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1. 发明授权

US08986524B2 DNA sequence using multiple metal layer structure with different organic coatings forming different transient bondings to DNA 有权
标题翻译： DNA序列使用多个金属层结构，不同的有机涂层与DNA形成不同的瞬时键合
公开(公告)号：US08986524B2
公开(公告)日：2015-03-24
申请号：US13359766
申请日：2012-01-27
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Philip S. Waggoner
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Stephen M. Rossnagel , Ajay K. Royyuru , Gustavo A. Stolovitzky , Philip S. Waggoner
IPC分类号： G01N27/447 , B82Y15/00 , G01N33/487 , C12Q1/68
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6869 , G01N27/44743 , G01N27/44791 , Y10S977/924 , C12Q2563/157
摘要： A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.
摘要翻译：纳米器件包括填充有导电流体的储存器和分离储存器的膜。通过具有由绝缘层分隔的电极层的膜形成纳米孔。某一电极层具有第一类型的有机涂层，并且一对电极层具有第二类型。第一类型的有机涂层形成运动控制瞬态键合到用于运动控制的纳米孔中的一个分子，而第二种类型形成与分子的基底的不同键合位点的第一和第二瞬态键。当对一对电极层施加电压时，由纳米孔中的基底产生隧穿电流，并且隧穿电流通过形成为要测量的第一和第二瞬态键作为用于区分基底的当前签名行进。运动控制瞬态键比第一和第二瞬态键强。

2. 发明授权

US08828138B2 FET nanopore sensor 有权
标题翻译： FET纳米孔传感器
公开(公告)号：US08828138B2
公开(公告)日：2014-09-09
申请号：US12781514
申请日：2010-05-17
申请人： Stephen W. Bedell , Christopher D'Emic , Hongbo Peng , Sufi Zafar
发明人： Stephen W. Bedell , Christopher D'Emic , Hongbo Peng , Sufi Zafar
IPC分类号： C30B1/06 , G01N27/414 , B82Y15/00
CPC分类号： B82Y15/00 , G01N27/02 , G01N27/4145 , G01N33/48721
摘要： A method of using a sensor comprising a field effect transistor (FET) embedded in a nanopore includes placing the sensor in an electrolyte comprising at least one of biomolecules and deoxyribonucleic acid (DNA); placing an electrode in the electrolyte; applying a gate voltage in the sub-threshold regime to the electrode; applying a drain voltage to a drain of the FET; applying a source voltage to a source of the FET; detecting a change in a drain current in the sensor in response to the at least one of biomolecules and DNA passing through the nanopore.
摘要翻译：使用包含嵌入在纳米孔中的场效应晶体管（FET）的传感器的方法包括将传感器放置在包含生物分子和脱氧核糖核酸（DNA）中的至少一种的电解质中; 将电极放置在电解质中; 将所述子阈值状态中的栅极电压施加到所述电极; 将漏极电压施加到FET的漏极; 将源电压施加到FET的源极; 响应于生物分子和通过纳米孔的DNA中的至少一个，检测传感器中的漏极电流的变化。

3. 发明授权

US08764968B2 DNA sequencing using multiple metal layer structure with organic coatings forming transient bonding to DNA bases 有权
标题翻译：使用多层金属层结构进行DNA测序，其中有机涂层形成与DNA碱基的瞬时键合
公开(公告)号：US08764968B2
公开(公告)日：2014-07-01
申请号：US13607070
申请日：2012-09-07
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Gustavo A. Stolovitzky , Philip S. Waggoner , George F. Walker
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stephen M. Rossnagel , Gustavo A. Stolovitzky , Philip S. Waggoner , George F. Walker
IPC分类号： G01N27/327
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2563/116 , C12Q2563/157 , C12Q2565/607 , C12Q2565/631
摘要： A technique for nanodevice is provided. A reservoir is filled with an ionic fluid. A membrane separates the reservoir, and the membrane includes electrode layers separated by insulating layers in which the electrode layers have an organic coating. A nanopore is formed through the membrane, and the organic coating on the electrode layers forms transient bonds to a base of a molecule in the nanopore. When a first voltage is applied to the electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels through the transient bonds formed to the base to be measured as a current signature for distinguishing the base.
摘要翻译：提供了一种纳米设备技术。储存器充满离子流体。膜分离储存器，并且膜包括由绝缘层分离的电极层，其中电极层具有有机涂层。通过膜形成纳米孔，并且电极层上的有机涂层与纳米孔中分子的碱基形成瞬态键。当向电极层施加第一电压时，通过纳米孔中的基底产生隧道电流，并且隧道电流通过形成到待测量的基极的瞬态键作为用于区分基极的电流特征行进。

4. 发明授权

US08691067B2 Charged entities as locomotive to control motion of polymers through a nanochannel 有权
标题翻译：充电实体作为机车，以控制聚合物通过纳米通道的运动
公开(公告)号：US08691067B2
公开(公告)日：2014-04-08
申请号：US13234276
申请日：2011-09-16
申请人： Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen M. Rossnagel , Ajay k. Royyuru , Gustavo A. Stolovitzky , George F. Walker
发明人： Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen M. Rossnagel , Ajay k. Royyuru , Gustavo A. Stolovitzky , George F. Walker
IPC分类号： G01N27/26
CPC分类号： B82Y15/00 , C12Q1/6869 , C12Q2565/631
摘要： A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the nanochannel. An array of electrodes is positioned along the nanochannel, where fluid fills the first reservoir, the second reservoir, and the nanochannel. A first electrode is in the first reservoir and a second electrode is in the second reservoir. The first and second electrodes are configured to direct the one or more charged entities linked to the polymer into the nanochannel. An array of electrodes is configured to trap the one or more charged entities in the nanochannel responsive to being controlled for trapping. The array of electrodes is configured to move the one or more charged entities along the nanochannel responsive to being controlled for moving.
摘要翻译：提供了一种用于控制通过纳米通道连接到聚合物的一个或多个带电实体的运动的技术。第一储存器和第二储存器通过纳米通道连接。电极阵列沿纳米通道定位，其中流体填充第一储存器，第二储存器和纳米通道。第一电极在第一储存器中，第二电极位于第二储存器中。第一和第二电极被配置为将连接到聚合物的一个或多个带电实体引导到纳米通道中。电极阵列被配置为捕捉纳米通道中的一个或多个带电实体，以响应于被捕获而被控制。电极阵列被配置为响应于被控制移动而沿着纳米通道移动一个或多个带电实体。

5. 发明授权

US08603303B2 Nanopore based device for cutting long DNA molecules into fragments 有权
标题翻译：用于将长DNA分子切割成片段的基于纳米孔的装置
公开(公告)号：US08603303B2
公开(公告)日：2013-12-10
申请号：US12723842
申请日：2010-03-15
申请人： Binquan Luan , Glenn J. Martyna , Hongbo Peng , Gustavo A. Stolovitsky
发明人： Binquan Luan , Glenn J. Martyna , Hongbo Peng , Gustavo A. Stolovitsky
IPC分类号： C07H21/04 , B01J19/08
CPC分类号： B82Y15/00 , C12Q1/6806 , C12Q2523/303 , C12Q2565/631
摘要： Apparatus, system, and method are provided for cutting a linear charged polymer inside a nanopore. A first voltage is applied to create an electric field in a first direction. A second voltage is applied to create an electric field in a second direction, and the first direction is opposite to the second direction. When the electric field in the first direction and the electric field in the second direction are applied to a linear charged polymer inside a nanopore, the linear charged polymer is cut at a location with predetermined accuracy.
摘要翻译：提供了用于在纳米孔内切割线性带电聚合物的装置，系统和方法。施加第一电压以在第一方向上产生电场。施加第二电压以在第二方向上产生电场，并且第一方向与第二方向相反。当将第一方向的电场和第二方向的电场施加到纳米孔内的线性带电聚合物时，线性带电聚合物在预定精度的位置被切割。

6. 发明授权

US08557529B2 Nanopore capture system 有权
标题翻译：纳米捕获系统
公开(公告)号：US08557529B2
公开(公告)日：2013-10-15
申请号：US12757433
申请日：2010-04-09
申请人： Stanislav Polonsky , Ali Afzali-Ardakani , Hongbo Peng , Gustavo A. Stolovitzky , Ajay A. Royyuru , Mark N. Wegman
发明人： Stanislav Polonsky , Ali Afzali-Ardakani , Hongbo Peng , Gustavo A. Stolovitzky , Ajay A. Royyuru , Mark N. Wegman
IPC分类号： C12Q1/68
CPC分类号： G01N33/48721 , G01N33/54373
摘要： A nanopore capture system may include a material configured to pass through a nanopore device in a controlled manner based upon its interaction with the nanopore device. The system may also include a capture mechanism connected to one end of the material. The capture mechanism may be configured to catch a particular type of molecule while ignoring other types of molecules. The system may also include a controller to manipulate and/or detect the particular type of molecule.
摘要翻译：纳米孔捕获系统可以包括配置为基于其与纳米孔装置的相互作用以受控方式穿过纳米孔装置的材料。系统还可以包括连接到材料的一端的捕获机构。捕获机制可以被配置为捕获特定类型的分子，同时忽略其它类型的分子。该系统还可以包括操纵和/或检测特定类型的分子的控制器。

7. 发明申请

US20130263946A1 FUNCTIONALLY SWITCHABLE SELF-ASSEMBLED COATING COMPOUND FOR CONTROLLING TRANSLOCATION OF MOLECULE THROUGH NANOPORES 审中-公开
标题翻译：功能可切换的自组装涂料化合物，用于控制通过纳米光子转移分子
公开(公告)号：US20130263946A1
公开(公告)日：2013-10-10
申请号：US13439265
申请日：2012-04-04
申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
发明人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
IPC分类号： F03B11/02
CPC分类号： B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N27/00 , Y10T137/8593
摘要： A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.
摘要翻译：提供了一种纳米设备的技术。纳米器件包括流体细胞和分离流体细胞的膜。通过膜形成纳米孔，并且纳米孔涂覆有机化合物。有机化合物的第一部分与纳米孔的表面结合，并且有机化合物的第二部分在纳米孔内自由地暴露。有机化合物的第二部分被配置为基于切换机制在第一中性亲水端基，第二带负电荷亲水端基和第三中性疏水端基之间切换。

8. 发明授权

US08491769B2 Embedding a nanotube inside a nanopore for DNA translocation 有权
标题翻译：在纳米孔内嵌入纳米管用于DNA易位
公开(公告)号：US08491769B2
公开(公告)日：2013-07-23
申请号：US13611701
申请日：2012-09-12
申请人： Ali Afzali-Ardakani , Binquan Luan , Hongbo Peng
发明人： Ali Afzali-Ardakani , Binquan Luan , Hongbo Peng
IPC分类号： G01N27/26 , B82Y40/00
CPC分类号： B82Y30/00 , B82Y40/00 , C12Q1/6869 , C25D3/665 , C25D5/028 , C25D13/04 , G01N33/48721
摘要： A technique for embedding a nanotube in a nanopore is provided. A membrane separates a reservoir into a first reservoir part and a second reservoir part, and the nanopore is formed through the membrane for connecting the first and second reservoir parts. An ionic fluid fills the nanopore, the first reservoir part, and the second reservoir part. A first electrode is dipped in the first reservoir part, and a second electrode is dipped in the second reservoir part. Driving the nanotube into the nanopore causes an inner surface of the nanopore to form a covalent bond to an outer surface of the nanotube via an organic coating so that the inner surface of the nanotube will be the new nanopore with a super smooth surface for studying bio-molecules while they translocate through the nanotube.
摘要翻译：提供了一种在纳米孔中嵌入纳米管的技术。膜将储存器分离成第一储存部分和第二储存部分，并且纳米孔通过膜形成，用于连接第一和第二储存部分。离子流体填充纳米孔，第一储存部分和第二储存部分。将第一电极浸入第一储存部分中，将第二电极浸入第二储存部分。将纳米管驱动到纳米孔中导致纳米孔的内表面通过有机涂层与纳米管的外表面形成共价键，使得纳米管的内表面将成为具有超光滑表面的新纳米孔，用于研究生物分子，同时它们转移通过纳米管。

9. 发明授权

US08448790B2 Surface charge enabled nanoporous semi-permeable membrane for desalination 有权
标题翻译：表面电荷使纳米多孔半透膜脱盐
公开(公告)号：US08448790B2
公开(公告)日：2013-05-28
申请号：US13534855
申请日：2012-06-27
申请人： John M. Cotte , Christopher V. Jahnes , Hongbo Peng , Stephen M. Rossnagel
发明人： John M. Cotte , Christopher V. Jahnes , Hongbo Peng , Stephen M. Rossnagel
IPC分类号： B01D71/02 , B01D69/00 , B05D1/00 , B05D3/00 , C25B7/00
CPC分类号： B01D67/0065 , B01D71/022 , B01D2323/283 , B01D2325/021 , Y10T428/249953
摘要： A filter includes a membrane having a plurality of nanochannels formed therein. A first surface charge material is deposited on an end portion of the nanochannels. The first surface charge material includes a surface charge to electrostatically influence ions in an electrolytic solution such that the nanochannels reflect ions back into the electrolytic solution while passing a fluid of the electrolytic solution. Methods for making and using the filter are also provided.
摘要翻译：过滤器包括其中形成有多个纳米通道的膜。第一表面电荷材料沉积在纳米通道的端部上。第一表面电荷材料包括静电地影响电解溶液中的离子的表面电荷，使得纳米通道在通过电解液的流体时将离子反射回电解溶液。还提供了制造和使用过滤器的方法。

10. 发明授权

US08354336B2 Forming an electrode having reduced corrosion and water decomposition on surface using an organic protective layer 失效
标题翻译：使用有机保护层形成表面上具有降低的腐蚀和水分解的电极
公开(公告)号：US08354336B2
公开(公告)日：2013-01-15
申请号：US12820543
申请日：2010-06-22
申请人： Ali Afzali-Ardakani , Shafaat Ahmed , Hariklia Deligianni , Dario L. Goldfarb , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Xiaoyan Shao , Gustavo A. Stolovitzky
发明人： Ali Afzali-Ardakani , Shafaat Ahmed , Hariklia Deligianni , Dario L. Goldfarb , Stefan Harrer , Binquan Luan , Glenn J. Martyna , Hongbo Peng , Stanislav Polonsky , Stephen Rossnagel , Xiaoyan Shao , Gustavo A. Stolovitzky
IPC分类号： H01L21/28 , H01L21/3205
CPC分类号： B82Y10/00 , H01L21/76834 , H01L29/0665 , H01L51/0093 , H01L51/0504 , H01L51/102
摘要： Accordingly, the present invention provides a method of forming an electrode having reduced corrosion and water decomposition on a surface thereof. A substrate which has a conductive layer disposed thereon is provided and the conductive layer has an oxide layer with an exposed surface. The exposed surface of the oxide layer contacts a solution of an organic surface active compound in an organic solvent to form a protective layer of the organic surface active compound over the oxide layer. The protective layer has a thickness of from about 0.5 nm to about 5 nm and ranges therebetween depending on a chemical structure of the surface active compound.
摘要翻译：因此，本发明提供一种在其表面上形成具有降低的腐蚀和水分解的电极的方法。提供了具有设置在其上的导电层的衬底，并且导电层具有具有暴露表面的氧化物层。氧化物层的暴露表面接触有机表面活性化合物在有机溶剂中的溶液，以在氧化物层上形成有机表面活性化合物的保护层。根据表面活性化合物的化学结构，保护层的厚度为约0.5nm至约5nm，并且其范围。

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