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1. 发明申请

US20110220802A1 USE OF FLAT PANEL MICROCHANNEL PHOTOMULTIPLIERS IN SAMPLING CALORIMETERS WITH TIMING 有权
标题翻译：平板微电子照相机在采样计时器中的使用
公开(公告)号：US20110220802A1
公开(公告)日：2011-09-15
申请号：US13044442
申请日：2011-03-09
申请人： Henry Frisch , Jean-Francois Genat , Hervé Grabas , Chien-Min Kao , Chin-Tu Chen , Heejong Kim , Fukun Tang
发明人： Henry Frisch , Jean-Francois Genat , Hervé Grabas , Chien-Min Kao , Chin-Tu Chen , Heejong Kim , Fukun Tang
IPC分类号： G01T1/164 , G01T1/202 , G01T1/208
CPC分类号： G01T1/208 , G01T1/2928 , G01T1/2985 , G01T1/363
摘要： Large-area, flat-panel photo-detectors with sub-nanosecond time resolution based on microchannel plates are provided. The large-area, flat-panel photo-detectors enable the economic construction of sampling calorimeters with, for example, enhanced capability to measure local energy deposition, depth-of-interaction, time-of-flight, and/or directionality of showers. In certain embodiments, sub-nanosecond timing resolution supplies correlated position and time measurements over large areas. The use of thin flat-panel viewing radiators on both sides of a radiation-creating medium allows simultaneous measurement of Cherenkov and scintillation radiation in each layer of the calorimeter. The detectors may be used in a variety of applications including, for example, medical imaging, security, and particle and nuclear physics.
摘要翻译：提供了基于微通道板的亚纳秒时间分辨率的大面积平板光电探测器。大面积的平板光电探测器能够对采样量热仪进行经济建设，例如增强测量局部能量沉积，相互作用深度，飞行时间和/或淋浴方向性的能力。在某些实施例中，亚纳秒定时分辨率在大面积上提供相关位置和时间测量。在辐射产生介质的两侧使用薄的平板观察辐射器允许同时测量量热计的每层中的切伦科夫和闪烁辐射。检测器可以用于各种应用，包括例如医学成像，安全性，粒子和核物理学。

2. 发明授权

US08605975B2 Image reconstruction from limited or incomplete data 有权
标题翻译：从有限或不完整的数据重建图像
公开(公告)号：US08605975B2
公开(公告)日：2013-12-10
申请号：US12223946
申请日：2007-02-12
申请人： Xiaochuan M. Pan , Emil Sidky , Chien-min Kao
发明人： Xiaochuan M. Pan , Emil Sidky , Chien-min Kao
IPC分类号： G06K9/00 , G06K9/46
CPC分类号： G06T11/006 , G06T11/005 , G06T2211/424 , G06T2211/432 , G06T2211/436
摘要： A system and method are provided for reconstructing images from limited or incomplete data, such as few view data or limited angle data or truncated data (including exterior and interior data) generated from divergent beams. In one aspect of the invention, the method and apparatus iteratively constrains the variation of an estimated image in order to reconstruct the image. As one example, a divergent beam maybe used to generate data (“actual data”). As discussed above, the actual data may be less than sufficient to exactly reconstruct the image by conventional techniques, such as FBP. In order to reconstruct an image, a first estimated image may be generated. Estimated data may be generated from the first estimated image, and compared with the actual data. The comparison of the estimated data with the actual data may include determining a difference between the estimated and actual data. The comparison may then be used to generate a new estimated image. For example, the first estimated image may be combined with an image generated from the difference data to generate a new estimated image. In order to generate the image for the next iteration, the variation of the new estimated image may be constrained. For example, the variation of the new estimated image may be at least partly constrained in order to lessen or reducing the total variation of the image.
摘要翻译：提供了一种系统和方法，用于从有限或不完整的数据重建图像，例如由发散光束产生的少量视图数据或有限角度数据或截断数据（包括外部和内部数据）。在本发明的一个方面，该方法和装置迭代地约束了估计图像的变化，以便重建图像。作为一个示例，可以使用发散光束来生成数据（“实际数据”）。如上所述，实际数据可能不足以通过诸如FBP的常规技术精确地重建图像。为了重建图像，可以生成第一估计图像。可以从第一估计图像生成估计数据，并与实际数据进行比较。估计数据与实际数据的比较可以包括确定估计数据和实际数据之间的差异。然后可以使用比较来生成新的估计图像。例如，第一估计图像可以与从差数据生成的图像组合以生成新的估计图像。为了生成用于下一次迭代的图像，新估计图像的变化可能受到约束。例如，新估计图像的变化可以至少部分地被限制，以便减少或减少图像的总变化。

3. 发明授权

US08121245B2 Imaging system 有权
标题翻译：成像系统
公开(公告)号：US08121245B2
公开(公告)日：2012-02-21
申请号：US12930856
申请日：2011-01-19
申请人： Xiaochuan Pan , Yu Zou , Lifeng Yu , Chien-Min Kao , Martin King , Maryellen Giger , Dan Xia , Howard Halpern , Charles Pelizzari , Emil Y. Sidky , Seungryong Cho
发明人： Xiaochuan Pan , Yu Zou , Lifeng Yu , Chien-Min Kao , Martin King , Maryellen Giger , Dan Xia , Howard Halpern , Charles Pelizzari , Emil Y. Sidky , Seungryong Cho
IPC分类号： G01T1/00
CPC分类号： A61B6/5288 , A61B6/027 , A61B6/032 , A61B6/037 , A61B6/484 , A61B6/508 , A61B6/5264 , A61B6/583 , A61B6/587
摘要： A method and apparatus for reconstruction of a region of interest for an object is provided. The reconstruction of the object may be based on chords which may fill a part, all, or more than all of the region of interest. Using chords for reconstruction may allow for reducing data acquired and/or processing for reconstructing a substantially exact image of the ROI. Moreover, various methodologies may be used in reconstructing the image, such as backprojection-filtration, and modified filtration backprojection.
摘要翻译：提供了一种用于重建对象的感兴趣区域的方法和装置。对象的重建可以基于可以填充所有感兴趣区域的全部或全部的和弦。使用和弦进行重建可以允许减少获得的数据和/或用于重建ROI的基本上精确的图像的处理。此外，各种方法可用于重建图像，例如反投影过滤和修改过滤反投影。

4. 发明申请

US20050247879A1 Device and method for digitizing gamma ray energy and characterizing peak time and decay time constant without the use of ADC 有权
标题翻译：用于数字化伽马射线能量并表征峰值时间和衰减时间常数而不使用ADC的装置和方法
公开(公告)号：US20050247879A1
公开(公告)日：2005-11-10
申请号：US11097121
申请日：2005-04-04
申请人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
发明人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
IPC分类号： G01T1/161 , A61B6/03 , G01T1/164 , G01T1/17 , G01T1/29
CPC分类号： G01T1/2985 , A61B6/037
摘要： A device and method used in high resolution positron emission tomography (PET) systems for digitizing gamma ray energy and characterizing peak time and decay time constant, models a voltage pulse generated upon a PET event detection as a fast linearly rising edge followed by a slower exponential decay. The model includes parameters of the voltage pulse that are relevant for PET event detection including a decay constant, a peak voltage value, and a peak time, which are determined from time interval measurements of the voltage pulse. The time interval measurements are made using comparators and counters in an exemplary electronic implementation.
摘要翻译：在用于数字化伽马射线能量并表征峰值时间和衰减时间常数的高分辨率正电子发射断层摄影（PET）系统中使用的装置和方法，将在PET事件检测时产生的电压脉冲建模为快速线性上升沿，随后是较慢的指数衰变。该模型包括与包括衰减常数，峰值电压值和峰值时间相关的PET事件检测的电压脉冲的参数，其由电压脉冲的时间间隔测量确定。在示例性电子实现中使用比较器和计数器进行时间间隔测量。

5. 发明授权

US06528793B1 Accurate image reconstruction for DOI-PET system 失效
标题翻译： DOI-PET系统的精确图像重建
公开(公告)号：US06528793B1
公开(公告)日：2003-03-04
申请号：US09693478
申请日：2000-10-20
申请人： Chin-Tu Chen , Xiaochuan Pan , Chien-Min Kao
发明人： Chin-Tu Chen , Xiaochuan Pan , Chien-Min Kao
IPC分类号： G01T1164
CPC分类号： G01V5/0008 , A61B6/037 , G01T1/2985 , G06T11/005
摘要： A method and apparatus are provided for reconstructing images from data obtained from scintillation events occurring within a projection space of a depth-of-interaction positron emission tomography system. The method includes the steps of identifying a segment of each depth-of-interaction detector of respective pairs of depth-of-interaction detectors detecting the scintillation-events of the data obtained within the projection space and estimating a set of sinograms from the data based upon a set of depth-independent point spread functions of the identified segments of the respective pairs of depth-of-interaction detectors.
摘要翻译：提供了一种方法和装置，用于根据在相互作用的深度正电子发射断层摄影系统的投影空间内发生的闪烁事件获得的数据重建图像。该方法包括以下步骤：识别检测在投影空间内获得的数据的闪烁事件的相互对的深度相互作用检测器的每个相互作用检测器的一段，并从基于数据的基础上估计一组中心图在相应的相互作用深度检测器对的所识别的段的一组与深度无关的点扩展函数上。

6. 发明授权

US09025843B2 Imaging system 有权
公开(公告)号：US09025843B2
公开(公告)日：2015-05-05
申请号：US13400503
申请日：2012-02-20
申请人： Xiaochuan Pan , Yu Zou , Lifeng Yu , Chien-Min Kao , Martin King , Maryellen Giger , Dan Xia , Howard Halpern , Charles Pelizzari , Emil Y. Sidky , Seungryong Cho
发明人： Xiaochuan Pan , Yu Zou , Lifeng Yu , Chien-Min Kao , Martin King , Maryellen Giger , Dan Xia , Howard Halpern , Charles Pelizzari , Emil Y. Sidky , Seungryong Cho
IPC分类号： G06K9/00 , A61B6/00 , A61B6/03 , A61B6/02
CPC分类号： A61B6/5288 , A61B6/027 , A61B6/032 , A61B6/037 , A61B6/484 , A61B6/508 , A61B6/5264 , A61B6/583 , A61B6/587
摘要： A method and apparatus for reconstruction of a region of interest for an object is provided. The reconstruction of the object may be based on chords which may fill a part, all, or more than all of the region of interest. Using chords for reconstruction may allow for reducing data acquired and/or processing for reconstructing a substantially exact image of the ROI. Moreover, various methodologies may be used in reconstructing the image, such as backprojection-filtration, and modified filtration backprojection.

7. 发明授权

US08604440B2 Use of flat panel microchannel photomultipliers in sampling calorimeters with timing 有权
标题翻译：平板微通道光电倍增器在采样量热仪中的使用
公开(公告)号：US08604440B2
公开(公告)日：2013-12-10
申请号：US13044442
申请日：2011-03-09
申请人： Henry Frisch , Jean-Francois Genat , Hervé Grabas , Chien-Min Kao , Chin-Tu Chen , Heejong Kim , Fukun Tang , Jeffrey W. Elam , Anil U. Mane
发明人： Henry Frisch , Jean-Francois Genat , Hervé Grabas , Chien-Min Kao , Chin-Tu Chen , Heejong Kim , Fukun Tang , Jeffrey W. Elam , Anil U. Mane
IPC分类号： G01T1/164
CPC分类号： G01T1/208 , G01T1/2928 , G01T1/2985 , G01T1/363
摘要： Large-area, flat-panel photo-detectors with sub-nanosecond time resolution based on microchannel plates are provided. The large-area, flat-panel photo-detectors enable the economic construction of sampling calorimeters with, for example, enhanced capability to measure local energy deposition, depth-of-interaction, time-of-flight, and/or directionality of showers. In certain embodiments, sub-nanosecond timing resolution supplies correlated position and time measurements over large areas. The use of thin flat-panel viewing radiators on both sides of a radiation-creating medium allows simultaneous measurement of Cherenkov and scintillation radiation in each layer of the calorimeter. The detectors may be used in a variety of applications including, for example, medical imaging, security, and particle and nuclear physics.
摘要翻译：提供了基于微通道板的亚纳秒时间分辨率的大面积平板光电探测器。大面积的平板光电探测器能够对采样量热仪进行经济建设，例如增强测量局部能量沉积，相互作用深度，飞行时间和/或淋浴方向性的能力。在某些实施例中，亚纳秒定时分辨率在大面积上提供相关位置和时间测量。在辐射产生介质的两侧使用薄的平板观察辐射器允许同时测量量热计的每层中的切伦科夫和闪烁辐射。检测器可以用于各种应用，包括例如医学成像，安全性，粒子和核物理学。

8. 发明申请

US20120215090A1 IMAGING SYSTEM 有权
标题翻译：成像系统
公开(公告)号：US20120215090A1
公开(公告)日：2012-08-23
申请号：US13400503
申请日：2012-02-20
申请人： Xiaochuan Pan , Yu Zou , Lifeng Yu , Chien-Min Kao , Martin King , Maryellen Giger , Dan Xia , Howard Halpern , Charles Pelizzari , Emil Y. Sidky , Seungryong Cho
发明人： Xiaochuan Pan , Yu Zou , Lifeng Yu , Chien-Min Kao , Martin King , Maryellen Giger , Dan Xia , Howard Halpern , Charles Pelizzari , Emil Y. Sidky , Seungryong Cho
IPC分类号： A61B6/00
CPC分类号： A61B6/5288 , A61B6/027 , A61B6/032 , A61B6/037 , A61B6/484 , A61B6/508 , A61B6/5264 , A61B6/583 , A61B6/587
摘要： A method and apparatus for reconstruction of a region of interest for an object is provided. The reconstruction of the object may be based on chords which may fill a part, all, or more than all of the region of interest. Using chords for reconstruction may allow for reducing data acquired and/or processing for reconstructing a substantially exact image of the ROI. Moreover, various methodologies may be used in reconstructing the image, such as backprojection-filtration, and modified filtration backprojection.
摘要翻译：提供了一种用于重建对象的感兴趣区域的方法和装置。对象的重建可以基于可以填充所有感兴趣区域的全部或全部的和弦。使用和弦进行重建可以允许减少获得的数据和/或用于重建ROI的基本上精确的图像的处理。此外，各种方法可用于重建图像，例如反投影过滤和修改过滤反投影。

9. 发明授权

US07199370B2 Device and method for digitizing gamma ray energy and characterizing peak time and decay time constant without the use of ADC 有权
标题翻译：用于数字化伽马射线能量并表征峰值时间和衰减时间常数而不使用ADC的装置和方法
公开(公告)号：US07199370B2
公开(公告)日：2007-04-03
申请号：US11097121
申请日：2005-04-04
申请人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
发明人： Qingguo Xie , Chien-Min Kao , Zekai Hsiau , Chin-Tu Chen
IPC分类号： G01T1/164
CPC分类号： G01T1/2985 , A61B6/037
摘要： A device and method used in high resolution positron emission tomography (PET) systems for digitizing gamma ray energy and characterizing peak time and decay time constant, models a voltage pulse generated upon a PET event detection as a fast linearly rising edge followed by a slower exponential decay. The model includes parameters of the voltage pulse that are relevant for PET event detection including a decay constant, a peak voltage value, and a peak time, which are determined from time interval measurements of the voltage pulse. The time interval measurements are made using comparators and counters in an exemplary electronic implementation.
摘要翻译：在用于数字化伽马射线能量并表征峰值时间和衰减时间常数的高分辨率正电子发射断层摄影（PET）系统中使用的装置和方法，将在PET事件检测时产生的电压脉冲建模为快速线性上升沿，随后是较慢的指数衰变。该模型包括与包括衰减常数，峰值电压值和峰值时间相关的PET事件检测的电压脉冲的参数，其由电压脉冲的时间间隔测量确定。在示例性电子实现中使用比较器和计数器进行时间间隔测量。

10. 发明申请

US20070036418A1 Imaging system 有权
标题翻译：成像系统
公开(公告)号：US20070036418A1
公开(公告)日：2007-02-15
申请号：US11410594
申请日：2006-04-24
申请人： Xiaochuan Pan , Yu Zou , Lifeng Yu , Chien-Min Kao , Martin King , Maryellen Giger , Dan Xia , Howard Halpern , Charles Pelizzari , Emil Sidky , Seungryong Cho
发明人： Xiaochuan Pan , Yu Zou , Lifeng Yu , Chien-Min Kao , Martin King , Maryellen Giger , Dan Xia , Howard Halpern , Charles Pelizzari , Emil Sidky , Seungryong Cho
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , A61B6/027 , A61B6/502 , A61B6/5288 , G06T2211/432 , G06T2211/436
摘要： A method and apparatus for reconstruction of a region of interest for an object is provided. The reconstruction of the object may be based on chords which may fill a part, all, or more than all of the region of interest. Using chords for reconstruction may allow for reducing data acquired and/or processing for reconstructing a substantially exact image of the ROI. Moreover, various methodologies may be used in reconstructing the image, such as backprojection-filtration, and modified filtration backprojection.
摘要翻译：提供了一种用于重建对象的感兴趣区域的方法和装置。对象的重建可以基于可以填充所有感兴趣区域的全部或全部的和弦。使用和弦进行重建可以允许减少获得的数据和/或用于重建ROI的基本上精确的图像的处理。此外，各种方法可用于重建图像，例如反投影过滤和修改过滤反投影。

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