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1. 发明授权

US09101306B2 Medical system having plug and play function 有权
标题翻译：医疗系统具有即插即用功能
公开(公告)号：US09101306B2
公开(公告)日：2015-08-11
申请号：US13240092
申请日：2011-09-22
申请人： Nicole Bernini , Harvey B. Buck, Jr. , Andreas Eberhart , Sybille Froech , Otto Gaa , Michael Marquant , Juergen Rasch-Menges , Bernd Roesicke , Joerg Scherer
发明人： Nicole Bernini , Harvey B. Buck, Jr. , Andreas Eberhart , Sybille Froech , Otto Gaa , Michael Marquant , Juergen Rasch-Menges , Bernd Roesicke , Joerg Scherer
IPC分类号： A61B5/00 , A61B5/145 , A61N1/372
CPC分类号： G06F19/3406 , A61B5/0015 , A61B5/0024 , A61B5/0031 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/4839 , A61B5/7271 , A61B5/74 , A61B90/98 , A61B2560/0406 , A61B2560/045 , A61N1/37235 , G06F19/00 , G06F21/32 , G06F21/445 , G16H40/63 , H04L67/12 , H04W4/70 , H04W4/80
摘要： A medical system is disclosed, which can be useable in particular for monitoring and/or controlling at least one bodily function of a user. The medical system comprises a control device and at least one medical user element embodied separately from the control device. The medical user element and the control device are designed to exchange data wirelessly. The medical system is designed to enable an automatic assignment step, wherein an exchange of personal data between the medical user element and the control device is enabled by the automatic assignment step. The medical system is furthermore designed to automatically initiate the automatic assignment step by means of an assignment coupling between the medical user element and the control device. The medical system is furthermore designed to enable a separation of the assignment coupling for medical operation of the medical system after the assignment step.
摘要翻译：公开了一种医疗系统，其可以特别用于监视和/或控制用户的至少一个身体功能。医疗系统包括控制装置和与控制装置分开体现的至少一个医疗用户元件。医疗用户元件和控制装置被设计为无线地交换数据。医疗系统被设计成能够进行自动分配步骤，其中通过自动分配步骤来实现医疗用户元件和控制装置之间的个人数据的交换。医疗系统还被设计成通过医疗用户元件和控制装置之间的分配耦合来自动启动自动分配步骤。医疗系统还被设计成能够在分配步骤之后分离用于医疗系统的医疗操作的分配耦合。

2. 发明授权

US08298828B2 System and method for determining the concentration of an analyte in a sample fluid 有权
标题翻译：用于确定样品流体中分析物浓度的系统和方法
公开(公告)号：US08298828B2
公开(公告)日：2012-10-30
申请号：US13418611
申请日：2012-03-13
申请人： Eric R. Diebold , Terry A. Beaty , Harvey B. Buck, Jr.
发明人： Eric R. Diebold , Terry A. Beaty , Harvey B. Buck, Jr.
IPC分类号： G01N27/00 , G01N27/06
CPC分类号： G01N27/3274 , G01N33/49
摘要： The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 3.0 seconds or less, and/or having a clinically low Total System Error.
摘要翻译：本公开涉及使用电化学测试方法测量存在于生物流体中的分析物的量的各种方法。公开了各种实施例，包括使用AC测试信号和在大约3.0秒或更短时间内具有总测试时间的测试和/或具有临床上低的总系统误差的测试。

3. 发明授权

US07751864B2 System and method for operating an electrochemical analyte sensor 有权
标题翻译：用于操作电化学分析物传感器的系统和方法
公开(公告)号：US07751864B2
公开(公告)日：2010-07-06
申请号：US11680963
申请日：2007-03-01
申请人： Harvey B. Buck, Jr.
发明人： Harvey B. Buck, Jr.
IPC分类号： A61B5/05
CPC分类号： G01N27/3274 , A61B5/14503 , A61B5/14532 , A61B5/1486 , A61B5/1495
摘要： A method of operating an electrochemical analyte sensor having one or more electrodes may comprise applying a time-varying input signal to at least one of the one or more electrodes, monitoring a time-varying output signal produced by the sensor in response to application of the time-varying input signal, determining a complex impedance of the sensor based on the time-varying input and output signals, and determining from the complex impedance information relating to operation of the sensor.
摘要翻译：操作具有一个或多个电极的电化学分析物传感器的方法可以包括将时变输入信号施加到所述一个或多个电极中的至少一个电极，监测响应于所述传感器的应用而由传感器产生的时变输出信号时变输入信号，基于时变输入和输出信号确定传感器的复阻抗，并根据与传感器的操作有关的复阻抗信息来确定。

4. 发明授权

US06294062B1 Method and device for electrochemical immunoassay of multiple analytes 有权
标题翻译：多种分析物的电化学免疫测定方法和装置
公开(公告)号：US06294062B1
公开(公告)日：2001-09-25
申请号：US09330422
申请日：1999-05-28
申请人： Harvey B. Buck, Jr. , Zhi David Deng , Eric R. Diebold
发明人： Harvey B. Buck, Jr. , Zhi David Deng , Eric R. Diebold
IPC分类号： G02N2726
CPC分类号： C07F15/0026 , C07K5/101 , C07K7/02 , C07K7/06 , C07K9/001 , C07K14/805 , G01N27/3277 , G01N33/532 , G01N33/536 , G01N33/58 , G01N33/723 , G01N2333/805 , G01N2458/30 , Y10S436/805 , Y10S436/806 , Y10T436/105831
摘要： A method and device for detection and quantification of biologically significant analytes in a liquid sample is described. The method includes contacting a volume of a liquid sample with predetermined amounts of at least a first and second redox reversible species having redox potentials differing by at least 50 millivolts. At least one of the redox reversible species comprises a liquid sample diffusible conjugate of a ligand analog of an analyte in the liquid sample and a redox reversible label. A predetermined amount of at least one specific binding partner for each analyte to be measured is combined with the sample and current flow is measured at first and second anodic and cathodic potentials and correlated with current flows for known concentrations of the respective diffusible redox reversible species. Diagnostic devices and kits, including such devices and the specified specific binding partner(s) and redox reversible species are also described.
摘要翻译：描述了用于在液体样品中检测和定量生物学显着性分析物的方法和装置。该方法包括使体积的液体样品与预定量的至少50毫伏的氧化还原电位的至少第一和第二氧化还原可逆物质接触。至少一种氧化还原可逆物质包括液体样品中分析物的配体类似物和氧化还原可逆标记的液体样品可扩散共轭物。将待测量的每种待测量分析物的至少一个特定结合配偶体的预定量与样品组合，并且在第一和第二阳极和阴极电位处测量电流，并且与已知浓度的各个可扩散的氧化还原可逆物质的电流相关。还描述了诊断装置和试剂盒，包括这些装置和指定的特异性结合配偶体和氧化还原可逆物质。

5. 发明授权

US4798577A Separator device and method 失效
标题翻译：分离装置及方法
公开(公告)号：US4798577A
公开(公告)日：1989-01-17
申请号：US862301
申请日：1986-05-12
申请人： Allen J. Brenneman , Harvey B. Buck, Jr. , Jerry T. Pugh , Steven P. Robertson
发明人： Allen J. Brenneman , Harvey B. Buck, Jr. , Jerry T. Pugh , Steven P. Robertson
IPC分类号： B04B1/02 , B04B5/04 , B04B7/08 , B04B1/04
CPC分类号： B04B7/08 , B04B5/0407
摘要： Separation device and method for the fractionation and separation of finely divided solid particulate material suspended in a liquid are disclosed. The separation device comprises upper and lower portions which are joined together to form an inner cavity retaining liquid and a capillary gap which extends outwardly radially from said cavity. During rotation solid particles present in the suspending liquid pass outwardly along and/or become entrapped in the capillary gap(s).
摘要翻译：公开了用于分离和分离悬浮在液体中的细碎固体颗粒材料的分离装置和方法。分离装置包括连接在一起以形成内腔保持液体的上部和下部，以及从所述腔径向向外延伸的毛细管间隙。在旋转期间，存在于悬浮液中的固体颗粒沿着和/或被夹带在毛细管间隙中向外通过。

6. 发明申请

US20120245438A1 MEDICAL SYSTEM HAVING PLUG AND PLAY FUNCTION 有权
标题翻译：具有插头和播放功能的医疗系统
公开(公告)号：US20120245438A1
公开(公告)日：2012-09-27
申请号：US13240092
申请日：2011-09-22
申请人： Nicole Bernini , Harvey B. Buck, JR. , Andreas Eberhart , Sybille Froech , Otto Gaa , Michael Marquant , Juergen Rasch-Menges , Bernd Roesicke , Joerg Scherer
发明人： Nicole Bernini , Harvey B. Buck, JR. , Andreas Eberhart , Sybille Froech , Otto Gaa , Michael Marquant , Juergen Rasch-Menges , Bernd Roesicke , Joerg Scherer
IPC分类号： A61B5/00 , A61B5/145
CPC分类号： G06F19/3406 , A61B5/0015 , A61B5/0024 , A61B5/0031 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/4839 , A61B5/7271 , A61B5/74 , A61B90/98 , A61B2560/0406 , A61B2560/045 , A61N1/37235 , G06F19/00 , G06F21/32 , G06F21/445 , G16H40/63 , H04L67/12 , H04W4/70 , H04W4/80
摘要： A medical system is disclosed, which can be useable in particular for monitoring and/or controlling at least one bodily function of a user. The medical system comprises a control device and at least one medical user element embodied separately from the control device. The medical user element and the control device are designed to exchange data wirelessly. The medical system is designed to enable an automatic assignment step, wherein an exchange of personal data between the medical user element and the control device is enabled by the automatic assignment step. The medical system is furthermore designed to automatically initiate the automatic assignment step by means of an assignment coupling between the medical user element and the control device. The medical system is furthermore designed to enable a separation of the assignment coupling for medical operation of the medical system after the assignment step.
摘要翻译：公开了一种医疗系统，其可以特别用于监测和/或控制用户的至少一个身体功能。医疗系统包括控制装置和与控制装置分开体现的至少一个医疗用户元件。医疗用户元件和控制装置被设计为无线地交换数据。医疗系统被设计成能够进行自动分配步骤，其中通过自动分配步骤来实现医疗用户元件和控制装置之间的个人数据的交换。医疗系统还被设计成通过医疗用户元件和控制装置之间的分配耦合来自动启动自动分配步骤。医疗系统还被设计成能够在分配步骤之后分离用于医疗系统的医疗操作的分配耦合。

7. 发明授权

US08148164B2 System and method for determining the concentration of an analyte in a sample fluid 有权
标题翻译：用于确定样品流体中分析物浓度的系统和方法
公开(公告)号：US08148164B2
公开(公告)日：2012-04-03
申请号：US12650065
申请日：2009-12-30
申请人： Eric R. Diebold , Terry A. Beaty , Harvey B. Buck, Jr.
发明人： Eric R. Diebold , Terry A. Beaty , Harvey B. Buck, Jr.
IPC分类号： G01N27/00 , G01N27/06
CPC分类号： G01N27/3274 , G01N33/49
摘要： The present disclosure relates to various methods for measuring the amount of an analyte present in a biological fluid using an electrochemical testing process. Various embodiments are disclosed, including the use of AC test signals and the performance of tests having a Total Test Time within about 2.0 seconds or less, and/or having a clinically low Total System Error.
摘要翻译：本公开涉及使用电化学测试方法测量存在于生物流体中的分析物的量的各种方法。公开了各种实施例，包括使用AC测试信号和在大约2.0秒或更短时间内具有总测试时间的测试和/或具有临床上低的总系统误差的测试。

8. 发明申请

US20110168575A1 SAMPLE CHARACTERIZATION BASED ON AC MEASUREMENT METHODS 审中-公开
标题翻译：基于交流测量方法的样本特征
公开(公告)号：US20110168575A1
公开(公告)日：2011-07-14
申请号：US12684277
申请日：2010-01-08
申请人： Georgeta Lica , Harvey B. Buck , Henning Groll
发明人： Georgeta Lica , Harvey B. Buck , Henning Groll
IPC分类号： G01N27/26
CPC分类号： G01N27/3274
摘要： One aspect concerns a technique for detecting analyte concentrations, such as glucose concentrations, in blood or other bodily fluids. This technique utilizes an electrochemical test strip that includes a mediator system that generates a linear faradic response at relatively low applied potential differences. An alternating current excitation signal is applied to blood in the test strip. The alternating current excitation signal includes a low frequency signal and a high frequency signal that has a higher frequency than the low frequency signal. The glucose concentration is determined by measuring a low frequency response to the low frequency signal, measuring a high frequency response to the high frequency signal, estimating the glucose concentration based on the low frequency response, and correcting the glucose concentration for one or more error-causing variables based on the high frequency response.
摘要翻译：一方面涉及用于检测血液或其他体液中的分析物浓度，例如葡萄糖浓度的技术。该技术利用电化学测试条，其包括在相对低的施加电位差下产生线性法拉第响应的介体系统。交流电激励信号被施加到测试条中的血液。交流励磁信号包括低频信号和具有比低频信号更高频率的高频信号。葡萄糖浓度通过测量对低频信号的低频响应，测量对高频信号的高频响应，基于低频响应估计葡萄糖浓度，以及校正一个或多个误差信号的葡萄糖浓度，导致基于高频响应的变量。

9. 发明授权

US07731835B2 Electrochemical sensor and method for continuous analyte monitoring 失效
标题翻译：电化学传感器和连续分析物监测方法
公开(公告)号：US07731835B2
公开(公告)日：2010-06-08
申请号：US11038970
申请日：2005-01-19
申请人： Harvey B. Buck , Matthias Essenpreis
发明人： Harvey B. Buck , Matthias Essenpreis
IPC分类号： G01N27/327
CPC分类号： C12Q1/006 , A61B5/14532 , A61B5/1486 , C12Q1/001 , C12Q1/004
摘要： Sensors and a method for detecting an analyte are described. Sensors each have a volume of a hydrophilic medium that retains an amount of analyte proportionate to the concentration of analyte in a biological fluid, electrodes and a redox enzyme in contact with medium, and an electron transfer mediator. The fluid contacts sensors and at initially predetermined intervals intermittently applies a potential to electrode sufficient to oxidize the mediator and sensing current through electrode as a function of the duration of the applied potential. The applied mediator oxidizing applied potential is maintained for a period of time sufficient to determine the rate of change of current with time through electrode. The current flow is correlated with the current flow for known concentrations of the analyte in medium.
摘要翻译：描述了传感器和检测分析物的方法。传感器各自具有一定量的亲水介质，其保留与生物流体，电极和与介质接触的氧化还原酶的分析物浓度成比例的分析物和电子转移介体。液体接触传感器并且以最初预定间隔间歇地将电位施加到足以氧化介体并将感应通过电极的电流作为施加电位的持续时间的函数。所施加的介体氧化施加电位保持足够长的时间以确定电流随时间的变化通过电极的速率。目前的流量与已知浓度的分析物在介质中的电流相关。

10. 发明申请

US20080275326A1 SENSOR FOR MONITORING A CONDITION OF A PATIENT 审中-公开
标题翻译：用于监测患者状况的传感器
公开(公告)号：US20080275326A1
公开(公告)日：2008-11-06
申请号：US11742998
申请日：2007-05-01
申请人： Joachim Kasielke , Ulrich Haueter , Ulrike Kamecke , Christian Hof , Matthew Reynolds , Timon Kasielke , Steven Gray , Harvey B. Buck , Michael Loukine , Fritz Hindelang
发明人： Joachim Kasielke , Ulrich Haueter , Ulrike Kamecke , Christian Hof , Matthew Reynolds , Timon Kasielke , Steven Gray , Harvey B. Buck , Michael Loukine , Fritz Hindelang
IPC分类号： A61B5/00
CPC分类号： A61B5/04 , A61B5/0002 , A61B5/05 , A61B5/1473 , A61B5/14865 , A61B5/6846 , A61B5/7405 , A61B5/742 , A61B5/7455 , A61B5/746 , H05K1/028 , H05K1/144 , H05K1/147 , H05K1/189 , H05K3/323 , H05K3/361 , H05K2201/042 , H05K2201/10098 , H05K2201/10151
摘要： A sensor may include a substrate having a sensing portion defining a sensor thereon and a circuit mounting portion defining at least one electrically conductive pad that is electrically connected to the sensor. The sensor may be configured to produce a signal indicative of a condition of the patient. An anisotropic medium may be disposed on the circuit mounting portion and may be electrically conductive in a direction through the medium and electrically insulating in directions along the medium. An electrical circuit may be mechanically mounted to the circuit mounting portion of the first substrate via the anisotropic medium with at least one electrically conductive terminal juxtaposed over the at least one electrically conductive pad. The anisotropic medium may establish local electrical contact between the at least one electrically conductive terminal and the at least one electrically conductive pad.
摘要翻译：传感器可以包括具有在其上限定传感器的感测部分的基板和限定电连接到传感器的至少一个导电焊盘的电路安装部分。传感器可以被配置为产生指示患者状况的信号。各向异性介质可以设置在电路安装部分上，并且可以在通过介质的方向上导电并且沿着介质的方向电绝缘。电路可以经由各向异性介质机械地安装到第一基板的电路安装部分，其中至少一个导电端子并置在至少一个导电焊盘上。各向异性介质可以在至少一个导电端子和至少一个导电焊盘之间建立局部电接触。

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