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1. 发明申请

US20080086273A1 ANALYTE SENSOR 有权
公开(公告)号：US20080086273A1
公开(公告)日：2008-04-10
申请号：US11691466
申请日：2007-03-26
申请人： Mark Shults , Apurv U. Kamath , Mark Brister , David K. Wong
发明人： Mark Shults , Apurv U. Kamath , Mark Brister , David K. Wong
IPC分类号： G06F19/00
CPC分类号： A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/412 , A61B5/6848 , A61B5/6849 , A61B2560/0223 , A61M5/14 , A61M5/16804 , A61M5/1723 , A61M2230/201
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

2. 发明授权

US6027479A Medical apparatus incorporating pressurized supply of storage liquid 失效
标题翻译：医疗器械结合加压储存液体供应
公开(公告)号：US6027479A
公开(公告)日：2000-02-22
申请号：US32752
申请日：1998-02-27
申请人： Philip E. Alei , David K. Wong , Joseph Y. Lucisano , Daniel Glazerman , David Buse
发明人： Philip E. Alei , David K. Wong , Joseph Y. Lucisano , Daniel Glazerman , David Buse
IPC分类号： A61B5/15 , A61B5/00 , A61B5/1473 , A61M37/00
CPC分类号： A61B5/14557 , A61M2209/06
摘要： An improved apparatus is disclosed for maintaining a medical assembly, e.g., a blood chemistry electrode assembly, filled with a bubble-free storage liquid for an extended storage time period. The apparatus achieves this result by connecting to the assembly a pressurized reservoir that supplies additional storage liquid, to replenish any storage liquid lost due to diffusion from the medical assembly.
摘要翻译：公开了一种改进的装置，用于维持医疗组件，例如血液化学电极组件，其填充有无气泡储存液体以延长存储时间段。该设备通过连接到组件来实现这一结果，加压容器提供额外的储存液体，以补充由于从医疗组件的扩散而损失的任何储存液体。

3. 发明授权

US5758643A Method and apparatus for monitoring blood chemistry 失效
标题翻译：监测血液化学的方法和装置
公开(公告)号：US5758643A
公开(公告)日：1998-06-02
申请号：US688153
申请日：1996-07-29
申请人： David K. Wong , James E. Gharib , Kenneth Curry , Luis Retana
发明人： David K. Wong , James E. Gharib , Kenneth Curry , Luis Retana
IPC分类号： A61B5/145 , A61B5/00 , A61B5/155 , A61B5/14
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14557 , A61B5/15003 , A61B5/150229 , A61B5/150992 , A61B5/155 , A61B5/150809 , A61B5/150946 , A61M2230/201
摘要： An improved system is disclosed for monitoring a patient's blood chemistry, wherein the system intermittently draws blood samples from the patient into a special sensor assembly having a plurality of analytical sensors, each sensitive to a particular parameter of the blood. After signals produced by these various sensors have been read, the system reinfuses the blood samples back into the patient. Withdrawal of the successive samples to a desired, optimal position within the sensor assembly is achieved by monitoring signals produced by one or more of the analytical sensors, themselves. This allows a catheter that connects the sensor assembly to the patient to have a variable length and internal volume and obviates the need for a separate, dedicated sensor for detecting the arrival of the blood sample at the desired position.
摘要翻译：公开了一种用于监测患者血液化学物质的改进的系统，其中系统间歇地将患者的血液样品从具有多个分析传感器的特殊传感器组件抽取，每个分析传感器对血液的特定参数敏感。在读取由这些各种传感器产生的信号之后，系统将血液样本重新灌注到患者体内。通过监测由一个或多个分析传感器本身产生的信号来实现将连续样品提取到传感器组件内所需的最佳位置。这允许将传感器组件连接到患者具有可变长度和内部体积的导管，并且不需要单独的专用传感器来检测血液样品到达所需位置。

4. 发明授权

US5505828A Calibration solutions useful for analysis of biological fluids and methods employing same 失效
标题翻译：用于分析生物流体的校准溶液和使用其的方法
公开(公告)号：US5505828A
公开(公告)日：1996-04-09
申请号：US379555
申请日：1995-02-02
申请人： David K. Wong , Kenneth M. Curry
发明人： David K. Wong , Kenneth M. Curry
IPC分类号： G01N33/483 , A61B5/00 , A61M5/168 , G01N1/00 , G01N27/26 , G01N27/27 , G01N33/487 , G01N33/49 , G01N33/84 , G01N33/94 , G01N33/96
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/1495 , G01N33/4925 , G01N33/84 , G01N33/96 , G01N2496/70 , G01N2496/80
摘要： Novel calibration solutions are provided which are useful, for example, with sensor assemblies used for analysis of CO.sub.2, and optionally, for concurrent analysis of O.sub.2, especially in combination infusion fluid delivery/blood chemistry analysis systems which include a sensor assembly with each of the assembly electrodes mounted in an electrode cavity in the assembly. The analysis system used in the practice of the present invention typically includes provision for delivering infusion fluid and measuring blood chemistry during reinfusion of the physiological fluid at approximately the same flow rates. The invention calibration solutions are useful for calibrating an array of sensors capable of simultaneously measuring a number of blood chemistry parameters, including the partial pressures (tensions) of carbon dioxide and oxygen, pH (hydrogen ion), sodium, potassium, ionized calcium, ionized magnesium, chloride, glucose, lactate and hematocrit, in body fluids. More particularly, this invention relates to the use of an infusible intravenous solution to facilitate calibration on a regular basis for every individual sensor in a sensor assembly, which is in constant fluid communication with the body regardless of whether the sensors are ex vivo or in vivo.
摘要翻译： PCT No.PCT / US93 / 08109 Sec。 371日期：1995年2月2日 102（e）日期1995年2月2日PCT提交1993年8月26日PCT公布。公开号WO94 / 06019 日期为1994年3月17日。提供了新的校准解决方案，例如，用于分析二氧化碳的传感器组件，以及可选地用于O2的并发分析，特别是组合输液输送/血液化学分析系统中，包括传感器组件，其中每个组装电极安装在组件中的电极腔中。在本发明的实践中使用的分析系统通常包括在大致相同的流速下在生理流体的再灌注期间输送输液和测量血液化学物质。本发明的校准解决方案可用于校准能够同时测量多个血液化学参数的传感器阵列，包括二氧化碳和氧气的分压（张力），pH（氢离子），钠，钾，离子化钙，离子化镁，氯化物，葡萄糖，乳酸盐和血细胞比容。更具体地说，本发明涉及使用不可渗透的静脉内溶液来促进传感器组件中与传感器组件恒定流体连通的每个传感器的定期校准，而不管传感器是离体还是体内。

5. 发明授权

US07775975B2 Analyte sensor 有权
标题翻译：分析物传感器
公开(公告)号：US07775975B2
公开(公告)日：2010-08-17
申请号：US11691432
申请日：2007-03-26
申请人： Mark Brister , Sean Saint , James R. Petisce , Mark Shults , Jacob S. Leach , David K. Wong , Kum Ming Woo
发明人： Mark Brister , Sean Saint , James R. Petisce , Mark Shults , Jacob S. Leach , David K. Wong , Kum Ming Woo
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/412 , A61B5/6848 , A61B5/6849 , A61B2560/0223 , A61M5/14 , A61M5/16804 , A61M5/1723 , A61M2230/201
摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
摘要翻译：提供了用于宿主血管系统的连续分析物测量的系统和方法。在一些实施例中，连续葡萄糖测量系统包括血管通路装置，传感器和传感器电子装置，所述系统被配置为插入与主机的循环系统的通信。

6. 发明授权

US06282504B1 Method of receiving a facsimile message 有权
标题翻译：接收传真信息的方法
公开(公告)号：US06282504B1
公开(公告)日：2001-08-28
申请号：US09128653
申请日：1998-08-04
申请人： David K. Wong , Nagesh Challa
发明人： David K. Wong , Nagesh Challa
IPC分类号： G06F944
CPC分类号： H04N1/00896 , H04M1/656 , H04M1/72519 , H04N1/00885 , H04N1/32704 , H04N1/32708 , H04N1/3271 , H04N1/32717 , H04N1/32719 , H04N1/32723 , H04N1/32728 , H04N1/32763
摘要： A low power recording devices permits various flexible power options, including a no-battery option in which the recording device satisfies its entire power requirements from the telephone wall socket and from the RS-232 socket of a computer, and a no-battery option in which the recording device satisfies its entire power requirements from the power source for the mobile telephone. Neither no-battery option exerts a significant additional load on the power source. Voice signals are digitized and stored in low power non-volatile memory. Facsimile signals either are digitized and stored in low power non-volatile memory, or are decoded and stored in low power non-volatile memory. An audio recording and playback capability through an integrated speaker-microphone pair is provided.
摘要翻译：低功率记录设备允许各种灵活的电源选项，包括无电池选项，其中记录装置满足来自电话墙壁插座和计算机的RS-232插座的全部电源要求，以及无电池选项记录装置满足来自移动电话的电源的整个功率要求。无电池选项都不会对电源施加显着的额外负载。语音信号被数字化并存储在低功率非易失性存储器中。传真信号被数字化并存储在低功率非易失性存储器中，或者被解码并存储在低功率非易失性存储器中。提供通过集成扬声器 - 麦克风对的音频记录和回放功能。

7. 发明授权

US5932175A Sensor apparatus for use in measuring a parameter of a fluid sample 失效
标题翻译：用于测量流体样品参数的传感器装置
公开(公告)号：US5932175A
公开(公告)日：1999-08-03
申请号：US719489
申请日：1996-09-25
申请人： Wallace L. Knute, deceased , David K. Wong , Joseph Y. Lucisano , Thomas J. Carlisle , Alfonso Del Toro
发明人： Wallace L. Knute, deceased , David K. Wong , Joseph Y. Lucisano , Thomas J. Carlisle , Alfonso Del Toro
IPC分类号： G01N27/40 , G01N33/487 , G01N27/406 , G01N33/48
CPC分类号： G01N27/3271
摘要： An improved sensor apparatus of a kind that positions a semi-permeable membrane adjacent to an electrode assembly, for measuring a predetermined parameter, e.g., glucose concentration, of an adjacent fluid sample. A special compressible ring serves a first function of tensioning the membrane so that it is maintained in intimate contact with the electrode assembly, and it further serves a second function of sealing the fluid sample from the external environment.
摘要翻译：一种改进的传感器装置，其一种将半透膜邻近电极组件定位，用于测量相邻流体样品的预定参数，例如葡萄糖浓度。特殊的可压缩环用于张紧膜的第一功能，使得其保持与电极组件的紧密接触，并且其进一步起到将流体样品与外部环境密封的第二功能。

8. 发明授权

US5862099A Non-volatile programmable memory having a buffering capability and method of operation thereof 失效
标题翻译：具有缓冲能力的非易失性可编程存储器及其操作方法
公开(公告)号：US5862099A
公开(公告)日：1999-01-19
申请号：US939785
申请日：1997-09-29
申请人： Michel E. Gannage , David K. Wong , Asim A. Bajwa
发明人： Michel E. Gannage , David K. Wong , Asim A. Bajwa
IPC分类号： G11C7/00 , G11C16/10
CPC分类号： G11C16/10 , G11C7/00
摘要： A computer system includes a computing device such as a microcontroller and a memory device. The memory device is illustratively a serial device connected to the serial port of the microcontroller. The memory device includes a page latch load circuit which provides serial I/O to the microcontroller and transfers I/O bits in a predetermined order to/from the page latches. Page latches are connected over many bit lines to a memory cell array. The page latches not only supports programming and reading of sectors in the memory cell array, but also provides one or more of the following functions: directly accessible to the microcontroller as an SRAM scratch pad, directly loadable from the memory cell array to facilitate single byte "read-modify-write" operations, and loadable during programming operations to support real time applications.
摘要翻译：计算机系统包括诸如微控制器和存储器设备的计算设备。存储器件例如是连接到微控制器的串行端口的串行设备。存储器件包括页锁存器负载电路，其向微控制器提供串行I / O并且以预定顺序向/从页锁存器传送I / O位。页锁存器通过许多位线连接到存储单元阵列。该页面锁存器不仅支持对存储单元阵列中的扇区进行编程和读取，而且还提供以下功能中的一个或多个：微控制器可直接作为SRAM临时存储器访问，可直接从存储单元阵列加载，以方便单字节 “读 - 修改 - 写”操作，并可在编程操作期间加载以支持实时应用程序。

9. 发明授权

US5330634A Calibration solutions useful for analyses of biological fluids and methods employing same 失效
标题翻译：用于分析生物液体的校准溶液和使用该液体的方法
公开(公告)号：US5330634A
公开(公告)日：1994-07-19
申请号：US937980
申请日：1992-08-28
申请人： David K. Wong , Kenneth M. Curry
发明人： David K. Wong , Kenneth M. Curry
IPC分类号： G01N33/483 , A61B5/00 , A61M5/168 , G01N1/00 , G01N27/26 , G01N27/27 , G01N33/487 , G01N33/49 , G01N33/84 , G01N33/94 , G01N33/96
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/1495 , G01N33/4925 , G01N33/84 , G01N33/96 , G01N2496/70 , G01N2496/80
摘要： Novel calibration solutions are provided which are useful, for example, with sensor assemblies used for analysis of CO.sub.2, especially in combination infusion fluid delivery/blood chemistry analysis systems which include a sensor assembly with each of the assembly electrodes mounted in an electrode cavity in the assembly. The analysis system used in the practice of the present invention typically includes provision for delivering infusion fluid and measuring blood chemistry during reinfusion of the physiological fluid at approximately the same flow rates. The invention calibration solutions are useful for calibrating an array of sensors capable of simultaneously measuring a number of blood chemistry parameters, including the partial pressures (tensions) of carbon dioxide and oxygen, pH (hydrogen ion), sodium, potassium, ionized calcium, ionized magnesium, chloride, glucose, lactate and hematocrit, in body fluids. More particularly, this invention relates to the use of an infusible intravenous solution to facilitate calibration on a regular basis for every individual sensor in a sensor assembly, which is in constant fluid communication with the body regardless of whether the sensors are ex vivo or in vivo.
摘要翻译：提供了新的校准解决方案，例如用于分析二氧化碳的传感器组件，特别是在组合输注液输送/血液化学分析系统中，其包括传感器组件，其中每个组装电极安装在电极腔中部件。在本发明的实践中使用的分析系统通常包括在大致相同的流速下在生理流体的再灌注期间输送输液和测量血液化学物质。本发明的校准解决方案可用于校准能够同时测量多个血液化学参数的传感器阵列，包括二氧化碳和氧气的分压（张力），pH（氢离子），钠，钾，离子化钙，离子化镁，氯化物，葡萄糖，乳酸盐和血细胞比容。更具体地说，本发明涉及使用不可渗透的静脉内溶液来促进传感器组件中与传感器组件恒定流体连通的每个传感器的定期校准，而不管传感器是离体还是体内。

10. 发明授权

US08958414B1 Intelligent chassis management 有权
标题翻译：智能机箱管理
公开(公告)号：US08958414B1
公开(公告)日：2015-02-17
申请号：US12152952
申请日：2008-05-19
申请人： David K. Wong
发明人： David K. Wong
IPC分类号： H04L12/66 , H04L12/28 , H04J3/16 , H04J3/22 , G06F15/173 , G06F9/455
CPC分类号： H04L49/40 , G06F15/161 , G08B21/18 , H04J3/047 , H04J3/247 , H04L12/403
摘要： A modular system uses point-to-point communication between field-programmable gate arrays (FPGAs) on a control module and each port module, respectively, to manage basic module functions, such as power, environmental monitoring, and health checks on the modules and their components. This allows a chassis to be managed without fully powering each card first, frees processors on the modules from having to perform health checks, allows dedicated resources to rapidly monitor the health of each card, and prevents one bad card from disabling management of all cards.
摘要翻译：模块化系统分别在控制模块和每个端口模块上使用现场可编程门阵列（FPGA）之间的点对点通信，以管理模块的基本模块功能，如电源，环境监控和健康检查; 他们的组件。这允许在不完全为每个卡供电的情况下管理机箱，使模块上的处理器不必执行健康检查，允许专用资源快速监控每个卡的健康状况，并防止一个坏卡禁用所有卡的管理。

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