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1. 发明授权

US09005987B2 Methods for quantitative target detection and related devices and systems 有权
标题翻译：定量目标检测方法及相关设备及系统
公开(公告)号：US09005987B2
公开(公告)日：2015-04-14
申请号：US12761299
申请日：2010-04-15
申请人： Emil P. Kartalov , Axel Scherer , Clive R. Taylor
发明人： Emil P. Kartalov , Axel Scherer , Clive R. Taylor
IPC分类号： G01N27/22 , B01L3/00 , G01N27/00
CPC分类号： B01L3/502753 , B01L2200/0647 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864
摘要： Described herein are methods for quantitative target detection in a sample through use of microbeads and related devices and systems.
摘要翻译：本文描述了通过使用微珠和相关装置和系统在样品中进行定量目标检测的方法。

2. 发明申请

US20100186840A1 MULTI-VALVE MICROFLUIDIC DEVICES AND METHODS 有权
标题翻译：多阀微流体装置和方法
公开(公告)号：US20100186840A1
公开(公告)日：2010-07-29
申请号：US12636086
申请日：2009-12-11
申请人： Emil P. KARTALOV , John LIU , Axel SCHERER , Clive R. TAYLOR
发明人： Emil P. KARTALOV , John LIU , Axel SCHERER , Clive R. TAYLOR
IPC分类号： F15C1/04
CPC分类号： G05D7/0694 , F16K99/0001 , F16K99/0015 , F16K99/0026 , F16K99/0057 , F16K2099/008 , Y10T137/0318 , Y10T137/218 , Y10T137/2202 , Y10T137/2224 , Y10T137/7795 , Y10T137/7796
摘要： Multi-valve autoregulatory microfluidic devices and methods are described. The described devices and methods offer improved performance and new means of tuning autoregulatory effects in microfluidic devices.
摘要翻译：描述了多瓣膜自动调节微流体装置和方法。所描述的装置和方法提供改进的性能和调整微流体装置中的自动调节效应的新手段。

3. 发明授权

US5658743A Antibody to antigen specifically expressed on the surface of B cells and Hodgkin's cells 失效
标题翻译：在B细胞和霍奇金细胞表面上特异性表达的抗原抗体
公开(公告)号：US5658743A
公开(公告)日：1997-08-19
申请号：US229364
申请日：1994-04-18
申请人： Ashraf Imam , Clive R. Taylor
发明人： Ashraf Imam , Clive R. Taylor
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , G01N33/53 , G01N33/574
CPC分类号： C07K14/705 , C07K16/28 , C07K16/3061 , C07K2317/73 , Y10S530/837
摘要： The invention relates to a new antigen termed BLA-36 specifically expressed on the surface of Hodgkin's cells, Reed-Sternberg cells and B lymphocytes, and to a new monoclonal antibody (anti-BLA-36) specific thereto. The antigen is characterized by the following properties:a molecular weight of about 36,000 D;the presence of an epitope recognized by antibody to said protein;specific expression by Hodgkin's cells and Reed-Sternberg cells in all subsets of Hodgkin's disease, and by activated and early proliferating B cells;no expression by T cells;capability of reacting with its antibody in both frozen and fixed/paraffin embedded tissues;a function associated with the growth of cells capable to express said antigen protein.
摘要翻译：本发明涉及在霍奇金细胞，Reed-Sternberg细胞和B淋巴细胞表面特异性表达的称为BLA-36的新抗原，以及与其特异性的新的单克隆抗体（抗BLA-36）。抗原的特征在于以下性质：分子量约36,000D; 存在抗体对所述蛋白质识别的表位; Hodgkin's细胞和Reed-Sternberg细胞在霍奇金病的所有亚型中的特异性表达，以及活化和早期增殖的B细胞; T细胞无表达; 在冷冻和固定/石蜡包埋组织中与其抗体反应的能力; 与能够表达所述抗原蛋白的细胞的生长相关的功能。

4. 发明授权

US5304635A Antigen specifically expressed on the surface of B cells and Hodgkin's cells 失效
标题翻译：抗原特异性表达于B细胞和霍奇金细胞表面
公开(公告)号：US5304635A
公开(公告)日：1994-04-19
申请号：US994082
申请日：1992-12-16
申请人： Ashraf Imam , Clive R. Taylor
发明人： Ashraf Imam , Clive R. Taylor
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , C07K15/00 , A61K35/14
CPC分类号： C07K14/705 , C07K16/28 , C07K16/3061 , C07K2317/73 , Y10S530/837
摘要： The invention relates to a new antigen termed BLA-35 specifically expressed on the surface of Hodgkin's cells, Reed-Sternberg cells and B lymphocytes, and to a new monoclonal antibody (anti-BLA-36) specific thereto. The antigen is characterized by the following properties:a molecular weight of about 36,000 D;the presence of an epitope recognized by antibody to said protein;specific expression by Hodgkin's cells and Reed-Sternberg cells in all subsets of Hodgkin's disease, and by activated and early proliferating B cells;no expression by T cells;capability of reacting with its antibody in both frozen and fixed/paraffin embedded tissues;a function associated with the growth of cells capable to express said antigen protein.
摘要翻译：本发明涉及在霍奇金细胞，Reed-Sternberg细胞和B淋巴细胞表面特异性表达的称为BLA-35的新抗原，以及与其特异性的新的单克隆抗体（抗BLA-36）。抗原的特征在于以下性质：分子量约36,000D; 存在抗体对所述蛋白质识别的表位; Hodgkin's细胞和Reed-Sternberg细胞在霍奇金病的所有亚型中的特异性表达，以及活化和早期增殖的B细胞; T细胞无表达; 在冷冻和固定/石蜡包埋组织中与其抗体反应的能力; 与能够表达所述抗原蛋白的细胞的生长相关的功能。

5. 发明授权

US5019368A Detection of necrotic malignant tissue and associated therapy 失效
标题翻译：检测坏死性恶性组织及相关治疗
公开(公告)号：US5019368A
公开(公告)日：1991-05-28
申请号：US314437
申请日：1989-02-23
申请人： Alan L. Epstein , Clive R. Taylor
发明人： Alan L. Epstein , Clive R. Taylor
IPC分类号： A61K38/00 , A61K47/48 , A61K49/04 , A61K49/16 , A61K51/10 , C07K16/30 , G01N33/574
CPC分类号： G01N33/57496 , A61K47/48384 , A61K47/48569 , A61K49/04 , A61K49/16 , A61K51/1018 , A61K51/1045 , C07K16/30 , C07K16/3061 , A61K2121/00 , A61K2123/00 , A61K38/00 , C07K2317/54
摘要： Disclosed is a method for enhancing the effects of therapy that kills malignant cells in vivo comprising the steps of obtaining monoclonal antibody that is specific to an internal cellular component of a mammal but not to external cellular components, wherein the monoclonal antibody is attached to an antineoplastic agent; initiating therapy in a mammal to kill malignant cells in vivo, thereby causing some of the malignant cells to become necrotic; and administering the antibodies to the mammal. The antibodies bind to the necrotic malignant cells thereby delivering antineoplastic agent to surrounding cells. Also disclosed is a method of de novo therapy comprising administration of antibody-antineoplastic agent conjugate such that antineoplastic agent is delivered to the tumor. Also disclosed are antibodies for use with the foregoing methods and for use with diagnositc methods.
摘要翻译：公开了一种用于增强在体内杀死恶性细胞的治疗效果的方法，包括获得对哺乳动物的内部细胞成分特异但不与外部细胞成分特异的单克隆抗体的步骤，其中单克隆抗体连接于抗肿瘤代理人在哺乳动物中开始治疗以在体内杀死恶性细胞，从而导致一些恶性细胞变坏; 并向哺乳动物施用抗体。抗体结合坏死性恶性细胞，从而将抗肿瘤剂递送至周围细胞。还公开了一种从头治疗的方法，其包括施用抗 - 抗肿瘤剂缀合物，使得抗肿瘤剂递送至肿瘤。还公开了与上述方法一起使用并用于诊断方法的抗体。

6. 发明申请

US20140113385A1 Compositions and Methods for Identifying Single Antigens or Other Molecules in Cell Preparations 审中-公开
标题翻译：在细胞制剂中鉴定单一抗原或其他分子的组合物和方法
公开(公告)号：US20140113385A1
公开(公告)日：2014-04-24
申请号：US13877436
申请日：2011-10-21
申请人： Clive R. Taylor
发明人： Clive R. Taylor
IPC分类号： G01N33/543
CPC分类号： G01N33/54313
摘要： Disclosed are compositions and methods for identifying and preferably quantifying single antigens/molecules in tissue sections and other cell preparations. The methods make use of specific antibodies or aptomers linked with beads or other micro-particles using bright field microscopy having the purpose to identify and quantify single antigens or other molecules.
摘要翻译：公开了用于鉴定和优选地定量组织切片和其它细胞制剂中的单个抗原/分子的组合物和方法。该方法利用具有目的来鉴定和定量单个抗原或其他分子的明视野显微镜，利用与珠粒或其他微粒子连接的特异性抗体或起始物。

7. 发明申请

US20100267162A1 METHODS FOR QUANTITATIVE TARGET DETECTION AND RELATED DEVICES AND SYSTEMS 有权
标题翻译：量化目标检测方法及相关设备和系统
公开(公告)号：US20100267162A1
公开(公告)日：2010-10-21
申请号：US12761299
申请日：2010-04-15
申请人： Emil P. KARTALOV , Axel Scherer , Clive R. Taylor
发明人： Emil P. KARTALOV , Axel Scherer , Clive R. Taylor
IPC分类号： G01N27/22 , G01N27/00
CPC分类号： B01L3/502753 , B01L2200/0647 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864
摘要： Described herein are methods for quantitative target detection in a sample through use of microbeads and related devices and systems.
摘要翻译：本文描述了通过使用微珠和相关装置和系统在样品中进行定量目标检测的方法。

8. 发明申请

US20110306064A1 Quantifiable Internal Reference Standards For Immunohistochemistry And Uses Thereof 审中-公开
标题翻译：可量化的内部参考标准用于免疫组化及其用途
公开(公告)号：US20110306064A1
公开(公告)日：2011-12-15
申请号：US13174585
申请日：2011-06-30
申请人： Clive R. Taylor , Shan Rong Shi
发明人： Clive R. Taylor , Shan Rong Shi
IPC分类号： G01N33/53
CPC分类号： G01N33/96 , G01N33/567 , G01N2001/2893
摘要： Methods for identifying Quantifiable Internal Reference Standards (QIRS) for immunohistochemistry (IHC). Also disclosed are methods for using QIRS to quantify test antigens in IHC.
摘要翻译：用于鉴定免疫组织化学（IHC）的可量化内部参考标准（QIRS）的方法。还公开了使用QIRS在IHC中定量测试抗原的方法。

9. 发明授权

US06682648B1 Electrochemical reporter system for detecting analytical immunoassay and molecular biology procedures 失效
标题翻译：电化学报告系统，用于检测分析免疫分析和分子生物学程序
公开(公告)号：US06682648B1
公开(公告)日：2004-01-27
申请号：US09105538
申请日：1998-06-26
申请人： Robert D. MacPhee , Clive R. Taylor , Rainer Hintsche , Rene Seitz
发明人： Robert D. MacPhee , Clive R. Taylor , Rainer Hintsche , Rene Seitz
IPC分类号： G02N2726
CPC分类号： C12Q1/005 , C12Q1/6825 , G01N27/3277 , G01N33/5438
摘要： An immunochemical and molecular biologic endpoint reporter system in which reaction products, coupled to electrochemically active molecules susceptible to redox recycling or coupled to enzymes capable of proportional generation of said electrochemically active molecules, are detected and/or quantitated using amperiometry in conjunction with a silicon microchip possessing a closely spaced interdigitated array of nobel metal electrodes.
摘要翻译：一种免疫化学和分子生物学终点报告系统，其中使用与硅微芯片结合的Amperionometry来检测和/或定量反应产物，其耦合到对氧化还原循环敏感的电化学活性分子或与能够成比例地产生所述电化学活性分子的酶偶联具有紧密间隔的诺贝尔金属电极的交错排列。

10. 发明授权

US6017514A Detection of necrotic malignant tissue and associated therapy 失效
标题翻译：检测坏死性恶性组织及相关治疗
公开(公告)号：US6017514A
公开(公告)日：2000-01-25
申请号：US268543
申请日：1999-03-11
申请人： Alan L. Epstein , Clive R. Taylor
发明人： Alan L. Epstein , Clive R. Taylor
IPC分类号： A61K38/00 , A61K47/48 , A61K49/04 , A61K49/16 , A61K51/10 , C07K16/30 , G01N33/574 , A61K49/00 , G01N31/00 , G01N33/48
CPC分类号： G01N33/57496 , A61K47/48384 , A61K47/48569 , A61K49/04 , A61K49/16 , A61K51/1018 , A61K51/1045 , C07K16/30 , C07K16/3061 , A61K2121/00 , A61K2123/00 , A61K38/00 , C07K2317/54
摘要： Disclosed is a method for measuring the effectiveness of therapy intended to kill malignant cells in vivo in a mammal, comprising the steps of obtaining monoclonal antibody that is specific to an internal cellular component of the mammal but not to external cellular components, wherein the monoclonal antibody is labeled; contacting the labeled antibody with tissue of a mammal that has received therapy to kill malignant cells in vivo, and determining the effectiveness of the therapy by measuring the binding of the labeled antibody to the internal cellular component. The internal cellular component is preferably insoluble intracellular antigen, and the label is preferably a radionuclide, a radiopaque material, or a magnetic resonance-enhancing material. Also disclosed is a method whereby the antibody to insoluble intracellular antigen is conjugated to an antineoplastic agent, so that upon administration of the antibody-antineoplastic agent conjugate, antineoplastic agent may be delivered to the tumor. Also disclosed are antibodies for use with the foregoing methods.
摘要翻译：公开了一种测量用于在哺乳动物体内杀死恶性细胞的治疗效果的方法，包括以下步骤：获得对哺乳动物的内部细胞成分特异但不与外部细胞成分特异的单克隆抗体，其中单克隆抗体被标记使标记的抗体与已经接受治疗以在体内杀死恶性细胞的哺乳动物的组织接触，并通过测量标记的抗体与内部细胞组分的结合来确定治疗的有效性。内部细胞组分优选为不溶性细胞内抗原，并且标记物优选为放射性核素，不透射线材料或磁共振增强材料。还公开了一种使不溶性细胞内抗原的抗体与抗肿瘤剂缀合的方法，使得在施用抗体 - 抗肿瘤剂缀合物时，可将抗肿瘤药递送至肿瘤。还公开了与上述方法一起使用的抗体。

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