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1. 发明授权

US09398882B2 Method and apparatus for providing analyte sensor and data processing device 有权
标题翻译：用于提供分析物传感器和数据处理装置的方法和装置
公开(公告)号：US09398882B2
公开(公告)日：2016-07-26
申请号：US11530473
申请日：2006-09-10
申请人： Gary Ashley Stafford
发明人： Gary Ashley Stafford
IPC分类号： A61B5/145 , A61B5/1468 , A61B5/1473 , A61B5/00
CPC分类号： A61B5/6849 , A61B5/0002 , A61B5/0022 , A61B5/14503 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/6833 , A61B2560/0214 , A61B2562/164
摘要： Method and apparatus for integrated sensor and data processing assembly is provided.
摘要翻译：提供了集成传感器和数据处理组件的方法和装置。

2. 发明授权

US08946405B2 Controlled release from solid supports 有权
标题翻译：从固体支持物控制释放
公开(公告)号：US08946405B2
公开(公告)日：2015-02-03
申请号：US13696300
申请日：2011-05-05
申请人： Gary Ashley , Daniel V. Santi
发明人： Gary Ashley , Daniel V. Santi
IPC分类号： A61K47/48 , A61K49/00 , A61L15/44 , A61L27/54 , A61L29/16 , A61L31/16
CPC分类号： A61K47/48215 , A61K47/58 , A61K47/60 , A61K47/6435 , A61K47/6903 , A61K47/6953 , A61K47/6957 , A61K49/0043 , A61K49/0054 , A61L15/44 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/252 , A61L2300/258
摘要： The invention relates to solid supports useful in medical applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the solid support through a linkage that releases the drug or a prodrug through controlled beta elimination.
摘要翻译：本发明涉及用于医疗应用中的固体支持物，其提供药物如肽，核酸和小分子的受控释放。这些药物通过通过控制β消除释放药物或前药的连接共价偶联到固体支持物上。

3. 发明授权

US08613892B2 Analyte meter with a moveable head and methods of using the same 有权
标题翻译：具有可移动头部的分析仪及其使用方法
公开(公告)号：US08613892B2
公开(公告)日：2013-12-24
申请号：US12495801
申请日：2009-06-30
申请人： Gary Ashley Stafford
发明人： Gary Ashley Stafford
IPC分类号： G01N35/00
CPC分类号： A61B5/14532 , A61B5/14546 , A61B2562/0295 , G01N21/8483 , G01N27/3273 , G01N33/48785 , G01N2021/8654 , Y10T436/144444
摘要： The present disclosure provides in vitro analyte meters that include a meter portion that is moveable relative to at least one other meter portion. Embodiments include moveable meters that are integrated with in vivo analyte systems. Also provided are methods, systems and kits.
摘要翻译：本公开提供体外分析物计量器，其包括相对于至少一个其他计量器部分可移动的计量器部分。实施例包括与体内分析物系统集成的可移动计量表。还提供了方法，系统和工具包。

4. 发明申请

US20120190952A1 Flexible Patch for Fluid Delivery and Monitoring Body Analytes 审中-公开
标题翻译：用于流体输送和监测身体分析物的柔性补片
公开(公告)号：US20120190952A1
公开(公告)日：2012-07-26
申请号：US13436820
申请日：2012-03-30
申请人： Gary Ashley Stafford
发明人： Gary Ashley Stafford
IPC分类号： A61B5/05
CPC分类号： A61M5/1723 , A61B5/0022 , A61B5/14503 , A61B5/14532 , A61B5/6833 , A61B2560/0252 , A61B2560/0412 , A61M5/14248 , A61M2005/1726 , A61M2205/3569 , A61M2205/3592 , A61M2205/82 , A61M2230/005 , A61M2230/201 , A61M2230/50
摘要： A wearable, conductive textile patch is provided that may include any of a number of features for monitoring body analytes and/or delivering fluids to a body. In one embodiment of the invention, a single, patch-mounted system monitors glucose levels of a diabetic person and provides appropriate doses of insulin in response to the glucose measurements. A hand-held user interface can be provided for wirelessly controlling the system and/or receiving information from it. Conductive pathways can be formed in the fabric of the patch. Components that can be integrated into the flexible patch include a power source, controller, transmitter, antenna, temperature and other sensors, fluid pump, infusion set, electrical pathways, switches, controls, electrodes, connectors, resistors and other circuit elements. Such components can be embedded, interwoven or coated on to the flexible patch instead of or in addition to surface mounting. Methods associated with use of the flexible patch system are also covered.
摘要翻译：提供了可穿戴的导电织物贴片，其可以包括用于监测身体分析物和/或将流体输送到身体的许多特征中的任何一个。在本发明的一个实施方案中，单个贴片安装的系统监测糖尿病人的葡萄糖水平并响应于葡萄糖测量提供适当剂量的胰岛素。可以提供用于无线控制系统和/或从其接收信息的手持式用户界面。可以在贴剂的织物中形成导电途径。可以集成到柔性贴片中的组件包括电源，控制器，发射器，天线，温度和其他传感器，流体泵，输液器，电路，开关，控制器，电极，连接器，电阻器和其他电路元件。这些组件可以嵌入，交织或涂覆到柔性贴片上，而不是表面安装或除表面安装之外。还涉及与使用柔性贴片系统相关的方法。

5. 发明申请

US20110144464A1 Integrated Transmitter Unit and Sensor Introducer Mechanism and Methods of Use 审中-公开
标题翻译：综合变送器单元和传感器引导机构及其使用方法
公开(公告)号：US20110144464A1
公开(公告)日：2011-06-16
申请号：US13022616
申请日：2011-02-07
申请人： Gary Ashley Stafford
发明人： Gary Ashley Stafford
IPC分类号： A61B5/1468
CPC分类号： A61B5/6828 , A61B5/0002 , A61B5/14532 , A61B5/6824 , A61B5/6849
摘要： Method and apparatus for providing an integrated transmitter unit and sensor insertion mechanism is provided.
摘要翻译：提供了一种用于提供集成发射机单元和传感器插入机构的方法和装置。

6. 发明申请

US20080096828A1 7-Quinolyl ketolide antibacterial agents 有权
标题翻译： 7-喹啉基酮内酯抗菌剂
公开(公告)号：US20080096828A1
公开(公告)日：2008-04-24
申请号：US11636206
申请日：2006-12-07
申请人： Simon Shaw , Gary Ashley , Mark Burlingame
发明人： Simon Shaw , Gary Ashley , Mark Burlingame
IPC分类号： A61K31/7048 , A61P11/00 , A61P17/00 , C07H17/08
CPC分类号： C07D405/14
摘要： 15-fluoroketolides of the formula having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections.
摘要翻译：具有改善的活性和安全性的式的15-氟代内酯类，包含它们的组合物，及其制备和用于治疗细菌感染的方法。

7. 发明申请

US20080033268A1 Method and Apparatus for Providing Analyte Sensor Insertion 有权
标题翻译：提供分析物传感器插入的方法和装置
公开(公告)号：US20080033268A1
公开(公告)日：2008-02-07
申请号：US11535983
申请日：2006-09-28
申请人： Gary Ashley Stafford
发明人： Gary Ashley Stafford
IPC分类号： A61B5/05
CPC分类号： A61B5/1473 , A61B5/0002 , A61B5/0015 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/14865
摘要： Devices and methods for positioning a portion of a sensor at a first predetermined location, displacing the portion of the sensor from the first predetermined location to a second predetermined location, and detecting one or signals associated with an analyte level of a patient at the second predetermined location are disclosed. Also provided are systems and kits for use in analyte monitoring.
摘要翻译：用于将传感器的一部分定位在第一预定位置处的装置和方法，将传感器的该部分从第一预定位置移位到第二预定位置，以及在第二预定位置处检测与患者的分析物水平相关联的一个或信号公开位置。还提供了用于分析物监测的系统和试剂盒。

8. 发明申请

US20050233431A1 Recombinant narbonolide polyketide synthase 审中-公开
标题翻译：重组纳博内酯聚酮化合物合成酶
公开(公告)号：US20050233431A1
公开(公告)日：2005-10-20
申请号：US10846335
申请日：2004-05-14
申请人： Gary Ashley , Melanie Betlach , Mary Betlach , Robert McDaniel , Li Tang
发明人： Gary Ashley , Melanie Betlach , Mary Betlach , Robert McDaniel , Li Tang
IPC分类号： C07B61/00 , C07D323/00 , C07H17/08 , C12N1/21 , C12N9/14 , C12N15/52 , C12N15/65 , C12P17/08 , C12P19/62 , C12N9/16 , C07H21/04 , C12N15/74
CPC分类号： C07D323/00 , C07H17/08 , C12N9/14 , C12N15/52 , C12N15/65 , C12P17/08 , C12P19/62 , C40B40/00
摘要： Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
摘要翻译：用于编码全部或部分纳博内酯聚酮化合物合成酶的重组DNA化合物用于在宿主细胞中表达重组聚酮化合物合成酶基因，用于生产可用作抗生素的纳博内酯，纳博内酯衍生物和聚酮化合物，并且作为合成具有药品价值。

9. 发明授权

US06927057B2 Macrolide analogs 失效
标题翻译：大环内酯类似物
公开(公告)号：US06927057B2
公开(公告)日：2005-08-09
申请号：US09859854
申请日：2001-05-16
申请人： Chaitan Khosla , Gary Ashley , Camilla M. Kao , Robert McDaniel
发明人： Chaitan Khosla , Gary Ashley , Camilla M. Kao , Robert McDaniel
IPC分类号： C07B61/00 , C07D309/36 , C07D311/92 , C07D323/00 , C07D407/06 , C07H17/08 , C12N9/00 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/16 , C12P1/00
CPC分类号： C07D407/06 , C07D309/36 , C07D311/92 , C07D323/00 , C07H17/08 , C12N9/93 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/162 , C40B40/00
摘要： Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
摘要翻译：聚酮化合物的组合文库可以通过适当操作宿主模块化聚酮化合物合成酶基因簇（例如编码红霉素的PKS的簇）来获得。组合文库可用作药物活性化合物的来源。此外，使用该方法制备新的聚酮化合物和抗生素。

10. 发明申请

US20050038086A1 Epothilone derivatives and methods for making and using the same 有权
标题翻译：埃坡霉素衍生物及其制备和使用方法
公开(公告)号：US20050038086A1
公开(公告)日：2005-02-17
申请号：US10845467
申请日：2004-05-12
申请人： Gary Ashley , Robert Arslanian , John Carney , Brian Metcalf , Li Tang
发明人： Gary Ashley , Robert Arslanian , John Carney , Brian Metcalf , Li Tang
IPC分类号： C07D313/00 , C07D405/06 , C07D413/06 , C07D417/06 , C07D491/04 , C12N1/20 , C12N9/00 , C12N15/52 , C12N15/74 , C12P17/16 , C12P17/18 , C07D417/02 , A61K31/427
CPC分类号： C07D405/06 , C07D313/00 , C07D413/06 , C07D417/06 , C07D491/04 , C12N1/20 , C12N9/00 , C12N15/52 , C12N15/74 , C12P17/16 , C12P17/181 , C12R1/01
摘要： This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐和溶剂化物，其中R 1，R 2，R 3，R 4，R 5，W，X，Y ，Ar如本文所定义。式（I）化合物可用于治疗以细胞过度增殖为特征的疾病或病症。本发明还涉及制备式（I）化合物的方法; 含有式（I）化合物的制剂; 以及在治疗以细胞过度增殖为特征的疾病或病症（包括癌症）中使用所述化合物和制剂的方法。

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