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1. 发明申请

US20180117172A1 SITE-SPECIFIC ANTIBODY-DRUG CONJUGATES 审中-公开
公开(公告)号：US20180117172A1
公开(公告)日：2018-05-03
申请号：US15566455
申请日：2016-04-15
申请人： Patricius Hendrikus cornelis VAN BERKEL , MEDIMMUNE LIMITED
发明人： PATRICIUS HENDRIKUS CORNELIS VAN BERKEL , PHILIP WILSON HOWARD
IPC分类号： A61K47/68 , C07K16/32 , A61K39/44 , A61P35/00
CPC分类号： A61K47/6803 , A61K39/44 , A61K47/6855 , A61K2039/505 , A61P35/00 , C07K16/32 , C07K2317/52 , C07K2317/94 , Y02P20/55
摘要： Site-specific anti-body-drug conjugates are described, in particular conjugates comprising an antibody, which binds HER2 and comprises an amino acid substitution of an interchain cysteine residue by an amino acid that is not cysteine, and pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antibody moiety, allows for improved safety and efficacy of the ADC.

2. 发明申请

US20130080711A1 DYNAMIC POWER SCALING OF AN INTERMEDIATE SYMBOL BUFFER ASSOCIATED WITH COVARIANCE COMPUTATIONS 有权
标题翻译：与协议计算相关的中间符号缓冲区的动态功率调整
公开(公告)号：US20130080711A1
公开(公告)日：2013-03-28
申请号：US13239586
申请日：2011-09-22
申请人： Ricky Nas , Cornelis Van Berkel , Jean-Paul Smeets
发明人： Ricky Nas , Cornelis Van Berkel , Jean-Paul Smeets
IPC分类号： G06F12/02
CPC分类号： H04B1/7115 , H04B2001/70935 , H04B2201/709727
摘要： An intermediate symbol buffer (ISB) configuration and method is provided such that the ISB memory comprises 15 portions, one for each HSDPA spreading code. Symbols associated with a spreading code are written to the memory portion associated with the same spreading code. When a covariance calculation is performed to obtain a more accurate channel estimate, only the symbols associated with spreading codes determined to be needed for the covariance calculation are written to the ISB by a buffer block and red from the ISB by a correlation core. The symbols associated with spreading codes that are not necessary for a covariance calculation may be masked from being written or read from the ISB. In some embodiments each memory portion is an individual memory block. In other embodiments a plurality of memory blocks may contain a plurality of memory portions, one memory partition designated, at least temporarily, for each spreading code.
摘要翻译：提供中间符号缓冲器（ISB）配置和方法，使得ISB存储器包括15个部分，每个HSDPA扩展码一个。与扩展码相关联的符号被写入与相同扩展码相关联的存储器部分。当执行协方差计算以获得更准确的信道估计时，只有与确定为协方差计算所需的扩展码相关联的符号由缓冲块写入ISB，并且通过相关核心从ISB写入红色。与协方差计算所不需要的扩展码相关联的符号可以从ISB中被写入或读取。在一些实施例中，每个存储器部分是单个存储器块。在其他实施例中，多个存储器块可以包含多个存储器部分，至少暂时为每个扩展码指定一个存储器分区。

3. 发明授权

US07560938B2 Object sensing 有权
标题翻译：物体感测
公开(公告)号：US07560938B2
公开(公告)日：2009-07-14
申请号：US10555847
申请日：2004-04-28
申请人： Cornelis Van Berkel , Asher J. Hoskins , David S. George
发明人： Cornelis Van Berkel , Asher J. Hoskins , David S. George
IPC分类号： G01R27/26
CPC分类号： H03K17/955 , G06F1/1626 , G06F1/169 , H03K2217/960775
摘要： An electric field object sensing system uses a charge pumping circuit to provide a voltage over a capacitor that varies dependent upon the capacitive coupling between a transmitter electrode and a receiver electrode. The output of the charge pump is preferably fed to a high impedance read-out means, such as an analog-digital converter (ADC). The system is preferably implemented in CMOS and integrated in control circuits of electronic products.
摘要翻译：电场对象感测系统使用电荷泵送电路来提供电容器上的电压，其根据发射器电极和接收器电极之间的电容耦合而变化。电荷泵的输出优选地馈送到诸如模数转换器（ADC）的高阻抗读出装置。该系统优选地在CMOS中实现并集成在电子产品的控制电路中。

4. 发明申请

US20090147160A1 DISPLAY DEVICE 失效
标题翻译：显示设备
公开(公告)号：US20090147160A1
公开(公告)日：2009-06-11
申请号：US11719779
申请日：2005-11-07
申请人： Sander J. Roosendaal , Cornelis Van Berkel
发明人： Sander J. Roosendaal , Cornelis Van Berkel
IPC分类号： G02F1/13363 , G02F1/1333
CPC分类号： G02F1/1335 , G02B27/2214 , G02B27/26 , G02F1/133526 , G02F2203/07 , H04N13/305 , H04N13/359 , H04N13/361
摘要： The present invention relates to a display device with a birefringent lens system having cylindrical lenses, extending in a main direction. The polarisation of light modulated by a LC layer is twisted by a rotator layer (25′) in order to be perpendicular or parallel with this main direction. A birefringent compensation layer (26) is used to remove any ellipticity introduced by the rotator layer (25′). This provides improved contrast when the display device is used e.g. in a switchable 2D/3D display.
摘要翻译：本发明涉及具有在主方向上延伸的柱面透镜的双折射透镜系统的显示装置。由LC层调制的光的偏振由旋转体层（25'）扭转，以便与该主方向垂直或平行。双折射补偿层（26）用于去除由旋转体层（25'）引入的任何椭圆率。当使用显示装置时，这提供了改善的对比度。在可切换的2D / 3D显示。

5. 发明申请

US20080218855A1 Autostereoscopic Display Apparatus and Filter Therefor 有权
标题翻译：自动立体显示装置及其过滤器
公开(公告)号：US20080218855A1
公开(公告)日：2008-09-11
申请号：US12066682
申请日：2006-09-11
申请人： Cornelis Van Berkel
发明人： Cornelis Van Berkel
IPC分类号： G02B27/22 , G02B5/22
CPC分类号： H04N13/317 , H04N13/305 , H04N13/359
摘要： An autostereoscopic display apparatus (8), comprising: a plurality of individually addressable display elements (2) arranged in an array of rows and columns; and light directing means (15) comprising a plurality of light directing elements (16) at a slant angle (α) to the column direction (6); wherein the shape of the individually addressable display elements (2) substantially comprises the shape remaining from a rectangular footprint when one or more cut-outs (2c) is removed; the one or more cut-outs (2c) being positioned relative to the slanted angle (α) of the light directing elements (16) such as to provide a reduction in brightness variation along the row direction (4) compared to what individually addressable display elements shaped according to the rectangular footprint would provide.
摘要翻译：一种自动立体显示装置（8），包括：排列成行和列阵列的多个单独可寻址的显示元件（2）以及光导向装置（15），其包括与列方向（6）成倾斜角（α）的多个导光元件（16）。其中所述单独可寻址显示元件（2）的形状基本上包括当去除一个或多个切口（2c）时从矩形足迹剩余的形状; 所述一个或多个切口（2c）相对于所述光导向元件（16）的倾斜角（α）定位，以便提供沿着所述行方向（4）的亮度变化的减少与可单独寻址的将提供根据矩形足迹成形的显示元件。

6. 发明授权

US07304039B2 Glucose-based compounds with affinity to P-selectin 失效
标题翻译：对P-选择素具有亲和力的葡萄糖基化合物
公开(公告)号：US07304039B2
公开(公告)日：2007-12-04
申请号：US10530601
申请日：2003-10-13
申请人： Chantal Catharina Maria Appeldoorn , Erik Anna Leonardus Biessen , Thomas Jacobus Maria Molenaar , Theodorus Josephus Cornelis Van Berkel
发明人： Chantal Catharina Maria Appeldoorn , Erik Anna Leonardus Biessen , Thomas Jacobus Maria Molenaar , Theodorus Josephus Cornelis Van Berkel
IPC分类号： A61K31/70 , A61K31/715 , A61K9/127
CPC分类号： C07H15/04 , A61K31/70
摘要： The present invention relates to certain glucose-based compounds that have an affinity to P-selectin. Further, the invention relates to the use of these glucose-based compounds for the preparation of pharmaceutical compositions for the treatment of disorders associated with P-selectin, to conjugates, pharmaceutical carriers and drug delivery systems comprising said compounds, and to a method for determining whether a compound is capable of binding to P-selectin.
摘要翻译：本发明涉及对P-选择蛋白具有亲和力的某些基于葡萄糖的化合物。此外，本发明涉及这些基于葡萄糖的化合物在制备用于治疗与P-选择蛋白相关的病症的药物组合物，缀合物，药物载体和包含所述化合物的药物递送系统中的用途，以及用于确定化合物是否能够结合P-选择蛋白。

7. 发明授权

US07273951B2 Polyhydroxy phenols and their use in binding p-selectin 失效
标题翻译：多羟基酚及其在结合p-选择素中的应用
公开(公告)号：US07273951B2
公开(公告)日：2007-09-25
申请号：US10558495
申请日：2004-05-07
申请人： Erik Anna Leonardus Biessen , Chantal Catharina Maria Appeldoorn , Arnaud Bonnefoy , Theodorus Josephus Cornelis Van Berkel , Johan Kuiper , Marc Florimond Hoylaerts
发明人： Erik Anna Leonardus Biessen , Chantal Catharina Maria Appeldoorn , Arnaud Bonnefoy , Theodorus Josephus Cornelis Van Berkel , Johan Kuiper , Marc Florimond Hoylaerts
IPC分类号： C07C229/00 , C07C69/96 , A01N37/18 , A61K38/00 , A61K51/00 , A61M36/14 , C07D209/04
CPC分类号： C07D209/20 , A61K9/107 , A61K9/127 , C07C69/96 , C07C237/22
摘要： Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenols as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P-selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.
摘要翻译：提供作为酰基肽的非肽模拟物的多羟基酚，以及使用没食子酸提供部分制备没食子酸衍生物的方法以及含有多羟基苯酚的药物和营养组合物。提供了使用多羟基酚作为药物，特别是制备用于预防，治疗或诊断其中涉及P-选择素的疾病或病症的药物。相同的化合物也可以用作组合物中表达P-选择蛋白的细胞或组织的靶向工具，还包含载体中的活性化合物。

8. 发明申请

US20070052428A1 Object sensing 有权
标题翻译：物体感测
公开(公告)号：US20070052428A1
公开(公告)日：2007-03-08
申请号：US10555847
申请日：2004-04-28
申请人： Cornelis Van Berkel
发明人： Cornelis Van Berkel
IPC分类号： G06F3/00
CPC分类号： H03K17/955 , G06F1/1626 , G06F1/169 , H03K2217/960775
摘要： An electric field object sensing system (1) and method. The system (1) comprises a transmitter electrode (2), a receiver electrode (4), a switching circuit (32) coupled to the receiver electrode, an alternating voltage source (3) coupled to the transmitter electrode (2) and the switching circuit (32), and an output connection (34) coupled to the receiver electrode (4). Charge pumping performed according to the alternating voltage cycle provides a voltage over a capacitor (43) of the switching circuit (32) that increases dependent upon the capacitive coupling between the transmitter electrode (2) and the receiver electrode (4). The voltage over the capacitor (43) of the switching circuit (32) is allowed to saturate, and the saturated voltage is used as an output (20) that varies when an object (8) is in the vicinity of the transmitter and receiver electrodes. The output (20) may be fed to a high impedance read-out means e.g. an (24). The system (1) may be implemented in CMOS and integrated in control circuits of electronic products.
摘要翻译：一种电场对象感测系统（1）及方法。系统（1）包括发射器电极（2），接收器电极（4），耦合到接收器电极的开关电路（32），耦合到发射器电极（2）的交流电压源（3）电路（32）和耦合到接收器电极（4）的输出连接（34）。根据交流电压周期执行的电荷泵送提供了开关电路（32）的电容器（43）上的电压，其依赖于发射器电极（2）和接收器电极（4）之间的电容耦合而增加。使开关电路（32）的电容器（43）上的电压饱和，并且饱和电压被用作当物体（8）处于发射器和接收器电极附近时改变的输出（20）。输出（20）可以被馈送到高阻抗读出装置，例如，（24）。系统（1）可以在CMOS中实现并集成在电子产品的控制电路中。

9. 发明申请

US20060269037A1 Configurable multi-step linear feedback shift register 有权
标题翻译：可配置的多步线性反馈移位寄存器
公开(公告)号：US20060269037A1
公开(公告)日：2006-11-30
申请号：US10552048
申请日：2004-03-30
申请人： Cornelis Van Berkel , Ricky Nas
发明人： Cornelis Van Berkel , Ricky Nas
IPC分类号： G11C19/00
CPC分类号： G06F7/584 , G06F7/72
摘要： The state transition of a linear feedback shift register (LFSR) controlled by a clock (310) with length N and step size W, W being at least two, is accomplished via a next-state function (320). The next-state function deploys a state transition matrix (350). The state vector (330), which represents the contents of the LFSR, is either multiplied sequentially by the state transition matrix or multiplied by the state transition matrix to the power of W (multiple state transition matrix). The method and the LFSR according to the invention are characterized in that the multiple state transition matrix is decomposed in a first matrix (360) and a second matrix (370), the first matrix comprising at most N+W+1 different expressions and the second matrix comprising at most N+W+1 different expressions. The LFSR further comprises means to multiply the state vector by the second matrix and the first matrix, and means for computing the first matrix. The invention overcomes the shortcomings of configurable multi-step linear feedback shift registers because the amount of time needed to generate the output can be reduced significantly.
摘要翻译：通过下一状态功能（320）实现由具有长度N和步长W，W至少为2的时钟（310）控制的线性反馈移位寄存器（LFSR）的状态转换。下一状态函数部署状态转换矩阵（350）。代表LFSR的内容的状态向量（330）被状态转移矩阵顺序相乘或乘以状态转移矩阵到W的幂（多状态转移矩阵）。根据本发明的方法和LFSR的特征在于，多状态转移矩阵在第一矩阵（360）和第二矩阵（370）中被分解，第一矩阵包括至多N + W + 1个不同表达式，并且第二矩阵包括至多N + W + 1个不同表达式。 LFSR还包括将状态向量乘以第二矩阵和第一矩阵的装置，以及用于计算第一矩阵的装置。本发明克服了可配置的多级线性反馈移位寄存器的缺点，因为可以显着地减少产生输出所需的时间量。

10. 发明授权

US07109726B2 Object sensing 失效
标题翻译：物体感测
公开(公告)号：US07109726B2
公开(公告)日：2006-09-19
申请号：US10197652
申请日：2002-07-17
申请人： Cornelis van Berkel
发明人： Cornelis van Berkel
IPC分类号： G01R27/26
CPC分类号： G01V3/088 , G01D5/24 , H03K2217/960775
摘要： A combined passive and active object sensing system (30; 50; 70) employing electric field sensing is described. An electric field sensing transmission electrode (2) generates a first electric field (11, 12, 13) that induces a current in an electric field sensing reception electrode (4). A passive object (10) is sensed from variation in this current. An active object (31; 51; 71) comprises a further electric field sensing transmission electrode (33; 53; 73) and generates a second electric field (35, 36, 37; 55, 56, 57; 75, 76, 77). This may be generated by the active object (31) coupling with and applying a phase shift to the first electric field (11, 12, 13). Alternatively the second electric field (55, 56, 57) may be generated at a different frequency to the first electric field (11, 12, 13). Alternatively the second electric field (75, 76, 77) may be generated by the active object (71) coupling with an alternating magnetic field generated by a coil (172). The second electric field (35, 36, 37; 55, 56, 57; 75, 76, 77) induces a current in the electric field sensing reception electrode (4) that varies with the position of the active object (31; 51; 71). The separate currents are distinguished by virtue of their different phase or frequency.
摘要翻译：描述了采用电场感测的组合的被动和主动物体感测系统（30; 50; 70）。电场感测传输电极（2）产生在电场感测接收电极（4）中引起电流的第一电场（11,12,13）。从该电流的变化中检测被动物体（10）。活动物体（31; 51; 71）包括另外的电场感测传输电极（33; 53; 73）并产生第二电场（35,36,37; 55,56,57; 75,76,77）。这可以由与第一电场（11,12,13）耦合并施加相移的活动对象（31）产生。或者，第二电场（55,56,57）可以以与第一电场（11,12,13）不同的频率生成。或者，第二电场（75,76,77）可以由与由线圈（172）产生的交变磁场耦合的主动对象（71）产生。所述第二电场（35,36,37; 55,56,57; 75,76,77）在所述电场感测接收电极（4）中感应电流随着所述活动物体（31; 51; 51）的位置而变化。 71）。单独的电流由于其不同的相位或频率而被区分开。

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