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1. 发明授权

US09028821B2 Method of treating an inflammatory disease comprising administering an NR 10 antibody antagonist 有权
标题翻译：治疗炎性疾病的方法，包括施用NR 10抗体拮抗剂
公开(公告)号：US09028821B2
公开(公告)日：2015-05-12
申请号：US12303684
申请日：2007-06-08
申请人： Masakazu Hasegawa , Hidetomo Kitamura , Hideki Adachi , Keiko Kasutani
发明人： Masakazu Hasegawa , Hidetomo Kitamura , Hideki Adachi , Keiko Kasutani
IPC分类号： A61K39/395 , A61P17/04 , A61P17/00 , A61P29/00 , A61P19/02 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/54 , C07K14/715 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present inventors obtained, from a phage library of human antibodies, an anti-mouse NR 10 neutralizing antibody-expressing BM095 clone that shows a strong proliferation-suppressing activity in an IL-31-dependent Ba/F3 cell proliferation assay system. When this anti-mouse NR 10 neutralizing antibody was administered to NC/Nga mice, a model of atopic dermatitis which is a mouse model of chronic dermatitis that arises as a result of repeated applications of picryl chloride, a mouse model of rheumatoid arthritis, and a mouse model of osteoarthritis, a significant effect of symptom suppression was observed. This revealed that the anti-NR 10 neutralizing antibody is indeed effective as a therapeutic agent for inflammatory diseases. In addition, the present inventors successfully obtained an anti-human NR 10 neutralizing antibody, providing extremely useful therapeutic agents with practical clinical applications.
摘要翻译：本发明人从人抗体的噬菌体文库获得了在IL-31依赖性Ba / F3细胞增殖分析系统中显示出强的增殖抑制活性的抗小鼠NR10中和抗体表达BM095克隆。当向NC / Nga小鼠施用这种抗小鼠NR 10中和抗体时，是由于重复使用苦基氯，类风湿性关节炎的小鼠模型和由此引起的慢性皮炎小鼠模型的特应性皮炎模型观察到骨关节炎的小鼠模型，观察到症状抑制的显着作用。这表明抗NR10中和抗体确实作为炎性疾病的治疗剂有效。此外，本发明人成功地获得了抗人NR10中和抗体，其具有实用的临床应用的非常有用的治疗剂。

2. 发明授权

US08506413B2 Rotary connector 有权
标题翻译：旋转接头
公开(公告)号：US08506413B2
公开(公告)日：2013-08-13
申请号：US12694571
申请日：2010-01-27
申请人： Norihito Suzuki , Hideki Adachi , Tsutomu Sawada
发明人： Norihito Suzuki , Hideki Adachi , Tsutomu Sawada
IPC分类号： F16D3/16
CPC分类号： B62D15/0215 , B60R16/027 , F16D3/185 , F16D2300/18 , Y10T464/20
摘要： A rotary connector, comprises an annular rotary body inserted outside a steering shaft and integrally rotated with a steering wheel, a rotator of a steering angle sensor inserted outside the steering shaft; and a tubular joint inserted outside the steering shaft and connecting the rotary body to the rotator; wherein the rotary body and the joint are connected together by a first universal joint, and the joint and the rotator are connected together by a second universal joint.
摘要翻译：旋转连接器包括插入转向轴外部并与方向盘整体旋转的环形旋转体，转向角传感器的旋转体插入转向轴外部; 以及插入转向轴外部并将旋转体连接到旋转体的管状接头; 其特征在于，所述旋转体和所述接头通过第一万向节连接在一起，并且所述接头和所述旋转体通过第二万向节连接在一起。

3. 发明授权

US08067665B2 Methods of using human tissue factor-producing knock-in mice 失效
标题翻译：使用人组织因子产生敲入小鼠的方法
公开(公告)号：US08067665B2
公开(公告)日：2011-11-29
申请号：US12461453
申请日：2009-08-12
申请人： Kiyoshi Habu , Kou-ichi Jishage , Hideki Adachi , Naohiro Yabuta
发明人： Kiyoshi Habu , Kou-ichi Jishage , Hideki Adachi , Naohiro Yabuta
IPC分类号： C12P21/00
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N2800/30
摘要： A non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor, said animal having a genome in which cDNA encoding human TF has been inserted upstream of the translation initiation codon for the non-human animal genomic TF gene.
摘要翻译：所述动物具有编码人TF的cDNA已被插入非人动物基因组的翻译起始密码子的上游的基因组，所述非人动物产生人组织因子（TF），而基本上不产生非人动物组织因子 TF基因。

4. 发明授权

US07920287B2 Layout apparatus, layout method, and program product 有权
标题翻译：布局设备，布局方法和程序产品
公开(公告)号：US07920287B2
公开(公告)日：2011-04-05
申请号：US12111343
申请日：2008-04-29
申请人： Hideki Adachi , Koichi Homma , Hiroshi Yamaguchi , Joji Oki , Naohiro Yoshikawa , Hideyuki Fujiwara , Akira Negishi , Shuji Someya
发明人： Hideki Adachi , Koichi Homma , Hiroshi Yamaguchi , Joji Oki , Naohiro Yoshikawa , Hideyuki Fujiwara , Akira Negishi , Shuji Someya
IPC分类号： G06F3/12 , G06F17/00 , G06F3/00 , G06K15/00 , G03F3/08
CPC分类号： G06F3/1204 , G06F3/1208 , G06F3/125 , G06F3/1257 , G06F3/1285
摘要： A layout apparatus lays out a document by referencing personal information registered on a per user basis. Even if no particular print setting is input for a print job by a user, excellent prints customized for each user are thus provided.
摘要翻译：布局装置通过参考在每个用户基础上注册的个人信息来布置文档。即使用户没有为打印作业输入特定的打印设置，因此提供了为每个用户定制的优秀打印。

5. 发明授权

US07732133B2 Screening methods for biologically active ligands 失效
标题翻译：生物活性配体的筛选方法
公开(公告)号：US07732133B2
公开(公告)日：2010-06-08
申请号：US10333103
申请日：2001-07-17
申请人： Naohiro Yabuta , Hideki Adachi , Yasushi Shimonaka , Kunihiro Hattori
发明人： Naohiro Yabuta , Hideki Adachi , Yasushi Shimonaka , Kunihiro Hattori
IPC分类号： G01Q1/68 , G01Q33/53 , G01N33/566 , C12P21/04 , C12N15/00
CPC分类号： G01N33/566 , G01N2500/00
摘要： In the case when there are two objective biological activities, and the aim is to isolate a compound having at least one biological activity, the present inventors developed an assay method wherein a common detection marker is utilized for separately detecting the presence or absence of each of the biological activities. The present inventors discovered that a compound having at least one of two or more distinct biological activities can be efficiently and conveniently detected by simultaneously assaying at least one test sample or more by the above-mentioned method. Furthermore, for a test sample that proved to be positive by the detection method, they found that it is possible to efficiently and conveniently screen for a test sample having an objective specific biological activity by combining with a method wherein an individual activity of a test sample can be detected to specify the biological activity.
摘要翻译：在存在两个目标生物活性的情况下，目的是分离具有至少一种生物活性的化合物时，本发明人开发了一种测定方法，其中使用常见的检测标记来分别检测每种化合物的存在或不存在生物活动。本发明人发现通过上述方法同时测定至少一种测试样品，可有效地方便地检测具有两种或更多种不同生物活性中至少一种的化合物。此外，对于通过检测方法证实为阳性的测试样品，他们发现可以通过结合其中测试样品的单独活性的方法有效和方便地筛选具有客观特异性生物活性的测试样品可以检测到指定生物活性。

6. 发明授权

US07592502B2 Knock-in non-human animal producing human tissue factor 失效
标题翻译：敲入非人类动物产生人体组织因子
公开(公告)号：US07592502B2
公开(公告)日：2009-09-22
申请号：US10478058
申请日：2002-05-17
申请人： Kiyoshi Habu , Kou-ichi Jishage , Hideki Adachi , Naohiro Yabuta
发明人： Kiyoshi Habu , Kou-ichi Jishage , Hideki Adachi , Naohiro Yabuta
IPC分类号： A01K67/027 , C12N15/00 , C12N15/87 , C12N5/00 , C12N5/02
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N2800/30
摘要： A non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor, said animal having a genome in which cDNA encoding human TF has been inserted upstream of the translation initiation codon for the non-human animal genomic TF gene.
摘要翻译：所述动物具有编码人TF的cDNA已被插入非人动物基因组的翻译起始密码子的上游的基因组，所述非人动物产生人组织因子（TF），而基本上不产生非人动物组织因子 TF基因。

7. 发明申请

US20050095887A1 Method of manufacturing connector for flat cable, connector for flat cable, and applying member for applying ultrasonic vibrations to be used for the same method 失效
标题翻译：制造扁平电缆连接器的方法，扁平电缆连接器和用于施加超声振动的施加部件用于相同的方法
公开(公告)号：US20050095887A1
公开(公告)日：2005-05-05
申请号：US10998546
申请日：2004-11-30
申请人： Hideki Adachi , Taro Imai
发明人： Hideki Adachi , Taro Imai
IPC分类号： B60R16/027 , B23K20/10 , H01R12/59 , H01R35/04 , H01R43/02 , H01R43/20 , H01R3/00
CPC分类号： B23K20/10 , B23K2101/32 , H01R12/592 , H01R43/0207 , Y10T29/49185 , Y10T29/4919 , Y10T29/49194 , Y10T29/49201
摘要： A first cable conductor portion is placed on a first connector terminal. The first cable conductor portion is accommodated in a pressing recessed portion formed in an applying member. Ultrasonic vibration is applied to the first cable conductor portion and the first connector terminal and the first cable conductor portion and the first connector terminal are pressed, and thereby to be welded to each other.
摘要翻译：第一电缆导体部分放置在第一连接器端子上。第一电缆导体部分容纳在形成在施加构件中的按压凹部中。对第一电缆导体部分施加超声波振动，并且第一连接器端子和第一电缆导体部分和第一连接器端子被按压，从而彼此焊接。

8. 发明授权

US06538871B2 Connecting structure of flat circuit member with reinforced connection boundary 有权
标题翻译：扁平电路构件与加强连接边界的连接结构
公开(公告)号：US06538871B2
公开(公告)日：2003-03-25
申请号：US09878340
申请日：2001-06-12
申请人： Hideki Adachi
发明人： Hideki Adachi
IPC分类号： H01H7300
CPC分类号： H01R12/62 , H01R4/02 , H01R35/025 , H05K3/281 , H05K3/363 , H05K2201/0394 , H05K2201/09063 , H05K2203/0455
摘要： In a connecting structure, an end portion (11A) of a flexible flat cable (FFC) (11), including a plurality of parallel connectors (12) held between base films (13 and 14), is joined by soldering to wiring terminal patterns (16) formed on a surface of a wiring board (15). The lower covering film (13), which is to be joined to the wiring terminal patterns (16) at the end portion (11A) of the FFC (11), is removed over a length corresponding to a region of soldering levelers (18) formed respectively on the wiring terminal patterns (16). The upper covering film (14) is removed at the end portion (11A) over a region closer to the end of the flat circuit member (11) than an end of the lower covering film (13), and covers part of the wiring terminal patterns (16).
摘要翻译：在连接结构中，包括保持在基膜（13和14）之间的多个平行连接器（12）的柔性扁平电缆（FFC）（11）的端部（11A）通过焊接连接到布线端子图案（16）形成在布线板（15）的表面上。要与FFC（11）的端部（11A）处的接线端子图案（16）接合的下覆盖膜（13）在对应于焊接矫直机（18）的区域的长度上被去除，分别形成在布线端子图案（16）上。上覆盖膜（14）在端部（11A）处比在下覆盖膜（13）的端部更靠近平坦电路部件（11）的端部的区域移除，并且覆盖部分布线端子图案（16）。

9. 发明授权

US06462834B1 Image processing system which forms two-color images 失效
标题翻译：形成双色图像的图像处理系统
公开(公告)号：US06462834B1
公开(公告)日：2002-10-08
申请号：US09019194
申请日：1998-02-05
申请人： Masahito Yamamoto , Hideki Adachi , Yoshiyuki Suzuki , Kazuhiko Hirooka , Hiroyuki Ichikawa , Tetsuya Nozaki
发明人： Masahito Yamamoto , Hideki Adachi , Yoshiyuki Suzuki , Kazuhiko Hirooka , Hiroyuki Ichikawa , Tetsuya Nozaki
IPC分类号： G06F1300
CPC分类号： H04N1/60
摘要： The color determination circuit 308 detects hue of the color image information, and the controller 205 decides a color component to be separated (separation color) in accordance with the detected hue. Output color by the printer 204 is set in correspondence with the separation color. The two-color-separating circuit 303 separates the color image information into image information on at least two color components in accordance with the decided separation colors. The separated image information on the each color is transmitted to the printer 204 via printer density correction circuits 304 and 305, and a buffer 306. Thereby it is possible to provide an image processing apparatus capable of setting and changing the separation color and the output color by automatic operation or by simple manual operation, thus the expression of the image forming can be improved.
摘要翻译：颜色确定电路308检测彩色图像信息的色调，并且控制器205根据检测到的色调来确定要分离的颜色分量（分离颜色）。打印机204的输出颜色与分离颜色对应地设定。双色分离电路303根据所确定的分离颜色将彩色图像信息分离成关于至少两个颜色分量的图像信息。通过打印机密度校正电路304和305以及缓冲器306将关于每种颜色的分离的图像信息发送到打印机204.由此，可以提供能够设置和改变分离颜色和输出颜色的图像处理装置通过自动操作或通过简单的手动操作，可以提高图像形成的表达。

10. 发明授权

US06393697B1 Method of manufacturing connector for flat cable 失效
标题翻译：制造扁平电缆连接器的方法
公开(公告)号：US06393697B1
公开(公告)日：2002-05-28
申请号：US09293770
申请日：1999-04-19
申请人： Hideki Adachi , Taro Imai
发明人： Hideki Adachi , Taro Imai
IPC分类号： H01R4300
CPC分类号： B23K20/10 , B23K2101/32 , H01R12/592 , H01R43/0207 , Y10T29/49185 , Y10T29/4919 , Y10T29/49194 , Y10T29/49201
摘要： A first cable conductor portion is placed on a first connector terminal. The first cable conductor portion is accommodated in a pressing recessed portion formed in an applying member. Ultrasonic vibration is applied to the first cable conductor portion and the first connector terminal and the first cable conductor portion and the first connector terminal are pressed, and thereby to be welded to each other.
摘要翻译：第一电缆导体部分放置在第一连接器端子上。第一电缆导体部分容纳在形成在施加构件中的按压凹部中。对第一电缆导体部分施加超声波振动，并且第一连接器端子和第一电缆导体部分和第一连接器端子被按压，从而彼此焊接。

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