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1. 发明授权

US07375319B1 Laser desorption ion source 有权
标题翻译：激光解吸离子源
公开(公告)号：US07375319B1
公开(公告)日：2008-05-20
申请号：US11500055
申请日：2006-08-07
申请人： Ross C. Willoughby , Edward W. Sheehan , Craig M. Whitehouse
发明人： Ross C. Willoughby , Edward W. Sheehan , Craig M. Whitehouse
IPC分类号： H01J49/04
CPC分类号： H01J49/0463 , H01J49/145
摘要： Atmospheric pressure, intermediate pressure and vacuum laser desorption ionization methods and ion sources are configured to increase ionization efficiency and the efficiency of transmitting ions to a mass to charge analyzer or ion mobility analyzer. An electric field is applied in the region of a sample target to accumulate ions generated from a local ion source on a solid or liquid phase sample prior to applying a laser desorption pulse. The electric field is changed just prior to or during the desorption laser pulse to promote the desorption of charged species and improve the ionization efficiency of desorbed sample species. After a delay, the electric field may be further changed to optimize focusing and transmission of ions into a mass spectrometer or ion mobility analyzer. Charged species may also be added to the region of the laser desorbed sample plume to promote ion-molecule reactions between the added ions and desorbed neutral sample species, increasing desorbed sample ionization efficiency and/or creating desired production species. The cycling of electric field changes is repeated in a timed sequence with one or more desorption laser pulse occurring per electric field change cycle. Embodiments of the invention comprise atmospheric pressure, intermediate pressure and vacuum pressure laser desorption ionization source methods and devices for increasing the analytical flexibility and improving the sensitivity of mass spectrometric analysis.
摘要翻译：大气压力，中压和真空激光解吸电离方法和离子源被配置为增加电离效率和将离子传输到质量计量分析器或离子迁移率分析仪的效率。在样品靶的区域内施加电场，以在施加激光解吸脉冲之前，在固相或液相样品上积聚从局部离子源产生的离子。电场在解吸激光脉冲之前或期间改变，以促进带电物质的解吸附并提高解吸样品的离子化效率。延迟后，可以进一步改变电场以优化离子聚焦和传输到质谱仪或离子迁移率分析仪中。带电物质也可以添加到激光解吸的样品羽毛的区域中，以促进添加的离子和解吸的中性样品物质之间的离子 - 分子反应，增加解吸的样品离子化效率和/或产生所需的生产物质。以定时序列重复电场变化的循环，每个电场变化周期发生一个或多个解吸激光脉冲。本发明的实施例包括大气压力，中压和真空压力激光解吸电离源的方法和装置，用于增加分析灵活性并提高质谱分析的灵敏度。

2. 发明授权

US06784424B1 Apparatus and method for focusing and selecting ions and charged particles at or near atmospheric pressure 失效
标题翻译：在大气压或接近大气压下聚焦和选择离子和带电粒子的装置和方法
公开(公告)号：US06784424B1
公开(公告)日：2004-08-31
申请号：US10155151
申请日：2002-05-25
申请人： Ross C Willoughby , Edward W Sheehan
发明人： Ross C Willoughby , Edward W Sheehan
IPC分类号： H01J4926
CPC分类号： H01J49/4215
摘要： The present invention relates to an apparatus and method for focusing, separating, and detecting gas-phase ions using the principles of quadrupole fields, substantially at or near atmospheric pressure. Ions are entrained in a concentric flow of gas and travel through a high-transmission element into a RF/DC quadrupole, through a second high-transmission element, and then impact on an ion detector, such as a faraday plate; or through an aperture with subsequent identification by a mass spectrometer. Ions with stable trajectories pass through the RF/DC quadrupole while ions with unstable trajectories drift off-axis collide with the rods and are lost. Embodiments of this invention are devices and methods for focusing, separating and detecting gas-phase ions without the need for a vacuum chamber when coupled to atmospheric ionization sources.
摘要翻译：本发明涉及一种基本上在大气压或接近大气压的四极场的原理聚焦，分离和检测气相离子的装置和方法。离子被夹带在同心圆的气体中，并通过第二高传导元件穿过高传输元件进入RF / DC四极杆，然后冲击到诸如法拉第板的离子检测器; 或通过孔径随后通过质谱仪进行识别。具有稳定轨迹的离子通过RF / DC四极杆，而具有不稳定轨迹的离子偏离轴与棒碰撞并丢失。本发明的实施例是用于在与大气电离源耦合时不需要真空室的情况下聚焦，分离和检测气相离子的装置和方法。

3. 发明授权

US07087898B2 Laser desorption ion source 有权
标题翻译：激光解吸离子源
公开(公告)号：US07087898B2
公开(公告)日：2006-08-08
申请号：US10862304
申请日：2004-06-07
申请人： Ross C. Willoughby , Edward W. Sheehan , Craig M. Whitehouse
发明人： Ross C. Willoughby , Edward W. Sheehan , Craig M. Whitehouse
IPC分类号： H01J49/04 , H01J49/10 , H01J49/40
CPC分类号： H01J49/164 , H01J49/06
摘要： Atmospheric pressure, intermediate pressure and vacuum laser desorption ionization methods and ion sources are configured to increase ionization efficiency and the efficiency of transmitting ions to a mass to charge analyzer or ion mobility analyzer. An electric field is applied in the region of a sample target to accumulate ions generated from a local ion source on a solid or liquid phase sample prior to applying a laser desorption pulse. The electric field is changed just prior to or during the desorption laser pulse to promote the desorption of charged species and improve the ionization efficiency of desorbed sample species. After a delay, the electric field may be further changed to optimize focusing and transmission of ions into a mass spectrometer or ion mobility analyzer. Charged species may also be added to the region of the laser desorbed sample plume to promote ion-molecule reactions between the added ions and desorbed neutral sample species, increasing desorbed sample ionization efficiency and/or creating desired product ion species. The cycling of electric field changes is repeated in a timed sequence with one or more desorption laser pulse occurring per electric field change cycle. Embodiments of the invention comprise atmospheric pressure, intermediate pressure and vacuum pressure laser desorption ionization source methods and devices for increasing the analytical flexibility and improving the sensitivity of mass spectrometric analysis.
摘要翻译：大气压力，中压和真空激光解吸电离方法和离子源被配置为增加电离效率和将离子传输到质量计量分析器或离子迁移率分析仪的效率。在样品靶的区域内施加电场，以在施加激光解吸脉冲之前，在固相或液相样品上积聚从局部离子源产生的离子。电场在解吸激光脉冲之前或期间改变，以促进带电物质的解吸附并提高解吸样品的离子化效率。延迟后，可以进一步改变电场以优化离子聚焦和传输到质谱仪或离子迁移率分析仪中。带电物质也可以加入到激光解吸样品羽流的区域中，以促进添加的离子和解吸的中性样品物质之间的离子 - 分子反应，增加解吸的样品电离效率和/或产生所需的产物离子种类。以定时序列重复电场变化的循环，每个电场变化周期发生一个或多个解吸激光脉冲。本发明的实施例包括大气压力，中压和真空压力激光解吸电离源的方法和装置，用于增加分析灵活性并提高质谱分析的灵敏度。

4. 发明授权

US07569812B1 Remote reagent ion generator 有权
标题翻译：远程试剂离子发生器
公开(公告)号：US07569812B1
公开(公告)日：2009-08-04
申请号：US11544252
申请日：2006-10-07
申请人： Timothy P. Karpetsky , John C. Berends, Jr. , Edward W. Sheehan , Ross C. Willoughby
发明人： Timothy P. Karpetsky , John C. Berends, Jr. , Edward W. Sheehan , Ross C. Willoughby
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/145 , H01J49/0468 , H01J49/067
摘要： An improved ion source and means for collecting and focusing dispersed gas-phase ions from a remote reagent chemical ionization source (R2CIS) at atmospheric or intermediate pressure is described. The R2CIS is under electronic control and can produce positive, negative, or positive and negative reagent ions simultaneously. This remote source of reagent ions is separated from a low-field sample ionization region by a stratified array of elements, each element populated with a plurality of openings, wherein DC potentials are applied to each element necessary for transferring reagent ions from the R2CIS into the low-field sample ionization region where the reagent ions react with neutral and/or ionic sample forming sample ionic species. The resulting sample ionic species are then introduced into a mass spectrometer, ion mobility spectrometer or other sensor capable of detecting the sample ions. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when gas and liquid chromatographic separation techniques are coupled to atmospheric and intermediate pressure photo-ionization, chemical ionization, and thermospray ionization sources; and improving the sensitivity of chemical detectors or probes.
摘要翻译：描述了改进的离子源和用于在大气压或中压下从远程试剂化学电离源（R2CIS）收集和聚焦分散的气相离子的装置。 R2CIS处于电子控制下，可以同时产生正，负或正，负反应离子。这种远程的试剂离子源通过分层阵列的元件与低场样品电离区域分开，每个元件填充有多个开口，其中DC电位被施加到将试剂离子从R2CIS转移到低场样品电离区域，其中试剂离子与形成样品离子物质的中性和/或离子样品反应。然后将所得样品离子物质引入质谱仪，离子迁移谱仪或能够检测样品离子的其他传感器。本发明的实施例是当气体和液相色谱分离技术耦合到大气和中压光电离，化学电离和热喷射电离源时提高质谱的灵敏度的方法和装置; 并提高化学检测器或探针的灵敏度。

5. 发明授权

US07095019B1 Remote reagent chemical ionization source 失效
标题翻译：远程试剂化学电离源
公开(公告)号：US07095019B1
公开(公告)日：2006-08-22
申请号：US11120363
申请日：2005-05-02
申请人： Edward W Sheehan , Ross C Willoughby
发明人： Edward W Sheehan , Ross C Willoughby
IPC分类号： H01J49/00
CPC分类号： H01J49/145 , H01J49/0468 , H01J49/067
摘要： An improved ion source and portable analyzer for collecting and focusing dispersed gas-phase ions from a reagent source at atmospheric or intermediate pressure, having a remote source of reagent ions generated by direct or alternating currents, separated from a low-field sample ionization region by a stratified array of elements, each element populated with a plurality of openings, wherein DC potentials are applied to each element necessary for transferring reagent ions from the remote source into the low-field sample ionization region where the reagent ions react with neutral and/or ionic sample forming ionic species. The resulting ionic species are then introduced into the vacuum system of a mass spectrometer or ion mobility spectrometer. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when gas and liquid chromatographic separation techniques or probes containing samples are coupled to atmospheric and intermediate pressure photo-ionization, chemical ionization, and thermospray ionization sources.
摘要翻译：一种改进的离子源和便携式分析仪，用于在大气压或中压下从试剂源收集和聚焦分散的气相离子，具有通过直接或交流产生的远程离子源，由低场样品电离区分离，元件的分层阵列，每个元件填充有多个开口，其中DC电势被施加到将试剂离子从远程源转移到低场样品电离区域中所需的每个元件，其中试剂离子与中性和/或离子样品形成离子物种。然后将所得的离子物质引入质谱仪或离子迁移谱仪的真空系统中。本发明的实施例是当气体和液相色谱分离技术或含有样品的探针与大气压和中压光电离，化学电离和热喷射电离源耦合时提高质谱灵敏度的方法和装置。

6. 发明授权

US06744041B2 Apparatus and method for focusing ions and charged particles at atmospheric pressure 失效
标题翻译：在大气压力下聚焦离子和带电粒子的装置和方法
公开(公告)号：US06744041B2
公开(公告)日：2004-06-01
申请号：US09877167
申请日：2001-06-08
申请人： Edward W Sheehan , Ross C Willoughby
发明人： Edward W Sheehan , Ross C Willoughby
IPC分类号： B01D5944
CPC分类号： H01J49/067
摘要： Improvements have been made for collection and focusing of ions generated from atmospheric pressure sources such as electrospray, atmospheric pressure chemical ionization, inductively coupled plasma, discharge, photoionization and atmospheric pressure matrix assisted laser desorption ionization. A high transmission electro-optical surface is placed between the source regions and the focusing regions to optimize the field geometries and strengths in each respective region. Compression ratios of greater than 5000 are capable of transferring virtually all ions from large volume dispersive ion regions into ion beam cross-sections of less than 1 mm. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when coupled to atmospheric pressure ionization sources.
摘要翻译：已经对电喷雾，大气压化学电离，电感耦合等离子体，放电，光电离和大气压力矩阵辅助激光解吸电离等大气压源产生的离子的收集和聚焦进行了改进。将高透射电光表面放置在源区域和聚焦区域之间，以优化每个相应区域中的场几何形状和强度。大于5000的压缩比能够将几乎所有的离子从大体积分散离子区转移到小于1mm的离子束横截面。本发明的实施方案是当与大气压电离源耦合时提高质谱灵敏度的方法和装置。

7. 发明授权

US07816646B1 Laser desorption ion source 有权
标题翻译：激光解吸离子源
公开(公告)号：US07816646B1
公开(公告)日：2010-10-19
申请号：US12123669
申请日：2008-05-20
申请人： Ross C. Willoughby , Edward W. Sheehan , Craig M. Whitehouse
发明人： Ross C. Willoughby , Edward W. Sheehan , Craig M. Whitehouse
IPC分类号： H01J49/04
CPC分类号： H01J49/0463 , H01J49/145
摘要： Atmospheric pressure, intermediate pressure and vacuum laser desorption ionization methods and ion sources are configured to increase ionization efficiency and the efficiency of transmitting ions to a mass to charge analyzer or ion mobility analyzer. An electric field is applied in the region of a sample target to accumulate ions generated from a local ion source on a solid or liquid phase sample prior to applying a laser desorption pulse. The electric field is changed just prior to or during the desorption laser pulse to promote the desorption of charged species and improve the ionization efficiency of desorbed sample species. After a delay, the electric field may be further changed to optimize focusing and transmission of ions into a mass spectrometer or ion mobility analyzer. Charged species may also be added to the region of the laser desorbed sample plume to promote ion-molecule reactions between the added ions and desorbed neutral sample species, increasing desorbed sample ionization efficiency and/or creating desired product ion species. The cycling of electric field changes is repeated in a timed sequence with one or more desorption laser pulse occurring per electric field change cycle. Embodiments of the invention comprise atmospheric pressure, intermediate pressure and vacuum pressure laser desorption ionization source methods and devices for increasing the analytical flexibility and improving the sensitivity of mass spectrometric analysis.
摘要翻译：大气压力，中压和真空激光解吸电离方法和离子源被配置为增加电离效率和将离子传输到质量计量分析器或离子迁移率分析仪的效率。在样品靶的区域内施加电场，以在施加激光解吸脉冲之前，在固相或液相样品上积聚从局部离子源产生的离子。电场在解吸激光脉冲之前或期间改变，以促进带电物质的解吸附并提高解吸样品的离子化效率。延迟后，可以进一步改变电场以优化离子聚焦和传输到质谱仪或离子迁移率分析仪中。带电物质也可以加入到激光解吸样品羽流的区域中，以促进添加的离子和解吸的中性样品物质之间的离子 - 分子反应，增加脱附的样品电离效率和/或产生所需的产物离子种类。以定时序列重复电场变化的循环，每个电场变化周期发生一个或多个解吸激光脉冲。本发明的实施例包括大气压力，中压和真空压力激光解吸电离源的方法和装置，用于增加分析灵活性并提高质谱分析的灵敏度。

8. 发明授权

US06888132B1 Remote reagent chemical ionization source 失效
标题翻译：远程试剂化学电离源
公开(公告)号：US06888132B1
公开(公告)日：2005-05-03
申请号：US10449344
申请日：2003-05-30
申请人： Edward W Sheehan , Ross C Willoughby
发明人： Edward W Sheehan , Ross C Willoughby
IPC分类号： H01J49/00
CPC分类号： H01J49/145
摘要： An improved ion source for collecting and focusing dispersed gas-phase ions from a reagent source at atmospheric or intermediate pressure, having a remote source of reagent ions separated from a low-field sample ionization region by a stratified array of elements, each element populated with a plurality of openings, wherein DC potentials are applied to each element necessary for transferring reagent ions from the remote source into the low-field sample ionization region where the reagent ions react with neutral and/or ionic sample forming ionic species. The resulting ionic species are then introduced into the vacuum system of a mass spectrometer or ion mobility spectrometer. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when gas and liquid chromatographic separation techniques are coupled to atmospheric and intermediate pressure photo-ionization, chemical ionization, and thermospray ionization sources.
摘要翻译：一种改进的离子源，用于在大气压或中压下从试剂源收集和聚焦分散的气相离子，其具有通过分层的元素阵列与低场样品电离区域分离的试剂离子的远程源，每个元素填充有多个开口，其中DC电位被施加到将试剂离子从远程源传输到低场样品电离区所需的每个元件，其中试剂离子与形成中性和/或离子样品的离子物质反应。然后将所得的离子物质引入质谱仪或离子迁移谱仪的真空系统中。本发明的实施例是当气体和液相色谱分离技术与大气和中压光电离，化学电离和热喷射电离源耦合时提高质谱灵敏度的方法和装置。

9. 发明授权

US5838002A Method and apparatus for improved electrospray analysis 失效
标题翻译：改善电喷雾分析的方法和装置
公开(公告)号：US5838002A
公开(公告)日：1998-11-17
申请号：US701050
申请日：1996-08-21
申请人： Edward W. Sheehan
发明人： Edward W. Sheehan
IPC分类号： H01J49/04 , H01J49/10
CPC分类号： H01J49/165 , H01J49/049
摘要： An electrospray ion production method and ion source designed to reduce overall gas load on the vacuum system and enhance the ion production and collection efficiencies. This ion source is for gas phase ion analysis of constituents dissolved in liquid solution comprising a needle (10) held at high electrical potential through which the solution flows into a first chamber (1) maintained at reduced pressure, forming a highly charged liquid cone-jet. The highly charged liquid jet is steered, in the first chamber, on-axis with an aperture into a second chamber (2) maintained at higher pressure than that of the first chamber. The second chamber is heated and pressurized to facilitate desolvation of the solution droplets originating from the breakup of the highly charged jet, resulting in the production of gas phase ions by the electrospray ionization process. The gas phase ions are then sampled and detected. Alternative reactions and/or inputs of energy via collision and/or radiation may occur in the second chamber to further facilitate ion production or fragmentation and may further enhance sample identification. This method and device may be useful in the implementation of liquid chromatography-mass spectrometry.
摘要翻译：电喷雾离子生产方法和离子源旨在减少真空系统上的总体气体负荷，并提高离子的生产和收集效率。该离子源用于溶解在液体溶液中的组分的气相离子分析，其包含保持在高电位的针（10），溶液流入通过其保持在减压下的第一腔室（1），形成高度带电的液体锥形 - 喷射。高度带电的液体射流在第一腔室中被轴向转动到具有比第一腔室更高的压力的第二腔室（2）中。第二室被加热和加压以促进源于高带电射流破裂的溶液液滴的去溶剂化，导致通过电喷雾电离过程产生气相离子。然后对气相离子进行采样和检测。通过碰撞和/或辐射的能量的替代反应和/或能量输入可能发生在第二室中，以进一步促进离子的产生或分裂，并可进一步增强样品鉴定。该方法和装置可用于实施液相色谱 - 质谱。

10. 发明授权

US08008617B1 Ion transfer device 有权
标题翻译：离子转移装置
公开(公告)号：US08008617B1
公开(公告)日：2011-08-30
申请号：US12344872
申请日：2008-12-29
申请人： John C. Berends, Jr. , Timothy P. Karpetsky , Ross C. Willoughby , Edward W. Sheehan
发明人： John C. Berends, Jr. , Timothy P. Karpetsky , Ross C. Willoughby , Edward W. Sheehan
IPC分类号： B01D59/44
CPC分类号： H01J49/0422
摘要： Ions carried in a flowing gas stream are transferred to another gas stream of different composition or purity through an ion selective aperture communicating between the gas streams. The ion selective aperture is formed of a central layer which has an electrically conductive layer on each of its surfaces. One or more open channels extend through the central layer and surface layers allowing physical movement of ions therethrough under the urging and influence of an electric field created by imposing a voltage differential between the conductive surface layers of the ion selective aperture. The gas flow rates of the different gas streams may be independently varied to allow adjustment of ion concentration and flow rate to meet the needs of the ion destination. This device can control sample ion introduction into gas-phase ion detectors, such as ion mobility analyzers, differential mobility analyzers, mass spectrometers, and combinations thereof.
摘要翻译：携带在流动气流中的离子通过在气流之间连通的离子选择孔转移到不同组成或纯度的另一种气流中。离子选择孔由中心层形成，在其每个表面上具有导电层。在通过在离子选择孔的导电表面层之间施加电压差而产生的电场的推动和影响下，一个或多个开放通道延伸穿过中心层和表面层，允许离子物理移动。可以独立地改变不同气流的气体流速，以允许调节离子浓度和流速以满足离子目的地的需要。该装置可以将样品离子引入气相离子检测器，例如离子迁移率分析仪，差速移动分析仪，质谱仪及其组合。

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