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1. 发明授权

US09816984B2 Device for detection of target molecules and uses thereof 有权
公开(公告)号：US09816984B2
公开(公告)日：2017-11-14
申请号：US15141141
申请日：2016-04-28
申请人： Invisible Sentinel, Inc.
发明人： Nicholas A. Siciliano , Martin Joseph Bouliane
IPC分类号： G01N33/558 , G01N33/53 , B01L3/00 , G01N33/569
CPC分类号： G01N33/5302 , B01L3/5023 , B01L2200/026 , B01L2200/04 , B01L2200/10 , B01L2300/041 , B01L2300/049 , B01L2300/0636 , B01L2300/069 , B01L2300/0809 , B01L2300/087 , G01N33/56911 , G01N33/56916 , G01N33/56922 , Y10S435/81 , Y10S435/97 , Y10S436/804 , Y10S436/805 , Y10S436/807
摘要： Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.

2. 发明授权

US09789481B2 Device for extracting nucleic acid from a sample 有权
公开(公告)号：US09789481B2
公开(公告)日：2017-10-17
申请号：US11977697
申请日：2007-10-24
申请人： Kurt E. Petersen , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
发明人： Kurt E. Petersen , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
IPC分类号： B01L3/00 , B01L7/00 , C12N1/06 , C12N13/00
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0809 , B01L2300/087 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12N1/066 , C12N13/00 , Y10S435/81 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809 , Y10S436/829 , Y10T137/87716 , Y10T137/88046 , Y10T436/255
摘要： The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.

3. 发明申请

US20170199182A1 QUANTITIVE ANALYTE ASSAY DEVICE AND METHOD 审中-公开
公开(公告)号：US20170199182A1
公开(公告)日：2017-07-13
申请号：US15410424
申请日：2017-01-19
申请人： Assurance LLC
发明人： Jin Po LEE
IPC分类号： G01N33/543 , G01N33/78 , G01N33/574 , G01N33/74
CPC分类号： G01N33/54373 , G01N21/78 , G01N33/54366 , G01N33/558 , G01N33/57434 , G01N33/57473 , G01N33/74 , G01N33/78 , G01N2021/6439 , G01N2021/7786 , G01N2021/7793 , G01N2021/7796 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81 , Y10S436/811 , Y10S436/813 , Y10S436/814 , Y10S436/818
摘要： The present invention relates to an assay device and a method for using such for the quantitative determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the test membrane and a porous downstream membrane in fluid connection with the test membrane, wherein the test membrane contains a test site having immobilized thereon a ligand capable of reacting with the analyte and binding such to the test site, and two standard band sites having immobilized thereon known high and low concentrations of a calibrator agent capable of reacting with a label conjugate and binding such to the standard sites, wherein the upstream membrane has a site for the application of a sample to be analyzed, and has a site downstream from the sample application site for depositing label conjugates capable of reacting with the analyte and label conjugates capable of reacting with the immobilized calibrator agents in the standard bands to provide a known label response in the standards bands, and the downstream membrane is capable of absorbing said sample and providing the capillary flow for the sample through the upstream and test membrane.

4. 发明授权

US09494596B2 Devices and methods for detecting amniotic fluid in vaginal secretions 有权
公开(公告)号：US09494596B2
公开(公告)日：2016-11-15
申请号：US13970342
申请日：2013-08-19
申请人： N-DIA, INC.
发明人： Boris Fuks , Dmitrii D. Petrunin , Evgeny I. Zaraisky , Marina N. Boltovskaya , Svetlana V. Nazimova , Nelly A. Starosvetskaya , Alexandr Konstantinov , Margarita I. Marshiskaia
IPC分类号： G01N33/558 , G01N33/68
CPC分类号： G01N33/6854 , G01N33/558 , G01N33/577 , G01N33/689 , G01N2333/471 , G01N2800/36 , G01N2800/368 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/807 , Y10S436/81 , Y10S436/811 , Y10S436/815 , Y10S436/817
摘要： The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies.

5. 发明授权

US09156032B2 Apparatus and method for analyzing fluid sample 有权
标题翻译：用于分析流体样品的装置和方法
公开(公告)号：US09156032B2
公开(公告)日：2015-10-13
申请号：US13081060
申请日：2011-04-06
申请人： Kurt E. Peterson , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas P. Dority , Philip Belgrader , M. Allen Northrup
发明人： Kurt E. Peterson , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas P. Dority , Philip Belgrader , M. Allen Northrup
IPC分类号： B01L3/00 , B01L7/00 , C12N1/06 , C12N13/00
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0809 , B01L2300/087 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12N1/066 , C12N13/00 , Y10S435/81 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809 , Y10S436/829 , Y10T137/87716 , Y10T137/88046 , Y10T436/255
摘要： The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.
摘要翻译：本发明提供一种用于分析流体样品的盒。盒提供用于有效分离样品中的细胞或病毒与剩余的样品流体，裂解细胞或病毒以从其中分离分析物（例如核酸），以及任选地分析物的化学反应和/或检测。墨盒可用于各种诊断，生命科学研究，环境或法医应用，用于确定样品中一种或多种分析物的存在或不存在。

6. 发明授权

US08961898B2 Method for producing bilayer membrane and planar bilayer membrane 有权
标题翻译：双层膜和平面双层膜的制备方法
公开(公告)号：US08961898B2
公开(公告)日：2015-02-24
申请号：US12450517
申请日：2008-03-28
申请人： Takasi Nisisako , Takahiro Baba
发明人： Takasi Nisisako , Takahiro Baba
IPC分类号： B01L3/00 , G01N33/487 , G01N27/447 , C12M3/06
CPC分类号： B01L3/502784 , B01L3/5027 , B01L3/502753 , B01L2200/0636 , B01L2300/0816 , B01L2300/0864 , C12M23/16 , G01N27/44791 , G01N33/48728 , Y10S435/808 , Y10S436/805 , Y10S436/809 , Y10T436/117497 , Y10T436/118339 , Y10T436/25
摘要： The present invention provides a bilayer membrane produced using a microchannel capable of easily forming bilayer membranes such as planar lipid bilayer membranes in large quantities, and a production method thereof. A process for producing a bilayer membrane of the present invention comprises forming a state where two liquid phases or liquid and gaseous phases each containing amphipathic molecules are alternately arranged in a microchannel, discharging one of the two liquid phases or the gaseous phase of the liquid and gaseous phases through branch minichannels formed in the wall on one side or in the walls on both sides to contact the remaining liquid phases adjacent to each other, and thereby forming a side-by-side arrangement of bilayer membranes comprising the amphipathic molecules.
摘要翻译：本发明提供一种使用能够容易地形成大量双平面脂质双层膜等双层膜的微通道的双层膜及其制造方法。本发明的双层膜的制造方法包括：形成两个液相或含有两亲性分子的液相和气相在微通道中交替排列的状态，排出两液相或液相中的一个，气相通过在一侧或两侧的壁上形成的分支微通道与彼此相邻的剩余液相接触，从而形成包含两亲性分子的双层膜的并排排列。

7. 发明申请

US20150004058A1 Methods for Forming a Channel Through a Polymer Layer Using One or More Photoresist Layers 有权
标题翻译：通过使用一个或多个光刻胶层的聚合物层形成通道的方法
公开(公告)号：US20150004058A1
公开(公告)日：2015-01-01
申请号：US13931086
申请日：2013-06-28
申请人： Google Inc.
发明人： Huanfen Yao , Jeffrey George Linhardt , Babak Parviz
IPC分类号： G03F7/16
CPC分类号： G03F7/16 , B29D11/00826 , G02B1/04 , G02C7/04 , G02C11/10 , G03F7/425 , Y10S435/808 , Y10S436/805 , Y10T436/25
摘要： A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.
摘要翻译：方法可以包括在位于结构上的传感器上形成一个或多个光致抗蚀剂层，使得传感器被一个或多个光致抗蚀剂层覆盖。传感器被配置为检测分析物。该方法可以包括形成第一聚合物层。此外，该方法可以包括将结构定位在第一聚合物层上。此外，该方法可以包括在第一聚合物层和结构上形成第二聚合物层，使得该结构被第一聚合物层，第二聚合物层和一个或多个光致抗蚀剂层完全包围。该方法还可以包括去除一个或多个光致抗蚀剂层以形成通过第二聚合物层的通道，其中传感器经配置以经由通道接收分析物。

8. 发明授权

US08920749B2 Microchip and liquid sending method for microchip 有权
标题翻译：微芯片和微芯片的送液方式
公开(公告)号：US08920749B2
公开(公告)日：2014-12-30
申请号：US13966933
申请日：2013-08-14
申请人： Konica Minolta, Inc.
发明人： Youichi Aoki , Akihisa Nakajima , Kusunoki Higashino , Yasuhiro Sando , Yoshikazu Kurihara
IPC分类号： B01L3/00 , G01N21/03 , G01N35/00
CPC分类号： B01L3/502746 , B01J2219/00619 , B01L3/5027 , B01L3/502723 , B01L2200/027 , B01L2200/0642 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , C12Q2565/629 , G01N2021/0346 , G01N2035/00158 , Y10S435/808 , Y10S436/805 , Y10S436/809 , Y10T137/0318 , Y10T137/8593 , Y10T436/25 , Y10T436/2575
摘要： A microchip capable of sending liquid in a micro flow channel to a predetermined place irrespective of the pressure difference and sending a mixture of two or more liquid masses to a predetermined place even if the channel structure is simple. The microchip comprises an intermediate reservoir portion provided in a micro flow channel and adapted for temporarily holding liquid sent through the micro flow channel. The microchip is characterized in that the intermediate reservoir portion has a side channel, the volume of the intermediate reservoir portion is smaller than the total volume of the liquid sent into the intermediate reservoir portion, the side channel is provided for communication of a micro flow channel on the upstream side of the intermediate reservoir portion with a micro flow channel on the downstream side thereof, and the cross-section area of the side channel is smaller than that of the micro flow channel.
摘要翻译：即使在通道结构简单的情况下，也能够将微流路内的液体送到规定的位置而与压力差无关，并且将两液体质量混合物送出到规定的位置。微芯片包括设置在微流动通道中并适于临时保持通过微流动通道传送的液体的中间储存部分。微芯片的特征在于，中间储存部分具有侧通道，中间储存器部分的体积小于送入中间储存器部分的液体的总体积，侧通道用于连通微流道在中间储存部的上游侧，在其下游侧具有微流路，并且侧流路的截面积小于微流路的截面积。

9. 发明授权

US08906672B2 Gradient injection for biosensing 有权
标题翻译：梯度注射用于生物传感
公开(公告)号：US08906672B2
公开(公告)日：2014-12-09
申请号：US12674290
申请日：2008-01-16
申请人： John Gerard Quinn
发明人： John Gerard Quinn
IPC分类号： C12M1/34 , G01N35/10 , G01N21/55 , G01N33/53 , G01N35/08 , G01N21/05
CPC分类号： G01N35/1097 , B01L2300/0636 , G01N21/55 , G01N21/553 , G01N33/53 , G01N35/08 , G01N35/085 , G01N2021/058 , Y10S435/808 , Y10S436/805 , Y10T436/117497
摘要： A single injection gradient with a biosensor, both structural and methodological, achieves the binding of analyte to immobilized ligand over a wide concentration range without the necessity of regeneration of the sensing area. A gradient of concentrations adjacent to or within a flow cell facilitates kinetic analysis of interactions without requiring multiple discrete volumes or injections to achieve a range of concentrations. A continuous gradient fluid is preferably formed directly adjacent to the flow cell inlet or a region of sample/buffer dispersion at an injection point into a flow channel of a flow cell. The analyte gradient may be flowed through the flow cell from a low analyte concentration. Multiple component gradients are also provided.
摘要翻译：具有结构和方法学的生物传感器的单次注射梯度实现了在宽浓度范围内分析物与固定化配体的结合，而不需要再生感测区域。与流动池相邻或相邻的浓度梯度促进了相互作用的动力学分析，而不需要多个离散的体积或注射来达到一定范围的浓度。连续梯度流体优选直接邻近流动池入口或在注入点处的流动池的流动通道中的样品/缓冲液分散区域形成。分析物梯度可以从低分析物浓度流过流动池。还提供了多组分梯度。

10. 发明授权

US08900881B2 Quantitative analyte assay device and method 有权
标题翻译：定量分析物测定装置及方法
公开(公告)号：US08900881B2
公开(公告)日：2014-12-02
申请号：US13199894
申请日：2011-09-12
申请人： Jin Po Lee
发明人： Jin Po Lee
IPC分类号： G01N33/558 , G01N21/78 , G01N33/74 , G01N21/77 , G01N21/64
CPC分类号： G01N33/54373 , G01N21/78 , G01N33/54366 , G01N33/558 , G01N33/57434 , G01N33/57473 , G01N33/74 , G01N33/78 , G01N2021/6439 , G01N2021/7786 , G01N2021/7793 , G01N2021/7796 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81 , Y10S436/811 , Y10S436/813 , Y10S436/814 , Y10S436/818
摘要： The present invention relates to a quantitative assay device and a method for the determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the test membrane and a porous downstream membrane in fluid connection with the test membrane, wherein the test membrane contains two bands having deposited on there high and low concentrations of different calibrator agents and a test band capable of reacting with conjugated analyte complexes giving rise to a measurable signal.
摘要翻译：本发明涉及一种定量测定装置和一种基于测试条测定分析物的方法，所述测试条包含允许被分析物和分析物复合物毛细管流动的多孔测试膜，流体中的多孔上游膜与测试膜的连接和与测试膜流体连接的多孔下游膜，其中测试膜包含沉积有高浓度和低浓度的不同校准剂的两个带和能够与共轭分析物复合物反应的测试带到可测量的信号。

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