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1. 发明授权

US07731835B2 Electrochemical sensor and method for continuous analyte monitoring 失效
标题翻译：电化学传感器和连续分析物监测方法
公开(公告)号：US07731835B2
公开(公告)日：2010-06-08
申请号：US11038970
申请日：2005-01-19
申请人： Harvey B. Buck , Matthias Essenpreis
发明人： Harvey B. Buck , Matthias Essenpreis
IPC分类号： G01N27/327
CPC分类号： C12Q1/006 , A61B5/14532 , A61B5/1486 , C12Q1/001 , C12Q1/004
摘要： Sensors and a method for detecting an analyte are described. Sensors each have a volume of a hydrophilic medium that retains an amount of analyte proportionate to the concentration of analyte in a biological fluid, electrodes and a redox enzyme in contact with medium, and an electron transfer mediator. The fluid contacts sensors and at initially predetermined intervals intermittently applies a potential to electrode sufficient to oxidize the mediator and sensing current through electrode as a function of the duration of the applied potential. The applied mediator oxidizing applied potential is maintained for a period of time sufficient to determine the rate of change of current with time through electrode. The current flow is correlated with the current flow for known concentrations of the analyte in medium.
摘要翻译：描述了传感器和检测分析物的方法。传感器各自具有一定量的亲水介质，其保留与生物流体，电极和与介质接触的氧化还原酶的分析物浓度成比例的分析物和电子转移介体。液体接触传感器并且以最初预定间隔间歇地将电位施加到足以氧化介体并将感应通过电极的电流作为施加电位的持续时间的函数。所施加的介体氧化施加电位保持足够长的时间以确定电流随时间的变化通过电极的速率。目前的流量与已知浓度的分析物在介质中的电流相关。

2. 发明授权

US07045054B1 Small volume biosensor for continuous analyte monitoring 失效
标题翻译：用于连续分析物监测的小体积生物传感器
公开(公告)号：US07045054B1
公开(公告)日：2006-05-16
申请号：US10069308
申请日：2000-09-19
申请人： Harvey B. Buck , Matthias Essenpreis
发明人： Harvey B. Buck , Matthias Essenpreis
IPC分类号： G01N27/327
CPC分类号： C12Q1/006 , A61B5/14532 , A61B5/1486 , C12Q1/001 , C12Q1/004
摘要： Sensors (10, 110, 210, 310, 410) and a method for detecting an analyte are described. Sensors (10, 110, 210, 310, 410) each have a volume of a hydrophilic medium (24) that retains an amount of analyte proportionate to the concentration of analyte in a biological fluid, electrodes (12) and a redox enzyme in contact with medium (24), and an electron transfer mediator. The fluid contacts sensors (10, 110, 210, 310, 410) and at initially predetermined intervals intermittently applies a potential to electrode (12) sufficient to oxidize the mediator and sensing current through electrode (12) as a function of the duration of the applied potential. The applied mediator oxidizing applied potential is maintained for a period of time sufficient to determine the rate of change of current with time through electrode (12). The current flow is correlated with the current flow for known concentrations of the analyte in medium (24).
摘要翻译：描述了传感器（10,110,210,310,410）和检测分析物的方法。传感器（10,110,210,310,410）各自具有体积的亲水介质（24），其保留与生物流体中的分析物浓度成比例的分析物的量，电极（12）和接触中的氧化还原酶与介质（24）和电子转移介体。流体接触传感器（10,110,210,310,410）并且以最初预定间隔间歇地向电极（12）施加足以氧化介体并且感测通过电极（12）的电流的电位，作为所述电极应用潜力。所施加的介体氧化施加电位被保持足以确定电流随时间的变化的速率通过电极（12）的时间。当前流量与介质（24）中已知浓度的分析物的当前流量相关。

3. 发明授权

US11350821B2 Ambulatory medical device and method for communication between medical devices 有权
公开(公告)号：US11350821B2
公开(公告)日：2022-06-07
申请号：US11832421
申请日：2007-08-01
申请人： Matthias Essenpreis , Ulrich Haueter , Nicole Bernini , Sybille Fankhauser , Sebastiaan La Bastide , Gunnar Meyer Olden , Michael Schoemaker , Kelly Heaton , Joel Jeckelmann
发明人： Matthias Essenpreis , Ulrich Haueter , Nicole Bernini , Sybille Fankhauser , Sebastiaan La Bastide , Gunnar Meyer Olden , Michael Schoemaker , Kelly Heaton , Joel Jeckelmann
IPC分类号： A61B5/00 , A61M5/142 , A61B5/145
摘要： An ambulatory medical device and a method of communication between medical devices are disclosed. In one embodiment, the medical device includes a module for communication with at least a second medical device wherein the module for communication is adapted to be activated by a value of a physiological parameter of an animal. In one embodiment, the method of the present invention involves a first medical device and at least a second medical device wherein the communication between said medical devices is activated by a value of a physiological parameter of an animal.

4. 发明授权

US08849458B2 Collection device with selective display of test results, method and computer program product thereof 有权
标题翻译：收集装置，具有选择性地显示测试结果，方法和计算机程序产品
公开(公告)号：US08849458B2
公开(公告)日：2014-09-30
申请号：US12818875
申请日：2010-06-18
申请人： Stefan Weinert , Matthias Essenpreis , Nigel Surridge , Remmert Laan
发明人： Stefan Weinert , Matthias Essenpreis , Nigel Surridge , Remmert Laan
IPC分类号： G05B21/00 , G06F19/00 , G06Q50/22 , A61B5/00 , A61B5/145
CPC分类号： A61B5/0002 , A61B5/14532 , G06F19/00 , G06F19/3418 , G06Q50/22 , G16H10/20 , G16H40/63
摘要： A collection device with a selective display of test results and method thereof are disclosed. A structured collection procedure defining data collection times and the associated context of the collection also defines what information regarding the results of the collection may be viewable by a user performing the structured collection procedure on the device. In this manner, the patient can be monitored according to the structured collection procedure while preventing the patient from modifying his or her behavior based on collection results.
摘要翻译：公开了具有选择性地显示测试结果的收集装置及其方法。定义数据收集时间的结构化收集过程和集合的关联上下文还定义了关于集合结果的什么信息可以由用户在设备上执行结构化收集过程来查看。以这种方式，可以根据结构化收集程序来监视患者，同时防止患者基于收集结果来修改他或她的行为。

5. 发明授权

US08734347B2 Analytical method and investigation system 有权
标题翻译：分析方法和调查制度
公开(公告)号：US08734347B2
公开(公告)日：2014-05-27
申请号：US12130091
申请日：2008-05-30
申请人： Arnulf Staib , Hans-Martin Kloetzer , Matthias Essenpreis
发明人： Arnulf Staib , Hans-Martin Kloetzer , Matthias Essenpreis
IPC分类号： A61B5/145 , G06G7/60
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/743 , A61B2560/0223 , G06F19/00 , G06F19/3456
摘要： Metabolism diseases are evaluated by using a sensor to measure concentration of a medically significant analyte in a human or animal body fluid. The measurement data are correlated with the concentration of a medically significant analyte in body fluid over a time period of at least eight hours. An analytical facility analyzes time intervals within the time period to determine a stability parameter that characterizes the analyte concentration dynamics of change. The analytical facility further analyzes the stability parameters to determine disease-related particularities of metabolism.
摘要翻译：通过使用传感器来测量人体或动物体液中医学上重要的分析物的浓度来评估代谢疾病。在至少8小时的时间内，测量数据与体液中医学上重要的分析物的浓度相关。分析设备分析时间段内的时间间隔，以确定表征变化的分析物浓度动力学的稳定性参数。分析设备进一步分析稳定性参数，以确定与疾病相关的新陈代谢特征。

6. 发明授权

US07766831B2 System, tools, devices and a program for diabetes care 有权
标题翻译：系统，工具，设备和糖尿病护理程序
公开(公告)号：US07766831B2
公开(公告)日：2010-08-03
申请号：US12044133
申请日：2008-03-07
申请人： Matthias Essenpreis , Michael Schoemaker , Sebastiaan La Bastide , Derek Brandt , Theodor Koschinsky , Sascha Heckermann
发明人： Matthias Essenpreis , Michael Schoemaker , Sebastiaan La Bastide , Derek Brandt , Theodor Koschinsky , Sascha Heckermann
IPC分类号： A61B5/00
CPC分类号： A61B5/743 , A61B5/14532 , A61B5/7275 , A61B5/7445 , G06F19/00
摘要： A method for diabetes care, the method (which also may be referred to as, involve or incorporate at least one of a tool, device or program) allowing for the characterization of the relevance of errors of parameters affecting glucose concentration on a postprandial glucose concentration outcome for a person with diabetes mellitusm, wherein the method involves at least one of sensing, determining, calculating, predicting, describing and communicating the effects of potential errors of parameters affecting glucose concentration on postprandial glucose concentration values within a clinically relevant glucose range.
摘要翻译：一种用于糖尿病护理的方法，该方法（其也可以被称为涉及或并入至少一种工具，装置或程序），其允许表征影响葡萄糖浓度的参数误差对餐后葡萄糖浓度的相关性糖尿病患者的结果，其中所述方法涉及感测，确定，计算，预测，描述和传达影响葡萄糖浓度的参数的潜在误差对临床相关葡萄糖范围内餐后葡萄糖浓度值的影响中的至少一种。

7. 发明授权

US5713352A Method for investigating a scattering medium with intensity-modulated light 失效
标题翻译：用强度调制光调查散射介质的方法
公开(公告)号：US5713352A
公开(公告)日：1998-02-03
申请号：US572641
申请日：1995-12-14
申请人： Matthias Essenpreis , Hans-Peter Haar , Dirk Boecker , Alexander Knuettel
发明人： Matthias Essenpreis , Hans-Peter Haar , Dirk Boecker , Alexander Knuettel
IPC分类号： G01N33/483 , A61B5/145 , A61B5/1455 , G01N21/27 , G01N21/41 , G01N21/49 , A61B5/00
CPC分类号： G01N21/49
摘要： The invention concerns a method for investigating a scattering medium, especially a biological matrix, with intensity-modulated light. In order, in such a frequency-domain measuring procedure, to reduce the expenditure on electronics without restricting accuracy of measurement, a method is proposed, in which, in order to investigate a scattering medium, especially a biological matrix, with intensity-modulated light, a high-frequency modulation signal is generated by a frequency generator (18), the intensity of a light emitter (10) is modulated with a modulation signal and the light from the light emitter (10) is radiated into the medium, the modulation signal includes frequency chirps during which the modulation frequency is tuned from an initial frequency to a final frequency, the modulation signal is delivered from the frequency generator (18) via at least two different signal paths (23A, 24) to a signal mixer (31), so that during a frequency chirp the input signals of the signal mixer (31) differ by a differential frequency whose magnitude is a function of the difference between the signal transit times over the at least two signal paths (23A, 24) and of the rate of change of the modulation frequency, wherein at least one of the signal paths includes a light path section (20A) passing through the medium as a measurement signal path (23A), and the output signal of the signal mixer (31) is further processed to produce information relating to the scattering medium (FIG. 2).
摘要翻译：本发明涉及用强度调制光来研究散射介质，特别是生物基质的方法。为了在这样的频域测量过程中，为了减少电子设备的开销而不限制测量精度，提出了一种方法，其中为了研究具有强度调制光的散射介质，特别是生物矩阵，由频率发生器（18）产生高频调制信号，用调制信号调制发光体（10）的强度，将来自发光体（10）的光照射到介质中，调制信号包括调制频率从初始频率调谐到最终频率的频率啁啾，调制信号经由至少两个不同的信号路径（23A，24）从频率发生器（18）传送到信号混合器（31 ），使得在频率啁啾期间，信号混合器（31）的输入信号相差一个差分频率，其幅度是在at信号传输时间之间的差值的函数至少两个信号路径（23A，24）和调制频率的变化率，其中信号路径中的至少一个包括通过介质作为测量信号路径（23A）的光路部分（20A），以及信号混合器（31）的输出信号被进一步处理以产生与散射介质有关的信息（图3）。 2）。

8. 发明授权

US10299737B2 System, tools, devices and a program for diabetes care 有权
公开(公告)号：US10299737B2
公开(公告)日：2019-05-28
申请号：US12786993
申请日：2010-05-25
申请人： Matthias Essenpreis , Michael Schoemaker , Sebastiaan La Bastide , Derek Brandt , Theodor Koschinsky , Sascha Heckermann
发明人： Matthias Essenpreis , Michael Schoemaker , Sebastiaan La Bastide , Derek Brandt , Theodor Koschinsky , Sascha Heckermann
IPC分类号： A61B5/00 , G06F19/00 , A61B5/145
摘要： A method for diabetes care, the method (which also may be referred to as, involve or incorporate at least one of a tool, device or program) allowing for the characterization of the relevance of errors of parameters affecting glucose concentration on a postprandial glucose concentration outcome for a person with diabetes mellitusm, wherein the method involves at least one of sensing, determining, calculating, predicting, describing and communicating the effects of potential errors of parameters affecting glucose concentration on postprandial glucose concentration values within a clinically relevant glucose range.

9. 发明申请

US20130211849A1 Device for supporting a patient with a chronic or a non-chronic disease and method for operating the device 审中-公开
标题翻译：用于支持患有慢性或非慢性疾病的患者的装置和用于操作该装置的方法
公开(公告)号：US20130211849A1
公开(公告)日：2013-08-15
申请号：US13586409
申请日：2012-08-15
申请人： Matthias Essenpreis , Dirk Voelkel , Stefan Weinert
发明人： Matthias Essenpreis , Dirk Voelkel , Stefan Weinert
IPC分类号： G06F19/00
CPC分类号： G16H40/20 , G16H40/63
摘要： A device and method are disclosed for supporting a patient with a disease, comprising a display facility, a user interface, a processor, and a user interface, and with an application module comprising program instructions, which are configured, on executing by the processor to bring about the following: providing medical protocols for diagnostic and/or therapeutic purposes, collecting time information concerning a future event which is a trigger for at least one medical protocol, selecting one of the medical protocols which indicates a group of cohesive protocol events which are spaced apart chronologically over a protocol period in accordance with a protocol regime, monitoring a chronological interval between a current date and the future event, and issuing a user start notice concerning the beginning of the medical protocol at a time which from a chronological point of view lies at least by the protocol period before the future event.
摘要翻译：公开了一种用于支持具有疾病的患者的装置和方法，包括显示设施，用户界面，处理器和用户界面，以及包括程序指令的应用模块，所述应用模块被配置为在由处理器执行时提供以下内容：提供用于诊断和/或治疗目的的医疗协议，收集关于未来事件的时间信息，该事件是至少一个医疗协议的触发器，选择指示一组内聚协议事件的医疗协议之一按照协议制度在协议周期上按时间顺序隔开，监视当前日期与未来事件之间的时间间隔，并且从按时间顺序的时间点发出关于医疗协议开始的用户启动通知至少在未来事件发生前的协议期限内。

10. 发明申请

US20110251472A1 SYSTEM FOR COLLECTING PATIENT INFORMATION FOR DIABETES MANAGEMENT 审中-公开
标题翻译：收集糖尿病患者信息的系统
公开(公告)号：US20110251472A1
公开(公告)日：2011-10-13
申请号：US13165510
申请日：2011-06-21
申请人： Stefan Weinert , Nicole Bernini , Derek Brandt , Matthias Essenpreis , Kelly Heaton , Joel Jeckelmann , Sebastiaan LaBastide , Gunnar Meyer-Olden , Michael Schoemaker , Robin Wagner
发明人： Stefan Weinert , Nicole Bernini , Derek Brandt , Matthias Essenpreis , Kelly Heaton , Joel Jeckelmann , Sebastiaan LaBastide , Gunnar Meyer-Olden , Michael Schoemaker , Robin Wagner
IPC分类号： A61B5/145
CPC分类号： G06F19/3456 , G06F19/3418 , G06F19/3475 , G16H10/20 , G16H10/60 , G16H40/63 , G16H50/20
摘要： A system is provided for collecting patient information from which diabetes therapy may be determined. The system may comprise a patient interface device, a patient notification device, an input device for entering patient information, and an information collecting unit. The information collecting unit may include a processor electrically coupled to a memory having stored therein at least one algorithm executable by the processor to activate the patient notification device followed by presenting instructions to the patient via the patient interface device for collecting specified information from the patient via the input device.
摘要翻译：提供了用于收集可以从其确定糖尿病治疗的患者信息的系统。该系统可以包括患者接口设备，患者通知设备，用于输入患者信息的输入设备和信息收集单元。信息收集单元可以包括处理器，电耦合到存储器，其中存储有至少一个算法，其可由处理器执行以激活患者通知装置，随后经由患者接口装置向患者呈现指令，用于从患者经由输入设备。

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