)日：2015-06-09
申请号：US14493375
申请日：2014-09-23
申请人： Chung-Ang University Industry-Academy Cooperation Foundation , Chungbuk National University Industry-Academic Cooperation Foundation , Industry Academic Cooperation Foundation, Hallym University
发明人： Jae Chan Kim , Kyoung Woo Kim , Yeoun Sook Chun , Soo Hyun Park , Sung Wook Wee , Soo Ik Chang , Kyong Mi Min , Kyu Wan Kim , Young Joo Shin
IPC分类号： A61K38/18 , A61K38/46 , C07K14/515
CPC分类号： A61K38/1891 , A61K38/465 , C07K14/515 , C12Y301/27008
摘要： Provided is a pharmaceutical composition for treating corneal endothelium wounds, the composition including angiogenin as an effective ingredient. The present invention relates to a new topical therapeutic use of angiogenin for treatment of corneal endothelium wounds, wherein the angiogenin that is generally known to be involved in angiogenesis activates a PI3K/Akt/eNOS pathway thereof in ocular corneal endothelium to increase migration and proliferation of corneal endothelial cells that are not capable of self-proliferation and to promote prevention and treatment of corneal endothelial cell wounds.
摘要翻译：本发明提供一种用于治疗角膜内皮伤口的药物组合物，该组合物包含血管生成素作为有效成分。本发明涉及用于治疗角膜内皮创伤的血管生成素的新的局部治疗用途，其中通常已知参与血管发生的血管生成素在眼角膜内皮中激活PI3K / Akt / eNOS途径以增加角膜内皮细胞的迁移和增殖角膜内皮细胞不能自我增殖并促进预防和治疗角膜内皮细胞创伤。

8. 发明申请

US20220413033A1 INSULATION MONITORING DEVICE AND CONTROL METHOD THEREFOR 有权
公开(公告)号：US20220413033A1
公开(公告)日：2022-12-29
申请号：US17756611
申请日：2020-04-02
申请人： LS ELECTRIC CO., LTD. , CHUNGBUK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , DONGWOO ELECTRIC CORP.
发明人： Suhyeong JANG , Jongphil HONG , Pyungjung KIM
IPC分类号： G01R31/12 , G01R31/14
摘要： The present disclosure includes: a signal generation unit for applying a pulse signal to an electric line; a signal measurement unit for measuring the voltage of an applied pulse signal from the ground, when the pulse signal is applied to the ground through insulation resistance; an average voltage calculation unit for calculating the average voltage of the voltages measured during a period depending on sampling intervals; and a control unit for calculating the sampling intervals on the basis of an initial sampling interval and a preset time multiple, calculating the average voltage during the sampling period according to the calculated sampling intervals, and, according to whether the difference between a calculated first average voltage and a second average voltage measured before the first average voltage is within a first error range, detecting the first average voltage as a normal voltage, or calculating the sampling intervals by applying different time multiples thereto.

9. 发明申请

US20220306709A1 AMPHIPHYSIN-I MUTANT HAVING ANTI-SENESCENCE ACTIVITY AND USE THEREOF 有权
公开(公告)号：US20220306709A1
公开(公告)日：2022-09-29
申请号：US17211808
申请日：2021-03-24
申请人： Chungbuk National University Industry-Academic Cooperation Foundation
发明人： Eung Gook KIM , Eun Young SHIN
IPC分类号： C07K14/47
摘要： Disclosed are an amphiphysin-I mutant having anti-senescence activity and the use thereof. More particularly, disclosed are an amphiphysin-I mutant (AMPH-I) wherein valine (V), which is the 392nd amino acid in the amino acid sequence of amphiphysin-I (AMPH-I) represented by SEQ ID NO: 1, is substituted with glycine (G), a composition for suppressing aging and cellular senescence containing the amphiphysin-I mutant as an active ingredient, a pharmaceutical composition for preventing or treating senescence or a senescence-associated disease, a method for suppressing aging and cellular senescence, and a method for screening an inhibitor for aging and cellular senescence. The amphiphysin-I mutant is capable of suppressing both promotion of aging and cellular senescence and reduction of endocytosis caused by suppression of expression of βPIX (PAK1-interacting exchange factor beta), of preventing cleavage of the amphiphysin-I protein caused by calpain, a protease involved in aging and cellular senescence caused by suppressed βPIX expression, and of suppressing the expression of aging and cellular senescence indicators. Thus, the amphiphysin-I mutant is effectively used as a novel therapeutic agent for senescence or senescence-associated diseases.

10. 发明申请

US20220259662A1 BIOMARKER COMPOSITION FOR PREDICTING THERAPEUTIC EFFECT OF MESENCHYMAL STEM CELLS ON RENAL FIBROSIS 有权
公开(公告)号：US20220259662A1
公开(公告)日：2022-08-18
申请号：US17765695
申请日：2020-09-29
申请人： CORESTEM CO.,LTD. , CHUNGBUK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Kyung Suk KIM , Sang Bae HAN , Tae Yong LEE , Hyung Sook KIM
IPC分类号： C12Q1/6883 , C12N5/0775 , G01N33/68 , A61K35/28
摘要： The present invention relates to a biomarker composition for predicting the therapeutic effect of mesenchymal stem cells on renal fibrosis.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式