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1. 发明申请

US20170322142A1 CELL CAPTURE SYSTEM AND METHOD OF USE 审中-公开
公开(公告)号：US20170322142A1
公开(公告)日：2017-11-09
申请号：US15657553
申请日：2017-07-24
申请人： DeNovo Sciences, Inc.
发明人： Kalyan Handique , Priyadarshini Gogoi , Christopher Siemer , Saedeh Sepehri Javdani
IPC分类号： G01N15/14 , B01L3/00 , G01N1/20 , G01N1/28 , G01N1/40 , C12M1/00 , G01N15/00 , G01N15/10
CPC分类号： G01N15/1484 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0636 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0819 , B01L2300/0848 , B01L2300/0877 , B01L2300/168 , B01L2400/086 , C12M47/04 , G01N1/20 , G01N1/28 , G01N1/40 , G01N1/405 , G01N2015/0065 , G01N2015/1006
摘要： A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.

2. 发明授权

US09612199B2 System for imaging captured cells 有权
公开(公告)号：US09612199B2
公开(公告)日：2017-04-04
申请号：US15199245
申请日：2016-06-30
申请人： DeNovo Sciences, Inc.
发明人： Kalyan Handique , Kyle Gleason , Christopher Siemer , Priyadarshini Gogoi , Saedeh Sepehri Javdani , Gene Parunak , Aaron Kehrer , Jon Meines
IPC分类号： G01N33/00 , G01N21/64
CPC分类号： G01N33/4833 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G01N2021/6439
摘要： A system for imaging captured cells comprising: an illumination module configured to illuminate a target object; a platform configured to position the target object in relation to the illumination module; a filter module configured to filter light transmitted to the target object and/or to filter light received from the target object, an optical sensor configured to receive light from the target object and to generate image data; and a focusing and optics module configured to manipulate light transmitted to the optical sensor. The system can further comprise one or more of: a control system configured to control at least one of the illumination module, the platform, the focusing and optics module, the filter module, and the optical sensor; a tag identifying system configured to identify and communicate tag information from system elements; a thermal control module configured to adjust temperature parameters of the system; and an image stabilization module.

3. 发明申请

US20140273194A1 SYSTEM FOR IMAGING CAPTURED CELLS 有权
标题翻译：用于成像捕获细胞的系统
公开(公告)号：US20140273194A1
公开(公告)日：2014-09-18
申请号：US14208458
申请日：2014-03-13
申请人： DeNovo Sciences, Inc.
发明人： Kalyan Handique , Kyle Gleason , Christopher Siemer , Priyadarshini Gogoi , Saedeh Sepehri Javdani
IPC分类号： G01N21/64
CPC分类号： G01N33/4833 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G01N2021/6439
摘要： A system for imaging captured cells comprising: an illumination module configured to illuminate a target object; a platform configured to position the target object in relation to the illumination module; a filter module configured to filter light transmitted to the target object and/or to filter light received from the target object, an optical sensor configured to receive light from the target object and to generate image data; and a focusing and optics module configured to manipulate light transmitted to the optical sensor. The system can further comprise one or more of: a control system configured to control at least one of the illumination module, the platform, the focusing and optics module, the filter module, and the optical sensor; a tag identifying system configured to identify and communicate tag information from system elements; a thermal control module configured to adjust temperature parameters of the system; and an image stabilization module.
摘要翻译：一种用于拍摄细胞成像的系统，包括：照明模块，被配置为照射目标物体; 被配置为相对于所述照明模块定位所述目标物体的平台; 滤波模块，被配置为过滤传输到目标物体的光和/或滤光从目标物体接收的光;光学传感器，被配置为从目标物体接收光并产生图像数据; 以及被配置为操纵传输到光学传感器的光的聚焦和光学模块。该系统还可以包括以下中的一个或多个：被配置为控制照明模块，平台，聚焦和光学模块，滤光器模块和光学传感器中的至少一个的控制系统; 标签识别系统，被配置为从系统元件识别和传达标签信息; 配置为调节系统的温度参数的热控制模块; 和图像稳定模块。

4. 发明授权

US10345219B2 Cell capture system and method of use 有权
公开(公告)号：US10345219B2
公开(公告)日：2019-07-09
申请号：US15657553
申请日：2017-07-24
申请人： DeNovo Sciences, Inc.
发明人： Kalyan Handique , Priyadarshini Gogoi , Christopher Siemer , Saedeh Sepehri Javdani
IPC分类号： G01N1/02 , G01N1/28 , G01N1/20 , B01L3/00 , G01N15/14 , G01N1/40 , C12M1/00 , G01N15/00 , G01N15/10
摘要： A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.

5. 发明申请

US20170153219A1 SYSTEM FOR IMAGING CAPTURED CELLS 审中-公开
公开(公告)号：US20170153219A1
公开(公告)日：2017-06-01
申请号：US15430833
申请日：2017-02-13
申请人： DeNovo Sciences, Inc.
发明人： Kalyan Handique , Kyle Gleason , Christopher Siemer , Priyadarshini Gogoi , Saedeh Sepehri Javdani , Gene Parunak , Aaron Kehrer , Jon Meines
IPC分类号： G01N33/483 , G01N21/64
CPC分类号： G01N33/4833 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G01N2021/6439
摘要： A system for imaging captured cells comprising: an illumination module configured to illuminate a target object; a platform configured to position the target object in relation to the illumination module; a filter module configured to filter light transmitted to the target object and/or to filter light received from the target object, an optical sensor configured to receive light from the target object and to generate image data; and a focusing and optics module configured to manipulate light transmitted to the optical sensor. The system can further comprise one or more of: a control system configured to control at least one of the illumination module, the platform, the focusing and optics module, the filter module, and the optical sensor; a tag identifying system configured to identify and communicate tag information from system elements; a thermal control module configured to adjust temperature parameters of the system; and an image stabilization module.

6. 发明授权

US09606102B2 System and method for capturing and analyzing cells 有权
公开(公告)号：US09606102B2
公开(公告)日：2017-03-28
申请号：US14163153
申请日：2014-01-24
申请人： DeNovo Sciences, Inc.
发明人： Kalyan Handique , Priyadarshini Gogoi , Yi Zhou , Saedeh Sepehri Javdani
IPC分类号： C12Q1/68 , G01N33/487 , G01N33/574 , G01N27/447
CPC分类号： C12Q1/6841 , C12Q1/6844 , C12Q1/686 , G01N27/44782 , G01N33/48721 , G01N33/574 , G01N33/57492 , G01N2333/70585 , G01N2333/70596
摘要： A system and method for capturing and analyzing a set of cells, comprising: an array including a set of parallel pores, each pore including a chamber including a chamber inlet and a chamber outlet, and configured to hold a single cell, and a pore channel fluidly connected to the chamber outlet; an inlet channel fluidly connected to each chamber inlet of the set of parallel pores; an outlet channel fluidly connected to each pore channel of the set of parallel pores; a set of electrophoresis channels fluidly coupled to the outlet channel, configured to receive a sieving matrix for electrophoretic separation; and a set of electrodes including a first electrode and a second electrode, wherein the set of electrodes is configured to provide an electric field that facilitates electrophoretic analysis of the set of cells.

7. 发明申请

US20150204766A1 CELL CAPTURE SYSTEM AND METHOD OF USE 有权
标题翻译：细胞捕获系统及其使用方法
公开(公告)号：US20150204766A1
公开(公告)日：2015-07-23
申请号：US14607918
申请日：2015-01-28
申请人： DeNovo Sciences, Inc.
发明人： Kalyan Handique , Priyadarshini Gogoi , Christopher Siemer , Saedeh Sepehri Javdani
IPC分类号： G01N1/40
CPC分类号： G01N15/1484 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0636 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0819 , B01L2300/0848 , B01L2300/0877 , B01L2300/168 , B01L2400/086 , C12M47/04 , G01N1/20 , G01N1/28 , G01N1/40 , G01N1/405 , G01N2015/0065 , G01N2015/1006
摘要： A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.
摘要翻译：包括阵列，入口歧管和出口歧管的细胞捕获系统。该阵列包括多个平行孔，每个孔包括腔室和孔隙通道，流体连接到孔腔室的入口通道; 出口通道流体连接到孔的孔通道。入口歧管流体连接到入口通道，出口通道流体连接到出口通道。还公开了一种细胞去除工具，其中所述细胞去除工具被配置为从孔室除去捕获的细胞。

8. 发明申请

US20180094324A1 SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS 审中-公开
公开(公告)号：US20180094324A1
公开(公告)日：2018-04-05
申请号：US15821329
申请日：2017-11-22
申请人： DeNovo Sciences, Inc.
发明人： Kalyan Handique , Priyadarshini Gogoi , Yi Zhou , Saedeh Sepehri , Christopher Siemer
IPC分类号： G01N33/574 , B01L3/00 , C12M1/32
摘要： A system and method for isolating cells, comprising: a substrate having a broad surface; an array comprising a set of wells defined at the broad surface of the substrate, each well including: a base surface, an open surface directly opposing the base surface, defined at the broad surface of the substrate, and configured to receive one of a single cell and a single cluster of cells from a direction perpendicular to the broad surface of the substrate, and a set of channels that fluidly couple each well to at least one adjacent well; wherein the set of wells includes an interior subset and an exterior subset fluidly coupled to and surrounding the interior subset by way of the set of channels; and a fluid delivery module surrounding the array and fluidly coupled to each well in the set of wells.

9. 发明申请

US20180021782A1 SYSTEM AND METHOD FOR CAPTURING AND ANALYZING CELLS 有权
公开(公告)号：US20180021782A1
公开(公告)日：2018-01-25
申请号：US15720194
申请日：2017-09-29
申请人： DeNovo Sciences, Inc.
发明人： Kalyan Handique , Kyle Gleason , Austin Payne , Priyadarshini Gogoi , Saedeh Sepehri Javdani , Christopher Siemer , Yi Zhou
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/68 , G01N35/00 , G01N35/10 , G01N33/569
CPC分类号： B01L3/502761 , B01L3/502715 , B01L3/527 , B01L3/5635 , B01L7/00 , B01L7/52 , B01L2200/027 , B01L2200/0652 , B01L2300/0816 , B01L2300/0832 , B01L2300/0864 , B01L2300/185 , B01L2400/0487 , B01L2400/0683 , C12Q1/6841 , C12Q1/686 , G01N33/56972 , G01N35/0098 , G01N35/1079 , G01N2333/46
摘要： A system and method for capturing and analyzing cells comprising: a fluid delivery module; a reservoir configured to receive a biological sample including a target cell population and at least one fluid from the fluid delivery module; a manifold configured to receive and distribute the biological sample and at least one fluid from the reservoir into a cell capture device; a waste chamber configured to couple to the manifold; and a pump configured to couple to the waste chamber. In embodiments of the system configured to promote further purification of captured cells, the system can further comprise a magnet that enables further separation of captured cells from undesired sample materials. The system can additionally further comprise a heater configured to heat at least one fluid and/or biological sample, and a cell capture device configured to couple to the manifold, in order to facilitate capture of the target cell population.

10. 发明授权

US09821311B2 System for capturing and analyzing cells 有权
公开(公告)号：US09821311B2
公开(公告)日：2017-11-21
申请号：US15432050
申请日：2017-02-14
申请人： DeNovo Sciences, Inc.
发明人： Kalyan Handique , Kyle Gleason , Austin Payne , Priyadarshini Gogoi , Christopher Siemer , Yi Zhou , Saedeh Javdani Sepehri
IPC分类号： A61J1/06 , B01L3/00 , G01N33/00 , B01L7/00
CPC分类号： B01L3/502761 , B01L3/502715 , B01L3/527 , B01L3/5635 , B01L7/00 , B01L2200/027 , B01L2200/0647 , B01L2200/0652 , B01L2200/0684 , B01L2300/06 , B01L2300/0816 , B01L2300/0832 , B01L2300/0864 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2400/0487 , B01L2400/0683 , G01N35/0098
摘要： A system for isolating cells in at least one of single-cell format and single-cluster format, comprising a reservoir, including a reservoir inlet and a reservoir outlet, configured to receive a biological sample and to receive at least one fluid, a manifold configured to receive and deliver the biological sample and the at least one fluid from the reservoir into a biological sample substrate, the manifold comprising a broad surface comprising a central region configured to receive the biological sample substrate, a set of openings configured to enable fluid flow transmission across the biological sample substrate, a manifold inlet configured to transmit flow from the reservoir the first subset of openings, a manifold outlet configured at a downstream end of the broad surface and coupled to the second subset of openings, the manifold outlet configured to transmit waste fluid from the manifold.

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