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1. 发明授权

US07569812B1 Remote reagent ion generator 有权
标题翻译：远程试剂离子发生器
公开(公告)号：US07569812B1
公开(公告)日：2009-08-04
申请号：US11544252
申请日：2006-10-07
申请人： Timothy P. Karpetsky , John C. Berends, Jr. , Edward W. Sheehan , Ross C. Willoughby
发明人： Timothy P. Karpetsky , John C. Berends, Jr. , Edward W. Sheehan , Ross C. Willoughby
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/145 , H01J49/0468 , H01J49/067
摘要： An improved ion source and means for collecting and focusing dispersed gas-phase ions from a remote reagent chemical ionization source (R2CIS) at atmospheric or intermediate pressure is described. The R2CIS is under electronic control and can produce positive, negative, or positive and negative reagent ions simultaneously. This remote source of reagent ions is separated from a low-field sample ionization region by a stratified array of elements, each element populated with a plurality of openings, wherein DC potentials are applied to each element necessary for transferring reagent ions from the R2CIS into the low-field sample ionization region where the reagent ions react with neutral and/or ionic sample forming sample ionic species. The resulting sample ionic species are then introduced into a mass spectrometer, ion mobility spectrometer or other sensor capable of detecting the sample ions. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when gas and liquid chromatographic separation techniques are coupled to atmospheric and intermediate pressure photo-ionization, chemical ionization, and thermospray ionization sources; and improving the sensitivity of chemical detectors or probes.
摘要翻译：描述了改进的离子源和用于在大气压或中压下从远程试剂化学电离源（R2CIS）收集和聚焦分散的气相离子的装置。 R2CIS处于电子控制下，可以同时产生正，负或正，负反应离子。这种远程的试剂离子源通过分层阵列的元件与低场样品电离区域分开，每个元件填充有多个开口，其中DC电位被施加到将试剂离子从R2CIS转移到低场样品电离区域，其中试剂离子与形成样品离子物质的中性和/或离子样品反应。然后将所得样品离子物质引入质谱仪，离子迁移谱仪或能够检测样品离子的其他传感器。本发明的实施例是当气体和液相色谱分离技术耦合到大气和中压光电离，化学电离和热喷射电离源时提高质谱的灵敏度的方法和装置; 并提高化学检测器或探针的灵敏度。

2. 发明授权

US08008617B1 Ion transfer device 有权
标题翻译：离子转移装置
公开(公告)号：US08008617B1
公开(公告)日：2011-08-30
申请号：US12344872
申请日：2008-12-29
申请人： John C. Berends, Jr. , Timothy P. Karpetsky , Ross C. Willoughby , Edward W. Sheehan
发明人： John C. Berends, Jr. , Timothy P. Karpetsky , Ross C. Willoughby , Edward W. Sheehan
IPC分类号： B01D59/44
CPC分类号： H01J49/0422
摘要： Ions carried in a flowing gas stream are transferred to another gas stream of different composition or purity through an ion selective aperture communicating between the gas streams. The ion selective aperture is formed of a central layer which has an electrically conductive layer on each of its surfaces. One or more open channels extend through the central layer and surface layers allowing physical movement of ions therethrough under the urging and influence of an electric field created by imposing a voltage differential between the conductive surface layers of the ion selective aperture. The gas flow rates of the different gas streams may be independently varied to allow adjustment of ion concentration and flow rate to meet the needs of the ion destination. This device can control sample ion introduction into gas-phase ion detectors, such as ion mobility analyzers, differential mobility analyzers, mass spectrometers, and combinations thereof.
摘要翻译：携带在流动气流中的离子通过在气流之间连通的离子选择孔转移到不同组成或纯度的另一种气流中。离子选择孔由中心层形成，在其每个表面上具有导电层。在通过在离子选择孔的导电表面层之间施加电压差而产生的电场的推动和影响下，一个或多个开放通道延伸穿过中心层和表面层，允许离子物理移动。可以独立地改变不同气流的气体流速，以允许调节离子浓度和流速以满足离子目的地的需要。该装置可以将样品离子引入气相离子检测器，例如离子迁移率分析仪，差速移动分析仪，质谱仪及其组合。

3. 发明授权

US07576322B2 Non-contact detector system with plasma ion source 有权
标题翻译：具有等离子体离子源的非接触检测器系统
公开(公告)号：US07576322B2
公开(公告)日：2009-08-18
申请号：US11594401
申请日：2006-11-08
申请人： Timothy P. Karpetsky , John C. Berends, Jr.
发明人： Timothy P. Karpetsky , John C. Berends, Jr.
IPC分类号： H01J49/00 , H01J49/10 , B01D59/44
CPC分类号： H01J49/142 , H05H1/46 , H05H2001/466
摘要： A system for the non-contact detection of analyte chemicals, including explosives, chemical warfare agents and the like, employs a non-equilibrium plasma that is maintained at a temperature sufficiently low so as to avoid thermal damage to a surface, such as clothing or skin, that is being examined to thereby produce analyte ions and other charged particles. The ions are collected and passed into a sensor for detection and identification.
摘要翻译：用于非接触检测分析物的物质（包括爆炸物，化学战剂等）的系统采用保持在足够低的温度的非平衡等离子体，以避免对表面的热损伤，例如衣服或皮肤，正在被检查，从而产生分析离子和其他带电粒子。离子被收集并传递到传感器中进行检测和鉴定。

4. 发明授权

US08308339B2 Method and means for precision mixing 有权
公开(公告)号：US08308339B2
公开(公告)日：2012-11-13
申请号：US13363327
申请日：2012-01-31
申请人： Timothy P. Karpetsky , John C. Berends, Jr.
发明人： Timothy P. Karpetsky , John C. Berends, Jr.
IPC分类号： B01F5/04
CPC分类号： B01F3/022 , B01F3/0865 , B01F5/0473 , B01F15/0241 , B01F15/0246 , B01F2215/0037
摘要： An extremely dilute mixture of a liquid in a flowing fluid stream is prepared by forming tiny droplets of the liquid and injecting the droplets individually into the flowing stream. The rate at which liquid is added to the flowing stream is determined by the number of droplet forming units that are provided and upon the frequency with which the units are activated, allowing a precise digital control of the concentration of the liquid in the flowing fluid stream.

5. 发明申请

US20120132669A1 Method and Means For Precision Mixing 有权
标题翻译：精密混合的方法和方法
公开(公告)号：US20120132669A1
公开(公告)日：2012-05-31
申请号：US13363327
申请日：2012-01-31
申请人： Timothy P. Karpetsky , John C. Berends, JR.
发明人： Timothy P. Karpetsky , John C. Berends, JR.
IPC分类号： B67D7/02
CPC分类号： B01F3/022 , B01F3/0865 , B01F5/0473 , B01F15/0241 , B01F15/0246 , B01F2215/0037
摘要： An extremely dilute mixture of a liquid in a flowing fluid stream is prepared by forming tiny droplets of the liquid and injecting the droplets individually into the flowing stream. The rate at which liquid is added to the flowing stream is determined by the number of droplet forming units that are provided and upon the frequency with which the units are activated, allowing a precise digital control of the concentration of the liquid in the flowing fluid stream.
摘要翻译：通过形成液体的微小液滴并将液滴分别注入流动流中来制备流动流体流中液体的极稀混合物。液体添加到流动流中的速率由提供的液滴形成单元的数量和单元被激活的频率确定，允许对流动流体流中的液体的浓度进行精确的数字控制。

6. 发明授权

US08123396B1 Method and means for precision mixing 有权
标题翻译：精密混合的方法和方法
公开(公告)号：US08123396B1
公开(公告)日：2012-02-28
申请号：US12153358
申请日：2008-05-16
申请人： Timothy P. Karpetsky , John C. Berends, Jr.
发明人： Timothy P. Karpetsky , John C. Berends, Jr.
IPC分类号： B01F5/04
CPC分类号： B01F3/022 , B01F3/0865 , B01F5/0473 , B01F15/0241 , B01F15/0246 , B01F2215/0037
摘要： An extremely dilute mixture of a liquid in a flowing fluid stream is prepared by forming tiny droplets of the liquid and injecting the droplets individually into the flowing stream. The rate at which liquid is added to the flowing stream is determined by the number of droplet forming units that are provided and upon the frequency with which the units are activated, allowing a precise digital control of the concentration of the liquid in the flowing fluid stream.
摘要翻译：通过形成液体的微小液滴并将液滴分别注入流动流中来制备流动流体流中液体的极稀混合物。液体添加到流动流中的速率由提供的液滴形成单元的数量和单元被激活的频率确定，允许对流动流体流中的液体的浓度进行精确的数字控制。

7. 发明授权

US4495279A Isoelectric focussing-polynucleotide/polyacrylamide gel electrophoresis 失效
标题翻译：等电聚焦 - 多核苷酸/聚丙烯酰胺凝胶电泳
公开(公告)号：US4495279A
公开(公告)日：1985-01-22
申请号：US402352
申请日：1982-07-27
申请人： Timothy P. Karpetsky , Glenn E. Brown
发明人： Timothy P. Karpetsky , Glenn E. Brown
IPC分类号： C12Q1/44 , G01N27/447 , C12Q1/68 , C12N9/14 , C12N9/22 , C12Q1/00 , C12Q1/34 , G01N27/26 , G01N33/50
CPC分类号： C12Q1/44 , G01N27/44721 , G01N27/44773 , G01N2333/922
摘要： An electrophoresis system which provides enhanced resolution and ability to identify nucleases through use of a two-dimensional technique involving isoelectric focussing of tube gels followed by the electrophoresis of second-dimension slab gels formed by the use of a holder allowing slab gels to be cast directly on the sides of the tube gels. DNA is employed as the substrate for casting the slab gels. The slab gels are electrophoresed for the second dimension in a chamber wherein the rack containing a stack of slab gels forms the partition between the anolyte and catholyte compartments. After the second-dimension electrophoresis, the slab gels are incubated in incubation buffer and placed in Pyronin Y to stain the unhydrolized DNA. After staining, they are destained in acetic acid. The DNAses are then visible as colorless spots in a reddish-colored gel.
摘要翻译：一种电泳系统，其通过使用管凝胶的等电聚焦的二维技术提供增强的分辨率和识别核酸酶的能力，然后通过使用允许直接铸造凝胶的保持器形成的第二维平板凝胶电泳在管凝胶的两侧。 DNA用作铸造板状凝胶的基材。板坯凝胶在腔室中进行电泳，用于第二尺寸，其中，包含一叠板状凝胶的支架在阳极电解液和阴极电解液室之间形成隔板。在二维电泳之后，将板状凝胶在温育缓冲液中温育并置于Pyronin Y中以染色未水解的DNA。染色后，它们在乙酸中脱色。然后DNAses可见为浅色凝胶中的无色斑点。

8. 发明授权

US07586092B1 Method and device for non-contact sampling and detection 有权
标题翻译：用于非接触式取样和检测的方法和装置
公开(公告)号：US07586092B1
公开(公告)日：2009-09-08
申请号：US11987632
申请日：2007-12-03
申请人： Timothy P. Karpetsky
发明人： Timothy P. Karpetsky
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/145 , G01N27/624 , H01J49/142
摘要： A system for the stand-off detection of trace amounts of analyte materials such as explosives, chemical warfare agents, toxic industrial chemicals, and the like includes an ion source that is operably connected to an ion collection means and to a sensor. The ion source employs a first gas that is passed through an electrical discharge to produce metastable gas molecules as well as charged particles of various kinds. Ions and other charged particles are removed from the first gas which is then reacted with a second gas having a lower ionization potential to obtain reactant ions of relatively uniform energy. The reactant ions are focused and accelerated into a beam that is directed upon a surface, such as luggage or clothing that is being interrogated, to produce analyte ions which are collected and passed into the sensor that is preferably a differential mobility spectrometer.
摘要翻译：用于对痕量检测微量分析物质例如爆炸物，化学战剂，有毒工业化学品等的系统包括可操作地连接到离子收集装置和传感器的离子源。离子源采用通过放电产生亚稳态气体分子以及各种带电粒子的第一气体。离子和其它带电粒子从第一气体中除去，然后与具有较低电离电位的第二气体反应，以获得相对均匀的能量的反应物离子。反应物离子被聚焦并加速成被引导到诸如被询问的行李或衣服的表面的波束，以产生分析物离子，所述分析物离子被收集并传递到传感器中，优选地是差动迁移谱仪。

9. 发明授权

US07429731B1 Method and device for non-contact sampling and detection 有权
标题翻译：用于非接触式取样和检测的方法和装置
公开(公告)号：US07429731B1
公开(公告)日：2008-09-30
申请号：US11580876
申请日：2006-10-16
申请人： Timothy P. Karpetsky
发明人： Timothy P. Karpetsky
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/145 , G01N27/624 , H01J49/142
摘要： A system for the stand-off detection of trace amounts of analyte materials such as explosives, chemical warfare agents, toxic industrial chemicals, and the like includes an ion source that is operably connected to an ion collection means and to a sensor. The ion source employs a first gas that is passed through an electrical discharge to produce metastable gas molecules as well as charged particles of various kinds. Ions and other charged particles are removed from the first gas which is then reacted with a second gas having a lower ionization potential to obtain reactant ions of relatively uniform energy. The reactant ions are focused and accelerated into a beam that is directed upon a surface, such as luggage or clothing that is being interrogated, to produce analyte ions which are collected and passed into the sensor that is preferably a differential mobility spectrometer.
摘要翻译：用于对痕量检测微量分析物质例如爆炸物，化学战剂，有毒工业化学品等的系统包括可操作地连接到离子收集装置和传感器的离子源。离子源采用通过放电产生亚稳态气体分子以及各种带电粒子的第一气体。离子和其它带电粒子从第一气体中除去，然后与具有较低电离电位的第二气体反应，以获得相对均匀的能量的反应物离子。反应物离子被聚焦并加速成被引导到诸如被询问的行李或衣服的表面的波束，以产生分析物离子，所述分析物离子被收集并传递到传感器中，优选地是差动迁移谱仪。

10. 发明授权

US07138626B1 Method and device for non-contact sampling and detection 有权
公开(公告)号：US07138626B1
公开(公告)日：2006-11-21
申请号：US11122459
申请日：2005-05-05
申请人： Timothy P. Karpetsky
发明人： Timothy P. Karpetsky
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/145 , G01N27/624 , H01J49/142
摘要： A system for the stand-off detection of trace amounts of analyte materials such as explosives, chemical warfare agents, toxic industrial chemicals, and the like includes an ion source that is operably connected to an ion collection means and to a sensor. The ion source employs a first gas that is passed through an electrical discharge to produce metastable gas molecules as well as charged particles of various kinds. Ions and other charged particles are removed from the first gas which is then reacted with a second gas having a lower ionization potential to obtain reactant ions of relatively uniform energy. The reactant ions are focused and accelerated into a beam that is directed upon a surface, such as luggage or clothing that is being interrogated, to produce analyte ions which are collected and passed into the sensor that is preferably a differential mobility spectrometer.

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