专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060188901A1 Labelled nucleotides 有权
公开(公告)号：US20060188901A1
公开(公告)日：2006-08-24
申请号：US11301578
申请日：2005-12-13
申请人： Colin Barnes , Shankar Balasubramanian , Xiaohai Liu , Harold Swerdlow , John Milton
发明人： Colin Barnes , Shankar Balasubramanian , Xiaohai Liu , Harold Swerdlow , John Milton
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.

2. 发明授权

US07566537B2 Labelled nucleotides 有权
标题翻译：标记核苷酸
公开(公告)号：US07566537B2
公开(公告)日：2009-07-28
申请号：US11301578
申请日：2005-12-13
申请人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , John Milton , Harold Swerdlow , Xiaolin Wu
发明人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , John Milton , Harold Swerdlow , Xiaolin Wu
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/34 , C07H21/00
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
摘要翻译：公开了通过可切割连接基团与可检测标记物连接的核苷和核苷酸。

3. 发明授权

US07057026B2 Labelled nucleotides 有权
公开(公告)号：US07057026B2
公开(公告)日：2006-06-06
申请号：US10227131
申请日：2002-08-23
申请人： Colin Barnes , Shankar Balasubramanian , Xiaohai Liu , Harold Swerdlow , John Milton
发明人： Colin Barnes , Shankar Balasubramanian , Xiaohai Liu , Harold Swerdlow , John Milton
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.

4. 发明授权

US07427673B2 Labelled nucleotides 有权
标题翻译：标记核苷酸
公开(公告)号：US07427673B2
公开(公告)日：2008-09-23
申请号：US10497594
申请日：2002-12-04
申请人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , Harold Swerdlow
发明人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , Harold Swerdlow
IPC分类号： C07H21/02 , C07H21/04 , C07H19/04 , C12Q1/68 , C12P19/34
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
摘要翻译：公开了通过可切割连接基团与可检测标记物连接的核苷和核苷酸。

5. 发明申请

US20060160075A1 Labelled nucleotides 有权
公开(公告)号：US20060160075A1
公开(公告)日：2006-07-20
申请号：US10497594
申请日：2002-12-04
申请人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , Harold Swerdlow
发明人： Shankar Balasubramanian , Colin Barnes , Xiaohai Liu , Harold Swerdlow
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12Q1/6869 , C12Q2525/186 , C12Q2535/113 , C12Q2525/197
摘要： Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.

6. 发明申请

US20100111768A1 SYSTEMS AND DEVICES FOR SEQUENCE BY SYNTHESIS ANALYSIS 有权
标题翻译：通过合成分析进行序列的系统和设备
公开(公告)号：US20100111768A1
公开(公告)日：2010-05-06
申请号：US12295337
申请日：2007-03-30
申请人： Saibal Banerjee , Colin Barnes , Kevin Benson , John Bridgham , Jason Bryant , Dale Buermann , Sergey Etchin , Jonny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Isabelle Rasolonjatovo , Mark Reed , Chiara Rodighiero , Subra Sankar , Gary Schroth , Ning Sizto , Harold Swerdlow , Eric Vermaas
发明人： Saibal Banerjee , Colin Barnes , Kevin Benson , John Bridgham , Jason Bryant , Dale Buermann , Sergey Etchin , Jonny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Isabelle Rasolonjatovo , Mark Reed , Chiara Rodighiero , Subra Sankar , Gary Schroth , Ning Sizto , Harold Swerdlow , Eric Vermaas
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6869 , C12Q2535/122 , C12Q2565/60 , G01N21/6456
摘要： The present invention comprises systems and devices for sequencing of nucleic acid, such as short DNA sequences from clonally amplified single-molecule arrays.
摘要翻译：本发明包括用于核酸测序的系统和装置，例如来自克隆扩增的单分子阵列的短DNA序列。

7. 发明申请

US20070269806A1 Polynucleotide Arrays 有权
标题翻译：多核苷酸阵列
公开(公告)号：US20070269806A1
公开(公告)日：2007-11-22
申请号：US10578460
申请日：2004-11-08
申请人： Darren Ellis , Colin Barnes , Harold Swerdlow , Tom Brown
发明人： Darren Ellis , Colin Barnes , Harold Swerdlow , Tom Brown
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C07F9/6512
CPC分类号： C07H21/00 , C12Q1/6837 , C12Q2525/301 , C12Q2525/113
摘要： The invention provides a hairpin polynucleotide, having a loop and a stem region, characterised in that a sulfur-based nucleophile is attached to an internal nucleotide in the hairpin through a linker to enable binding to a solid support.
摘要翻译：本发明提供了具有环和茎区的发夹多核苷酸，其特征在于通过连接体将硫基亲核试剂连接到发夹中的内部核苷酸以使得能够结合固体支持物。

8. 发明申请

US20060246449A1 Dna sequence analysis 有权
标题翻译： Dna序列分析
公开(公告)号：US20060246449A1
公开(公告)日：2006-11-02
申请号：US10547062
申请日：2004-02-26
申请人： Harold Swerdlow , Colin Barnes , John Todd , Richard Durbin
发明人： Harold Swerdlow , Colin Barnes , John Todd , Richard Durbin
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6827 , C12Q2525/301 , C12Q2561/125
摘要： There is disclosed a method for determining the identity of one or more mutations or single nucleotide polymorphisms (SNPs) in a genome, comprising: a contacting a sample genome, under conditions which permit template dependant oligonucleotide ligation, with a plurality of different oligonucleotide molecules which comprise (i) a first set of oligonucleotides each comprising a sequence of nucleotides that is complementary to a region on said genome that includes a known SNP site and which oligonucleotides are complementary to said region other than at a base at or near the 5′ end of said oligonucleotides that is to be tested for complementarity to a base at the SNP site, each of said oligonucleotides comprising a unique label to identify both the base to be tested and the position of the SNP to be scored, (ii) a second set of oligonucleotides each comprising a sequence of nucleotides complementary to a region on said target genome for hybridisation with said target genome adjacent the 5′ end of an oligonucleotide of said first oligonucleotide set, and a surface capture moiety, a phosphate moiety being located at any of either the 5′ end of said first set of oligonucleotides or the 3′ end of said second set of oligonucleotides, any resulting ligated oligonucleotide being immobilised on a solid support via the surface capture moiety, b. analysing said solid support for the identity of one or more of said unique labels and comparing the defined bases in any of said immobilised oligonucleotides to those of the reference one or more SNPs.
摘要翻译：公开了一种用于确定基因组中一个或多个突变或单核苷酸多态性（SNP）的身份的方法，其包括：在允许模板依赖性寡核苷酸连接的条件下使样品基因组与多种不同的寡核苷酸分子接触，所述寡核苷酸分子包括（i）第一组寡核苷酸，每组寡核苷酸包含与所述基因组上包含已知SNP位点的区域互补的核苷酸序列，并且哪些寡核苷酸除了在5'端或附近的碱基处与所述区域互补待测试的与SNP位点的碱基互补的所述寡核苷酸，每个所述寡核苷酸包含唯一的标记，以鉴别要测试的碱基和待评估的SNP的位置，（ii）第二组的寡核苷酸，其各自包含与所述靶基因组上的区域互补的核苷酸序列，用于与所述靶基因组相邻5相杂交末端的所述第一寡核苷酸组的寡核苷酸，以及表面捕获部分，磷酸酯部分位于所述第一组寡核苷酸的5'端或所述第二组寡核苷酸的3'末端中的任一个，任何所得连接的寡核苷酸通过表面捕获部分固定在固体支持物上，b。分析所述固体支持物中的一种或多种所述独特标记的身份，并将任何所述固定的寡核苷酸中的所定义的碱基与所述参考的一个或多个SNP的那些进行比较。

9. 发明授权

US08241573B2 Systems and devices for sequence by synthesis analysis 有权
标题翻译：通过合成分析进行序列的系统和装置
公开(公告)号：US08241573B2
公开(公告)日：2012-08-14
申请号：US12295337
申请日：2007-03-30
申请人： Saibal Banerjee , Colin Barnes , Kevin Benson , Jason Bryant , Dale Buermann , Sergey Etchin , Johnny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Mark Reed , Chiara Rodighiero , Subra Sankar , Harold Swerdlow , Eric Vermaas
发明人： Saibal Banerjee , Colin Barnes , Kevin Benson , Jason Bryant , Dale Buermann , Sergey Etchin , Johnny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Mark Reed , Chiara Rodighiero , Subra Sankar , Harold Swerdlow , Eric Vermaas
IPC分类号： G01N21/64 , G06K9/00 , C12M1/36
CPC分类号： C12Q1/6869 , C12Q2535/122 , C12Q2565/60 , G01N21/6456
摘要： The present invention comprises systems and devices for sequencing of nucleic acid, such as short DNA sequences from clonally amplified single-molecule arrays.
摘要翻译：本发明包括用于核酸测序的系统和装置，例如来自克隆扩增的单分子阵列的短DNA序列。

10. 发明授权

US08460910B2 Modified polymerases for improved incorporation of nucleotide analogues 有权
标题翻译：用于改善核苷酸类似物掺入的修饰聚合酶
公开(公告)号：US08460910B2
公开(公告)日：2013-06-11
申请号：US10571706
申请日：2004-09-10
申请人： Geoffrey Paul Smith , David Mark Dunstan Bailey , Raquel Maria Sanches , Harold Swerdlow , David James Earnshaw
发明人： Geoffrey Paul Smith , David Mark Dunstan Bailey , Raquel Maria Sanches , Harold Swerdlow , David James Earnshaw
IPC分类号： C12N9/12 , C12P19/34
CPC分类号： C12N9/1252 , C12Q1/6869 , C12Y207/07007
摘要： The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3′ position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
摘要翻译：本发明涉及修饰的聚合酶，其表现出在糖部分的3'位置具有比天然存在的3'羟基更大尺寸的具有取代基的核苷酸类似物的改进掺入。还描述了使用聚合酶将核苷酸掺入多核苷酸的方法，特别是在DNA测序的上下文中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式